Result of FASTA (omim) for
pFN21AE4307
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4307, 312 aa
1>>>pF1KE4307 312 - 312 aa - 312 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2344+/-0.000332; mu= 16.7247+/- 0.021
mean_var=70.4101+/-14.040, 0's: 0 Z-trim(116.1): 73 B-trim: 858 in 1/55
Lambda= 0.152847
statistics sampled from 26929 (27002) to 26929 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.699), E-opt: 0.2 (0.317), width: 16
Scan time: 6.800
The best scores are: opt bits E(85289)
NP_000708 (OMIM: 114760,600852) carbonic anhydrase ( 312) 2102 472.3 5.7e-133
XP_016880501 (OMIM: 114760,600852) PREDICTED: carb ( 222) 1483 335.7 5.3e-92
XP_005257696 (OMIM: 114760,600852) PREDICTED: carb ( 336) 1169 266.5 5.2e-71
XP_011523485 (OMIM: 114760,600852) PREDICTED: carb ( 246) 945 217.1 3e-56
NP_996808 (OMIM: 143860,603263) carbonic anhydrase ( 343) 518 123.0 8.6e-28
NP_001209 (OMIM: 143860,603263) carbonic anhydrase ( 354) 502 119.5 1e-26
XP_005245116 (OMIM: 604832) PREDICTED: carbonic an ( 336) 497 118.4 2.1e-26
NP_036245 (OMIM: 604832) carbonic anhydrase 14 pre ( 337) 495 117.9 2.8e-26
XP_006711322 (OMIM: 604832) PREDICTED: carbonic an ( 318) 492 117.2 4.3e-26
XP_011540385 (OMIM: 114780) PREDICTED: carbonic an ( 294) 490 116.8 5.5e-26
NP_001206 (OMIM: 114780) carbonic anhydrase 6 isof ( 308) 490 116.8 5.7e-26
NP_001257429 (OMIM: 114780) carbonic anhydrase 6 i ( 313) 490 116.8 5.8e-26
XP_005245117 (OMIM: 604832) PREDICTED: carbonic an ( 319) 490 116.8 5.9e-26
XP_011540386 (OMIM: 114780) PREDICTED: carbonic an ( 324) 490 116.8 5.9e-26
NP_005173 (OMIM: 114770) carbonic anhydrase 7 isof ( 264) 468 111.9 1.5e-24
XP_005265410 (OMIM: 176886) PREDICTED: receptor-ty (1416) 464 111.5 1e-23
NP_002832 (OMIM: 176886) receptor-type tyrosine-pr (1445) 464 111.5 1e-23
NP_000058 (OMIM: 259730,611492) carbonic anhydrase ( 260) 451 108.1 1.9e-23
XP_006711324 (OMIM: 604832) PREDICTED: carbonic an ( 281) 430 103.5 5.1e-22
NP_005172 (OMIM: 114750) carbonic anhydrase 3 [Hom ( 260) 427 102.9 7.6e-22
XP_016856382 (OMIM: 604832) PREDICTED: carbonic an ( 263) 425 102.4 1e-21
NP_001280571 (OMIM: 143860,603263) carbonic anhydr ( 283) 424 102.2 1.3e-21
XP_011507681 (OMIM: 604832) PREDICTED: carbonic an ( 323) 423 102.0 1.7e-21
NP_940986 (OMIM: 611436) carbonic anhydrase 13 [Ho ( 262) 418 100.9 3e-21
XP_011521613 (OMIM: 114770) PREDICTED: carbonic an ( 242) 415 100.2 4.5e-21
XP_016884736 (OMIM: 300230) PREDICTED: carbonic an ( 278) 408 98.7 1.5e-20
XP_005274499 (OMIM: 300230) PREDICTED: carbonic an ( 317) 408 98.7 1.6e-20
NP_009151 (OMIM: 300230) carbonic anhydrase 5B, mi ( 317) 408 98.7 1.6e-20
NP_004047 (OMIM: 114815,613227) carbonic anhydrase ( 290) 398 96.5 6.9e-20
NP_001308766 (OMIM: 114815,613227) carbonic anhydr ( 290) 398 96.5 6.9e-20
XP_011521614 (OMIM: 114770) PREDICTED: carbonic an ( 208) 391 94.8 1.6e-19
XP_005256193 (OMIM: 114770) PREDICTED: carbonic an ( 208) 391 94.8 1.6e-19
NP_001014435 (OMIM: 114770) carbonic anhydrase 7 i ( 208) 391 94.8 1.6e-19
NP_001207 (OMIM: 603179) carbonic anhydrase 9 prec ( 459) 394 95.7 1.8e-19
NP_001730 (OMIM: 114761,615751) carbonic anhydrase ( 305) 390 94.7 2.5e-19
NP_001193768 (OMIM: 176891,600263) receptor-type t (1448) 391 95.4 7.3e-19
NP_001193767 (OMIM: 176891,600263) receptor-type t (1455) 391 95.4 7.4e-19
NP_001122301 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18
NP_001729 (OMIM: 114800) carbonic anhydrase 1 isof ( 261) 380 92.5 1e-18
NP_001122302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18
NP_001122303 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18
NP_001158302 (OMIM: 114800) carbonic anhydrase 1 i ( 261) 380 92.5 1e-18
