Result of FASTA (omim) for
pFN21AE4420
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4420, 435 aa
1>>>pF1KE4420 435 - 435 aa - 435 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3218+/-0.000358; mu= 17.5618+/- 0.022
mean_var=71.4104+/-14.507, 0's: 0 Z-trim(114.9): 27 B-trim: 934 in 1/52
Lambda= 0.151773
statistics sampled from 25031 (25058) to 25031 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.669), E-opt: 0.2 (0.294), width: 16
Scan time: 8.130
The best scores are: opt bits E(85289)
XP_011531971 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 3080 683.6 2.6e-196
NP_695013 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 3080 683.6 2.6e-196
XP_011531970 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 3080 683.6 2.6e-196
XP_011531969 (OMIM: 601492,607071) PREDICTED: hyal ( 435) 3080 683.6 2.6e-196
NP_149349 (OMIM: 601492,607071) hyaluronidase-1 is ( 435) 3080 683.6 2.6e-196
NP_695014 (OMIM: 601492,607071) hyaluronidase-1 is ( 405) 2137 477.1 3.6e-134
NP_695015 (OMIM: 601492,607071) hyaluronidase-1 is ( 253) 1786 400.1 3.3e-111
NP_695017 (OMIM: 601492,607071) hyaluronidase-1 is ( 176) 1222 276.5 3.7e-74
NP_036401 (OMIM: 604510) hyaluronidase-4 [Homo sap ( 481) 1205 273.1 1.1e-72
XP_011514292 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 1205 273.1 1.1e-72
XP_016867400 (OMIM: 604510) PREDICTED: hyaluronida ( 481) 1205 273.1 1.1e-72
XP_005265582 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1183 268.3 3.1e-71
NP_003764 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1183 268.3 3.1e-71
NP_149348 (OMIM: 603551) hyaluronidase-2 precursor ( 473) 1183 268.3 3.1e-71
XP_005265581 (OMIM: 603551) PREDICTED: hyaluronida ( 473) 1183 268.3 3.1e-71
NP_001167516 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 1130 256.7 1e-67
NP_694859 (OMIM: 600930) hyaluronidase PH-20 isofo ( 509) 1130 256.7 1e-67
NP_001167515 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 1130 256.7 1e-67
NP_001167517 (OMIM: 600930) hyaluronidase PH-20 is ( 509) 1130 256.7 1e-67
NP_003108 (OMIM: 600930) hyaluronidase PH-20 isofo ( 511) 1130 256.7 1e-67
NP_001186958 (OMIM: 604038) hyaluronidase-3 isofor ( 417) 1056 240.4 6.6e-63
NP_003540 (OMIM: 604038) hyaluronidase-3 isoform 1 ( 417) 1056 240.4 6.6e-63
XP_011514293 (OMIM: 604510) PREDICTED: hyaluronida ( 451) 862 198.0 4.3e-50
NP_001186959 (OMIM: 604038) hyaluronidase-3 isofor ( 387) 805 185.4 2.2e-46
NP_001186960 (OMIM: 604038) hyaluronidase-3 isofor ( 168) 375 91.1 2.4e-18
NP_001186961 (OMIM: 604038) hyaluronidase-3 isofor ( 138) 181 48.5 1.3e-05
>>XP_011531971 (OMIM: 601492,607071) PREDICTED: hyaluron (435 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 3645.3 bits: 683.6 E(85289): 2.6e-196
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)
10 20 30 40 50 60
pF1KE4 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
370 380 390 400 410 420
430
pF1KE4 YPGWQAPWCERKSMW
:::::::::::::::
XP_011 YPGWQAPWCERKSMW
430
>>NP_695013 (OMIM: 601492,607071) hyaluronidase-1 isofor (435 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 3645.3 bits: 683.6 E(85289): 2.6e-196
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)
10 20 30 40 50 60
pF1KE4 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
370 380 390 400 410 420
430
pF1KE4 YPGWQAPWCERKSMW
:::::::::::::::
NP_695 YPGWQAPWCERKSMW
430
>>XP_011531970 (OMIM: 601492,607071) PREDICTED: hyaluron (435 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 3645.3 bits: 683.6 E(85289): 2.6e-196
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)
10 20 30 40 50 60
pF1KE4 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
370 380 390 400 410 420
430
pF1KE4 YPGWQAPWCERKSMW
:::::::::::::::
XP_011 YPGWQAPWCERKSMW
430
>>XP_011531969 (OMIM: 601492,607071) PREDICTED: hyaluron (435 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 3645.3 bits: 683.6 E(85289): 2.6e-196
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)
10 20 30 40 50 60
pF1KE4 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
370 380 390 400 410 420
430
pF1KE4 YPGWQAPWCERKSMW
:::::::::::::::
XP_011 YPGWQAPWCERKSMW
430
>>NP_149349 (OMIM: 601492,607071) hyaluronidase-1 isofor (435 aa)
initn: 3080 init1: 3080 opt: 3080 Z-score: 3645.3 bits: 683.6 E(85289): 2.6e-196
