FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4401, 417 aa 1>>>pF1KE4401 417 - 417 aa - 417 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.1015+/-0.00034; mu= 18.1818+/- 0.021 mean_var=69.9551+/-14.422, 0's: 0 Z-trim(115.0): 312 B-trim: 304 in 1/53 Lambda= 0.153343 statistics sampled from 24834 (25170) to 24834 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.66), E-opt: 0.2 (0.295), width: 16 Scan time: 9.080 The best scores are: opt bits E(85289) XP_016882220 (OMIM: 142440) PREDICTED: serine prot ( 417) 2903 651.4 1.2e-186 XP_006723244 (OMIM: 142440) PREDICTED: serine prot ( 417) 2903 651.4 1.2e-186 XP_005258895 (OMIM: 142440) PREDICTED: serine prot ( 417) 2903 651.4 1.2e-186 NP_892028 (OMIM: 142440) serine protease hepsin pr ( 417) 2903 651.4 1.2e-186 NP_002142 (OMIM: 142440) serine protease hepsin pr ( 417) 2903 651.4 1.2e-186 XP_016882221 (OMIM: 142440) PREDICTED: serine prot ( 393) 2483 558.5 1.1e-158 NP_001243246 (OMIM: 605511) transmembrane protease ( 453) 909 210.3 8e-54 NP_076927 (OMIM: 605511) transmembrane protease se ( 454) 898 207.9 4.3e-53 NP_115780 (OMIM: 605511) transmembrane protease se ( 327) 856 198.5 2.1e-50 NP_001275679 (OMIM: 606751) transmembrane protease ( 413) 792 184.4 4.6e-46 NP_001275680 (OMIM: 606751) transmembrane protease ( 448) 792 184.4 4.9e-46 NP_110397 (OMIM: 606751) transmembrane protease se ( 457) 792 184.4 5e-46 XP_011528035 (OMIM: 602060) PREDICTED: transmembra ( 384) 747 174.4 4.3e-43 XP_005261100 (OMIM: 602060) PREDICTED: transmembra ( 452) 747 174.5 4.9e-43 NP_005647 (OMIM: 602060) transmembrane protease se ( 492) 747 174.5 5.2e-43 XP_011528033 (OMIM: 602060) PREDICTED: transmembra ( 492) 747 174.5 5.2e-43 NP_001128571 (OMIM: 602060) transmembrane protease ( 529) 747 174.5 5.5e-43 NP_002763 (OMIM: 226200,606635) enteropeptidase pr (1019) 745 174.3 1.3e-42 XP_011527961 (OMIM: 226200,606635) PREDICTED: ente (1034) 743 173.8 1.7e-42 XP_011527960 (OMIM: 226200,606635) PREDICTED: ente (1037) 743 173.8 1.7e-42 XP_011527959 (OMIM: 226200,606635) PREDICTED: ente (1049) 743 173.8 1.8e-42 XP_011527957 (OMIM: 226200,606635) PREDICTED: ente (1064) 743 173.8 1.8e-42 XP_011527956 (OMIM: 226200,606635) PREDICTED: ente (1064) 743 173.8 1.8e-42 XP_011527958 (OMIM: 226200,606635) PREDICTED: ente (1064) 743 173.8 1.8e-42 XP_011520753 (OMIM: 613797) PREDICTED: serine prot ( 280) 730 170.5 4.6e-42 XP_011520754 (OMIM: 613797) PREDICTED: serine prot ( 280) 730 170.5 4.6e-42 NP_690851 (OMIM: 613797) serine protease 33 precur ( 280) 730 170.5 4.6e-42 NP_001305325 (OMIM: 229000,612423) plasma kallikre ( 436) 710 166.3 1.4e-40 XP_016863673 (OMIM: 229000,612423) PREDICTED: plas ( 436) 710 166.3 1.4e-40 NP_000883 (OMIM: 229000,612423) plasma kallikrein ( 638) 710 166.4 1.9e-40 XP_016863670 (OMIM: 229000,612423) PREDICTED: plas ( 649) 710 166.4 1.9e-40 XP_011530232 (OMIM: 229000,612423) PREDICTED: plas ( 649) 710 166.4 1.9e-40 NP_001275930 (OMIM: 206200,609862) transmembrane p ( 802) 708 166.0 3e-40 NP_705837 (OMIM: 206200,609862) transmembrane prot ( 811) 708 166.0 3.1e-40 NP_114154 (OMIM: 608018) serine protease 27 isofor ( 290) 698 163.5 6.4e-40 NP_002764 (OMIM: 600823) prostasin preproprotein [ ( 343) 672 157.8 3.9e-38 NP_068813 (OMIM: 606797) suppressor of tumorigenic ( 855) 674 158.5 5.9e-38 XP_005262880 (OMIM: 264900,612416) PREDICTED: coag ( 536) 671 157.7 6.5e-38 XP_006714200 (OMIM: 264900,612416) PREDICTED: coag ( 610) 671 157.7 7.1e-38 NP_000119 (OMIM: 264900,612416) coagulation factor ( 625) 671 157.7 7.3e-38 XP_005262878 (OMIM: 264900,612416) PREDICTED: coag ( 626) 671 157.7 7.3e-38 XP_016878460 (OMIM: 610560) PREDICTED: polyserase- ( 621) 667 156.9 1.3e-37 XP_016878459 (OMIM: 610560) PREDICTED: polyserase- ( 634) 667 156.9 1.4e-37 XP_016878458 (OMIM: 610560) PREDICTED: polyserase- ( 637) 667 156.9 1.4e-37 NP_001245220 (OMIM: 610560) polyserase-2 isoform 3 ( 752) 667 156.9 1.6e-37 XP_016878457 (OMIM: 610560) PREDICTED: polyserase- ( 761) 667 156.9 1.6e-37 NP_001245219 (OMIM: 610560) polyserase-2 