Result of FASTA (omim) for
pFN21AE4269
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4269, 1129 aa
1>>>pF1KE4269 1129 - 1129 aa - 1129 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 16.7182+/-0.000523; mu= -31.5468+/- 0.033
mean_var=685.3615+/-142.083, 0's: 0 Z-trim(122.8): 110 B-trim: 0 in 0/58
Lambda= 0.048991
statistics sampled from 41283 (41402) to 41283 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.76), E-opt: 0.2 (0.485), width: 16
Scan time: 15.560
The best scores are: opt bits E(85289)
NP_060952 (OMIM: 605953) arf-GAP with SH3 domain, (1129) 7507 546.7 3e-154
XP_006716626 (OMIM: 605953) PREDICTED: arf-GAP wit (1132) 7491 545.5 6.5e-154
XP_005250982 (OMIM: 605953) PREDICTED: arf-GAP wit (1132) 7491 545.5 6.5e-154
XP_011515354 (OMIM: 605953) PREDICTED: arf-GAP wit (1132) 7491 545.5 6.5e-154
NP_001234925 (OMIM: 605953) arf-GAP with SH3 domai (1122) 7380 537.7 1.5e-151
XP_006716627 (OMIM: 605953) PREDICTED: arf-GAP wit (1125) 7364 536.6 3.3e-151
XP_011515355 (OMIM: 605953) PREDICTED: arf-GAP wit (1125) 7364 536.6 3.3e-151
XP_016868957 (OMIM: 605953) PREDICTED: arf-GAP wit (1073) 7104 518.2 1.1e-145
XP_016868956 (OMIM: 605953) PREDICTED: arf-GAP wit (1087) 7103 518.1 1.1e-145
XP_006716628 (OMIM: 605953) PREDICTED: arf-GAP wit (1076) 7101 518.0 1.2e-145
XP_016868958 (OMIM: 605953) PREDICTED: arf-GAP wit (1072) 5386 396.7 3.8e-109
XP_006716629 (OMIM: 605953) PREDICTED: arf-GAP wit (1075) 5370 395.6 8.4e-109
NP_003878 (OMIM: 603817) arf-GAP with SH3 domain, (1006) 3494 263.0 6.5e-69
XP_006711961 (OMIM: 603817) PREDICTED: arf-GAP wit (1009) 3465 261.0 2.7e-68
NP_001128663 (OMIM: 603817) arf-GAP with SH3 domai ( 961) 3446 259.6 6.6e-68
XP_006711965 (OMIM: 603817) PREDICTED: arf-GAP wit ( 964) 3411 257.1 3.7e-67
XP_011508706 (OMIM: 603817) PREDICTED: arf-GAP wit (1017) 3295 248.9 1.1e-64
XP_006711964 (OMIM: 603817) PREDICTED: arf-GAP wit ( 970) 3268 247.0 4.1e-64
XP_011508708 (OMIM: 603817) PREDICTED: arf-GAP wit ( 978) 3268 247.0 4.1e-64
XP_011508705 (OMIM: 603817) PREDICTED: arf-GAP wit (1020) 3266 246.9 4.7e-64
XP_011508709 (OMIM: 603817) PREDICTED: arf-GAP wit ( 975) 3212 243.1 6.4e-63
XP_011508710 (OMIM: 603817) PREDICTED: arf-GAP wit ( 959) 3147 238.5 1.5e-61
XP_011508711 (OMIM: 603817) PREDICTED: arf-GAP wit ( 891) 2952 224.7 2e-57
XP_011508707 (OMIM: 603817) PREDICTED: arf-GAP wit ( 995) 2852 217.6 3e-55
XP_016857174 (OMIM: 616594) PREDICTED: arf-GAP wit ( 924) 1956 154.3 3.2e-36
XP_011540057 (OMIM: 616594) PREDICTED: arf-GAP wit ( 926) 1944 153.4 5.8e-36
NP_060177 (OMIM: 616594) arf-GAP with SH3 domain, ( 903) 1909 150.9 3.2e-35
XP_016857175 (OMIM: 616594) PREDICTED: arf-GAP wit ( 905) 1897 150.1 5.7e-35
XP_016857176 (OMIM: 616594) PREDICTED: arf-GAP wit ( 883) 1810 143.9 4e-33
XP_016857177 (OMIM: 616594) PREDICTED: arf-GAP wit ( 793) 1603 129.3 9.2e-29
XP_016857178 (OMIM: 616594) PREDICTED: arf-GAP wit ( 774) 1544 125.1 1.6e-27
NP_001137250 (OMIM: 616594) arf-GAP with SH3 domai ( 894) 1468 119.8 7.6e-26
NP_036419 (OMIM: 607766) arf-GAP with coiled-coil, ( 778) 512 52.2 1.5e-05
XP_011510905 (OMIM: 607766) PREDICTED: arf-GAP wit ( 813) 512 52.2 1.5e-05
XP_016861538 (OMIM: 607766) PREDICTED: arf-GAP wit ( 806) 483 50.1 6.3e-05
XP_016861536 (OMIM: 607766) PREDICTED: arf-GAP wit ( 841) 483 50.1 6.5e-05
NP_055729 (OMIM: 608651) arf-GAP with GTPase, ANK ( 804) 434 46.7 0.00069
XP_005246116 (OMIM: 608651) PREDICTED: arf-GAP wit ( 808) 434 46.7 0.0007
XP_006712298 (OMIM: 608651) PREDICTED: arf-GAP wit ( 882) 435 46.8 0.00071
XP_006712297 (OMIM: 608651) PREDICTED: arf-GAP wit ( 886) 435 46.8 0.00071
NP_001032208 (OMIM: 608651) arf-GAP with GTPase, A ( 857) 434 46.7 0.00073
