Result of FASTA (omim) for
pFN21AE4406
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4406, 421 aa
1>>>pF1KE4406 421 - 421 aa - 421 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9098+/-0.000412; mu= 18.9604+/- 0.025
mean_var=54.5201+/-11.049, 0's: 0 Z-trim(109.2): 59 B-trim: 86 in 1/53
Lambda= 0.173698
statistics sampled from 17249 (17315) to 17249 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.563), E-opt: 0.2 (0.203), width: 16
Scan time: 6.160
The best scores are: opt bits E(85289)
NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 2801 710.3 2.3e-204
NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 2783 705.8 5.3e-203
NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 2517 639.1 5.6e-183
NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 2150 547.2 3.1e-155
NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 1509 386.4 4e-107
NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 895 232.7 1.4e-60
NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 832 216.9 8e-56
NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 793 207.1 6.8e-53
XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 782 204.3 4.5e-52
NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 780 203.8 6.6e-52
XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 753 197.1 7.3e-50
XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 753 197.1 7.6e-50
XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 753 197.1 7.6e-50
NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 744 194.8 2.8e-49
NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 734 192.3 1.9e-48
NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 731 191.6 4.5e-48
XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 720 188.8 2.1e-47
NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 720 188.8 2.2e-47
NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 709 186.0 1.4e-46
XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 709 186.1 1.5e-46
XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 709 186.1 1.6e-46
XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 669 176.0 1.5e-43
XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 669 176.0 1.5e-43
XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 653 172.1 2.8e-42
XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 647 170.6 8.7e-42
XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 644 169.8 1.3e-41
NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 636 167.8 6.3e-41
NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 636 167.8 6.8e-41
NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 636 167.9 7e-41
XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 636 167.9 7e-41
NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 636 167.9 7.2e-41
XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 632 166.8 1.3e-40
XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 632 166.8 1.3e-40
XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 593 156.9 7.1e-38
XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 588 155.7 1.6e-37
XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 582 154.3 6.7e-37
XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 573 152.0 3e-36
XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 573 152.0 3e-36
XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 571 151.5 3.8e-36
XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 566 150.2 9.6e-36
XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 559 148.4 2.2e-35
XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 548 145.7 1.8e-34
XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 522 139.2 1.7e-32
NP_000150 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 438) 489 130.9 6.1e-30
XP_005271562 (OMIM: 604773,611283) PREDICTED: isob ( 249) 470 126.1 1e-28
XP_016873038 (OMIM: 604773,611283) PREDICTED: isob ( 249) 470 126.1 1e-28
XP_016873037 (OMIM: 604773,611283) PREDICTED: isob ( 268) 470 126.1 1.1e-28
XP_011526201 (OMIM: 231670,608801) PREDICTED: glut ( 446) 463 124.4 5.6e-28
NP_039663 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 428) 455 122.4 2.2e-27
XP_006722784 (OMIM: 231670,608801) PREDICTED: glut ( 442) 455 122.4 2.2e-27
>>NP_000007 (OMIM: 201450,607008) medium-chain specific (421 aa)
initn: 2801 init1: 2801 opt: 2801 Z-score: 3790.0 bits: 710.3 E(85289): 2.3e-204
Smith-Waterman score: 2801; 99.8% identity (100.0% similar) in 421 aa overlap (1-421:1-421)
10 20 30 40 50 60
pF1KE4 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 DEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEAT
:::::::::::::::::::::::::::::::::::::::::::::::.::::::::::::
NP_000 GQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEAT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 KYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 KYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK
370 380 390 400 410 420
pF1KE4 N
:
NP_000 N
>>NP_001120800 (OMIM: 201450,607008) medium-chain specif (425 aa)
initn: 2721 init1: 2721 opt: 2783 Z-score: 3765.6 bits: 705.8 E(85289): 5.3e-203
Smith-Waterman score: 2783; 98.8% identity (99.1% similar) in 425 aa overlap (1-421:1-425)
10 20 30 40 50
pF1KE4 MAAGFGRCCR----VLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFA
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAGFGRCCRCSLQVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFA
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 REEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRAL
