Result of FASTA (omim) for
pFN21AE4233
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4233, 850 aa
1>>>pF1KE4233 850 - 850 aa - 850 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9467+/-0.000507; mu= 18.3188+/- 0.032
mean_var=125.1541+/-25.976, 0's: 0 Z-trim(111.6): 254 B-trim: 162 in 1/48
Lambda= 0.114644
statistics sampled from 19914 (20233) to 19914 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.595), E-opt: 0.2 (0.237), width: 16
Scan time: 8.850
The best scores are: opt bits E(85289)
NP_001290174 (OMIM: 601589) ras GTPase-activating ( 850) 5641 945.7 0
NP_006497 (OMIM: 601589) ras GTPase-activating pro ( 849) 5624 942.9 0
NP_001290175 (OMIM: 601589) ras GTPase-activating ( 853) 5608 940.3 0
XP_011511361 (OMIM: 601589) PREDICTED: ras GTPase- ( 853) 5364 899.9 0
XP_016862457 (OMIM: 601589) PREDICTED: ras GTPase- ( 872) 5364 899.9 0
XP_016862458 (OMIM: 601589) PREDICTED: ras GTPase- ( 871) 5347 897.1 0
XP_016862459 (OMIM: 601589) PREDICTED: ras GTPase- ( 707) 3999 674.0 6.3e-193
NP_031394 (OMIM: 605182) ras GTPase-activating pro ( 834) 3522 595.2 4e-169
NP_001307751 (OMIM: 605182) ras GTPase-activating ( 802) 3437 581.1 6.6e-165
XP_011533143 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 3437 581.1 6.6e-165
XP_011533144 (OMIM: 605182) PREDICTED: ras GTPase- ( 802) 3437 581.1 6.6e-165
XP_016862460 (OMIM: 601589) PREDICTED: ras GTPase- ( 573) 3251 550.2 9.6e-156
XP_016862461 (OMIM: 601589) PREDICTED: ras GTPase- ( 442) 2953 500.8 5.5e-141
NP_001307750 (OMIM: 605182) ras GTPase-activating ( 451) 1821 313.6 1.3e-84
XP_016875927 (OMIM: 605182) PREDICTED: ras GTPase- ( 451) 1821 313.6 1.3e-84
XP_016875928 (OMIM: 605182) PREDICTED: ras GTPase- ( 451) 1821 313.6 1.3e-84
NP_008920 (OMIM: 607943) ras GTPase-activating pro ( 803) 829 149.8 4.7e-35
XP_016867150 (OMIM: 607943) PREDICTED: ras GTPase- ( 840) 816 147.7 2.2e-34
NP_004649 (OMIM: 604118) rasGAP-activating-like pr ( 804) 711 130.3 3.5e-29
XP_011537155 (OMIM: 604118) PREDICTED: rasGAP-acti ( 804) 711 130.3 3.5e-29
XP_006719705 (OMIM: 604118) PREDICTED: rasGAP-acti ( 805) 709 129.9 4.4e-29
NP_001288131 (OMIM: 604118) rasGAP-activating-like ( 805) 674 124.2 2.5e-27
XP_016875517 (OMIM: 604118) PREDICTED: rasGAP-acti ( 805) 674 124.2 2.5e-27
XP_005254007 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 672 123.8 3.1e-27
XP_011537154 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 672 123.8 3.1e-27
NP_001180449 (OMIM: 604118) rasGAP-activating-like ( 806) 672 123.8 3.1e-27
XP_006719704 (OMIM: 604118) PREDICTED: rasGAP-acti ( 806) 672 123.8 3.1e-27
XP_016875520 (OMIM: 604118) PREDICTED: rasGAP-acti ( 779) 612 113.9 2.9e-24
XP_011514025 (OMIM: 607943) PREDICTED: ras GTPase- ( 682) 610 113.5 3.4e-24
XP_016875519 (OMIM: 604118) PREDICTED: rasGAP-acti ( 780) 610 113.6 3.7e-24
XP_016875518 (OMIM: 604118) PREDICTED: rasGAP-acti ( 780) 610 113.6 3.7e-24
NP_001073346 (OMIM: 607943) ras GTPase-activating ( 757) 608 113.2 4.6e-24
XP_016867151 (OMIM: 607943) PREDICTED: ras GTPase- ( 794) 608 113.2 4.7e-24
XP_011537156 (OMIM: 604118) PREDICTED: rasGAP-acti ( 447) 537 101.2 1.1e-20
NP_001180450 (OMIM: 604118) rasGAP-activating-like ( 776) 482 92.4 8.7e-18
XP_011516572 (OMIM: 609205) PREDICTED: disabled ho (1065) 398 78.6 1.6e-13
XP_016869789 (OMIM: 609205) PREDICTED: disabled ho (1065) 398 78.6 1.6e-13
XP_011516573 (OMIM: 609205) PREDICTED: disabled ho (1065) 398 78.6 1.6e-13
NP_619723 (OMIM: 609205) disabled homolog 2-intera (1065) 398 78.6 1.6e-13
XP_005251781 (OMIM: 609205) PREDICTED: disabled ho (1128) 398 78.7 1.7e-13
XP_011516569 (OMIM: 609205) PREDICTED: disabled ho (1131) 398 78.7 1.7e-13
NP_115941 (OMIM: 609205) disabled homolog 2-intera (1132) 398 78.7 1.7e-13
XP_016869788 (OMIM: 609205) PREDICTED: disabled ho (1141) 398 78.7 1.7e-13
XP_011516568 (OMIM: 609205) PREDICTED: disabled ho (1153) 398 78.7 1.7e-13