XP_011508850 (OMIM: 608651) PREDICTED: arf-GAP wit (1098) 435 46.8 0.00085
XP_016858771 (OMIM: 608651) PREDICTED: arf-GAP wit (1106) 435 46.8 0.00086
XP_011508851 (OMIM: 608651) PREDICTED: arf-GAP wit (1073) 434 46.7 0.00088
XP_006712300 (OMIM: 608651) PREDICTED: arf-GAP wit (1147) 435 46.8 0.00088
XP_006712302 (OMIM: 608651) PREDICTED: arf-GAP wit (1151) 435 46.8 0.00089
XP_011508849 (OMIM: 608651) PREDICTED: arf-GAP wit (1126) 434 46.8 0.00091
XP_016867224 (OMIM: 616813) PREDICTED: arf-GAP wit ( 462) 413 45.0 0.0012
XP_016867222 (OMIM: 616813) PREDICTED: arf-GAP wit ( 527) 413 45.1 0.0014
XP_016867223 (OMIM: 616813) PREDICTED: arf-GAP wit ( 580) 413 45.1 0.0015
>>NP_060952 (OMIM: 605953) arf-GAP with SH3 domain, ANK (1129 aa)
initn: 7507 init1: 7507 opt: 7507 Z-score: 2890.3 bits: 546.7 E(85289): 3e-154
Smith-Waterman score: 7507; 100.0% identity (100.0% similar) in 1129 aa overlap (1-1129:1-1129)
10 20 30 40 50 60
pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE4 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE4 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE4 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE4 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120
pF1KE4 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
1090 1100 1110 1120
>>XP_006716626 (OMIM: 605953) PREDICTED: arf-GAP with SH (1132 aa)
initn: 5582 init1: 5582 opt: 7491 Z-score: 2884.2 bits: 545.5 E(85289): 6.5e-154
Smith-Waterman score: 7491; 99.7% identity (99.7% similar) in 1132 aa overlap (1-1129:1-1132)
10 20 30 40 50 60
pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
250 260 270 280 290 300
310 320 330 340 350
pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120
pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
1090 1100 1110 1120 1130
>>XP_005250982 (OMIM: 605953) PREDICTED: arf-GAP with SH (1132 aa)
initn: 5582 init1: 5582 opt: 7491 Z-score: 2884.2 bits: 545.5 E(85289): 6.5e-154
Smith-Waterman score: 7491; 99.7% identity (99.7% similar) in 1132 aa overlap (1-1129:1-1132)
10 20 30 40 50 60
pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
250 260 270 280 290 300
310 320 330 340 350
pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120
pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
1090 1100 1110 1120 1130
>>XP_011515354 (OMIM: 605953) PREDICTED: arf-GAP with SH (1132 aa)
initn: 5582 init1: 5582 opt: 7491 Z-score: 2884.2 bits: 545.5 E(85289): 6.5e-154
Smith-Waterman score: 7491; 99.7% identity (99.7% similar) in 1132 aa overlap (1-1129:1-1132)
10 20 30 40 50 60
pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
250 260 270 280 290 300
310 320 330 340 350
pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120
pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
1090 1100 1110 1120 1130
>>NP_001234925 (OMIM: 605953) arf-GAP with SH3 domain, A (1122 aa)
initn: 7379 init1: 7379 opt: 7380 Z-score: 2841.8 bits: 537.7 E(85289): 1.5e-151
Smith-Waterman score: 7380; 99.8% identity (99.8% similar) in 1112 aa overlap (18-1129:13-1122)
10 20 30 40 50 60
pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
: ::::::::::::::::::::::::::::::::::::::::
NP_001 MVSNLKRIMAQKW--MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKEDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHAT
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALT
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE4 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGI
420 430 440 450 460 470
490 500 510 520 530 540
pF1KE4 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRK
480 490 500 510 520 530
550 560 570 580 590 600
pF1KE4 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQEL
540 550 560 570 580 590
