Result of FASTA (omim) for
pFN21AE4365
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4365, 383 aa
1>>>pF1KE4365 383 - 383 aa - 383 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.0483+/-0.000496; mu= 9.5896+/- 0.030
mean_var=243.2952+/-48.362, 0's: 0 Z-trim(117.4): 521 B-trim: 24 in 1/53
Lambda= 0.082226
statistics sampled from 28767 (29378) to 28767 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.344), width: 16
Scan time: 8.750
The best scores are: opt bits E(85289)
NP_003827 (OMIM: 176290) protein delta homolog 1 i ( 383) 2788 344.2 3.1e-94
NP_001304101 (OMIM: 176290) protein delta homolog ( 310) 1778 224.2 3.2e-58
XP_005266991 (OMIM: 606582) PREDICTED: delta-like ( 524) 832 112.3 2.7e-24
NP_005609 (OMIM: 606582) delta-like protein 1 prec ( 723) 832 112.5 3.2e-24
NP_061947 (OMIM: 605185,616589) delta-like protein ( 685) 800 108.7 4.3e-23
XP_016883196 (OMIM: 118450,187500,601920) PREDICTE (1059) 750 103.0 3.4e-21
NP_000205 (OMIM: 118450,187500,601920) protein jag (1218) 750 103.1 3.7e-21
NP_660142 (OMIM: 602570) protein jagged-2 isoform (1200) 742 102.1 7e-21
NP_002217 (OMIM: 602570) protein jagged-2 isoform (1238) 733 101.1 1.5e-20
NP_001186930 (OMIM: 102500,600275,610205) neurogen (1235) 627 88.5 9.1e-17
XP_005270958 (OMIM: 102500,600275,610205) PREDICTE (2432) 627 88.9 1.4e-16
XP_016856862 (OMIM: 102500,600275,610205) PREDICTE (2432) 627 88.9 1.4e-16
XP_011539822 (OMIM: 102500,600275,610205) PREDICTE (2432) 627 88.9 1.4e-16
XP_016856861 (OMIM: 102500,600275,610205) PREDICTE (2455) 627 88.9 1.4e-16
XP_011539821 (OMIM: 102500,600275,610205) PREDICTE (2467) 627 88.9 1.4e-16
NP_077719 (OMIM: 102500,600275,610205) neurogenic (2471) 627 88.9 1.4e-16
XP_011517019 (OMIM: 109730,190198,616028) PREDICTE (2314) 622 88.3 2e-16
NP_060087 (OMIM: 109730,190198,616028) neurogenic (2555) 622 88.4 2.1e-16
XP_005259981 (OMIM: 125310,130720,600276,615293) P (2269) 592 84.7 2.3e-15
NP_000426 (OMIM: 125310,130720,600276,615293) neur (2321) 592 84.7 2.3e-15
NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 543 78.8 1.2e-13
NP_982353 (OMIM: 277300,602768) delta-like protein ( 587) 530 76.6 1.7e-13
NP_058637 (OMIM: 277300,602768) delta-like protein ( 618) 530 76.6 1.8e-13
NP_001136272 (OMIM: 602772,612424) protein eyes sh (3144) 505 74.6 3.6e-12
NP_001278938 (OMIM: 602772,612424) protein eyes sh (3165) 505 74.6 3.6e-12
NP_001244895 (OMIM: 172870,600105,604210,613835) p ( 870) 495 72.6 3.9e-12
XP_011507669 (OMIM: 172870,600105,604210,613835) P (1297) 495 72.9 4.9e-12
XP_011507667 (OMIM: 172870,600105,604210,613835) P (1349) 495 72.9 5e-12
NP_957705 (OMIM: 172870,600105,604210,613835) prot (1406) 495 72.9 5.1e-12
XP_016856341 (OMIM: 172870,600105,604210,613835) P (1451) 495 73.0 5.2e-12
NP_001180569 (OMIM: 172870,600105,604210,613835) p (1294) 485 71.7 1.1e-11
NP_001258875 (OMIM: 603745) slit homolog 3 protein (1530) 469 69.9 4.5e-11
NP_001244894 (OMIM: 172870,600105,604210,613835) p (1382) 465 69.4 6e-11
XP_011512212 (OMIM: 603746) PREDICTED: slit homolo (1159) 459 68.5 8.8e-11
XP_016865268 (OMIM: 603745) PREDICTED: slit homolo (1460) 460 68.8 9.3e-11
NP_003053 (OMIM: 603745) slit homolog 3 protein is (1523) 460 68.8 9.5e-11
XP_016864334 (OMIM: 603746) PREDICTED: slit homolo (1495) 459 68.7 1e-10
XP_011512211 (OMIM: 603746) PREDICTED: slit homolo (1499) 459 68.7 1e-10
XP_006714049 (OMIM: 603746) PREDICTED: slit homolo (1509) 459 68.7 1e-10
NP_001276065 (OMIM: 603746) slit homolog 2 protein (1521) 459 68.7 1e-10
NP_001276064 (OMIM: 603746) slit homolog 2 protein (1525) 459 68.7 1e-10
NP_004778 (OMIM: 603746) slit homolog 2 protein is (1529) 459 68.7 1e-10
XP_005248268 (OMIM: 603746) PREDICTED: slit homolo (1533) 459 68.7 1e-10
NP_003052 (OMIM: 603742) slit homolog 1 protein pr (1534) 455 68.2 1.4e-10
NP_620711 (OMIM: 607299) delta and Notch-like epid ( 737) 443 66.4 2.5e-10
XP_005247007 (OMIM: 607299) PREDICTED: delta and N ( 696) 437 65.6 4e-10
NP_938024 (OMIM: 602772,612424) protein eyes shut ( 594) 412 62.6 2.8e-09
NP_001136273 (OMIM: 602772,612424) protein eyes sh ( 619) 412 62.6 2.9e-09
XP_005252032 (OMIM: 187380,615629) PREDICTED: tena (1564) 413 63.3 4.6e-09
XP_005252031 (OMIM: 187380,615629) PREDICTED: tena (1655) 413 63.3 4.8e-09
>>NP_003827 (OMIM: 176290) protein delta homolog 1 isofo (383 aa)