XP_011516567 (OMIM: 609205) PREDICTED: disabled ho (1160) 398 78.7 1.7e-13
XP_005251778 (OMIM: 609205) PREDICTED: disabled ho (1161) 398 78.7 1.7e-13
XP_016869787 (OMIM: 609205) PREDICTED: disabled ho (1164) 398 78.7 1.7e-13
XP_011516566 (OMIM: 609205) PREDICTED: disabled ho (1182) 398 78.7 1.8e-13
XP_005251776 (OMIM: 609205) PREDICTED: disabled ho (1189) 398 78.7 1.8e-13
XP_016858344 (OMIM: 606136) PREDICTED: ras GTPase- (1138) 379 75.5 1.5e-12
>>NP_001290174 (OMIM: 601589) ras GTPase-activating prot (850 aa)
initn: 5641 init1: 5641 opt: 5641 Z-score: 5051.3 bits: 945.7 E(85289): 0
Smith-Waterman score: 5641; 100.0% identity (100.0% similar) in 850 aa overlap (1-850:1-850)
10 20 30 40 50 60
pF1KE4 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE4 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS
790 800 810 820 830 840
850
pF1KE4 KENPIVGKAS
::::::::::
NP_001 KENPIVGKAS
850
>>NP_006497 (OMIM: 601589) ras GTPase-activating protein (849 aa)
initn: 4271 init1: 4271 opt: 5624 Z-score: 5036.2 bits: 942.9 E(85289): 0
Smith-Waterman score: 5624; 99.9% identity (99.9% similar) in 850 aa overlap (1-850:1-849)
10 20 30 40 50 60
pF1KE4 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILA
::::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
NP_006 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPG-KDAIYTIPVKNILA
610 620 630 640 650
670 680 690 700 710 720
pF1KE4 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVY
660 670 680 690 700 710
730 740 750 760 770 780
pF1KE4 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 LNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEAC
720 730 740 750 760 770
790 800 810 820 830 840
pF1KE4 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGS
780 790 800 810 820 830
850
pF1KE4 KENPIVGKAS
::::::::::
NP_006 KENPIVGKAS
840
>>NP_001290175 (OMIM: 601589) ras GTPase-activating prot (853 aa)
initn: 5614 init1: 4263 opt: 5608 Z-score: 5021.8 bits: 940.3 E(85289): 0
Smith-Waterman score: 5608; 99.4% identity (99.4% similar) in 853 aa overlap (1-850:1-853)
10 20 30 40 50 60
pF1KE4 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAAAAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DCFCTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAIKKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKAC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGLPLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQ
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FQVEEEDIEKLEIRIDLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SKTDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLPLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKV
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLKPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IFYSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISKTIQTLGSWGSLSKSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGT
550 560 570 580 590 600
610 620 630 640 650
pF1KE4 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPG---SKDAIYTIPVKN
:::::::::::::::::::::::::::::::::::::::::::: :::::::::::
NP_001 SEPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPEFIERKDAIYTIPVKN
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE4 ILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILAVEKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHP
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE4 SVYLNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVYLNGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKME
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE4 EACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EACGTIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAK
790 800 810 820 830 840
840 850
pF1KE4 YGSKENPIVGKAS
:::::::::::::
NP_001 YGSKENPIVGKAS
850
>>XP_011511361 (OMIM: 601589) PREDICTED: ras GTPase-acti (853 aa)
initn: 5364 init1: 5364 opt: 5364 Z-score: 4803.7 bits: 899.9 E(85289): 0