isoform 2 ( 850) 667 157.0 1.7e-37 NP_775773 (OMIM: 610560) polyserase-2 isoform 1 pr ( 855) 667 157.0 1.7e-37 NP_001088 (OMIM: 102480) acrosin precursor [Homo s ( 421) 659 155.0 3.4e-37 XP_011526282 (OMIM: 610477) PREDICTED: transmembra ( 690) 656 154.5 7.8e-37 >>XP_016882220 (OMIM: 142440) PREDICTED: serine protease (417 aa) initn: 2903 init1: 2903 opt: 2903 Z-score: 3471.8 bits: 651.4 E(85289): 1.2e-186 Smith-Waterman score: 2903; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KE4 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 370 380 390 400 410 >>XP_006723244 (OMIM: 142440) PREDICTED: serine protease (417 aa) initn: 2903 init1: 2903 opt: 2903 Z-score: 3471.8 bits: 651.4 E(85289): 1.2e-186 Smith-Waterman score: 2903; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KE4 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_006 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 370 380 390 400 410 >>XP_005258895 (OMIM: 142440) PREDICTED: serine protease (417 aa) initn: 2903 init1: 2903 opt: 2903 Z-score: 3471.8 bits: 651.4 E(85289): 1.2e-186 Smith-Waterman score: 2903; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KE4 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_005 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 370 380 390 400 410 >>NP_892028 (OMIM: 142440) serine protease hepsin precur (417 aa) initn: 2903 init1: 2903 opt: 2903 Z-score: 3471.8 bits: 651.4 E(85289): 1.2e-186 Smith-Waterman score: 2903; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KE4 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_892 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 370 380 390 400 410 >>NP_002142 (OMIM: 142440) serine protease hepsin precur (417 aa) initn: 2903 init1: 2903 opt: 2903 Z-score: 3471.8 bits: 651.4 E(85289): 1.2e-186 Smith-Waterman score: 2903; 100.0% identity (100.0% similar) in 417 aa overlap (1-417:1-417) 10 20 30 40 50 60 pF1KE4 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSAD 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 ARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCV 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DEGRLPHTQRLLEVISVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSL 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 RYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYH 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 GGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQ 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCE 310 320 330 340 350 360 370 380 390 400 410 pF1KE4 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL ::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_002 DSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL 370 380 390 400 410 >>XP_016882221 (OMIM: 142440) PREDICTED: serine protease (393 aa) initn: 2483 init1: 2483 opt: 2483 Z-score: 2970.0 bits: 558.5 E(85289): 1.1e-158 Smith-Waterman score: 2483; 99.2% identity (99.4% similar) in 355 aa overlap (51-405:23-377) 30 40 50 60 70 80 pF1KE4 LTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSR : .:::::::::::::::::::::::::: XP_016 MCKMRTREDMQLGNEGPGTALRLIHLQVSSADARLMVFDKTEGTWRLLCSSR 10 20 30 40 50 90 100 110 120 130 140 pF1KE4 SNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 SNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVISVCDC 60 70 80 90 100 110 150 160 170 180 190 200 pF1KE4 PRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLT :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 PRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLT 120 130 140 150 160 170 210 220 230 240 250 260 pF1KE4 AAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIAL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 AAHCFPERNRVLSRWRVFAGAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIAL 180 190 200 210 220 230 270 280 290 300 310 320 pF1KE4 VHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISND :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISND 240 250 260 270 280 290 330 340 350 360 370 380 