initn: 2788 init1: 2788 opt: 2788 Z-score: 1812.7 bits: 344.2 E(85289): 3.1e-94
Smith-Waterman score: 2788; 99.7% identity (100.0% similar) in 383 aa overlap (1-383:1-383)
10 20 30 40 50 60
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
:::::::::::::::::::.::::::::::::::::::::::::::::::::::::::::
NP_003 GLTCVKKRALSPQQVTRLPSGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
310 320 330 340 350 360
370 380
pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI
:::::::::::::::::::::::
NP_003 VNIIFPEKIDMTTFSKEAGDEEI
370 380
>>NP_001304101 (OMIM: 176290) protein delta homolog 1 is (310 aa)
initn: 1774 init1: 1774 opt: 1778 Z-score: 1166.1 bits: 224.2 E(85289): 3.2e-58
Smith-Waterman score: 2145; 80.9% identity (80.9% similar) in 383 aa overlap (1-383:1-310)
10 20 30 40 50 60
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCDQCVTS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSCAPGYS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCE
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFT
::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQ------------
190 200 210 220
250 260 270 280 290 300
pF1KE4 GLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLT
NP_001 ------------------------------------------------------------
310 320 330 340 350 360
pF1KE4 EGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -GQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSGEDLA
230 240 250 260 270 280
370 380
pF1KE4 VNIIFPEKIDMTTFSKEAGDEEI
:::::::::::::::::::::::
NP_001 VNIIFPEKIDMTTFSKEAGDEEI
290 300 310
>>XP_005266991 (OMIM: 606582) PREDICTED: delta-like prot (524 aa)
initn: 797 init1: 345 opt: 832 Z-score: 557.3 bits: 112.3 E(85289): 2.7e-24
Smith-Waterman score: 832; 43.4% identity (67.0% similar) in 221 aa overlap (26-244:226-440)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD
:.:.:. :.:::. . :.:. :::: ::
XP_005 DDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD
200 210 220 230 240 250
60 70 80 90 100 110
pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS
.:. :::::: : .: :: : .:: : .:..:. :. :: :..::.. .: : ::
XP_005 ECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC
: :::.: :. : . :::..::.:.: : . :: ::::: :..::. : .:
XP_005 CRPGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTC
320 330 340 350 360 370
180 190 200 210 220 230
pF1KE4 TPNPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC
. .:: : : :.: : . ::::.:. .: . . :.::::.::. :.. . .: :
XP_005 ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLC
380 390 400 410 420
240 250 260 270 280 290
pF1KE4 LCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELN
:. :.: :
XP_005 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSSGEASE
430 440 450 460 470 480
>>NP_005609 (OMIM: 606582) delta-like protein 1 precurso (723 aa)
initn: 742 init1: 345 opt: 832 Z-score: 555.8 bits: 112.5 E(85289): 3.2e-24
Smith-Waterman score: 832; 43.4% identity (67.0% similar) in 221 aa overlap (26-244:226-440)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD
:.:.:. :.:::. . :.:. :::: ::
NP_005 DDAFGHFTCGERGEKVCNPGWKGPYCTEPICLPGCDEQHGFCDKPGECKCRVGWQGRYCD
200 210 220 230 240 250
60 70 80 90 100 110
pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS
.:. :::::: : .: :: : .:: : .:..:. :. :: :..::.. .: : ::
NP_005 ECIRYPGCLHGTCQQPWQCNCQEGWGGLFCNQDLNYCTHHKPCKNGATCTNTGQGSYTCS
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC
: :::.: :. : . :::..::.:.: : . :: ::::: :..::. : .:
NP_005 CRPGYTGATCELGIDEC--DPSPCKNGGSCTDLE---NSYSCTCPPGFYGKICELSAMTC
320 330 340 350 360 370
180 190 200 210 220 230
pF1KE4 TPNPCENDGVCTDI-GGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYEC
. .:: : : :.: : . ::::.:. .: . . :.::::.::. :.. . .: :
NP_005 ADGPCFNGGRCSDSPDGGYSCRCPVGYSGFNCEKKIDYCSSSPCSNGAKCVDLGD-AYLC
380 390 400 410 420
240 250 260 270 280 290
pF1KE4 LCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELN
:. :.: :
NP_005 RCQAGFSGRHCDDNVDDCASSPCANGGTCRDGVNDFSCTCPPGYTGRNCSAPVSRCEHAP
430 440 450 460 470 480
>>NP_061947 (OMIM: 605185,616589) delta-like protein 4 p (685 aa)
initn: 794 init1: 329 opt: 800 Z-score: 535.5 bits: 108.7 E(85289): 4.3e-23
Smith-Waterman score: 801; 36.3% identity (60.1% similar) in 311 aa overlap (26-331:222-518)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLCD
:. .:. :::.: : :.::::: ::.