Smith-Waterman score: 5364; 100.0% identity (100.0% similar) in 805 aa overlap (46-850:49-853)
20 30 40 50 60 70
pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
::::::::::::::::::::::::::::::
XP_011 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
20 30 40 50 60 70
80 90 100 110 120 130
pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
200 210 220 230 240 250
260 270 280 290 300 310
pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
260 270 280 290 300 310
320 330 340 350 360 370
pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
320 330 340 350 360 370
380 390 400 410 420 430
pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
380 390 400 410 420 430
440 450 460 470 480 490
pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
440 450 460 470 480 490
500 510 520 530 540 550
pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
500 510 520 530 540 550
560 570 580 590 600 610
pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
560 570 580 590 600 610
620 630 640 650 660 670
pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF
620 630 640 650 660 670
680 690 700 710 720 730
pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT
680 690 700 710 720 730
740 750 760 770 780 790
pF1KE4 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD
740 750 760 770 780 790
800 810 820 830 840 850
pF1KE4 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
800 810 820 830 840 850
>>XP_016862457 (OMIM: 601589) PREDICTED: ras GTPase-acti (872 aa)
initn: 5364 init1: 5364 opt: 5364 Z-score: 4803.6 bits: 899.9 E(85289): 0
Smith-Waterman score: 5364; 100.0% identity (100.0% similar) in 805 aa overlap (46-850:68-872)
20 30 40 50 60 70
pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
::::::::::::::::::::::::::::::
XP_016 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
100 110 120 130 140 150
140 150 160 170 180 190
pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
160 170 180 190 200 210
200 210 220 230 240 250
pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
220 230 240 250 260 270
260 270 280 290 300 310
pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
460 470 480 490 500 510
500 510 520 530 540 550
pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
520 530 540 550 560 570
560 570 580 590 600 610
pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
580 590 600 610 620 630
620 630 640 650 660 670
pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF
640 650 660 670 680 690
680 690 700 710 720 730
pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT
700 710 720 730 740 750
740 750 760 770 780 790
pF1KE4 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD
760 770 780 790 800 810
800 810 820 830 840 850
pF1KE4 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
820 830 840 850 860 870
>>XP_016862458 (OMIM: 601589) PREDICTED: ras GTPase-acti (871 aa)
initn: 3994 init1: 3994 opt: 5347 Z-score: 4788.4 bits: 897.1 E(85289): 0
Smith-Waterman score: 5347; 99.9% identity (99.9% similar) in 805 aa overlap (46-850:68-871)
20 30 40 50 60 70
pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
::::::::::::::::::::::::::::::
XP_016 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
100 110 120 130 140 150
140 150 160 170 180 190
pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
160 170 180 190 200 210
200 210 220 230 240 250
pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
220 230 240 250 260 270
260 270 280 290 300 310
pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
460 470 480 490 500 510
500 510 520 530 540 550
pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
520 530 540 550 560 570
560 570 580 590 600 610
pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
580 590 600 610 620 630
620 630 640 650 660 670
pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_016 QGRTRIGKKNFKKRWFCLTSRELTYHKQPG-KDAIYTIPVKNILAVEKLEESSFNKKNMF
640 650 660 670 680 690