610 620 630 640 650 660
pF1KE4 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSK
600 610 620 630 640 650
670 680 690 700 710 720
pF1KE4 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDD
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE4 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTST
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE4 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSD
780 790 800 810 820 830
850 860 870 880 890 900
pF1KE4 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQK
840 850 860 870 880 890
910 920 930 940 950 960
pF1KE4 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPG
900 910 920 930 940 950
970 980 990 1000 1010 1020
pF1KE4 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLK
960 970 980 990 1000 1010
1030 1040 1050 1060 1070 1080
pF1KE4 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQA
1020 1030 1040 1050 1060 1070
1090 1100 1110 1120
pF1KE4 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
1080 1090 1100 1110 1120
>>XP_006716627 (OMIM: 605953) PREDICTED: arf-GAP with SH (1125 aa)
initn: 5582 init1: 5582 opt: 7364 Z-score: 2835.7 bits: 536.6 E(85289): 3.3e-151
Smith-Waterman score: 7364; 99.6% identity (99.6% similar) in 1115 aa overlap (18-1129:13-1125)
10 20 30 40 50 60
pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
: ::::::::::::::::::::::::::::::::::::::::
XP_006 MVSNLKRIMAQKW--MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
240 250 260 270 280 290
310 320 330 340 350
pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
660 670 680 690 700 710
720 730 740 750 760 770
pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
720 730 740 750 760 770
780 790 800 810 820 830
pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
780 790 800 810 820 830
840 850 860 870 880 890
pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
840 850 860 870 880 890
900 910 920 930 940 950
pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
900 910 920 930 940 950
960 970 980 990 1000 1010
pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
960 970 980 990 1000 1010
1020 1030 1040 1050 1060 1070
pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
1020 1030 1040 1050 1060 1070
1080 1090 1100 1110 1120
pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
1080 1090 1100 1110 1120
>>XP_011515355 (OMIM: 605953) PREDICTED: arf-GAP with SH (1125 aa)
initn: 5582 init1: 5582 opt: 7364 Z-score: 2835.7 bits: 536.6 E(85289): 3.3e-151
Smith-Waterman score: 7364; 99.6% identity (99.6% similar) in 1115 aa overlap (18-1129:13-1125)
10 20 30 40 50 60
pF1KE4 MRSSASRLSSFSSRDSLWNRMPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
: ::::::::::::::::::::::::::::::::::::::::
XP_011 MVSNLKRIMAQKW--MPDQISVSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLL
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEALDQDRTALQKVKKSVKAIYNSGQDHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FSTLTKELSTLLKNLLQGLSHNVIFTLDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKI
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKEKREHAKQHGMIRTEITGAEIAEEMEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IKYYHAQCNFFQDGLKTADKLKQYIEKLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLD
240 250 260 270 280 290
310 320 330 340 350
pF1KE4 QKE---DSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
::: ::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QKESRRDSQSRQGGYSMHQLQGNKEYGSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTIS
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HATSNRQPAKLNLLTCQVKPNAEDKKSFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEE
360 370 380 390 400 410
420 430 440 450 460 470
