Result of FASTA (ccds) for
pFN21AE4322
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4322, 325 aa
1>>>pF1KE4322 325 - 325 aa - 325 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6451+/-0.000957; mu= 13.7908+/- 0.057
mean_var=61.2112+/-12.156, 0's: 0 Z-trim(103.8): 24 B-trim: 0 in 0/48
Lambda= 0.163930
statistics sampled from 7574 (7586) to 7574 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.61), E-opt: 0.2 (0.233), width: 16
Scan time: 2.500
The best scores are: opt bits E(32554)
CCDS243.1 HMGCL gene_id:3155|Hs108|chr1 ( 325) 2087 502.2 2.3e-142
CCDS43474.1 HMGCLL1 gene_id:54511|Hs108|chr6 ( 340) 1479 358.4 4.5e-99
CCDS43475.1 HMGCLL1 gene_id:54511|Hs108|chr6 ( 370) 1479 358.4 4.9e-99
CCDS75473.1 HMGCLL1 gene_id:54511|Hs108|chr6 ( 308) 1038 254.1 1e-67
CCDS53279.1 HMGCL gene_id:3155|Hs108|chr1 ( 254) 900 221.5 5.8e-58
CCDS75472.1 HMGCLL1 gene_id:54511|Hs108|chr6 ( 237) 714 177.5 9.5e-45
>>CCDS243.1 HMGCL gene_id:3155|Hs108|chr1 (325 aa)
initn: 2087 init1: 2087 opt: 2087 Z-score: 2669.5 bits: 502.2 E(32554): 2.3e-142
Smith-Waterman score: 2087; 100.0% identity (100.0% similar) in 325 aa overlap (1-325:1-325)
10 20 30 40 50 60
pF1KE4 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS24 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS24 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS24 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS24 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS24 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
250 260 270 280 290 300
310 320
pF1KE4 EAGNFICQALNRKTSSKVAQATCKL
:::::::::::::::::::::::::
CCDS24 EAGNFICQALNRKTSSKVAQATCKL
310 320
>>CCDS43474.1 HMGCLL1 gene_id:54511|Hs108|chr6 (340 aa)
initn: 1538 init1: 1478 opt: 1479 Z-score: 1892.1 bits: 358.4 E(32554): 4.5e-99
Smith-Waterman score: 1479; 71.0% identity (90.8% similar) in 303 aa overlap (20-322:35-337)
10 20 30 40
pF1KE4 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKN
: ::... ::. ::::::::::::::::
CCDS43 PSAVKHCLSYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQNEKV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 IVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPN
:: : .::..:. ::..::::::.::::: .:::::.:::::.:::...::. :::::::
CCDS43 IVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGVRYPVLTPN
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 LKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVS
:.::. :::::: :. .:::::: :.:::::::::::. .:. ..:.:. :: .:::::
CCDS43 LQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVS
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE4 CALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAA
:::::::::.:.: ::.::.:..:.:::::::::::::::::: :: :: .::.:.: .:
CCDS43 CALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGA
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE4 LAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLG
::::::::::::::: : :::::..::::.:.::::::::.:::::.:::::.:::.:::
CCDS43 LAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLG
250 260 270 280 290 300
290 300 310 320
pF1KE4 IHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
..::::: :..:::.:::.:.:. :.::::::.
CCDS43 LNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
310 320 330 340
>>CCDS43475.1 HMGCLL1 gene_id:54511|Hs108|chr6 (370 aa)
initn: 1538 init1: 1478 opt: 1479 Z-score: 1891.5 bits: 358.4 E(32554): 4.9e-99
Smith-Waterman score: 1479; 69.5% identity (89.7% similar) in 311 aa overlap (12-322:57-367)
10 20 30 40
pF1KE4 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPR
:.: .. ::... ::. :::::::::
CCDS43 SVAGALDPAQTSLLTNLHCFQPDVSGFSVSLAGTVACIHWETSQLSGLPEFVKIVEVGPR
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE4 DGLQNEKNIVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGI
::::::: :: : .::..:. ::..::::::.::::: .:::::.:::::.:::...::.
CCDS43 DGLQNEKVIVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQMADHTEVMKGIHQYPGV
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE4 NYPVLTPNLKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSAN
::::::::.::. :::::: :. .:::::: :.:::::::::::. .:. ..:.:. :
CCDS43 RYPVLTPNLQGFHHAVAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMN
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE4 ISVRGYVSCALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAV
: .::::::::::::::.:.: ::.::.:..:.:::::::::::::::::: :: :: .:
CCDS43 IPARGYVSCALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESV
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE4 MQEVPLAALAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDL
:.:.: .:::::::::::::::: : :::::..::::.:.::::::::.:::::.:::::
CCDS43 MKEIPPGALAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDL
270 280 290 300 310 320
290 300 310 320
pF1KE4 VYMLEGLGIHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
.:::.:::..::::: :..:::.:::.:.:. :.::::::.