680 690 700 710 720 730
pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT
700 710 720 730 740 750
740 750 760 770 780 790
pF1KE4 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDD
760 770 780 790 800 810
800 810 820 830 840 850
pF1KE4 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
820 830 840 850 860 870
>>XP_016862459 (OMIM: 601589) PREDICTED: ras GTPase-acti (707 aa)
initn: 3999 init1: 3999 opt: 3999 Z-score: 3584.6 bits: 674.0 E(85289): 6.3e-193
Smith-Waterman score: 3999; 100.0% identity (100.0% similar) in 601 aa overlap (46-646:68-668)
20 30 40 50 60 70
pF1KE4 PAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
::::::::::::::::::::::::::::::
XP_016 VGLSFKKKSKLCRRETSKKKERLKNKKAESEAKNLLPYLGPHKMRDCFCTINLDQEEVYR
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE4 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKE
100 110 120 130 140 150
140 150 160 170 180 190
pF1KE4 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYA
160 170 180 190 200 210
200 210 220 230 240 250
pF1KE4 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRI
220 230 240 250 260 270
260 270 280 290 300 310
pF1KE4 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DLWNNGNLVQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICY
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE4 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLV
340 350 360 370 380 390
380 390 400 410 420 430
pF1KE4 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKS
400 410 420 430 440 450
440 450 460 470 480 490
pF1KE4 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPN
460 470 480 490 500 510
500 510 520 530 540 550
pF1KE4 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLS
520 530 540 550 560 570
560 570 580 590 600 610
pF1KE4 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSKSSFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRA
580 590 600 610 620 630
620 630 640 650 660 670
pF1KE4 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMF
:::::::::::::::::::::::::::::::
XP_016 QGRTRIGKKNFKKRWFCLTSRELTYHKQPGSCVYALLWGFSWFSVKVSLPLIVTLVNPFS
640 650 660 670 680 690
680 690 700 710 720 730
pF1KE4 QVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENT
XP_016 NITVVYGFSH
700
>>NP_031394 (OMIM: 605182) ras GTPase-activating protein (834 aa)
initn: 2923 init1: 1943 opt: 3522 Z-score: 3157.3 bits: 595.2 E(85289): 4e-169
Smith-Waterman score: 3522; 61.5% identity (87.0% similar) in 818 aa overlap (34-849:8-818)
10 20 30 40 50 60
pF1KE4 AAPAAAAASSEAPAASATAEPEAGDQDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCF
.::.::.. :: ::::: : :: :::::.
NP_031 MAVEDEGLRVFQSVKIKIGEAKNLPSYPGPSKMRDCY
10 20 30
70 80 90 100 110 120
pF1KE4 CTINLDQEEVYRTQVVEKSLSPFFSEEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAI
::.:::::::.::..::::: ::..:.:: ::::.:..::::..:..:..:: ::::::
NP_031 CTVNLDQEEVFRTKIVEKSLCPFYGEDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAI
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 KKEDLCNHSGKETWFSLQPVDSNSEVQGKVHLELKLNELITENGTVCQQLVVHIKACHGL
.:::: .. ...:::.:: ::..:::::::::::.:.:.::..:.::..:...: :.::
NP_031 QKEDLQKYHNRDTWFQLQHVDADSEVQGKVHLELRLSEVITDTGVVCHKLATRIVECQGL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 PLINGQSCDPYATVSLVGPSRNDQKKTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQV
:..::: :::::::.:.:: :.. ::::::.::.::::.:.::::::: ::..::.:.
NP_031 PIVNGQ-CDPYATVTLAGPFRSEAKKTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDF
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 EEEDIEKLEIRIDLWNNGNL-VQDVFLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSK
::::..:::::.:::: .:: : ::::...:..::: .::..:::.:::::::.:: :
NP_031 EEEDVDKLEIRVDLWNASNLKFGDEFLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLK
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE4 TDDLGSLRLNICYTEDYVLPSEYYGPLKTLLLKSPDVQPISASAAYILSEICRDKNDAVL
:::::::::. ::::.:. :.::.::. ::::: ::.:.:::::.::.:.::.:..:..