NP_061 NDHFGHYVCQPDGNLSCLPGWTGEYCQQPICLSGCHEQNGYCSKPAECLCRPGWQGRLCN
200 210 220 230 240 250
60 70 80 90 100 110
pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYECS
.:. :: :: :. : :: : .:: : .::.:. :. .:: :..:: . . : :.
NP_061 ECIPHNGCRHGTCSTPWQCTCDEGWGGLFCDQDLNYCTHHSPCKNGATCSNSGQRSYTCT
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE4 CAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSC
: :::.: ::. . . : ...::..::.: :.: . : ::::::. : :: . ::
NP_061 CRPGYTGVDCELELSEC--DSNPCRNGGSCKDQED-GYH--CLCPPGYYGLHCEHSTLSC
320 330 340 350 360
180 190 200 210 220 230
pF1KE4 TPNPCENDGVCTD--IGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE
. .:: : : : . :... :.:: .: ..: . : :.:.:: ::: ::.. :
NP_061 ADSPCFNGGSCRERNQGANYACECPPNFTGSNCEKKVDRCTSNPCANGGQCLNRGP-SRM
370 380 390 400 410 420
240 250 260 270 280 290
pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYG-LAYRLTPGVH-ELPVQQPEHRILKVSMK
: :.: ::: : : .. .: : ..: . : :. :. .: .
NP_061 CRCRPGFTGTYC----ELHVSDCARNPCAHGGTCHDLENGLMCTCPAGFSGRRCEVRTSI
430 440 450 460 470 480
300 310 320 330 340 350
pF1KE4 ELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLL
. ..: . ..: :.: :.. ..: :.: ..::
NP_061 DACASSPCF--NRATCYTDLST-DTFVCNCPYGFVG-SRCEFPVGLPPSFPWVAVSLGVG
490 500 510 520 530
360 370 380
pF1KE4 LQYNSGEDLAVNIIFPEKIDMTTFSKEAGDEEI
NP_061 LAVLLVLLGMVAVAVRQLRLRRPDDGSREAMNNLSDFQKDNLIPAAQLKNTNQKKELEVD
540 550 560 570 580 590
>>XP_016883196 (OMIM: 118450,187500,601920) PREDICTED: p (1059 aa)
initn: 972 init1: 297 opt: 750 Z-score: 501.5 bits: 103.0 E(85289): 3.4e-21
Smith-Waterman score: 750; 39.2% identity (64.4% similar) in 222 aa overlap (24-244:73-288)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPL
: : .:.:..: :. . :::: ::::
XP_016 PRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLY
50 60 70 80 90 100
60 70 80 90 100 110
pF1KE4 CDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYE
::.:. :::.::.:.:: ::.: .: :.:::.:. :.. :: :.::: . :.
XP_016 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ
110 120 130 140 150 160
120 130 140 150 160 170
pF1KE4 CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVAN
::: :::: .:. . :. ..::.. :.: . . : : ::..: : .
XP_016 CSCPEGYSGPNCEIAEHACL--SDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNID
170 180 190 200 210
180 190 200 210 220 230
pF1KE4 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE
.:.:: : . :.: :. . :.: :: . :::. ...: ..:: :. .: .. .::
XP_016 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSC-KNLIASYY
220 230 240 250 260 270
240 250 260 270 280 290
pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKEL
: : : . : .:
XP_016 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP
280 290 300 310 320 330
>--
initn: 736 init1: 265 opt: 521 Z-score: 354.7 bits: 75.8 E(85289): 5.1e-13
Smith-Waterman score: 624; 37.7% identity (64.0% similar) in 228 aa overlap (30-244:440-658)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN----VCRCQPGWQGPLC-
:.:. : :.... .: :. :. : :
XP_016 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH-GKCKSQSGGKFTCDCNKGFTGTYCH
410 420 430 440 450 460
60 70 80 90 100
pF1KE4 ---DQCVTSPGCLHG-LCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD
..: ..: : .: : . .:::.:::.: :. .. ::. :: :.::: .:
XP_016 ENINDCESNP-CRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV
470 480 490 500 510 520
110 120 130 140 150 160
pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC
. .: :.: :..:: :...:. : . . :..:::: : :: : .:.:: :. :. :
XP_016 NDFY-CDCKNGWKGKTCHSRDSQC--DEATCNNGGTCYD-EGDAF--KCMCPGGWEGTTC
530 540 550 560 570 580
170 180 190 200 210 220
pF1KE4 EIVANS-CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH
.:. :: : ::::.: :.:. : .: : : :. :.. ...:. :: :.:::..
