Result of FASTA (omim) for
pFN21AE4390
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4390, 412 aa
1>>>pF1KE4390 412 - 412 aa - 412 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9594+/-0.000393; mu= 19.0171+/- 0.024
mean_var=67.4625+/-13.680, 0's: 0 Z-trim(110.5): 65 B-trim: 0 in 0/54
Lambda= 0.156150
statistics sampled from 18754 (18819) to 18754 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.572), E-opt: 0.2 (0.221), width: 16
Scan time: 8.640
The best scores are: opt bits E(85289)
NP_000008 (OMIM: 201470,606885) short-chain specif ( 412) 2669 610.6 2.2e-174
NP_001289483 (OMIM: 201470,606885) short-chain spe ( 408) 2303 528.2 1.4e-149
NP_001600 (OMIM: 600301,610006) short/branched cha ( 432) 947 222.7 1.4e-57
NP_000007 (OMIM: 201450,607008) medium-chain speci ( 421) 901 212.4 1.8e-54
NP_001120800 (OMIM: 201450,607008) medium-chain sp ( 425) 901 212.4 1.8e-54
NP_001272971 (OMIM: 201450,607008) medium-chain sp ( 385) 897 211.4 3.1e-54
NP_001317103 (OMIM: 600301,610006) short/branched ( 330) 894 210.7 4.3e-54
NP_002216 (OMIM: 243500,607036) isovaleryl-CoA deh ( 426) 858 202.7 1.5e-51
XP_016877645 (OMIM: 243500,607036) PREDICTED: isov ( 407) 857 202.4 1.6e-51
NP_055199 (OMIM: 604773,611283) isobutyryl-CoA deh ( 415) 854 201.8 2.7e-51
NP_001152980 (OMIM: 243500,607036) isovaleryl-CoA ( 396) 814 192.7 1.3e-48
XP_016877643 (OMIM: 243500,607036) PREDICTED: isov ( 436) 814 192.8 1.4e-48
XP_016877641 (OMIM: 243500,607036) PREDICTED: isov ( 455) 814 192.8 1.5e-48
XP_016873032 (OMIM: 604773,611283) PREDICTED: isob ( 434) 810 191.9 2.7e-48
XP_011541052 (OMIM: 604773,611283) PREDICTED: isob ( 451) 810 191.9 2.7e-48
XP_016873031 (OMIM: 604773,611283) PREDICTED: isob ( 451) 810 191.9 2.7e-48
NP_001272972 (OMIM: 201450,607008) medium-chain sp ( 454) 778 184.7 4.1e-46
NP_054768 (OMIM: 611103,611126) acyl-CoA dehydroge ( 621) 755 179.6 1.9e-44
XP_005254407 (OMIM: 243500,607036) PREDICTED: isov ( 487) 740 176.1 1.6e-43
XP_006720555 (OMIM: 243500,607036) PREDICTED: isov ( 447) 738 175.7 2.1e-43
XP_005246574 (OMIM: 609576) PREDICTED: long-chain ( 409) 734 174.7 3.6e-43
NP_001599 (OMIM: 609576) long-chain specific acyl- ( 430) 727 173.2 1.1e-42
NP_001257377 (OMIM: 201475,609575) very long-chain ( 579) 715 170.6 9.2e-42
XP_011522132 (OMIM: 201475,609575) PREDICTED: very ( 621) 715 170.6 9.7e-42
XP_011522131 (OMIM: 201475,609575) PREDICTED: very ( 628) 715 170.6 9.8e-42
NP_001029031 (OMIM: 201475,609575) very long-chain ( 633) 715 170.6 9.9e-42
NP_000009 (OMIM: 201475,609575) very long-chain sp ( 655) 715 170.6 1e-41
XP_006721579 (OMIM: 201475,609575) PREDICTED: very ( 662) 715 170.6 1e-41
NP_001257376 (OMIM: 201475,609575) very long-chain ( 678) 715 170.6 1e-41
XP_016873034 (OMIM: 604773,611283) PREDICTED: isob ( 391) 712 169.8 1.1e-41
XP_016873033 (OMIM: 604773,611283) PREDICTED: isob ( 391) 712 169.8 1.1e-41
XP_016877639 (OMIM: 243500,607036) PREDICTED: isov ( 478) 697 166.4 1.3e-40
XP_016877638 (OMIM: 243500,607036) PREDICTED: isov ( 516) 696 166.2 1.6e-40
XP_016877640 (OMIM: 243500,607036) PREDICTED: isov ( 476) 694 165.8 2.1e-40
XP_016877644 (OMIM: 243500,607036) PREDICTED: isov ( 418) 688 164.4 4.9e-40
XP_016877642 (OMIM: 243500,607036) PREDICTED: isov ( 447) 687 164.2 6e-40
XP_016873036 (OMIM: 604773,611283) PREDICTED: isob ( 317) 682 162.9 1e-39