NP_031 PDDLGSLRLNVVYTEDHVFSSDYYSPLRDLLLKSADVEPVSASAAHILGEVCREKQEAAV
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE4 PLVRLLLHHDKLVPFATAVAELDLKDTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTL
:::::.::. ..::: .:.: ..: ::: ::::::::::..:.:: ::..: :::.:::
NP_031 PLVRLFLHYGRVVPFISAIASAEVKRTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE4 KPILDEICDSSKSCEIDPIKLKEGDNVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIF
:: ..:::.: : :::::.:::.:.:.::: :::: :::..:..:..:..::::::::::
NP_031 KPAIEEICQSHKPCEIDPVKLKDGENLENNMENLRQYVDRVFHAITESGVSCPTVMCDIF
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE4 YSLRQMATQRFPNDPHVQYSAVSSFVFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLIS
.:::. :..:: .:: :.:.:::::.:::::: :..::. :.: ::: : :: :::::::
NP_031 FSLREAAAKRFQDDPDVRYTAVSSFIFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLIS
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE4 KTIQTLGSWGSLSKSKS-SFKETFMCEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTS
::.:::: ::::::: ::::..: :...:.:. : :::.::: :::. .. ...
NP_031 KTVQTLG---SLSKSKSASFKESYMATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVE
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE4 EPVHLKEGEMYKRAQGRTRIGKKNFKKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAV
.:. :::: : :::::: :.: :::::::: ::..:.::::. :.. .:.::..:::::
NP_031 QPIVLKEGFMIKRAQGRKRFGMKNFKKRWFRLTNHEFTYHKSKGDQP-LYSIPIENILAV
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE4 EKLEESSFNKKNMFQVIHTEKPLYVQANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYL
::::: ::. :::::::. :. ::.::::::::..:::.: .::.:::.::. ::::.::
NP_031 EKLEEESFKMKNMFQVIQPERALYIQANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYL
640 650 660 670 680 690
730 740 750 760 770 780
pF1KE4 NGNWLCCQETGENTLGCKPCTAGVPADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACG
.:.::::. .... ::.:::.:.::.::.::: :::::::::::.: . ::.::.::::
NP_031 SGHWLCCRAPSDSAPGCSPCTGGLPANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACG
700 710 720 730 740 750
790 800 810 820 830 840
pF1KE4 TIAVYQGPQKEPDDYSNFVIEDSVTTFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSK
. .::.::..: .::.:::.: :.::..:. . . :.. : .:.. . ...::::.
NP_031 SKSVYDGPEQE--EYSTFVIDDPQETYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQ
760 770 780 790 800 810
850
pF1KE4 ENPIVGKAS
:.:: :.
NP_031 EHPIGDKSFQNYIRQQSETSTHSI
820 830
>>NP_001307751 (OMIM: 605182) ras GTPase-activating prot (802 aa)
initn: 2838 init1: 1858 opt: 3437 Z-score: 3081.6 bits: 581.1 E(85289): 6.6e-165
Smith-Waterman score: 3437; 61.5% identity (87.4% similar) in 793 aa overlap (59-849:1-786)
30 40 50 60 70 80
pF1KE4 QDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFS
::::.::.:::::::.::..::::: ::..
NP_001 MRDCYCTVNLDQEEVFRTKIVEKSLCPFYG
10 20 30
90 100 110 120 130 140
pF1KE4 EEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSE
:.:: ::::.:..::::..:..:..:: ::::::.:::: .. ...:::.:: ::..::
NP_001 EDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE4 VQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQK
:::::::::.:.:.::..:.::..:...: :.:::..::: :::::::.:.:: :.. :
NP_001 VQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQ-CDPYATVTLAGPFRSEAK
100 110 120 130 140
210 220 230 240 250 260
pF1KE4 KTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNL-VQDV
:::::.::.::::.:.::::::: ::..::.:. ::::..:::::.:::: .:: :
NP_001 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE
150 160 170 180 190 200
270 280 290 300 310 320
pF1KE4 FLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYG
::::...:..::: .::..:::.:::::::.:: : :::::::::. ::::.:. :.::.
NP_001 FLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYS
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE4 PLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLK
::. ::::: ::.:.:::::.::.:.::.:..:..:::::.::. ..::: .:.: ..:
NP_001 PLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVK
270 280 290 300 310 320
390 400 410 420 430 440
pF1KE4 DTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGD
::: ::::::::::..:.:: ::..: :::.::::: ..:::.: : :::::.:::.:.