Smith-Waterman score: 3080; 100.0% identity (100.0% similar) in 435 aa overlap (1-435:1-435)
10 20 30 40 50 60
pF1KE4 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_149 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
370 380 390 400 410 420
430
pF1KE4 YPGWQAPWCERKSMW
:::::::::::::::
NP_149 YPGWQAPWCERKSMW
430
>>NP_695014 (OMIM: 601492,607071) hyaluronidase-1 isofor (405 aa)
initn: 2894 init1: 2137 opt: 2137 Z-score: 2529.8 bits: 477.1 E(85289): 3.6e-134
Smith-Waterman score: 2812; 93.1% identity (93.1% similar) in 435 aa overlap (1-435:1-405)
10 20 30 40 50 60
pF1KE4 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 MAAHLLPICALFLTLLDMAQGFRGPLLPNRPFTTVWNANTQWCLERHGVDVDVSVFDVVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 NPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIAHLARTFQDILAAIPAP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 DFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPAPQVEAVAQDQFQGAAR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 AWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSGIRAQNDQLGWLWGQSR
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 ALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQIFYDTTNHFLPL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFILNVTSGALLCSQ
::::::::::::::::::::::::::::::
NP_695 ------------------------------ESCQAIKEYMDTTLGPFILNVTSGALLCSQ
310 320 330
370 380 390 400 410 420
pF1KE4 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 ALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQAQMAVEFKCRC
340 350 360 370 380 390
430
pF1KE4 YPGWQAPWCERKSMW
:::::::::::::::
NP_695 YPGWQAPWCERKSMW
400
>>NP_695015 (OMIM: 601492,607071) hyaluronidase-1 isofor (253 aa)
initn: 1786 init1: 1786 opt: 1786 Z-score: 2117.4 bits: 400.1 E(85289): 3.3e-111
Smith-Waterman score: 1786; 100.0% identity (100.0% similar) in 253 aa overlap (183-435:1-253)
160 170 180 190 200 210
pF1KE4 ALVQAQHPDWPAPQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDF
::::::::::::::::::::::::::::::
NP_695 MAGTLQLGRALRPRGLWGFYGFPDCYNYDF
10 20 30
220 230 240 250 260 270
pF1KE4 LSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 LSPNYTGQCPSGIRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRV
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE4 AVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 AVAAGDPNLPVLPYVQIFYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKES
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE4 CQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 CQAIKEYMDTTLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLT
160 170 180 190 200 210
400 410 420 430
pF1KE4 PGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
:::::::::::::::::::::::::::::::::::::::::::
NP_695 PGGGPLSLRGALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
220 230 240 250
>>NP_695017 (OMIM: 601492,607071) hyaluronidase-1 isofor (176 aa)
initn: 1222 init1: 1222 opt: 1222 Z-score: 1452.3 bits: 276.5 E(85289): 3.7e-74
Smith-Waterman score: 1222; 100.0% identity (100.0% similar) in 176 aa overlap (260-435:1-176)
230 240 250 260 270 280
pF1KE4 DQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVAVAAGDPNLPVLPYVQI
::::::::::::::::::::::::::::::
NP_695 MYVQHRVAEAFRVAVAAGDPNLPVLPYVQI
10 20 30
290 300 310 320 330 340
pF1KE4 FYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 FYDTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDTTLGPFIL
40 50 60 70 80 90
350 360 370 380 390 400
pF1KE4 NVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_695 NVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRGALSLEDQ
100 110 120 130 140 150
410 420 430
pF1KE4 AQMAVEFKCRCYPGWQAPWCERKSMW
::::::::::::::::::::::::::
NP_695 AQMAVEFKCRCYPGWQAPWCERKSMW
160 170
>>NP_036401 (OMIM: 604510) hyaluronidase-4 [Homo sapiens (481 aa)
initn: 1129 init1: 815 opt: 1205 Z-score: 1425.8 bits: 273.1 E(85289): 1.1e-72
Smith-Waterman score: 1205; 41.4% identity (68.8% similar) in 430 aa overlap (4-429:18-446)
10 20 30 40
pF1KE4 MAAHLLPICALFLTLLDMA--QGFRGPLLPNRPFTTVWNANTQWCL
:: .:. : ... . : :. .:: ..::: :. ::
NP_036 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQCL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 ERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIA
.... .....: :...: :: ..:::: ..:: ::.:: : :. :::::: :: .