XP_016867966 (OMIM: 176891,600263) PREDICTED: rece (2301) 391 95.5 1.1e-18
XP_005250576 (OMIM: 176891,600263) PREDICTED: rece (2308) 391 95.5 1.1e-18
NP_002842 (OMIM: 176891,600263) receptor-type tyro (2315) 391 95.5 1.1e-18
XP_016862453 (OMIM: 176886) PREDICTED: receptor-ty (1329) 383 93.6 2.3e-18
NP_001257430 (OMIM: 114780) carbonic anhydrase 6 i ( 248) 374 91.2 2.4e-18
NP_001308767 (OMIM: 114815,613227) carbonic anhydr ( 263) 368 89.8 6.3e-18
NP_001076003 (OMIM: 604642) carbonic anhydrase-rel ( 328) 346 85.1 2.2e-16
NP_064563 (OMIM: 604642) carbonic anhydrase-relate ( 328) 346 85.1 2.2e-16
>>NP_000708 (OMIM: 114760,600852) carbonic anhydrase 4 p (312 aa)
initn: 2102 init1: 2102 opt: 2102 Z-score: 2508.3 bits: 472.3 E(85289): 5.7e-133
Smith-Waterman score: 2102; 100.0% identity (100.0% similar) in 312 aa overlap (1-312:1-312)
10 20 30 40 50 60
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
250 260 270 280 290 300
310
pF1KE4 PMLACLLAGFLR
::::::::::::
NP_000 PMLACLLAGFLR
310
>>XP_016880501 (OMIM: 114760,600852) PREDICTED: carbonic (222 aa)
initn: 1483 init1: 1483 opt: 1483 Z-score: 1772.7 bits: 335.7 E(85289): 5.3e-92
Smith-Waterman score: 1483; 100.0% identity (100.0% similar) in 222 aa overlap (91-312:1-222)
70 80 90 100 110 120
pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
::::::::::::::::::::::::::::::
XP_016 MMLLENKASISGGGLPAPYQAKQLHLHWSD
10 20 30
130 140 150 160 170 180
pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVNEGF
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE4 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTVFRE
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE4 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGRPLPWALPALLG
160 170 180 190 200 210
310
pF1KE4 PMLACLLAGFLR
::::::::::::
XP_016 PMLACLLAGFLR
220
>>XP_005257696 (OMIM: 114760,600852) PREDICTED: carbonic (336 aa)
initn: 1169 init1: 1169 opt: 1169 Z-score: 1395.9 bits: 266.5 E(85289): 5.2e-71
Smith-Waterman score: 2044; 92.9% identity (92.9% similar) in 336 aa overlap (1-312:1-336)
10 20 30 40 50 60
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
70 80 90 100 110 120
130 140 150 160 170
pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVE---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEIGRMNWPPP
130 140 150 160 170 180
180 190 200 210
pF1KE4 ---------------AGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH
:::::::::::::::::::::::::::::::::::::::::::::
XP_005 LAPCRLSQDPSLPFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE4 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL
250 260 270 280 290 300
280 290 300 310
pF1KE4 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
::::::::::::::::::::::::::::::::::::
XP_005 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
310 320 330
>>XP_011523485 (OMIM: 114760,600852) PREDICTED: carbonic (246 aa)
initn: 942 init1: 942 opt: 945 Z-score: 1130.9 bits: 217.1 E(85289): 3e-56
Smith-Waterman score: 1425; 90.2% identity (90.2% similar) in 246 aa overlap (91-312:1-246)
70 80 90 100 110 120
pF1KE4 AKVDKKLGRFFFSGYDKKQTWTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHWSD
::::::::::::::::::::::::::::::
XP_011 MMLLENKASISGGGLPAPYQAKQLHLHWSD
10 20 30
130 140 150 160 170
pF1KE4 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVE---------
:::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEIGRMNWPPP
40 50 60 70 80 90
180 190 200 210
pF1KE4 ---------------AGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH
:::::::::::::::::::::::::::::::::::::::::::::
XP_011 LAPCRLSQDPSLPFQAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRH
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE4 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YFRYLGSLTTPTCDEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQL
160 170 180 190 200 210
280 290 300 310
pF1KE4 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
::::::::::::::::::::::::::::::::::::
XP_011 GQRTVIKSGAPGRPLPWALPALLGPMLACLLAGFLR
220 230 240
>>NP_996808 (OMIM: 143860,603263) carbonic anhydrase 12 (343 aa)
initn: 287 init1: 191 opt: 518 Z-score: 619.9 bits: 123.0 E(85289): 8.6e-28
Smith-Waterman score: 518; 32.6% identity (60.1% similar) in 316 aa overlap (3-311:12-315)
10 20 30 40 50
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQ
.::..: . . :. :.: : ... : .: :
NP_996 MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYP-----SCGGLLQ
10 20 30 40 50
60 70 80 90 100
pF1KE4 SPINIVTTKAKVDKKLGRFFFSGYD--KKQTWTVQNNGHSVMMLLENKASISGGGLPAPY
:::.. . . : .: . :.::. .. . . :::::: . : . :.: : . :
NP_996 SPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQG--LQSRY
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 QAKQLHLHWSDLPY--KGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLA
.: ::::::.. : .::::...:.::: :.:::: . . ... :.. . .::::
NP_996 SATQLHLHWGN-PNDPHGSEHTVSGQHFAAELHIVHYN-SDLYPDASTASNKSEGLAVLA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 FLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTP
:.: :. : ... . :... . . . .. .::: :. .:.:: ::::::
NP_996 VLIEMGS-FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLP--ERTAEYYRYRGSLTTP
180 190 200 210 220
230 240 250 260 270 280
pF1KE4 TCDEKVVWTVFREPIQLHREQILAFSQKLY---YDKEQTVSMKDNVRPLQQLGQRTVIKS
:. :.:::::.:.:. .::.::. :: .: . : .: : .:.. .: : :
NP_996 PCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTS
230 240 250 260 270 280
290 300 310
pF1KE4 GAPGRPLPWALPALLGPMLACLLAGFLR
. : : :: ..:: .. ... .:
NP_996 FSQGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATKMETEAHA
290 300 310 320 330 340
>>NP_001209 (OMIM: 143860,603263) carbonic anhydrase 12 (354 aa)
initn: 394 init1: 191 opt: 502 Z-score: 600.7 bits: 119.5 E(85289): 1e-26
Smith-Waterman score: 502; 32.9% identity (59.5% similar) in 316 aa overlap (3-311:12-314)
10 20 30 40 50
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQ
.::..: . . :. :.: : ... : .: :
NP_001 MPRRSLHAAAVLLLVILKEQPSSPAPVNGSKWTYFGPDGENSWSKKYP-----SCGGLLQ
10 20 30 40 50
60 70 80 90 100
pF1KE4 SPINIVTTKAKVDKKLGRFFFSGYD--KKQTWTVQNNGHSVMMLLENKASISGGGLPAPY
:::.. . . : .: . :.::. .. . . :::::: . : . :.: : . :
NP_001 SPIDLHSDILQYDASLTPLEFQGYNLSANKQFLLTNNGHSVKLNLPSDMHIQG--LQSRY
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 QAKQLHLHWSDLPY--KGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLA
.: ::::::.. : .::::...:.::: :.:::: . . ... :.. . .::::
NP_001 SATQLHLHWGN-PNDPHGSEHTVSGQHFAAELHIVHYN-SDLYPDASTASNKSEGLAVLA
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 FLVEAGTQVNEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTP
:.: :. : ... . :... . . . .. .::: :. .:.:: ::::::
NP_001 VLIEMGS-FNPSYDKIFSHLQHVKYKGQEAFVPGFNIEELLP--ERTAEYYRYRGSLTTP
180 190 200 210 220
230 240 250 260 270 280
pF1KE4 TCDEKVVWTVFREPIQLHREQILAFSQKLY---YDKEQTVSMKDNVRPLQQLGQRTVIKS
:. :.:::::.:.:. .::.::. :: .: . : .: : .:.. .: : :
NP_001 PCNPTVLWTVFRNPVQISQEQLLALETALYCTHMDDPSPREMINNFRQVQKFDERLVYTS
230 240 250 260 270 280
290 300 310
pF1KE4 GAPGRPLPWALPALLGPMLACLLAGFLR
. . . : :: .:. :::.:
NP_001 FSQVQ-VCTAAGLSLGIILSLALAGILGICIVVVVSIWLFRRKSIKKGDNKGVIYKPATK
290 300 310 320 330 340
>>XP_005245116 (OMIM: 604832) PREDICTED: carbonic anhydr (336 aa)
initn: 475 init1: 202 opt: 497 Z-score: 595.0 bits: 118.4 E(85289): 2.1e-26
Smith-Waterman score: 497; 33.7% identity (61.3% similar) in 297 aa overlap (16-306:15-301)
10 20 30 40 50 60
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
.:.. .:: :: ....: : .: .. ::::.: : .