NP_001 RTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGE
330 340 350 360 370 380
450 460 470 480 490 500
pF1KE4 NVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSF
:.::: :::: :::..:..:..:..::::::::::.:::. :..:: .:: :.:.:::::
NP_001 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSF
390 400 410 420 430 440
510 520 530 540 550 560
pF1KE4 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKS-SFKETFM
.:::::: :..::. :.: ::: : :: :::::::::.:::: ::::::: ::::..:
NP_001 IFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLG---SLSKSKSASFKESYM
450 460 470 480 490 500
570 580 590 600 610 620
pF1KE4 CEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNF
:...:.:. : :::.::: :::. .. ... .:. :::: : :::::: :.: :::
NP_001 ATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNF
510 520 530 540 550 560
630 640 650 660 670 680
pF1KE4 KKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYV
::::: ::..:.::::. :.. .:.::..:::::::::: ::. :::::::. :. ::.
NP_001 KKRWFRLTNHEFTYHKSKGDQP-LYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYI
570 580 590 600 610 620
690 700 710 720 730 740
pF1KE4 QANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVP
::::::::..:::.: .::.:::.::. ::::.::.:.::::. .... ::.:::.:.:
NP_001 QANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLP
630 640 650 660 670 680
750 760 770 780 790 800
pF1KE4 ADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVT
:.::.::: :::::::::::.: . ::.::.::::. .::.::..: .::.:::.:
NP_001 ANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQE--EYSTFVIDDPQE
690 700 710 720 730 740
810 820 830 840 850
pF1KE4 TFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
:.::..:. . . :.. : .:.. . ...::::.:.:: :.
NP_001 TYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI
750 760 770 780 790 800
>>XP_011533143 (OMIM: 605182) PREDICTED: ras GTPase-acti (802 aa)
initn: 2838 init1: 1858 opt: 3437 Z-score: 3081.6 bits: 581.1 E(85289): 6.6e-165
Smith-Waterman score: 3437; 61.5% identity (87.4% similar) in 793 aa overlap (59-849:1-786)
30 40 50 60 70 80
pF1KE4 QDSREVRVLQSLRGKICEAKNLLPYLGPHKMRDCFCTINLDQEEVYRTQVVEKSLSPFFS
::::.::.:::::::.::..::::: ::..
XP_011 MRDCYCTVNLDQEEVFRTKIVEKSLCPFYG
10 20 30
90 100 110 120 130 140
pF1KE4 EEFYFEIPRTFQYLSFYVYDKNVLQRDLRIGKVAIKKEDLCNHSGKETWFSLQPVDSNSE
:.:: ::::.:..::::..:..:..:: ::::::.:::: .. ...:::.:: ::..::
XP_011 EDFYCEIPRSFRHLSFYIFDRDVFRRDSIIGKVAIQKEDLQKYHNRDTWFQLQHVDADSE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE4 VQGKVHLELKLNELITENGTVCQQLVVHIKACHGLPLINGQSCDPYATVSLVGPSRNDQK
:::::::::.:.:.::..:.::..:...: :.:::..::: :::::::.:.:: :.. :
XP_011 VQGKVHLELRLSEVITDTGVVCHKLATRIVECQGLPIVNGQ-CDPYATVTLAGPFRSEAK
100 110 120 130 140
210 220 230 240 250 260
pF1KE4 KTKVKKKTSNPQFNEIFYFEVTRSSSYTRKSQFQVEEEDIEKLEIRIDLWNNGNL-VQDV
:::::.::.::::.:.::::::: ::..::.:. ::::..:::::.:::: .:: :
XP_011 KTKVKRKTNNPQFDEVFYFEVTRPCSYSKKSHFDFEEEDVDKLEIRVDLWNASNLKFGDE
150 160 170 180 190 200
270 280 290 300 310 320
pF1KE4 FLGEIKVPVNVLRTDSSHQAWYLLQPRDNGNKSSKTDDLGSLRLNICYTEDYVLPSEYYG
::::...:..::: .::..:::.:::::::.:: : :::::::::. ::::.:. :.::.