pF1KE4 VCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTG :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: XP_016 VCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTG 300 310 320 330 340 350 390 400 410 pF1KE4 CALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL ::::::::::::::::::::::::: XP_016 CALAQKPGVYTKVSDFREWIFQAIKVKVGSRWEPGWGRLGV 360 370 380 390 >>NP_001243246 (OMIM: 605511) transmembrane protease ser (453 aa) initn: 758 init1: 441 opt: 909 Z-score: 1087.3 bits: 210.3 E(85289): 8e-54 Smith-Waterman score: 909; 39.8% identity (67.9% similar) in 364 aa overlap (47-405:100-448) 20 30 40 50 60 70 pF1KE4 KVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYP-VQVSSADARLMVFDKTEGTWRL : : : :.:.. .: :.:: : ..:. NP_001 HFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF--TAASWKT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE4 LCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQ--RLLE .::. ... :...: ..:: .. ..: : . .. : .:. :: . : . NP_001 MCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDH-LLPDDKVTALHH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE4 VISVCD-CPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSL . : . : :. .. : ::.:. .::::: . :..::::.::...: ::::::. NP_001 SVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSV 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 LSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQA-SPHGLQLGVQAVVYHGGYLPFRDPNS .. :..::::: . . . : . .: :. .: .: :. .:::. : : : NP_001 ITPLWIITAAHCVYDL-YLPKSWTIQVGLVSLLDNPAPSHL-VEKIVYHSKYKPKRL--- 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 EENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQYYGQQAGVLQE .:::::..:..:: ..:.::::::: . . . :::.: ..::: :. :. . ::.. NP_001 ---GNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGGDASPVLNH 310 320 330 340 350 320 330 340 350 360 370 pF1KE4 ARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRL : ::.::: .:: : ::. :.:.:.:::: ::.:.::::::::.::.. : :.: NP_001 AAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQER--RL--WKL 360 370 380 390 400 410 380 390 400 410 pF1KE4 CGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL : .:.: ::: ..::::::.:..: .:: . .. NP_001 VGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 420 430 440 450 >>NP_076927 (OMIM: 605511) transmembrane protease serine (454 aa) initn: 777 init1: 263 opt: 898 Z-score: 1074.1 bits: 207.9 E(85289): 4.3e-53 Smith-Waterman score: 898; 39.7% identity (67.7% similar) in 365 aa overlap (47-405:100-449) 20 30 40 50 60 70 pF1KE4 KVAALTAGTLLLLTAIGAASWAIVAVLLRSDQEPLYP-VQVSSADARLMVFDKTEGTWRL : : : :.:.. .: :.:: : ..:. NP_076 HFDCSGKYRCRSSFKCIELIARCDGVSDCKDGEDEYRCVRVGGQNAVLQVF--TAASWKT 70 80 90 100 110 120 80 90 100 110 120 130 pF1KE4 LCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGTSGFFCVDEGRLPHTQ--RLLE .::. ... :...: ..:: .. ..: : . .. : .:. :: . : . NP_076 MCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFREEFVSIDH-LLPDDKVTALHH 130 140 150 160 170 180 140 150 160 170 180 190 pF1KE4 VISVCD-CPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSL . : . : :. .. : ::.:. .::::: . :..::::.::...: ::::::. NP_076 SVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLSQWPWQASLQFQGYHLCGGSV 190 200 210 220 230 240 200 210 220 230 240 250 pF1KE4 LSGDWVLTAAHCFPERNRVLSRWRVFAGAVAQA-SPHGLQLGVQAVVYHGGYLPFRDPNS .. :..::::: . . . : . .: :. .: .: :. .:::. : : : NP_076 ITPLWIITAAHCVYDL-YLPKSWTIQVGLVSLLDNPAPSHL-VEKIVYHSKYKPKRL--- 250 260 270 280 290 300 260 270 280 290 300 310 pF1KE4 EENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGKICTVTGWGNTQY-YGQQAGVLQ .:::::..:..:: ..:.::::::: . . . :::.: ..::: :. :. . ::. NP_076 ---GNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGWGATEDGAGDASPVLN 310 320 330 340 350 320 330 340 350 360 370 pF1KE4 EARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWR .: ::.::: .:: : ::. :.:.:.:::: ::.:.::::::::.::.. : :. NP_076 HAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGGPLVCQER--RL--WK 360 370 380 390 400 410 380 390 400 410 pF1KE4 