XP_016 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG
590 600 610 620 630 640
230 240 250 260 270 280
pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK
. :.: : : :.: :
XP_016 DNW-YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS
650 660 670 680 690 700
>--
initn: 257 init1: 257 opt: 411 Z-score: 284.2 bits: 62.8 E(85289): 4.3e-09
Smith-Waterman score: 411; 37.0% identity (63.8% similar) in 138 aa overlap (86-223:289-419)
60 70 80 90 100 110
pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSC
: .. : . : :...: .: .: :.: :
XP_016 AKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG-YRCIC
260 270 280 290 300 310
120 130 140 150 160 170
pF1KE4 APGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT
:::.: :.. :. : :: .:: : .. .: .:::: :::::.:.. . :
XP_016 PPGYAGDHCERDIDECASN--PCLNGGHCQNEINRF---QCLCPTGFSGNLCQLDIDYCE
320 330 340 350 360 370
180 190 200 210 220 230
pF1KE4 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC
::::.: . : . ..:. :.:: . :.::. .: ..::. .:
XP_016 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG
380 390 400 410 420 430
240 250 260 270 280 290
pF1KE4 KPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK
XP_016 VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS
440 450 460 470 480 490
>>NP_000205 (OMIM: 118450,187500,601920) protein jagged- (1218 aa)
initn: 972 init1: 297 opt: 750 Z-score: 500.9 bits: 103.1 E(85289): 3.7e-21
Smith-Waterman score: 750; 39.2% identity (64.4% similar) in 222 aa overlap (24-244:232-447)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPL
: : .:.:..: :. . :::: ::::
NP_000 PRDDFFGHYACDQNGNKTCMEGWMGPECNRAICRQGCSPKHGSCKLPGDCRCQYGWQGLY
210 220 230 240 250 260
60 70 80 90 100 110
pF1KE4 CDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSS-APCANNGTCVSLDDGLYE
::.:. :::.::.:.:: ::.: .: :.:::.:. :.. :: :.::: . :.
NP_000 CDKCIPHPGCVHGICNEPWQCLCETNWGGQLCDKDLNYCGTHQPCLNGGTCSNTGPDKYQ
270 280 290 300 310 320
120 130 140 150 160 170
pF1KE4 CSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVAN
::: :::: .:. . :. ..::.. :.: . . : : ::..: : .
NP_000 CSCPEGYSGPNCEIAEHACL--SDPCHNRGSCKET---SLGFECECSPGWTGPTCSTNID
330 340 350 360 370
180 190 200 210 220 230
pF1KE4 SCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYE
.:.:: : . :.: :. . :.: :: . :::. ...: ..:: :. .: .. .::
NP_000 DCSPNNCSHGGTCQDLVNGFKCVCPPQWTGKTCQLDANECEAKPCVNAKSC-KNLIASYY
380 390 400 410 420 430
240 250 260 270 280 290
pF1KE4 CLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKEL
: : : . : .:
NP_000 CDCLPGWMGQNCDININDCLGQCQNDASCRDLVNGYRCICPPGYAGDHCERDIDECASNP
440 450 460 470 480 490
>--
initn: 736 init1: 265 opt: 521 Z-score: 354.1 bits: 75.9 E(85289): 5.5e-13
Smith-Waterman score: 624; 37.7% identity (64.0% similar) in 228 aa overlap (30-244:599-817)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN----VCRCQPGWQGPLC-
:.:. : :.... .: :. :. : :
NP_000 TTPCEVIDSCTVAMASNDTPEGVRYISSNVCGPH-GKCKSQSGGKFTCDCNKGFTGTYCH
570 580 590 600 610 620
60 70 80 90 100
pF1KE4 ---DQCVTSPGCLHG-LCGE---PGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLD
..: ..: : .: : . .:::.:::.: :. .. ::. :: :.::: .:
NP_000 ENINDCESNP-CRNGGTCIDGVNSYKCICSDGWEGAYCETNINDCSQNPCHNGGTCRDLV
630 640 650 660 670 680
110 120 130 140 150 160
pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC
. .: :.: :..:: :...:. : . . :..:::: : :: : .:.:: :. :. :
NP_000 NDFY-CDCKNGWKGKTCHSRDSQC--DEATCNNGGTCYD-EGDAF--KCMCPGGWEGTTC
690 700 710 720 730 740
170 180 190 200 210 220
pF1KE4 EIVANS-CTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH
.:. :: : ::::.: :.:. : .: : : :. :.. ...:. :: :.:::..