XP_005 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYP-----ECGNNAQSPIDIQTDS
10 20 30 40 50
70 80 90 100 110
pF1KE4 AKVDKKLGRFFFSGYDKKQT--WTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHW
. : : . :::. : ..::::.:.. : . .. :::: : : ::::::
XP_005 VTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLPS--TLYLGGLPRKYVAAQLHLHW
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 SDLPYKG-SEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVN
.. : :::....: :.:::: .. . ...:: . . .:::..:.:.: :
XP_005 GQKGSPGGSEHQINSEATFAELHIVHY-DSDSYDSLSEAAERPQGLAVLGILIEVGETKN
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 EGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTV
... .. : .. . ...:.. .: .::::. : .:::: :::::: : ..:.:::
XP_005 IAYEHILSHLHEVRHKDQKTSVPPFNLRELLPKQ--LGQYFRYNGSLTTPPCYQSVLWTV
180 190 200 210 220
240 250 260 270 280 290
pF1KE4 FREPIQLHREQILAFSQKLYYDKEQTVSMK-DNVRPLQQLGQRTVIKSGAPGRPLPWA--
: . :. ::. .. :. .:. .. .: : :: :.:: :. : : .
XP_005 FYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQGSSYTTGEM
230 240 250 260 270 280
300 310
pF1KE4 LPALLGPMLACLLAGFLR
: .: ...::
XP_005 LSLGVGILVGCLCLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
290 300 310 320 330
>>NP_036245 (OMIM: 604832) carbonic anhydrase 14 precurs (337 aa)
initn: 355 init1: 213 opt: 495 Z-score: 592.6 bits: 117.9 E(85289): 2.8e-26
Smith-Waterman score: 495; 34.0% identity (61.7% similar) in 303 aa overlap (16-307:15-305)
10 20 30 40 50 60
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
.:.. .:: :: ....: : .: .. ::::.: : .
NP_036 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYP-----ECGNNAQSPIDIQTDS
10 20 30 40 50
70 80 90 100 110
pF1KE4 AKVDKKLGRFFFSGYDKKQT--WTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHW
. : : . :::. : ..::::.:.. : ... :::: : : ::::::
NP_036 VTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLP--STLYLGGLPRKYVAAQLHLHW
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 SDLPYKG-SEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVN
.. : :::....: :.:::: .. . ...:: . . .:::..:.:.: :
NP_036 GQKGSPGGSEHQINSEATFAELHIVHY-DSDSYDSLSEAAERPQGLAVLGILIEVGETKN
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 EGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTV
... .. : .. . ...:.. .: .:::: .: .:::: :::::: : ..:.:::
NP_036 IAYEHILSHLHEVRHKDQKTSVPPFNLRELLPK--QLGQYFRYNGSLTTPPCYQSVLWTV
180 190 200 210 220
240 250 260 270 280
pF1KE4 FREPIQLHREQILAFSQKLYYDKEQTVSMK-DNVRPLQQLGQRTV----IKSGAP---GR
: . :. ::. .. :. .:. .. .: : :: :.:: : :..:. :.
NP_036 FYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQAGSSYTTGE
230 240 250 260 270 280
290 300 310
pF1KE4 PLPWALPALLGPMLACLLAGFLR
: .. :.: . :::
NP_036 MLSLGVGILVGCL--CLLLAVYFIARKIRKKRLENRKSVVFTSAQATTEA
290 300 310 320 330
>>XP_006711322 (OMIM: 604832) PREDICTED: carbonic anhydr (318 aa)
initn: 437 init1: 202 opt: 492 Z-score: 589.4 bits: 117.2 E(85289): 4.3e-26
Smith-Waterman score: 492; 34.7% identity (62.5% similar) in 277 aa overlap (16-288:15-281)
10 20 30 40 50 60
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQAESSNYPCLVPVKWGGNCQKDRQSPINIVTTK
.:.. .:: :: ....: : .: .. ::::.: : .