XP_006720558 (OMIM: 243500,607036) PREDICTED: isov ( 347) 657 157.3 5.3e-38
XP_016861753 (OMIM: 611103,611126) PREDICTED: acyl ( 537) 651 156.1 1.9e-37
XP_016873035 (OMIM: 604773,611283) PREDICTED: isob ( 353) 638 153.1 1e-36
XP_016877646 (OMIM: 243500,607036) PREDICTED: isov ( 376) 613 147.4 5.5e-35
NP_000150 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 438) 597 143.9 7.5e-34
NP_001272973 (OMIM: 201450,607008) medium-chain sp ( 232) 588 141.7 1.9e-33
XP_016859444 (OMIM: 609576) PREDICTED: long-chain ( 289) 587 141.5 2.6e-33
XP_011526201 (OMIM: 231670,608801) PREDICTED: glut ( 446) 576 139.2 2e-32
NP_039663 (OMIM: 231670,608801) glutaryl-CoA dehyd ( 428) 568 137.3 6.8e-32
XP_016882069 (OMIM: 231670,608801) PREDICTED: glut ( 442) 568 137.4 7e-32
XP_006722784 (OMIM: 231670,608801) PREDICTED: glut ( 442) 568 137.4 7e-32
XP_011526202 (OMIM: 231670,608801) PREDICTED: glut ( 443) 568 137.4 7e-32
NP_079523 (OMIM: 611181) acyl-CoA dehydrogenase fa (1059) 507 123.9 1.9e-27
>>NP_000008 (OMIM: 201470,606885) short-chain specific a (412 aa)
initn: 2669 init1: 2669 opt: 2669 Z-score: 3251.8 bits: 610.6 E(85289): 2.2e-174
Smith-Waterman score: 2669; 99.8% identity (100.0% similar) in 412 aa overlap (1-412:1-412)
10 20 30 40 50 60
pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLN
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GTKAWITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKEDKLGIRGSSTAN
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_000 GTKAWITNAWEASAAVVFASTDRALQNKGISAFLVPMPTPGLTLGKKEDKLGIRGSSTAN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 LIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 GAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 GAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAIS
310 320 330 340 350 360
370 380 390 400 410
pF1KE4 HQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 HQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
370 380 390 400 410
>>NP_001289483 (OMIM: 201470,606885) short-chain specifi (408 aa)
initn: 2336 init1: 1296 opt: 2303 Z-score: 2806.2 bits: 528.2 E(85289): 1.4e-149
Smith-Waterman score: 2303; 89.2% identity (91.8% similar) in 417 aa overlap (1-412:1-408)
10 20 30 40 50 60
pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNN
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLN
:::::::::::::::::::::::::::::::::::::: : : . : ..:
NP_001 SLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGP-SLLGPT-------GPIFAL-
130 140 150 160 170
190 200 210 220 230
pF1KE4 GTKAWITNAWEASAAVVFA-STDRA----LQNKSISAFLVPMPTPGLTLGKKEDKLGIRG
: . . :. : .: : .:. : ..::::::::::::::::::::::::::
NP_001 GQVGCPCPSSAATEACTFPRSRQRVSRPELLREGISAFLVPMPTPGLTLGKKEDKLGIRG
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 SSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAE
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 NRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 ATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
360 370 380 390 400
>>NP_001600 (OMIM: 600301,610006) short/branched chain s (432 aa)
initn: 878 init1: 756 opt: 947 Z-score: 1155.0 bits: 222.7 E(85289): 1.4e-57
Smith-Waterman score: 947; 40.8% identity (72.0% similar) in 375 aa overlap (36-410:59-432)
10 20 30 40 50 60
pF1KE4 LARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKEHL
. ..:. .. . ::.... :... .:..
