FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4326, 328 aa
  1>>>pF1KE4326 328 - 328 aa - 328 aa
Library: human.CCDS.faa
  18511270 residues in 32554 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 6.2746+/-0.00063; mu= 14.9078+/- 0.039
 mean_var=148.0931+/-29.679, 0's: 0 Z-trim(117.5): 25  B-trim: 161 in 2/54
 Lambda= 0.105392
 statistics sampled from 18184 (18210) to 18184 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.842), E-opt: 0.2 (0.559), width:  16
 Scan time:  2.860

The best scores are:                                      opt bits E(32554)
CCDS42815.1 IGFBP2 gene_id:3485|Hs108|chr2         ( 325) 2331 365.0 4.6e-101
CCDS82570.1 IGFBP2 gene_id:3485|Hs108|chr2         ( 181) 1261 202.0 2.9e-52
CCDS5505.1 IGFBP3 gene_id:3486|Hs108|chr7          ( 291)  503 87.0   2e-17
CCDS34632.1 IGFBP3 gene_id:3486|Hs108|chr7         ( 297)  456 79.9 2.9e-15


>>CCDS42815.1 IGFBP2 gene_id:3485|Hs108|chr2              (325 aa)
 initn: 2227 init1: 2227 opt: 2331  Z-score: 1927.9  bits: 365.0 E(32554): 4.6e-101
Smith-Waterman score: 2331; 99.1% identity (99.1% similar) in 328 aa overlap (1-328:1-325)

               10        20        30        40        50        60
pF1KE4 MLPRVGCPALPLPPPPLLPLLPLLLLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPP
       :::::::::::::::::::::   ::::::::::::::::::::::::::::::::::::
CCDS42 MLPRVGCPALPLPPPPLLPLL---LLLLGASGGGGGARAEVLFRCPPCTPERLAACGPPP
               10        20           30        40        50       

               70        80        90       100       110       120
pF1KE4 VAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGS
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 VAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPHPGS
        60        70        80        90       100       110       

              130       140       150       160       170       180
pF1KE4 ELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAG
       120       130       140       150       160       170       

              190       200       210       220       230       240
pF1KE4 RKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 RKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLER
       180       190       200       210       220       230       

              250       260       270       280       290       300
pF1KE4 ISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS42 ISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGA
       240       250       260       270       280       290       

              310       320        
pF1KE4 PTIRGDPECHLFYNEQQEARGVHTQRMQ
       ::::::::::::::::::::::::::::
CCDS42 PTIRGDPECHLFYNEQQEARGVHTQRMQ
       300       310       320     

>>CCDS82570.1 IGFBP2 gene_id:3485|Hs108|chr2              (181 aa)
 initn: 1261 init1: 1261 opt: 1261  Z-score: 1051.7  bits: 202.0 E(32554): 2.9e-52
Smith-Waterman score: 1261; 99.4% identity (100.0% similar) in 178 aa overlap (151-328:4-181)

              130       140       150       160       170       180
pF1KE4 ELPLQALVMGEGTCEKRRDAEYGASPEQVADNGDDHSEGGLVENHVDSTMNMLGGGGSAG
                                     .:::::::::::::::::::::::::::::
CCDS82                            MPCNNGDDHSEGGLVENHVDSTMNMLGGGGSAG
                                          10        20        30   

              190       200       210       220       230       240
pF1KE4 RKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLER
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 RKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEEPKKLRPPPARTPCQQELDQVLER
            40        50        60        70        80        90   

              250       260       270       280       290       300
pF1KE4 ISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGA
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS82 ISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWCVNPNTGKLIQGA
           100       110       120       130       140       150   

              310       320        
pF1KE4 PTIRGDPECHLFYNEQQEARGVHTQRMQ
       ::::::::::::::::::::::::::::
CCDS82 PTIRGDPECHLFYNEQQEARGVHTQRMQ
           160       170       180 

>>CCDS5505.1 IGFBP3 gene_id:3486|Hs108|chr7               (291 aa)
 initn: 542 init1: 303 opt: 503  Z-score: 426.4  bits: 87.0 E(32554): 2e-17
Smith-Waterman score: 539; 33.2% identity (57.6% similar) in 304 aa overlap (21-312:13-286)

               10        20           30        40        50       
pF1KE4 MLPRVGCPALPLPPPPLLPLLPLLLLLLG---ASGGGGGARAEVLFRCPPCTPERLAACG
                           : ::.:: :   : .:...:    . :: ::  . :: :.
CCDS55         MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCA
                       10        20        30        40        50  