pF1KE4 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALTMAFRGEQSAGENSLEDLTKAIIEDVQRLPGNDICCDCGSSEPTWLSTNLGILTCIEC
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE4 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGIHREMGVHISRIQSLELDKLGTSELLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMT
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE4 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VRKEYITAKYVDHRFSRKTCSTSSAKLNELLEAIKSRDLLALIQVYAEGVELMEPLLEPG
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE4 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QELGETALHLAVRTADQTSLHLVDFLVQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLL
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE4 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSKPTVDIVNQAGETALDIAKRLKATQCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDES
660 670 680 690 700 710
720 730 740 750 760 770
pF1KE4 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDDLDDKPSPIKKERSPRPQSFCHSSSISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVS
720 730 740 750 760 770
780 790 800 810 820 830
pF1KE4 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSTDSPTSPTTEAPPLPPRNAGKGPTGPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRT
780 790 800 810 820 830
840 850 860 870 880 890
pF1KE4 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSDPPSPLPHGPPNKGAVPWGNDGGPSSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKL
840 850 860 870 880 890
900 910 920 930 940 950
pF1KE4 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQKVALRKTDHLSLDKATIPPEIFQKSSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPP
900 910 920 930 940 950
960 970 980 990 1000 1010
pF1KE4 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KPGELPPKPQLGDLPPKPQLSDLPPKPQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEV
960 970 980 990 1000 1010
1020 1030 1040 1050 1060 1070
pF1KE4 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLKSHPLDLSPNVQSRDAIQKQASEDSNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYD
1020 1030 1040 1050 1060 1070
1080 1090 1100 1110 1120
pF1KE4 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CQADNDDELTFIEGEVIIVTGEEDQEWWIGHIEGQPERKGVFPVSFVHILSD
1080 1090 1100 1110 1120
>>XP_016868957 (OMIM: 605953) PREDICTED: arf-GAP with SH (1073 aa)
initn: 5582 init1: 5582 opt: 7104 Z-score: 2736.7 bits: 518.2 E(85289): 1.1e-145
Smith-Waterman score: 7104; 99.5% identity (99.6% similar) in 1073 aa overlap (60-1129:1-1073)
30 40 50 60 70 80
pF1KE4 FIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQDHV
.: :::::::::::::::::::::::::::
XP_016 MESALDQDRTALQKVKKSVKAIYNSGQDHV
10 20 30
90 100 110 120 130 140
pF1KE4 QNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFTLDS
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE4 LLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEEMEK
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE4 ERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIEKLA
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE4 ADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKE---DSQSRQGGYSMHQLQGNKEYGSE
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::
XP_016 ADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEYGSE
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE4 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKKSFD
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE4 LISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIEDVQ
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE4 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSELLL
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE4 AKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAKLNE
460 470 480 490 500 510