NP_001 PPHVSKSSQSEALLNITNNGIHFAPLQTFTDEEMMIKSSVKKFAQEQIAPLVSTMDENSK
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE4 FPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNSLYLG
. . .. . ::....: : ::.: ..:. ....::... ::..:. ..:.:
NP_001 MEKSVIQGLFQQGLMGIEVDPEYGGTGASFLSTVLVIEELAKVDASVAVFCEIQNTLINT
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE4 PILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNGTKAW
: : :..::: ... .:. .:.: : ::: : :::. : .: : ::: .::::.: :
NP_001 LIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTRADKEGDYYVLNGSKMW
150 160 170 180 190 200
190 200 210 220 230 240
pF1KE4 ITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKEDKLGIRGSSTANLIFED
:..: .:. .:.:..: .. :.:..::: :::: .:: :.:::.:.::: : ::.
NP_001 ISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPENKLGLRASSTCPLTFEN
210 220 230 240 250 260
250 260 270 280 290 300
pF1KE4 CRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMAFGAPLT
..:. .:::. : :.: :. .:. ::::::.: ::.:: .: .. : ..:. :: :
NP_001 VKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDYTIPYIKERIQFGKRLF
270 280 290 300 310 320
310 320 330 340 350 360
pF1KE4 KLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAISHQAIQ
.: .: ..: .: ::.:::::. :: : . :::::::.::: ::: : . . :.
NP_001 DFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAKYYASEIAGQTTSKCIE
330 340 350 360 370 380
370 380 390 400 410
pF1KE4 ILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
.::.::. ..:.:...:::.: ::::.:.:: .:: :. :
NP_001 WMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAEY
390 400 410 420 430
>>NP_000007 (OMIM: 201450,607008) medium-chain specific (421 aa)
initn: 726 init1: 549 opt: 901 Z-score: 1099.1 bits: 212.4 E(85289): 1.8e-54
Smith-Waterman score: 904; 37.5% identity (66.7% similar) in 411 aa overlap (15-412:13-421)
10 20 30 40 50
pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQ---------SVELPETHQMLLQTCRDFAEK
:.. ::. :: . : :. : .. . : : ::..
NP_000 MAAGFGRCCRVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFARE
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 ELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCAS
:..:.::. :: .:. ... :::. .::. :: :: . . ::.. ::
NP_000 EIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC--
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 TGVIMSVN-NSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTA
::: ... ::: ::. :. .::. .. .: . . ..::: :::... .: :
NP_000 TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKA
120 130 140 150 160 170
180 190 200 210 220
pF1KE4 RAEGDSWVLNGTKAWITNAWEASAAVVFASTD---RALQNKSISAFLVPMPTPGLTLGKK
. .:: ...:: : ::::. .:. ..: .: .: ::....:.: :::. .:.:
NP_000 EKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRK
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 EDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTAL
: ..: : :.: ...::: ..::...: : :::.:: ..: : .:. :.:.:: ::
NP_000 ELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRAL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 DCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAM
: :..:: .: .:: :.. :.:.: ::.::. .: ::. ::: :. . :..
NP_000 DEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASI
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 AKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLL
:: :.. :. .. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: . .
NP_000 AKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHI
360 370 380 390 400 410
410
pF1KE4 RSYRS
.:..
NP_000 DKYKN
420
>>NP_001120800 (OMIM: 201450,607008) medium-chain specif (425 aa)
initn: 726 init1: 549 opt: 901 Z-score: 1099.1 bits: 212.4 E(85289): 1.8e-54
Smith-Waterman score: 908; 37.2% identity (66.0% similar) in 427 aa overlap (1-412:1-425)
10 20 30 40
pF1KE4 MAAAL--LARASGPARRALCPRAWRQLHTIYQ---------SVELPETHQMLLQTCRDFA
:::.. : : . :.. ::. :: . : :. : .. . : : ::
NP_001 MAAGFGRCCRCSLQVLRSISRFHWRSQHTKANRQREPGLGFSFEFTEQQKEFQATARKFA
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 EKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGC
..:..:.::. :: .:. ... :::. .::. :: :: . . ::.. ::
NP_001 REEIIPVAAEYDKTGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 ASTGVIMSVN-NSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAAST
::: ... ::: ::. :. .::. .. .: . . ..::: :::... .:
NP_001 --TGVQTAIEGNSLGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKT
130 140 150 160 170
170 180 190 200 210 220
pF1KE4 TARAEGDSWVLNGTKAWITNAWEASAAVVFASTD---RALQNKSISAFLVPMPTPGLTLG
:. .:: ...:: : ::::. .:. ..: .: .: ::....:.: :::. .:
NP_001 KAEKKGDEYIINGQKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIG
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 KKEDKLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQT
.:: ..: : :.: ...::: ..::...: : :::.:: ..: : .:. :.:.::
NP_001 RKELNMGQRCSDTRGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQR
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 ALDCAVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEA
::: :..:: .: .:: :.. :.:.: ::.::. .: ::. ::: :. . :
NP_001 ALDEATKYALERKTFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYA
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 AMAKLAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGH
..:: :.. :. .. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: .
NP_001 SIAKAFAGDIANQLATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVARE
360 370 380 390 400 410
410
pF1KE4 LLRSYRS
. .:..
NP_001 HIDKYKN
420
>>NP_001272971 (OMIM: 201450,607008) medium-chain specif (385 aa)
initn: 722 init1: 549 opt: 897 Z-score: 1094.8 bits: 211.4 E(85289): 3.1e-54
Smith-Waterman score: 897; 38.5% identity (68.8% similar) in 384 aa overlap (33-412:4-385)
10 20 30 40 50 60
pF1KE4 AALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDK
:. : .. . : : ::..:..:.::. ::
NP_001 MLQEFTEQQKEFQATARKFAREEIIPVAAEYDK
10 20 30
70 80 90 100 110 120
pF1KE4 EHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVN-NS
.:. ... :::. .::. :: :: . . ::.. :: ::: ... ::
NP_001 TGEYPVPLIRRAWELGLMNTHIPENCGGLGLGTFDACLISEELAYGC--TGVQTAIEGNS
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 LYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNG
: ::. :. .::. .. .: . . ..::: :::... .: :. .:: ...::
NP_001 LGQMPIIIAGNDQQKKKYLGRMTEEPLMCAYCVTEPGAGSDVAGIKTKAEKKGDEYIING
100 110 120 130 140 150
190 200 210 220 230
pF1KE4 TKAWITNAWEASAAVVFASTD---RALQNKSISAFLVPMPTPGLTLGKKEDKLGIRGSST
: ::::. .:. ..: .: .: ::....:.: :::. .:.:: ..: : :.:
NP_001 QKMWITNGGKANWYFLLARSDPDPKAPANKAFTGFIVEADTPGIQIGRKELNMGQRCSDT
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE4 ANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRM
...::: ..::...: : :::.:: ..: : .:. :.:.:: ::: :..:: .:
NP_001 RGIVFEDVKVPKENVLIGDGAGFKVAMGAFDKTRPVVAAGAVGLAQRALDEATKYALERK
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE4 AFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATA
.:: :.. :.:.: ::.::. .: ::. ::: :. . :..:: :.. :.
NP_001 TFGKLLVEHQAISFMLAEMAMKVELARMSYQRAAWEVDSGRRNTYYASIAKAFAGDIANQ
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE4 ISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
.. .:.::::: :. ::.:.:. .:::.: .::::::.::::..: . . .:..
NP_001 LATDAVQILGGNGFNTEYPVEKLMRDAKIYQIYEGTSQIQRLIVAREHIDKYKN
340 350 360 370 380
>>NP_001317103 (OMIM: 600301,610006) short/branched chai (330 aa)
initn: 850 init1: 756 opt: 894 Z-score: 1092.1 bits: 210.7 E(85289): 4.3e-54
Smith-Waterman score: 894; 44.1% identity (72.8% similar) in 331 aa overlap (80-410:1-330)
50 60 70 80 90 100
pF1KE4 EKELFPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGC
....: : ::.: ..:. ....::...
NP_001 MGIEVDPEYGGTGASFLSTVLVIEELAKVD
10 20 30
110 120 130 140 150 160
pF1KE4 ASTGVIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTT
::..:. ..:.: : : :..::: ... .:. .:.: : ::: : :::. : .:
NP_001 ASVAVFCEIQNTLINTLIRKHGTEEQKATYLPQLTT-EKVGSFCLSEAGAGSDSFALKTR
40 50 60 70 80
170 180 190 200 210 220
pF1KE4 ARAEGDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKED
: ::: .::::.: ::..: .:. .:.:..: .. :.:..::: :::: .:: :.