NP_000 NIARNSSCLPNPCHNGGTCVVNGESFTCVCKEGWEGPICAQNTNDCSPHPCYNSGTCVDG
750 760 770 780 790 800
230 240 250 260 270 280
pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK
. :.: : : :.: :
NP_000 DNW-YRCECAPGFAGPDCRININECQSSPCAFGATCVDEINGYRCVCPPGHSGAKCQEVS
810 820 830 840 850
>--
initn: 257 init1: 257 opt: 411 Z-score: 283.6 bits: 62.9 E(85289): 4.7e-09
Smith-Waterman score: 411; 37.0% identity (63.8% similar) in 138 aa overlap (86-223:448-578)
60 70 80 90 100 110
pF1KE4 QCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGLYECSC
: .. : . : :...: .: .: :.: :
NP_000 AKPCVNAKSCKNLIASYYCDCLPGWMGQNCDININDCLGQ-CQNDASCRDLVNG-YRCIC
420 430 440 450 460 470
120 130 140 150 160 170
pF1KE4 APGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCT
:::.: :.. :. : :: .:: : .. .: .:::: :::::.:.. . :
NP_000 PPGYAGDHCERDIDECASN--PCLNGGHCQNEINRF---QCLCPTGFSGNLCQLDIDYCE
480 490 500 510 520 530
180 190 200 210 220 230
pF1KE4 PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLC
::::.: . : . ..:. :.:: . :.::. .: ..::. .:
NP_000 PNPCQNGAQCYNRASDYFCKCPEDYEGKNCSHLKDHCRTTPCEVIDSCTVAMASNDTPEG
540 550 560 570 580 590
240 250 260 270 280 290
pF1KE4 KPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKK
NP_000 VRYISSNVCGPHGKCKSQSGGKFTCDCNKGFTGTYCHENINDCESNPCRNGGTCIDGVNS
600 610 620 630 640 650
>>NP_660142 (OMIM: 602570) protein jagged-2 isoform b pr (1200 aa)
initn: 1053 init1: 302 opt: 742 Z-score: 495.8 bits: 102.1 E(85289): 7e-21
Smith-Waterman score: 748; 37.2% identity (57.7% similar) in 298 aa overlap (18-311:237-518)
10 20 30 40
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP
:. : : .:: .: : . :::.
NP_660 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY
210 220 230 240 250 260
50 60 70 80 90 100
pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL
:::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::..
NP_660 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA
270 280 290 300 310 320
110 120 130 140 150 160
pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF
. :.:.: ::::..:.: . :. : :: .::.: . : : :: :.::
NP_660 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT
330 340 350 360 370 380
170 180 190 200 210 220
pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH
: . . :. ::: :.:.: :.: :: .. ::. :..: . ::.:::: .
NP_660 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDVNDC-RGQCQHGGTC-KD
390 400 410 420 430
230 240 250 260 270 280
pF1KE4 TQVSYECLCKPEFTGLTCVKKR---ALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR
.:.:.: : : : .: : :: . .: :: :. : : :
NP_660 LVNGYQCVCPRGFGGRHCELERDECASSPCH-----SG-GLCEDLADGFHCHCPQGFSGP
440 450 460 470 480 490
290 300 310 320 330 340
pF1KE4 ILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHML
. .:.. .: . .: .. : :... :
NP_660 LCEVDV-DLCEPSP--CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDG
500 510 520 530 540 550
>--
initn: 604 init1: 256 opt: 477 Z-score: 325.9 bits: 70.7 E(85289): 2e-11
Smith-Waterman score: 591; 36.4% identity (55.6% similar) in 239 aa overlap (21-244:593-824)
10 20 30 40
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQ----NGFCEDDN---VC
:: : . : : .: : :. :
NP_660 AASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCLGQPCRNGGTCIDEVDAFRC
570 580 590 600 610 620
50 60 70 80 90
pF1KE4 RCQPGWQGPLCD----QCVTSPGCLHGLCGE---PGQCICTDGWDGELCDRDVRACSSAP
: ::.: ::: .:. .: .: : . : : ::: :. : :..
NP_660 FCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGWKGKTCHSREFQCDAYT
630 640 650 660 670 680
100 110 120 130 140 150
pF1KE4 CANNGTCVSLDDGLYECSCAPGYSGKDCQ-KKDGPCVINGSPCQHGGTCVDDEGRASHAS
:.:.::: . : ..:.: ::..:. : :.. :. : :: .::::: : .. :
NP_660 CSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPN--PCVNGGTCV---GSGASFS
690 700 710 720 730
160 170 180 190 200 210
pF1KE4 CLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASS
:.: :. : : .:.:.: :: : :.:.: . :::.: :: : . .: ::
NP_660 CICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPDCRINIDECQSS
740 750 760 770 780 790
220 230 240 250 260 270
pF1KE4 PCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHEL
:: :.::... . .:.: : : .: :
NP_660 PCAYGATCVDEIN-GYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPHGSSWVEDCNSCR
800 810 820 830 840 850
>>NP_002217 (OMIM: 602570) protein jagged-2 isoform a pr (1238 aa)
initn: 1253 init1: 302 opt: 733 Z-score: 489.9 bits: 101.1 E(85289): 1.5e-20
Smith-Waterman score: 733; 39.9% identity (61.8% similar) in 228 aa overlap (18-244:237-458)
10 20 30 40
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDNVCRCQP
:. : : .:: .: : . :::.
NP_002 CNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNLLHGGCTVPGECRCSY
210 220 230 240 250 260
50 60 70 80 90 100
pF1KE4 GWQGPLCDQCVTSPGCLHGLCGEPGQCICTDGWDGELCDRDVRACSSA-PCANNGTCVSL
:::: .::.:: :::.:: : :: :: : .: : :::.:. :.: ::.:.:::..