570 580 590 600 610 620
pF1KE4 LLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFLVQN
520 530 540 550 560 570
630 640 650 660 670 680
pF1KE4 CGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKATQCE
580 590 600 610 620 630
690 700 710 720 730 740
pF1KE4 DLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSSSIS
640 650 660 670 680 690
750 760 770 780 790 800
pF1KE4 PQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPTGPP
700 710 720 730 740 750
810 820 830 840 850 860
pF1KE4 STLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 STLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGPSSS
760 770 780 790 800 810
870 880 890 900 910 920
pF1KE4 SKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQKSSQ
820 830 840 850 860 870
930 940 950 960 970 980
pF1KE4 LAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPKPQM
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KE4 KDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSND
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASEDSND
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KE4 LTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQEWWI
1000 1010 1020 1030 1040 1050
1110 1120
pF1KE4 GHIEGQPERKGVFPVSFVHILSD
:::::::::::::::::::::::
XP_016 GHIEGQPERKGVFPVSFVHILSD
1060 1070
>>XP_016868956 (OMIM: 605953) PREDICTED: arf-GAP with SH (1087 aa)
initn: 5582 init1: 5582 opt: 7103 Z-score: 2736.2 bits: 518.1 E(85289): 1.1e-145
Smith-Waterman score: 7103; 99.5% identity (99.5% similar) in 1076 aa overlap (57-1129:14-1087)
30 40 50 60 70 80
pF1KE4 VSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQ
::: :::::::::::::::::::::::::
XP_016 MHCSALPHLRDPPVTL--EALDQDRTALQKVKKSVKAIYNSGQ
10 20 30 40
90 100 110 120 130 140
pF1KE4 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE4 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE4 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE4 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKE---DSQSRQGGYSMHQLQGNKEY
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_016 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEY
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE4 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK
290 300 310 320 330 340
390 400 410 420 430 440
pF1KE4 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE
350 360 370 380 390 400
450 460 470 480 490 500
pF1KE4 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE
410 420 430 440 450 460
510 520 530 540 550 560
pF1KE4 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK
470 480 490 500 510 520
570 580 590 600 610 620
pF1KE4 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL
530 540 550 560 570 580
630 640 650 660 670 680
pF1KE4 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT
590 600 610 620 630 640
690 700 710 720 730 740
pF1KE4 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS
650 660 670 680 690 700
750 760 770 780 790 800
pF1KE4 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT
710 720 730 740 750 760
810 820 830 840 850 860
pF1KE4 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP
770 780 790 800 810 820
870 880 890 900 910 920
pF1KE4 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK
830 840 850 860 870 880
930 940 950 960 970 980
pF1KE4 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK
890 900 910 920 930 940
990 1000 1010 1020 1030 1040
pF1KE4 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED
950 960 970 980 990 1000
1050 1060 1070 1080 1090 1100
pF1KE4 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE
1010 1020 1030 1040 1050 1060
1110 1120
pF1KE4 WWIGHIEGQPERKGVFPVSFVHILSD
::::::::::::::::::::::::::
XP_016 WWIGHIEGQPERKGVFPVSFVHILSD
1070 1080