:::::::::::::::::::::::::::::::::::::::::::::::::::.::::::::
NP_001 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRAL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI
370 380 390 400 410 420
420
pF1KE4 DKYKN
:::::
NP_001 DKYKN
>>NP_001272971 (OMIM: 201450,607008) medium-chain specif (385 aa)
initn: 2517 init1: 2517 opt: 2517 Z-score: 3406.0 bits: 639.1 E(85289): 5.6e-183
Smith-Waterman score: 2517; 99.7% identity (100.0% similar) in 382 aa overlap (40-421:4-385)
10 20 30 40 50 60
pF1KE4 RVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDK
::::::::::::::::::::::::::::::
NP_001 MLQEFTEQQKEFQATARKFAREEIIPVAAEYDK
10 20 30
70 80 90 100 110 120
pF1KE4 TGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLG
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 QMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQK
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 MWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRG
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 IVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATKYALERKTF
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_001 IVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTF
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE4 GKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLA
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE4 TDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
340 350 360 370 380
>>NP_001272972 (OMIM: 201450,607008) medium-chain specif (454 aa)
initn: 2143 init1: 2143 opt: 2150 Z-score: 2907.9 bits: 547.2 E(85289): 3.1e-155
Smith-Waterman score: 2718; 92.5% identity (92.7% similar) in 453 aa overlap (2-421:2-454)
10 20 30 40 50 60
pF1KE4 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEI
10 20 30 40 50 60
70 80 90
pF1KE4 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENC-------------------------
:::::::::::::::::::::::::::::::::::
NP_001 IPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCDYSVCPLLEACTLYLDAFFLLLTGS
70 80 90 100 110 120
100 110 120 130 140
pF1KE4 --------GGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLG
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLNLHLNLGGLGLGTFDACLISEELAYGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLG
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 RMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARS
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 DPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE4 AGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMA
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
NP_001 AGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMA
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE4 MKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPV
370 380 390 400 410 420
390 400 410 420
pF1KE4 EKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
::::::::::::::::::::::::::::::::::
NP_001 EKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
430 440 450
>>NP_001272973 (OMIM: 201450,607008) medium-chain specif (232 aa)
initn: 1509 init1: 1509 opt: 1509 Z-score: 2044.2 bits: 386.4 E(85289): 4e-107
Smith-Waterman score: 1509; 99.6% identity (100.0% similar) in 232 aa overlap (190-421:1-232)
160 170 180 190 200 210
pF1KE4 VTEPGAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAF
::::::::::::::::::::::::::::::
NP_001 MWITNGGKANWYFLLARSDPDPKAPANKAF
10 20 30
220 230 240 250 260 270
pF1KE4 TGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGFIVEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDK
40 50 60 70 80 90
280 290 300 310 320 330
pF1KE4 TRPVVAAGVVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQR
::::::::.:::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TRPVVAAGAVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQR
100 110 120 130 140 150
340 350 360 370 380 390
pF1KE4 AAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AAWEVDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQI
160 170 180 190 200 210
400 410 420
pF1KE4 YEGTSQIQRLIVAREHIDKYKN
::::::::::::::::::::::
NP_001 YEGTSQIQRLIVAREHIDKYKN
220 230
>>NP_000008 (OMIM: 201470,606885) short-chain specific a (412 aa)
initn: 720 init1: 543 opt: 895 Z-score: 1208.8 bits: 232.7 E(85289): 1.4e-60
Smith-Waterman score: 898; 37.2% identity (66.7% similar) in 411 aa overlap (13-421:15-412)
10 20 30 40 50
pF1KE4 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFARE
:.. ::. :: . : :. : .. . : : ::..
NP_000 MAAALLARASGPARRALCPRAWRQLHTIYQ---------SVELPETHQMLLQTCRDFAEK
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 EIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC--
:..:.::. :: .:. ... :::. .::. :: :: . . ::.. ::
NP_000 ELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCAS
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA
::: ... ::: ::. :. .::. .. .: . . ..::: :::... .: :
NP_000 TGVIMSVN-NSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTA
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK
. .:: ...:: : ::::. .:. ..: .: .: ::....:.: :::. .:.:
NP_000 RAEGDSWVLNGTKAWITNAWEASAAVVFASTD---RALQNKGISAFLVPMPTPGLTLGKK
180 190 200 210 220
240 250 260 270 280 290
pF1KE4 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRAL
: ..: : :.: ...::: ..::...: : :::.:: ..: : .:. ..:.:: ::
NP_000 EDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTAL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE4 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI
: :..:: .: .:: :.. :.:.: ::.::. .: ::. ::: :. . :..