CCDS43 IYMLNGLGLNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
330 340 350 360 370
>>CCDS75473.1 HMGCLL1 gene_id:54511|Hs108|chr6 (308 aa)
initn: 1338 init1: 1038 opt: 1038 Z-score: 1329.1 bits: 254.1 E(32554): 1e-67
Smith-Waterman score: 1238; 63.7% identity (80.9% similar) in 303 aa overlap (20-322:35-305)
10 20 30 40
pF1KE4 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKN
: ::... ::. ::::::::::::::::
CCDS75 PSAVKHCLSYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQNEKV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 IVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPN
:: : .::..:. ::..::::::.::::: .::::
CCDS75 IVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQ-------------------------
70 80 90
110 120 130 140 150 160
pF1KE4 LKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVS
::::: :. .:::::: :.:::::::::::. .:. ..:.:. :: .:::::
CCDS75 -------VAAGATEISVFGAASESFSKKNINCSIEESMGKFEEVVKSARHMNIPARGYVS
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE4 CALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAA
:::::::::.:.: ::.::.:..:.:::::::::::::::::: :: :: .::.:.: .:
CCDS75 CALGCPYEGSITPQKVTEVSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGA
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 LAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLG
::::::::::::::: : :::::..::::.:.::::::::.:::::.:::::.:::.:::
CCDS75 LAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLG
220 230 240 250 260 270
290 300 310 320
pF1KE4 IHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
..::::: :..:::.:::.:.:. :.::::::.
CCDS75 LNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
280 290 300
>>CCDS53279.1 HMGCL gene_id:3155|Hs108|chr1 (254 aa)
initn: 900 init1: 900 opt: 900 Z-score: 1154.1 bits: 221.5 E(32554): 5.8e-58
Smith-Waterman score: 1484; 78.2% identity (78.2% similar) in 325 aa overlap (1-325:1-254)
10 20 30 40 50 60
pF1KE4 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKNIVSTPVKIKLI
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAVAAG
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 DMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPNLKGFEAAV---
70 80 90 100 110
130 140 150 160 170 180
pF1KE4 AKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVSCALGCPYEGKI
CCDS53 ------------------------------------------------------------
190 200 210 220 230 240
pF1KE4 SPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 --------TKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAALAVHCHDTYGQ
120 130 140 150 160
250 260 270 280 290 300
pF1KE4 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS53 ALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLGIHTGVNLQKLL
170 180 190 200 210 220
310 320
pF1KE4 EAGNFICQALNRKTSSKVAQATCKL
:::::::::::::::::::::::::
CCDS53 EAGNFICQALNRKTSSKVAQATCKL
230 240 250
>>CCDS75472.1 HMGCLL1 gene_id:54511|Hs108|chr6 (237 aa)
initn: 980 init1: 680 opt: 714 Z-score: 916.9 bits: 177.5 E(32554): 9.5e-45
Smith-Waterman score: 763; 47.9% identity (60.4% similar) in 303 aa overlap (20-322:35-234)
10 20 30 40
pF1KE4 MAAMRKALPRRLVGLASLRAVSTSSMGTLPKRVKIVEVGPRDGLQNEKN
: ::... ::. ::::::::::::::::
CCDS75 PSAVKHCLSYQQLLREHLWIGDSVAGALDPAQETSQLSGLPEFVKIVEVGPRDGLQNEKV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 IVSTPVKIKLIDMLSEAGLSVIETTSFVSPKWVPQMGDHTEVLKGIQKFPGINYPVLTPN
:: : .::..:. ::..::::::.::::: .::::
CCDS75 IVPTDIKIEFINRLSQTGLSVIEVTSFVSSRWVPQ-------------------------
70 80 90
110 120 130 140 150 160
pF1KE4 LKGFEAAVAAGAKEVVIFGAASELFTKKNINCSIEESFQRFDAILKAAQSANISVRGYVS
CCDS75 ------------------------------------------------------------
170 180 190 200 210 220
pF1KE4 CALGCPYEGKISPAKVAEVTKKFYSMGCYEISLGDTIGVGTPGIMKDMLSAVMQEVPLAA
:.:..:.:::::::::::::::::: :: :: .::.:.: .:
CCDS75 ------------------VSKRLYGMGCYEISLGDTIGVGTPGSMKRMLESVMKEIPPGA
100 110 120 130 140
230 240 250 260 270 280
pF1KE4 LAVHCHDTYGQALANTLMALQMGVSVVDSSVAGLGGCPYAQGASGNLATEDLVYMLEGLG
::::::::::::::: : :::::..::::.:.::::::::.:::::.:::::.:::.:::
CCDS75 LAVHCHDTYGQALANILTALQMGINVVDSAVSGLGGCPYAKGASGNVATEDLIYMLNGLG
150 160 170 180 190 200
290 300 310 320
pF1KE4 IHTGVNLQKLLEAGNFICQALNRKTSSKVAQATCKL
..::::: :..:::.:::.:.:. :.::::::.
CCDS75 LNTGVNLYKVMEAGDFICKAVNKTTNSKVAQASFNA
210 220 230
325 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:11:19 2016 done: Sat Nov 5 23:11:19 2016
Total Scan time: 2.500 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]