        60        70        80        90       100       110       
pF1KE4 PPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPH
       :::..               ::::::::::::: .::  ::. ::.:: :::.:::: : 
CCDS55 PPPAV---------------CAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPS
                            60        70        80        90       

       120       130             140         150       160         
pF1KE4 PGSELPLQALVMGEGTC------EKRRDAEYGASPE--QVADNGDDHSEGGLVENHVDST
       :    :::::. :.: :       . :     : :   ..... .:.: :..    :.::
CCDS55 PDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGNASESEEDRSAGSVESPSVSST
       100       110       120       130       140       150       

     170       180       190       200       210        220        
pF1KE4 MNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEE-PKKLRPPPART
         .    ..   .::.:  : . . . .. ...:      ..    ..  .. .      
CCDS55 HRV----SDPKFHPLHS--KIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESKRETEYG
       160           170         180       190       200       210 

      230       240       250       260       270       280        
pF1KE4 PCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQRGECWC
       ::..:....:.... . . . ::       .:::::::.:.:. :::. : . .:: :::
CCDS55 PCRREMEDTLNHLKFLNVLSPRG-------VHIPNCDKKGFYKKKQCRPSKGRKRGFCWC
             220       230              240       250       260    

      290       300       310       320        
pF1KE4 VNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ
       :. . :. . :  : .:  . : .                
CCDS55 VD-KYGQPLPGYTT-KGKEDVHCYSMQSK           
           270        280       290            

>>CCDS34632.1 IGFBP3 gene_id:3486|Hs108|chr7              (297 aa)
 initn: 542 init1: 303 opt: 456  Z-score: 387.6  bits: 79.9 E(32554): 2.9e-15
Smith-Waterman score: 527; 32.6% identity (56.5% similar) in 310 aa overlap (21-312:13-292)

               10        20           30        40        50       
pF1KE4 MLPRVGCPALPLPPPPLLPLLPLLLLLLG---ASGGGGGARAEVLFRCPPCTPERLAACG
                           : ::.:: :   : .:...:    . :: ::  . :: :.
CCDS34         MQRARPTLWAAALTLLVLLRGPPVARAGASSAGLGPVVRCEPCDARALAQCA
                       10        20        30        40        50  

        60        70        80        90       100       110       
pF1KE4 PPPVAPPAAVAAVAGGARMPCAELVREPGCGCCSVCARLEGEACGVYTPRCGQGLRCYPH
       :::..               ::::::::::::: .::  ::. ::.:: :::.:::: : 
CCDS34 PPPAV---------------CAELVREPGCGCCLTCALSEGQPCGIYTERCGSGLRCQPS
                            60        70        80        90       

       120       130             140               150       160   
pF1KE4 PGSELPLQALVMGEGTC------EKRRDAEYGASPE--------QVADNGDDHSEGGLVE
       :    :::::. :.: :       . :     : :         ..... .:.: :..  
CCDS34 PDEARPLQALLDGRGLCVNASAVSRLRAYLLPAPPAPGEPPAPGNASESEEDRSAGSVES
       100       110       120       130       140       150       

           170       180       190       200       210        220  
pF1KE4 NHVDSTMNMLGGGGSAGRKPLKSGMKELAVFREKVTEQHRQMGKGGKHHLGLEE-PKKLR
         :.::  .    ..   .::.:  : . . . .. ...:      ..    ..  .. .
CCDS34 PSVSSTHRV----SDPKFHPLHS--KIIIIKKGHAKDSQRYKVDYESQSTDTQNFSSESK
       160           170         180       190       200       210 

            230       240       250       260       270       280  
pF1KE4 PPPARTPCQQELDQVLERISTMRLPDERGPLEHLYSLHIPNCDKHGLYNLKQCKMSLNGQ
             ::..:....:.... . . . ::       .:::::::.:.:. :::. : . .
CCDS34 RETEYGPCRREMEDTLNHLKFLNVLSPRG-------VHIPNCDKKGFYKKKQCRPSKGRK
             220       230       240              250       260    

            290       300       310       320        
pF1KE4 RGECWCVNPNTGKLIQGAPTIRGDPECHLFYNEQQEARGVHTQRMQ
       :: ::::. . :. . :  : .:  . : .                
CCDS34 RGFCWCVD-KYGQPLPGYTT-KGKEDVHCYSMQSK           
          270        280        290                  




328 residues in 1 query   sequences
18511270 residues in 32554 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sat Nov  5 23:09:30 2016 done: Sat Nov  5 23:09:31 2016
 Total Scan time:  2.860 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]