NP_002 GWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGGLLCDKDLNYCGSHHPCTNGGTCINA
270 280 290 300 310 320
110 120 130 140 150 160
pF1KE4 DDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNF
. :.:.: ::::..:.: . :. : :: .::.: . : : :: :.::
NP_002 EPDQYRCTCPDGYSGRNCEKAEHACTSN--PCANGGSCHE---VPSGFECHCPSGWSGPT
330 340 350 360 370 380
170 180 190 200 210 220
pF1KE4 CEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQH
: . . :. ::: :.:.: :.: :: .. ::. ...: ..:: :. .: ..
NP_002 CALDIDECASNPCAAGGTCVDQVDGFECICPEQWVGATCQLDANECEGKPCLNAFSC-KN
390 400 410 420 430 440
230 240 250 260 270 280
pF1KE4 TQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILK
.: : : : . :..:
NP_002 LIGGYYCDCIPGWKGINCHINVNDCRGQCQHGGTCKDLVNGYQCVCPRGFGGRHCELERD
450 460 470 480 490 500
>--
initn: 638 init1: 266 opt: 376 Z-score: 261.0 bits: 58.7 E(85289): 8.4e-08
Smith-Waterman score: 526; 33.6% identity (55.5% similar) in 247 aa overlap (25-237:501-740)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCED--DNV-CRCQPGWQG
:: . ..:.::: :. :.: :..:
NP_002 HGGTCKDLVNGYQCVCPRGFGGRHCELERDECASSPCHSGGLCEDLADGFHCHCPQGFSG
480 490 500 510 520 530
60 70 80 90
pF1KE4 PLC----DQCVTSPGCLHGL-CGE-PGQ--CICTDGWDGELCD-----------RDVRAC
::: : : :: : .: : . :. : : : . :. :. : . .:
NP_002 PLCEVDVDLCEPSP-CRNGARCYNLEGDYYCACPDDFGGKNCSVPREPCPGGACRVIDGC
540 550 560 570 580
100 110 120 130 140
pF1KE4 SS--AP----------CANNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQH
.: .: :. .: ::: : . : : :..: :... :. :.::..
NP_002 GSDAGPGMPGTAASGVCGPHGRCVSQPGGNFSCICDSGFTGTYCHENIDDCL--GQPCRN
590 600 610 620 630 640
150 160 170 180 190 200
pF1KE4 GGTCVDDEGRASHASCLCPPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGF
::::.:. .. :.:: :. :..:. :.: :.::.. : : :. .:: : : :.
NP_002 GGTCIDE---VDAFRCFCPSGWEGELCDTNPNDCLPDPCHSRGRCYDLVNDFYCACDDGW
650 660 670 680 690 700
210 220 230 240 250 260
pF1KE4 IDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPN
::: .: . :.::::: . . ...: : :
NP_002 KGKTCHSREFQCDAYTCSNGGTCYDSGD-TFRCACPPGWKGSTCAVAKNSSCLPNPCVNG
710 720 730 740 750 760
270 280 290 300 310 320
pF1KE4 GYGLAYRLTPGVHELPVQQPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLG
NP_002 GTCVGSGASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICVDGVNWFRCECAPGFAGPD
770 780 790 800 810 820
>--
initn: 249 init1: 249 opt: 361 Z-score: 251.4 bits: 57.0 E(85289): 2.9e-07
Smith-Waterman score: 433; 32.1% identity (55.0% similar) in 280 aa overlap (48-306:741-992)
20 30 40 50 60
pF1KE4 GHSTYGAECFPACNPQNGFCEDDNVCRCQPGWQGPLC-----DQCVTSPGCLHG-LC---
::.: : ..:. .: :..: :
NP_002 SREFQCDAYTCSNGGTCYDSGDTFRCACPPGWKGSTCAVAKNSSCLPNP-CVNGGTCVGS
720 730 740 750 760
70 80 90 100 110 120
pF1KE4 GEPGQCICTDGWDGELCDRDVRACSSAPCANNGTCVSLDDGL--YECSCAPGYSGKDCQK
: .::: :::.:. : ... :. :: :.: :: ::. ..: ::::..: ::.
NP_002 GASFSCICRDGWEGRTCTHNTNDCNPLPCYNGGICV---DGVNWFRCECAPGFAGPDCRI
770 780 790 800 810 820
130 140 150 160 170
pF1KE4 KDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC-EIVA--NSC----TPNPC
. : ..::: .:.::::. . : :::: .: : :... :: :: :
NP_002 NIDEC--QSSPCAYGATCVDE---INGYRCSCPPGRAGPRCQEVIGFGRSCWSRGTPFPH
830 840 850 860 870 880
180 190 200 210 220 230
pF1KE4 ENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHTQVSYECLCKPEF
.. : : .. ::: : : ::. . :. .:: .: : .: .: :
NP_002 GSSWV-EDCNS---CRCLDGRRD--CSK--VWCGWKPCLLAG---QPEALSAQC---P--
890 900 910 920
240 250 260 270 280 290
pF1KE4 TGLTCVKKRALSPQQVTRLP-NGYG-LAYRLTPGVHELPVQ-QPEHRILKVSMKELNKKT
: :..: .: : : : ...: . . :.. :: . . .. ..... ..