XP_006 MLFSALLLEVIWILAADGGQHWTYEGPHGQDHWPASYP-----ECGNNAQSPIDIQTDS
10 20 30 40 50
70 80 90 100 110
pF1KE4 AKVDKKLGRFFFSGYDKKQT--WTVQNNGHSVMMLLENKASISGGGLPAPYQAKQLHLHW
. : : . :::. : ..::::.:.. : ... :::: : : ::::::
XP_006 VTFDPDLPALQPHGYDQPGTEPLDLHNNGHTVQLSLP--STLYLGGLPRKYVAAQLHLHW
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 SDLPYKG-SEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLVEAGTQVN
.. : :::....: :.:::: .. . ...:: . . .:::..:.:.: :
XP_006 GQKGSPGGSEHQINSEATFAELHIVHY-DSDSYDSLSEAAERPQGLAVLGILIEVGETKN
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 EGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTCDEKVVWTV
... .. : .. . ...:.. .: .:::: .: .:::: :::::: : ..:.:::
XP_006 IAYEHILSHLHEVRHKDQKTSVPPFNLRELLPK--QLGQYFRYNGSLTTPPCYQSVLWTV
180 190 200 210 220
240 250 260 270 280 290
pF1KE4 FREPIQLHREQILAFSQKLYYDKEQTVSMK-DNVRPLQQLGQRTVIKSGAPGRPLPWALP
: . :. ::. .. :. .:. .. .: : :: :.:: :. : :
XP_006 FYRRSQISMEQLEKLQGTLFSTEEEPSKLLVQNYRALQPLNQRMVFASFIQGSSYTTGRR
230 240 250 260 270 280
300 310
pF1KE4 ALLGPMLACLLAGFLR
XP_006 GWKTERVWSSPQHKPRLRHKFLLRYHGCG
290 300 310
>>XP_011540385 (OMIM: 114780) PREDICTED: carbonic anhydr (294 aa)
initn: 282 init1: 126 opt: 490 Z-score: 587.5 bits: 116.8 E(85289): 5.5e-26
Smith-Waterman score: 490; 33.1% identity (62.8% similar) in 296 aa overlap (1-289:5-285)
10 20 30 40 50
pF1KE4 MRMLLALLALSAARPSASAESHWCYEVQA-ESSNYPCLVPVKWGGNCQKDRQSPIN
:: :. ::.: .:. : : : : . ...: :. : .::::::
XP_011 MCSTMRALVLLLSLFLLGGQAQHVSDWTYSEGALDEAHWPQHYPA-----CGGQRQSPIN
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 IVTTKAKVDKKLGRFFFSGYDKKQ-TWTVQNNGHSVMMLLEN--KASISGGGLPAPYQAK
. ::.. . .: . ..::. . . . ::::.:.. : . . ... : . : :.
XP_011 LQRTKVRYNPSLKGLNMTGYETQAGEFPMVNNGHTVQISLPSTMRMTVADGTV---YIAQ
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 QLHLHW--SDLPYKGSEHSLDGEHFAMEMHIVHEKEKGTSRNVKEAQDPEDEIAVLAFLV
:.:.:: .. .::::..:: . ..:.:::: . : : .. ::: : .:::: .:
XP_011 QMHFHWGGASSEISGSEHTVDGIRHVIEIHIVHYNSKYKSYDI--AQDAPDGLAVLAAFV
120 130 140 150 160 170
180 190 200 210 220
pF1KE4 EAGTQV-NEGFQPLVEALSNIPKPEMSTTMAESSLLDLLPKEEKLRHYFRYLGSLTTPTC
:. . : .. .. :.:: : . ::.. .. :.::.. :.::. : :::::: :
XP_011 EVKNYPENTYYSNFISHLANIKYPGQRTTLTGLDVQDMLPRN--LQHYYTYHGSLTTPPC
180 190 200 210 220
230 240 250 260 270 280
pF1KE4 DEKVVWTVFREPIQLHREQILAFSQKLYYDKEQTVSMKDNVRPLQQLGQRTVIKSGAPGR
:.: : :. . ..: : :. . ..: ...:. ... : : :..: :..:. :..
XP_011 TENVHWFVLADFVKLSRTQVWKLENSLLDHRNKTI--HNDYRRTQPLNHR-VVESNFPNQ
230 240 250 260 270 280
290 300 310
pF1KE4 PLPWALPALLGPMLACLLAGFLR
XP_011 ENCIPAGLI
290
312 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sat Nov 5 23:27:34 2016 done: Sat Nov 5 23:27:35 2016
Total Scan time: 6.800 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]