>>XP_006716628 (OMIM: 605953) PREDICTED: arf-GAP with SH (1076 aa)
initn: 5582 init1: 5582 opt: 7101 Z-score: 2735.5 bits: 518.0 E(85289): 1.2e-145
Smith-Waterman score: 7101; 99.3% identity (99.5% similar) in 1076 aa overlap (57-1129:1-1076)
30 40 50 60 70 80
pF1KE4 VSEFIAETTEDYNSPTTSSFTTRLHNCRNTVTLLEEALDQDRTALQKVKKSVKAIYNSGQ
.:. . ::::::::::::::::::::::::
XP_006 MTMYNGALDQDRTALQKVKKSVKAIYNSGQ
10 20 30
90 100 110 120 130 140
pF1KE4 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DHVQNEENYAQVLDKFGSNFLSRDNPDLGTAFVKFSTLTKELSTLLKNLLQGLSHNVIFT
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE4 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDSLLKGDLKGVKGDLKKPFDKAWKDYETKFTKIEKEKREHAKQHGMIRTEITGAEIAEE
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE4 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MEKERRLFQLQMCEYLIKVNEIKTKKGVDLLQNLIKYYHAQCNFFQDGLKTADKLKQYIE
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE4 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKE---DSQSRQGGYSMHQLQGNKEY
::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::
XP_006 KLAADLYNIKQTQDEEKKQLTALRDLIKSSLQLDQKESRRDSQSRQGGYSMHQLQGNKEY
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE4 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSEKKGYLLKKSDGIRKVWQRRKCSVKNGILTISHATSNRQPAKLNLLTCQVKPNAEDKK
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE4 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SFDLISHNRTYHFQAEDEQDYVAWISVLTNSKEEALTMAFRGEQSAGENSLEDLTKAIIE
340 350 360 370 380 390
450 460 470 480 490 500
pF1KE4 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DVQRLPGNDICCDCGSSEPTWLSTNLGILTCIECSGIHREMGVHISRIQSLELDKLGTSE
400 410 420 430 440 450
510 520 530 540 550 560
pF1KE4 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLLAKNVGNNSFNDIMEANLPSPSPKPTPSSDMTVRKEYITAKYVDHRFSRKTCSTSSAK
460 470 480 490 500 510
570 580 590 600 610 620
pF1KE4 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LNELLEAIKSRDLLALIQVYAEGVELMEPLLEPGQELGETALHLAVRTADQTSLHLVDFL
520 530 540 550 560 570
630 640 650 660 670 680
pF1KE4 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VQNCGNLDKQTALGNTVLHYCSMYSKPECLKLLLRSKPTVDIVNQAGETALDIAKRLKAT
580 590 600 610 620 630
690 700 710 720 730 740
pF1KE4 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QCEDLLSQAKSGKFNPHVHVEYEWNLRQEEIDESDDDLDDKPSPIKKERSPRPQSFCHSS
640 650 660 670 680 690
750 760 770 780 790 800
pF1KE4 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SISPQDKLALPGFSTPRDKQRLSYGAFTNQIFVSTSTDSPTSPTTEAPPLPPRNAGKGPT
700 710 720 730 740 750
810 820 830 840 850 860
pF1KE4 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GPPSTLPLSTQTSSGSSTLSKKRPPPPPPGHKRTLSDPPSPLPHGPPNKGAVPWGNDGGP
760 770 780 790 800 810
870 880 890 900 910 920
pF1KE4 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSSSKTTNKFEGLSQQSSTSSAKTALGPRVLPKLPQKVALRKTDHLSLDKATIPPEIFQK
820 830 840 850 860 870
930 940 950 960 970 980
pF1KE4 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSQLAELPQKPPPGDLPPKPTELAPKPQIGDLPPKPGELPPKPQLGDLPPKPQLSDLPPK
880 890 900 910 920 930
990 1000 1010 1020 1030 1040
pF1KE4 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQMKDLPPKPQLGDLLAKSQTGDVSPKAQQPSEVTLKSHPLDLSPNVQSRDAIQKQASED
940 950 960 970 980 990
1050 1060 1070 1080 1090 1100
pF1KE4 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SNDLTPTLPETPVPLPRKINTGKNKVRRVKTIYDCQADNDDELTFIEGEVIIVTGEEDQE
1000 1010 1020 1030 1040 1050
1110 1120
pF1KE4 WWIGHIEGQPERKGVFPVSFVHILSD
::::::::::::::::::::::::::
XP_006 WWIGHIEGQPERKGVFPVSFVHILSD
1060 1070
1129 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 03:11:14 2016 done: Tue Nov 8 03:11:17 2016
Total Scan time: 15.560 Total Display time: 0.370
Function used was FASTA [36.3.4 Apr, 2011]