NP_002 LGQRCLEK---APGQCLRPPCEAWGECGAEEPPSTPCLPRSGHLDNNCARLTLHFNRDHV
930 940 950 960 970 980
300 310 320 330 340 350
pF1KE4 PLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLRYNHMLRKKKNLLLQYNSG
: : :::
NP_002 PQGTTVGAICSGIRSLPATRAVARDRLLVLLCDRASSGASAVEVAVSFSPARDLPDSSLI
990 1000 1010 1020 1030 1040
>>NP_001186930 (OMIM: 102500,600275,610205) neurogenic l (1235 aa)
initn: 1105 init1: 309 opt: 627 Z-score: 422.0 bits: 88.5 E(85289): 9.1e-17
Smith-Waterman score: 633; 39.4% identity (59.3% similar) in 236 aa overlap (25-244:341-567)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAEC-FPACNPQNGFCEDDNV---CRCQPGWQ
.: : .:.: .. : : . : : :
NP_001 NGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP-GSTCIDRVASFSCMCPEGKA
320 330 340 350 360
60 70 80 90
pF1KE4 GPLC---DQCVTSPGCLHG-LCG-EP--GQ--CICTDGWDGELCDRDVRACS---SAPCA
: :: : :...: : .: :: .: :: : : .:. : : .:: :. : ::
NP_001 GLLCHLDDACISNP-CHKGALCDTNPLNGQYICTCPQGYKGADCTEDVDECAMANSNPCE
370 380 390 400 410 420
100 110 120 130 140 150
pF1KE4 NNGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLC
. : ::. : : ..: : ::.: :. . : ...:::. .::.: : .:::
NP_001 HAGKCVNTD-GAFHCECLKGYAGPRCEMDINEC--HSDPCQNDATCLDKIG---GFTCLC
430 440 450 460 470 480
160 170 180 190 200 210
pF1KE4 PPGFSGNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ
:::.: ::. : : ::: :.: :.: . :.: :: :: .:. . .:.:.::
NP_001 MPGFKGVHCELEINECQSNPCVNNGQCVDKVNRFQCLCPPGFTGPVCQIDIDDCSSTPCL
490 500 510 520 530 540
220 230 240 250 260 270
pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ
::. :..: . .::: : :::. :
NP_001 NGAKCIDHPN-GYECQCATGFTGVLCEENIDNCDPDPCHHGQCQDGIDSYTCICNPGYMG
550 560 570 580 590 600
>--
initn: 1105 init1: 309 opt: 627 Z-score: 422.0 bits: 88.5 E(85289): 9.1e-17
Smith-Waterman score: 627; 38.5% identity (61.9% similar) in 231 aa overlap (25-244:876-1098)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCEDDN---VCRCQPGWQG
::. ..:.:.. . .:.: ::..:
NP_001 AVCKESPNFESYTCLCAPGWQGQRCTIDIDECISKPCMNHGLCHNTQGSYMCECPPGFSG
850 860 870 880 890 900
60 70 80 90 100
pF1KE4 PLC----DQCVTSPGCLHGLCGEPG----QCICTDGWDGELCDRDVRACSSAPCANNGTC
: :.:...: : .: : .:.: :. :. :. :. : : :: :.:::
NP_001 MDCEEDIDDCLANP-CQNGGSCMDGVNTFSCLCLPGFTGDKCQTDMNECLSEPCKNGGTC
910 920 930 940 950 960
110 120 130 140 150 160
pF1KE4 VSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFS
. .. : :.: :..: :... . :. : : .:::::: : : ::::: ::.
NP_001 SDYVNS-YTCKCQAGFDGVHCENNINECT--ESSCFNGGTCVD--GINSF-SCLCPVGFT
970 980 990 1000 1010
170 180 190 200 210 220
pF1KE4 GNFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTC
:.:: : :. .:: :.:.:.: : .:: :: :. :.:. :. :. :::.: :::
NP_001 GSFCLHEINECSSHPCLNEGTCVDGLGTYRCSCPLGYTGKNCQTLVNLCSRSPCKNKGTC
1020 1030 1040 1050 1060 1070
230 240 250 260 270 280
pF1KE4 LQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHR
.:. : .::: ..: :
NP_001 VQKKAES-QCLCPSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCINAGNTHYCQC
1080 1090 1100 1110 1120 1130
>--
initn: 262 init1: 262 opt: 589 Z-score: 397.6 bits: 84.0 E(85289): 2.1e-15
Smith-Waterman score: 589; 34.9% identity (59.2% similar) in 238 aa overlap (25-252:610-836)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLLLAFGHSTYGAECFPACNPQNGFCED---DNVCRCQPGWQG
::. . ..: : : : :::: .:
NP_001 HHGQCQDGIDSYTCICNPGYMGAICSDQIDECYSSPCLNDGRCIDLVNGYQCNCQPGTSG
580 590 600 610 620 630
60 70 80 90 100
pF1KE4 PLC----DQCVTSPGCLHGLCGEP---GQCICTDGWDGELCDRDVRACSSAPCANNGTCV
: :.:...: :.::.: . .:.:. :. :. :. :. :.: :: ...::.