NP_000 DCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAM
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI
:: :.. :. .. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: . .
NP_000 AKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLL
350 360 370 380 390 400
420
pF1KE4 DKYKN
.:..
NP_000 RSYRS
410
>>NP_001600 (OMIM: 600301,610006) short/branched chain s (432 aa)
initn: 780 init1: 490 opt: 832 Z-score: 1123.2 bits: 216.9 E(85289): 8e-56
Smith-Waterman score: 832; 36.2% identity (68.5% similar) in 409 aa overlap (20-417:26-429)
10 20 30 40
pF1KE4 MAAGFGRCCRVLRSISRFHWR-SQHTKANRQREPGL-----GFSFE----FTEQ
:. :.. . : : : :. : ::..
NP_001 MEGLAVRLLRGSRLLRRNFLTCLSSWKIPPHVSKSSQSEALLNITNNGIHFAPLQTFTDE
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 QKEFQATARKFAREEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFD
. ......:::.:.: :... .:..... .:. .. :::. .. . :: : . ..
NP_001 EMMIKSSVKKFAQEQIAPLVSTMDENSKMEKSVIQGLFQQGLMGIEVDPEYGGTGASFLS
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 ACLISEELAYGCTGVQTAIE-GNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEP
. :. :::: ..: . : :.: . : :...:: :: ..: : . ..:..:
NP_001 TVLVIEELAKVDASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTTEKVG-SFCLSEA
130 140 150 160 170
170 180 190 200 210 220
pF1KE4 GAGSDVAGIKTKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFI
::::: ..::.:.:.:: :..::.::::... .:. ....: :: . . :..:.:.
NP_001 GAGSDSFALKTRADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDP---TIGYKGITSFL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 VEADTPGIQIGRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPV
:. ::::..::. : ..: : :.: ..::.::::. :.: : :.: :.:.... :
NP_001 VDRDTPGLHIGKPENKLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIG
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 VAAGVVGLAQRALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWE
.:: ..:::: .: . : :: ::: : . :... ..:..: ..: ::. ::
NP_001 IAAQMLGLAQGCFDYTIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 VDSGRRNTYYASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGT
...:. ::.:: .:..::.: .. .. .:: :.. .::::: .::::: ::::.
NP_001 LEAGKPFIKEASMAKYYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGA
360 370 380 390 400 410
410 420
pF1KE4 SQIQRLIVAREHIDKYKN
:.:: .:. :::
NP_001 SNIQLNTIAK-HIDAEY
420 430
>>NP_055199 (OMIM: 604773,611283) isobutyryl-CoA dehydro (415 aa)
initn: 772 init1: 400 opt: 793 Z-score: 1070.6 bits: 207.1 E(85289): 6.8e-53
Smith-Waterman score: 793; 33.7% identity (68.1% similar) in 383 aa overlap (32-413:36-410)
10 20 30 40 50 60
pF1KE4 AAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEII
.:..:.. :.::::: .: :: .:.
NP_055 CRRFGARLGCLPGGLRVLVQTGHRSLTSCIDPSMGLN----EEQKEFQKVAFDFAAREMA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGCTGVQT
: ::.:. .:: ..:.: .::. ...: . :: ::. .:. .: : :: :::.. .
NP_055 PNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLSRLDTSVIFEALATGCTSTTA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGD
: ... : ::..:..:. . . .::.::::.:::.:.. :.:.:.::
NP_055 YISIHNMCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQGD
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMG
.::.::.: .:...:... : .. :. .:. :... ..:: :::...:.:: ..:
NP_055 HYILNGSKAFISGAGESDIYVVMCRTG----GPGPKGISCIVVEKGTPGLSFGKKEKKVG
190 200 210 220 230
250 260 270 280 290 300
pF1KE4 QRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATK
. ::...::: :: : . ..: :: .:. ... : .:. .: :. .. .