NP_001 ADKEGDYYVLNGSKMWISSAEHAGLFLVMANVDPTIGYKGITSFLVDRDTPGLHIGKPEN
90 100 110 120 130 140
230 240 250 260 270 280
pF1KE4 KLGIRGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDC
:::.:.::: : ::. ..:. .:::. : :.: :. .:. ::::::.: ::.:: .:
NP_001 KLGLRASSTCPLTFENVKVPEANILGQIGHGYKYAIGSLNEGRIGIAAQMLGLAQGCFDY
150 160 170 180 190 200
290 300 310 320 330 340
pF1KE4 AVNYAENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAK
.. : ..:. :: : .: .: ..: .: ::.:::::. :: : . :::::::.:::
NP_001 TIPYIKERIQFGKRLFDFQGLQHQVAHVATQLEAARLLTYNAARLLEAGKPFIKEASMAK
210 220 230 240 250 260
350 360 370 380 390 400
pF1KE4 LAASEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRS
::: : . . :. .::.::. ..:.:...:::.: ::::.:.:: .:: :.
NP_001 YYASEIAGQTTSKCIEWMGGVGYTKDYPVEKYFRDAKIGTIYEGASNIQLNTIAKHIDAE
270 280 290 300 310 320
410
pF1KE4 YRS
:
NP_001 Y
330
>>NP_002216 (OMIM: 243500,607036) isovaleryl-CoA dehydro (426 aa)
initn: 798 init1: 487 opt: 858 Z-score: 1046.7 bits: 202.7 E(85289): 1.5e-51
Smith-Waterman score: 858; 37.8% identity (70.5% similar) in 373 aa overlap (34-402:45-417)
10 20 30 40 50 60
pF1KE4 ALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQVDKE
: : ...: :: : ...: : : ..:.
NP_002 VASWRLRPPLAGFVSQRAHSLLPVDDAINGLSEEQRQLRQTMAKFLQEHLAPKAQEIDRS
20 30 40 50 60 70
70 80 90 100 110 120
pF1KE4 HLFPAAQV--KKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSVNNS
. : . :..:.::.:.. .: . ::.:: :: ....::::::. ...:. ......
NP_002 NEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGAHSN
80 90 100 110 120 130
130 140 150 160 170 180
pF1KE4 LYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWVLNG
: .. ... :.. ::. .. . ::. :: .:.:::. :::. . . :. .:. ..:::
NP_002 LCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYILNG
140 150 160 170 180 190
190 200 210 220 230
pF1KE4 TKAWITNAWEASAAVVFASTDRAL--QNKSISAFLVPMPTPGLTLGKKEDKLGIRGSSTA
.: ::::. .:.. .:.:.:: : ...:.::.: ::.. .:: ::::.:::.:
NP_002 NKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGSNTC
200 210 220 230 240 250
240 250 260 270 280 290
pF1KE4 NLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAENRMA
.::::::.:: .:::. . : . :. ::. :. .:. ::. :..:: .. : . : :
NP_002 ELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHVREA
260 270 280 290 300 310
300 310 320 330 340 350
pF1KE4 FGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAATAI
:: . ..:..: :.::: : . : .. .: :. . :. : . : ..: :: .
NP_002 FGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECATQV
320 330 340 350 360 370
360 370 380 390 400 410
pF1KE4 SHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
. ..:: .:: ::....: : :::.. :: ::::..::::
NP_002 ALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
380 390 400 410 420
>>XP_016877645 (OMIM: 243500,607036) PREDICTED: isovaler (407 aa)
initn: 833 init1: 487 opt: 857 Z-score: 1045.7 bits: 202.4 E(85289): 1.6e-51
Smith-Waterman score: 857; 37.2% identity (68.7% similar) in 387 aa overlap (20-402:13-398)
10 20 30 40 50 60
pF1KE4 MAAALLARASGPARRALCPRAWRQLHTIYQSVELPETHQMLLQTCRDFAEKELFPIAAQV
: :.. : :: . : :: : ...: : : ..
XP_016 MVFWWRIGQATYRLWHKGPQSVCSSLTPEQAE-LRQTMAKFLQEHLAPKAQEI
10 20 30 40 50
70 80 90 100 110
pF1KE4 DKEHLFPAAQV--KKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTGVIMSV
:. . : . :..:.::.:.. .: . ::.:: :: ....::::::. ...:. ...
XP_016 DRSNEFKNLREFWKQLGNLGVLGITAPVQYGGSGLGYLEHVLVMEEISRASGAVGLSYGA
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 NNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAEGDSWV
...: .. ... :.. ::. .. . ::. :: .:.:::. :::. . . :. .:. ..