LCGIVSWGTGCALAQKPGVYTKVSDFREWIFQAIKTHSEASGMVTQL : : .:.: ::: ..::::::.:..: .:: . .. NP_076 LVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDLKT 420 430 440 450 >>NP_115780 (OMIM: 605511) transmembrane protease serine (327 aa) initn: 777 init1: 263 opt: 856 Z-score: 1025.9 bits: 198.5 E(85289): 2.1e-50 Smith-Waterman score: 856; 40.0% identity (68.1% similar) in 335 aa overlap (76-405:1-322) 50 60 70 80 90 100 pF1KE4 SDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELD .::. ... :...: ..:: .. ..: NP_115 MCSDDWKGHYANVACAQLGFPSYVSSDNLR 10 20 30 110 120 130 140 150 160 pF1KE4 VRTAGANGTSGFFCVDEGRLPHTQ--RLLEVISVCD-CPRGRFLAAICQDCGRRKLPVDR : . .. : .:. :: . : . . : . : :. .. : ::.:. .: NP_115 VSSLEGQFREEFVSIDH-LLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSR 40 50 60 70 80 170 180 190 200 210 220 pF1KE4 IVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAGAV :::: . :..::::.::...: ::::::... :..::::: . . . : . .: : NP_115 IVGGNMSLLSQWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDL-YLPKSWTIQVGLV 90 100 110 120 130 140 230 240 250 260 270 280 pF1KE4 AQA-SPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAA . .: .: :. .:::. : : : .:::::..:..:: ..:.::::::: . NP_115 SLLDNPAPSHL-VEKIVYHSKYKPKRL------GNDIALMKLAGPLTFNEMIQPVCLPNS 150 160 170 180 190 200 290 300 310 320 330 340 pF1KE4 GQALVDGKICTVTGWGNTQY-YGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAG . . :::.: ..::: :. :. . ::..: ::.::: .:: : ::. :.:.:.::: NP_115 EENFPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAG 210 220 230 240 250 260 350 360 370 380 390 400 pF1KE4 YPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI : ::.:.::::::::.::.. : :.: : .:.: ::: ..::::::.:..: .:: NP_115 YLTGGVDSCQGDSGGPLVCQE--RRL--WKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 270 280 290 300 310 410 pF1KE4 FQAIKTHSEASGMVTQL . .. NP_115 HEQMERDLKT 320 >>NP_001275679 (OMIM: 606751) transmembrane protease ser (413 aa) initn: 697 init1: 221 opt: 792 Z-score: 948.0 bits: 184.4 E(85289): 4.6e-46 Smith-Waterman score: 800; 34.6% identity (61.9% similar) in 396 aa overlap (11-400:30-404) 10 20 30 40 pF1KE4 MAQKEGGRTVPCCSRPKVAALTAGTLLLLTAIGAASWAIVA : :.: ..: . : . ..: :.. NP_001 MRRGCAVLGALGLLAGAGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLP 10 20 30 40 50 60 50 60 70 80 90 100 pF1KE4 VLLRSDQEPLYPVQVSSADARLMVFDKTEGTWRLLCSSRSNARVAGLSCEEMGFLRALTH .: .. ...: : : . . . : :.: . .. : .: :: : NP_001 ALPKT-----VSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHH 70 80 90 100 110 110 120 130 140 150 pF1KE4 SELDVRTAGANGTSGFFCVDEGRLPHTQRLLEVI--SVCDCPRGRFLAAICQDCGRRKLP . ... :... : .. :. .:: .: :. .. :..:: : : NP_001 KGVNLTDIKLNSSQEFAQLS----PRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPL- 120 130 140 150 160 170 160 170 180 190 200 210 pF1KE4 VDRIVGGRDTSLGRWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE-RNRVLSRWRVF ..:::::.... ::::::.:. : ::::.:. ::.:::::. : :: ::: NP_001 ASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVH 180 190 200 210 220 230 220 230 240 250 260 270 pF1KE4 AGAVAQAS--PHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPV :: :.... :: : :. .. : : ...... :.::..:.. : ... . : NP_001 AGLVSHSAVRPHQGAL-VERIIPHPLY------SAQNHDYDVALLRLQTALNFSDTVGAV 240 250 260 270 280 280 290 300 310 320 330 pF1KE4 CLPAAGQALVDGKICTVTGWGNTQ-YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPK :::: : . :. : :.:::.:. . .. .::.. ::..:...::.. :.. . :. NP_001 CLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPR 290 300 310 320 330 340 340 350 360 370 380 390 pF1KE4 MFCAGYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSD :.:::: .: ::::::::::.:: :. . ::: :.:::: ::: ..::::.::.. NP_001 MLCAGYLDGRADACQGDSGGPLVCPDGDT----WRLVGVVSWGRGCAEPNHPGVYAKVAE 350 360 370 380 390 400 410 pF1KE4 FREWIFQAIKTHSEASGMVTQL : .:: NP_001 FLDWIHDTAQDSLL 400 410 417 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Sun Nov 6 01:21:46 2016 done: Sun Nov 6 01:21:47 2016 Total Scan time: 9.080 Total Display time: 0.040 Function used was FASTA [36.3.4 Apr, 2011]