XP_011 FLGELRIPLKVLRQSSSYEAWYFLQPRDNGSKSLKPDDLGSLRLNVVYTEDHVFSSDYYS
210 220 230 240 250 260
330 340 350 360 370 380
pF1KE4 PLKTLLLKSPDVQPISASAAYILSEICRDKNDAVLPLVRLLLHHDKLVPFATAVAELDLK
::. ::::: ::.:.:::::.::.:.::.:..:..:::::.::. ..::: .:.: ..:
XP_011 PLRDLLLKSADVEPVSASAAHILGEVCREKQEAAVPLVRLFLHYGRVVPFISAIASAEVK
270 280 290 300 310 320
390 400 410 420 430 440
pF1KE4 DTQDANTIFRGNSLATRCLDEMMKIVGGHYLKVTLKPILDEICDSSKSCEIDPIKLKEGD
::: ::::::::::..:.:: ::..: :::.::::: ..:::.: : :::::.:::.:.
XP_011 RTQDPNTIFRGNSLASKCIDETMKLAGMHYLHVTLKPAIEEICQSHKPCEIDPVKLKDGE
330 340 350 360 370 380
450 460 470 480 490 500
pF1KE4 NVENNKENLRYYVDKLFNTIVKSSMSCPTVMCDIFYSLRQMATQRFPNDPHVQYSAVSSF
:.::: :::: :::..:..:..:..::::::::::.:::. :..:: .:: :.:.:::::
XP_011 NLENNMENLRQYVDRVFHAITESGVSCPTVMCDIFFSLREAAAKRFQDDPDVRYTAVSSF
390 400 410 420 430 440
510 520 530 540 550 560
pF1KE4 VFLRFFAVAVVSPHTFHLRPHHPDAQTIRTLTLISKTIQTLGSWGSLSKSKS-SFKETFM
.:::::: :..::. :.: ::: : :: :::::::::.:::: ::::::: ::::..:
XP_011 IFLRFFAPAILSPNLFQLTPHHTDPQTSRTLTLISKTVQTLG---SLSKSKSASFKESYM
450 460 470 480 490 500
570 580 590 600 610 620
pF1KE4 CEFFKMFQEEGYIIAVKKFLDEISSTETKESSGTSEPVHLKEGEMYKRAQGRTRIGKKNF
:...:.:. : :::.::: :::. .. ... .:. :::: : :::::: :.: :::
XP_011 ATFYEFFNEQKYADAVKNFLDLISSSGRRDPKSVEQPIVLKEGFMIKRAQGRKRFGMKNF
510 520 530 540 550 560
630 640 650 660 670 680
pF1KE4 KKRWFCLTSRELTYHKQPGSKDAIYTIPVKNILAVEKLEESSFNKKNMFQVIHTEKPLYV
::::: ::..:.::::. :.. .:.::..:::::::::: ::. :::::::. :. ::.
XP_011 KKRWFRLTNHEFTYHKSKGDQP-LYSIPIENILAVEKLEEESFKMKNMFQVIQPERALYI
570 580 590 600 610 620
690 700 710 720 730 740
pF1KE4 QANNCVEANEWIDVLCRVSRCNQNRLSFYHPSVYLNGNWLCCQETGENTLGCKPCTAGVP
::::::::..:::.: .::.:::.::. ::::.::.:.::::. .... ::.:::.:.:
XP_011 QANNCVEAKDWIDILTKVSQCNQKRLTVYHPSAYLSGHWLCCRAPSDSAPGCSPCTGGLP
630 640 650 660 670 680
750 760 770 780 790 800
pF1KE4 ADIQIDIDEDRETERIYSLFTLSLLKLQKMEEACGTIAVYQGPQKEPDDYSNFVIEDSVT
:.::.::: :::::::::::.: . ::.::.::::. .::.::..: .::.:::.:
XP_011 ANIQLDIDGDRETERIYSLFNLYMSKLEKMQEACGSKSVYDGPEQE--EYSTFVIDDPQE
690 700 710 720 730 740
810 820 830 840 850
pF1KE4 TFKTIQQIKSIIEKLDEPHEKYRKKRSSSAKYGSKENPIVGKAS
:.::..:. . . :.. : .:.. . ...::::.:.:: :.
XP_011 TYKTLKQVIAGVGALEQEHAQYKRDKFKKTKYGSQEHPIGDKSFQNYIRQQSETSTHSI
750 760 770 780 790 800
850 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Wed Nov 9 12:20:12 2016 done: Wed Nov 9 12:20:13 2016
Total Scan time: 8.850 Total Display time: 0.320
Function used was FASTA [36.3.4 Apr, 2011]