XP_016 HSNLCINQLVRNGNEAQKEKYLPKLISGEYIGALAMSEPNAGSDVVSMKLKAEKKGNHYI
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 LNGTKAWITNAWEASAAVVFASTDRAL--QNKSISAFLVPMPTPGLTLGKKEDKLGIRGS
:::.: ::::. .:.. .:.:.:: : ...:.::.: ::.. .:: ::::.:::
XP_016 LNGNKFWITNGPDADVLIVYAKTDLAAVPASRGITAFIVEKGMPGFSTSKKLDKLGMRGS
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 STANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNYAEN
.: .::::::.:: .:::. . : . :. ::. :. .:. ::. :..:: .. : .
XP_016 NTCELIFEDCKIPAANILGHENKGVYVLMSGLDLERLVLAGGPLGLMQAVLDHTIPYLHV
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 RMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAMLKDNKKPFIKEAAMAKLAASEAA
: ::: . ..:..: :.::: : . : .. .: :. . :. : . : ..: :
XP_016 REAFGQKIGHFQLMQGKMADMYTRLMACRQYVYNVAKACDEGHCTAKDCAGVILYSAECA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 TAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
: .. ..:: .:: ::....: : :::.. :: ::::..::::
XP_016 TQVALDGIQCFGGNGYINDFPMGRFLRDAKLYEIGAGTSEVRRLVIGRAFNADFH
360 370 380 390 400
>>NP_055199 (OMIM: 604773,611283) isobutyryl-CoA dehydro (415 aa)
initn: 737 init1: 318 opt: 854 Z-score: 1042.0 bits: 201.8 E(85289): 2.7e-51
Smith-Waterman score: 854; 36.9% identity (69.7% similar) in 396 aa overlap (15-408:21-414)
10 20 30 40 50
pF1KE4 MAAALLARASGPARRALCPRAWRQLHT-IYQSVELPETHQMLLQTCRDFAEKEL
:.: . :.: . : :. : : .. . .. ::: .:.
NP_055 MLWSGCRRFGARLGCLPGGLRVLVQTGHRSLTSCIDPSMGLNEEQKEFQKVAFDFAAREM
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 FPIAAQVDKEHLFPAAQVKKMGGLGLLAMDVPEELGGAGLDYLAYAIAMEEISRGCASTG
: :. :...:::. ..: . ::. .. . ..::.::. : .. .: .. ::.::
NP_055 APNMAEWDQKELFPVDVMRKAAQLGFGGVYIQTDVGGSGLSRLDTSVIFEALATGCTSTT
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 VIMSVNNSLYLGPILKFGSKEQKQAWVTPFTSGDKIGCFALSEPGNGSDAGAASTTARAE
. .:..: . : .::..::.. . :. . .:.. . :.:::.::::.. :.:. .
NP_055 AYISIHN-MCAWMIDSFGNEEQRHKFCPPLCTMEKFASYCLTEPGSGSDAASLLTSAKKQ
130 140 150 160 170
180 190 200 210 220 230
pF1KE4 GDSWVLNGTKAWITNAWEASAAVVFASTDRALQNKSISAFLVPMPTPGLTLGKKEDKLGI
:: ..:::.::.:..: :.. ::. : :.:: ..: ::::..:::: :.:
NP_055 GDHYILNGSKAFISGAGESDIYVVMCRTGGP-GPKGISCIVVEKGTPGLSFGKKEKKVGW
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 RGSSTANLIFEDCRIPKDSILGEPGMGFKIAMQTLDMGRIGIASQALGIAQTALDCAVNY
.. : .::::: .: . .: :.:: ::.. :. :::.::: .:: :.... . ..
NP_055 NSQPTRAVIFEDCAVPVANRIGSEGQGFLIAVRGLNGGRINIASCSLGAAHASVILTRDH
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 AENRMAFGAPLTKLQVIQFKLADMALALESARLLTWRAAM-LKDNKKPFIKEAAMAKLAA
. : :: ::.. : .:: ::::: : .:::.. ::. :....: . .:::: :
NP_055 LNVRKQFGEPLASNQYLQFTLADMATRLVAARLMVRNAAVALQEERKDAVALCSMAKLFA
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 SEAATAISHQAIQILGGMGYVTEMPAERHYRDARITEIYEGTSEIQRLVIAGHLLRSYRS
.. :: .::.:. ::.::. .. .... ::.:. .: ::..:..:..:. ::.
NP_055 TDECFAICNQALQMHGGYGYLKDYAVQQYVRDSRVHQILEGSNEVMRILISRSLLQE
360 370 380 390 400 410
412 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 22:56:24 2016 done: Sat Nov 5 22:56:26 2016
Total Scan time: 8.640 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]