NP_001 VNCEINFDDCASNP-CIHGICMDGINRYSCVCSPGFTGQRCNIDIDECASNPCRKGATCI
640 650 660 670 680 690
110 120 130 140 150 160
pF1KE4 SLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSG
. .: ..: : : .: .. . :. : :: ::. :. : : .::: :. :
NP_001 NGVNG-FRCICPEGPHHPSCYSQVNECLSN--PCIHGN-CT---GGLSGYKCLCDAGWVG
700 710 720 730 740 750
170 180 190 200 210 220
pF1KE4 NFCEIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCL
::. : : :::.: :.: .. . .:: : :: .:. . .:::.:: : :::.
NP_001 INCEVDKNECLSNPCQNGGTCDNLVNGYRCTCKKGFKGYNCQVNIDECASNPCLNQGTCF
760 770 780 790 800 810
230 240 250 260 270 280
pF1KE4 QHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRI
. . .: : : .:: .: . .:.:
NP_001 DDIS-GYTCHCVLPYTGKNC--QTVLAPCSPNPCENAAVCKESPNFESYTCLCAPGWQGQ
820 830 840 850 860
>--
initn: 491 init1: 263 opt: 587 Z-score: 396.3 bits: 83.8 E(85289): 2.5e-15
Smith-Waterman score: 587; 34.7% identity (58.5% similar) in 277 aa overlap (6-261:7-272)
10 20 30 40 50
pF1KE4 MTATEALLRVLLLL-LAFGHSTYGAECFPACNP--QNGFC----EDDNVCRCQPGWQGP
::: .:: : : . ... .: . .: ..:.: . . :.: :. :
NP_001 MPALRPALLWALLALWLCCAAPAHALQCRDGYEPCVNEGMCVTYHNGTGYCKCPEGFLGE
10 20 30 40 50 60
60 70 80 90
pF1KE4 LCDQCVTSPGCLHGLCGEPGQCI-----------CTDGWDGELCDRDV-RAC-SSAPCAN
:.. .: : .. : . : :. :..:. :: :. .. . : : :: :
NP_001 YCQH--RDP-CEKNRCQNGGTCVAQAMLGKATCRCASGFTGEDCQYSTSHPCFVSRPCLN
70 80 90 100 110
100 110 120 130 140 150
pF1KE4 NGTCVSLDDGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCP
.::: :. :::.: :..::.:: :. :. . :: .:.::. :.. :: :
NP_001 GGTCHMLSRDTYECTCQVGFTGKECQWTDA-CL--SHPCANGSTCTT---VANQFSCKCL
120 130 140 150 160 170
160 170 180 190 200 210
pF1KE4 PGFSGNFCEIVANSCT-PNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQ
::.:. :: .: : :. :.. :.: .. :...:.:: :: . :. . :: :::
NP_001 TGFTGQKCETDVNECDIPGHCQHGGTCLNLPGSYQCQCPQGFTGQYCDSLYVPCAPSPCV
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE4 NGGTCLQHTQVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQ
::::: : . ..:: : : : : :: .. :.. : ::
NP_001 NGGTCRQTGDFTFECNCLPGFEGSTCERNIDDCPNH--RCQNGGVCVDGVNTYNCRCPPQ
240 250 260 270 280
280 290 300 310 320 330
pF1KE4 QPEHRILKVSMKELNKKTPLLTEGQAICFTILGVLTSLVVLGTVGIVFLNKCETWVSNLR
NP_001 WTGQFCTEDVDECLLQPNACQNGGTCANRNGGYGCVCVNGWSGDDCSENIDDCAFASCTP
290 300 310 320 330 340
>--
initn: 433 init1: 265 opt: 340 Z-score: 238.0 bits: 54.5 E(85289): 1.6e-06
Smith-Waterman score: 340; 37.1% identity (67.6% similar) in 105 aa overlap (138-242:1120-1220)
110 120 130 140 150 160
pF1KE4 DGLYECSCAPGYSGKDCQKKDGPCVINGSPCQHGGTCVDDEGRASHASCLCPPGFSGNFC
:::.:.:.. : . . : :: :..:..:
NP_001 PSGWAGAYCDVPNVSCDIAASRRGVLVEHLCQHSGVCIN-AGNTHY--CQCPLGYTGSYC
1090 1100 1110 1120 1130 1140
170 180 190 200 210 220
pF1KE4 EIVANSCTPNPCENDGVCTDIGGDFRCRCPAGFIDKTCSRPVTNCASSPCQNGGTCLQHT
: . :. :::.. ..:.:. : .::.: :. .: : .: ..::::::::.. .
NP_001 EEQLDECASNPCQHGATCSDFIGGYRCECVPGYQGVNCEYEVDECQNQPCQNGGTCIDLV
1150 1160 1170 1180 1190 1200
230 240 250 260 270 280
pF1KE4 QVSYECLCKPEFTGLTCVKKRALSPQQVTRLPNGYGLAYRLTPGVHELPVQQPEHRILKV
. ..: : : :.
NP_001 N-HFKCSCPPGTRGMKSSLSIFHPGHCLKL
1210 1220 1230
383 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 02:02:44 2016 done: Sun Nov 6 02:02:46 2016
Total Scan time: 8.750 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]