NP_036 IKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQGVPINGGLPQNISLQV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 HLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPA
:: .. ::: ::: ::::::::::: :::.:: ::..::.:::.:: :.. . . :
NP_036 HLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNVSA
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 PQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSG
..: .:. :. .:.:.: :..:: ::.::::.: .:::.::. .:::.:.::
NP_036 TDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCPED
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 IRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVA-VAAGDPNLPV
.:..:.:::..: :::::: . : . . . . :: :..:.. ... : :::
NP_036 EVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYALPV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 LPYVQIFY-DTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDT
. :... : : :: ..: ..::::: ::::.:.: . . : .: .: .:.....
NP_036 FVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFVSS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 TLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRG
:: .: ::: .: .:: :: ..:::.:. . . : :::::. :. . : ....:
NP_036 DLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDG-EFTVKG
370 380 390 400 410
410 420 430
pF1KE4 ALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
: : : :: :.:.:: :... :
NP_036 KASDTDLAVMADTFSCHCYQGYEGADCREIKTADGCSGVSPSPGSLMTLCLLLLASYRSI
420 430 440 450 460 470
>>XP_011514292 (OMIM: 604510) PREDICTED: hyaluronidase-4 (481 aa)
initn: 1129 init1: 815 opt: 1205 Z-score: 1425.8 bits: 273.1 E(85289): 1.1e-72
Smith-Waterman score: 1205; 41.4% identity (68.8% similar) in 430 aa overlap (4-429:18-446)
10 20 30 40
pF1KE4 MAAHLLPICALFLTLLDMA--QGFRGPLLPNRPFTTVWNANTQWCL
:: .:. : ... . : :. .:: ..::: :. ::
XP_011 MKVLSEGQLKLCVVQPVHLTSWLLIFFILKSISCLKPARLPIYQRKPFIAAWNAPTDQCL
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 ERHGVDVDVSVFDVVANPGQTFRGPDMTIFYSSQLGTYPYYTPTGEPVFGGLPQNASLIA
.... .....: :...: :: ..:::: ..:: ::.:: : :. :::::: :: .
XP_011 IKYNLRLNLKMFPVIGSPLAKARGQNVTIFYVNRLGYYPWYTSQGVPINGGLPQNISLQV
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 HLARTFQDILAAIPAPDFSGLAVIDWEAWRPRWAFNWDTKDIYRQRSRALVQAQHPDWPA
:: .. ::: ::: ::::::::::: :::.:: ::..::.:::.:: :.. . . :
XP_011 HLEKADQDINYYIPAEDFSGLAVIDWEYWRPQWARNWNSKDVYRQKSRKLISDMGKNVSA
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 PQVEAVAQDQFQGAARAWMAGTLQLGRALRPRGLWGFYGFPDCYNYDFLSPNYTGQCPSG
..: .:. :. .:.:.: :..:: ::.::::.: .:::.::. .:::.:.::
XP_011 TDIEYLAKVTFEESAKAFMKETIKLGIKSRPKGLWGYYLYPDCHNYNVYAPNYSGSCPED
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 IRAQNDQLGWLWGQSRALYPSIYMPAVLEGTGKSQMYVQHRVAEAFRVA-VAAGDPNLPV
.:..:.:::..: :::::: . : . . . . :: :..:.. ... : :::
XP_011 EVLRNNELSWLWNSSAALYPSIGVWKSLGDSENILRFSKFRVHESMRISTMTSHDYALPV
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE4 LPYVQIFY-DTTNHFLPLDELEHSLGESAAQGAAGVVLWVSWENTRTKESCQAIKEYMDT
. :... : : :: ..: ..::::: ::::.:.: . . : .: .: .:.....
XP_011 FVYTRLGYRDEPLFFLSKQDLVSTIGESAALGAAGIVIWGDMNLTASKANCTKVKQFVSS
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE4 TLGPFILNVTSGALLCSQALCSGHGRCVRRTSHPKALLLLNPASFSIQLTPGGGPLSLRG
:: .: ::: .: .:: :: ..:::.:. . . : :::::. :. . : ....:
XP_011 DLGSYIANVTRAAEVCSLHLCRNNGRCIRKMWNAPSYLHLNPASYHIEASEDG-EFTVKG
370 380 390 400 410
410 420 430
pF1KE4 ALSLEDQAQMAVEFKCRCYPGWQAPWCERKSMW
: : : :: :.:.:: :... :
XP_011 KASDTDLAVMADTFSCHCYQGYEGADCREIKTADGCSGVSPSPGSLMTLCLLLLASYRSI
420 430 440 450 460 470
435 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:13:42 2016 done: Sun Nov 6 01:13:43 2016
Total Scan time: 8.130 Total Display time: 0.050
Function used was FASTA [36.3.4 Apr, 2011]