NP_055 WNSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIASCSLGAAHASVILTRD
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 YALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTY-YASIAKAF
. :: ::. :. .: ..: ::.:: .. ::. . :: .. :... :.:: :
NP_055 HLNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLF
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 AGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYK
: : . ..:.:. :: :. .: :.. .::....:: ::.....:....:
NP_055 ATDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRILISRSLLQE
360 370 380 390 400 410
pF1KE4 N
>>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa)
initn: 658 init1: 434 opt: 782 Z-score: 1055.9 bits: 204.3 E(85289): 4.5e-52
Smith-Waterman score: 782; 34.5% identity (65.8% similar) in 403 aa overlap (18-413:3-400)
10 20 30 40 50
pF1KE4 MAAGFGRCCRVLRSISRFHWR-SQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREE
: :: .: : .. : : .: .: :.. : :: .:.
XP_016 MVFWWRIGQATYRLWHKGPQSVCS-SLTPEQAELRQTMAKFLQEH
10 20 30 40
60 70 80 90 100 110
pF1KE4 IIPVAAEYDKTGEYPVPLIRRAWE----LGLMNTHIPENCGGLGLGTFDACLISEEL--A
. : : : :...:. .:. :. ::... : . :: ::: .. :. ::. :
XP_016 LAPKAQEIDRSNEFKN--LREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 YGCTGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIK
: .:.. . ..: : .. ::. ::.::: .. . : ..::.:::::...:
XP_016 SGAVGLSYGAHSN-LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMK
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 TKAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQI
::::::..::.::.:.::::: :. .. :..: .::....:.:::: ::..
XP_016 LKAEKKGNHYILNGNKFWITNGPDADVLIVYAKTDL-AAVPASRGITAFIVEKGMPGFST
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE4 GRKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQ
..: ..:.: :.: ..::: :.: :.: .. : : :...: : :.:.: .:: :
XP_016 SKKLDKLGMRGSNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQ
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE4 RALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYY
.::.. : :..::. . . : .. .:.: .. :. .: : :. ..
XP_016 AVLDHTIPYLHVREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKD
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 ASIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAR
. . .... :.:.: :..: .::::. ...:. ...::::.:.: :::...::...:
XP_016 CAGVILYSAECATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGR
350 360 370 380 390 400
420
pF1KE4 EHIDKYKN
XP_016 AFNADFH
>>NP_002216 (OMIM: 243500,607036) isovaleryl-CoA dehydro (426 aa)
initn: 658 init1: 434 opt: 780 Z-score: 1052.9 bits: 203.8 E(85289): 6.6e-52
Smith-Waterman score: 780; 34.6% identity (67.8% similar) in 379 aa overlap (41-413:45-419)
20 30 40 50 60 70
pF1KE4 VLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFAREEIIPVAAEYDKT
..:.:.... : :: .:.. : : : :..
NP_002 VASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRS
20 30 40 50 60 70
80 90 100 110 120
pF1KE4 GEYPVPLIRRAWE----LGLMNTHIPENCGGLGLGTFDACLISEEL--AYGCTGVQTAIE
.:. .:. :. ::... : . :: ::: .. :. ::. : : .:.. . .
NP_002 NEFKN--LREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAH
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE4 GNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYI
.: : .. ::. ::.::: .. . : ..::.:::::...: ::::::..::
NP_002 SN-LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYI
140 150 160 170 180 190
190 200 210 220 230 240
pF1KE4 INGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRC
.::.:.::::: :. .. :..: .::....:.:::: ::.. ..: ..:.:
NP_002 LNGNKFWITNGPDADVLIVYAKTDL-AAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRG
200 210 220 230 240 250
250 260 270 280 290 300
pF1KE4 SDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGVVGLAQRALDEATKYAL
:.: ..::: :.: :.: .. : : :...: : :.:.: .:: : .::.. :
NP_002 SNTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLH
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE4 ERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDI
:..::. . . : .. .:.: .. :. .: : :. .. . . ....
NP_002 VREAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAEC
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE4 ANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
:.:.: :..: .::::. ...:. ...::::.:.: :::...::...:
NP_002 ATQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
380 390 400 410 420
421 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:19:14 2016 done: Sun Nov 6 01:19:15 2016
Total Scan time: 6.160 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]