Result of FASTA (omim) for
pFN21AE4226
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4226, 801 aa
1>>>pF1KE4226 801 - 801 aa - 801 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.2119+/-0.000383; mu= -7.5149+/- 0.024
mean_var=311.3150+/-65.643, 0's: 0 Z-trim(121.4): 98 B-trim: 715 in 1/57
Lambda= 0.072690
statistics sampled from 37942 (38045) to 37942 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.768), E-opt: 0.2 (0.446), width: 16
Scan time: 15.990
The best scores are: opt bits E(85289)
NP_079174 (OMIM: 613634) DENN domain-containing pr ( 801) 5423 582.9 1.8e-165
NP_001277260 (OMIM: 613634) DENN domain-containing ( 757) 5103 549.3 2.2e-155
XP_011526620 (OMIM: 613634) PREDICTED: DENN domain ( 757) 5103 549.3 2.2e-155
XP_006722969 (OMIM: 613634) PREDICTED: DENN domain ( 757) 5103 549.3 2.2e-155
XP_006722968 (OMIM: 613634) PREDICTED: DENN domain ( 715) 3064 335.5 4.9e-91
NP_001182144 (OMIM: 613292) DENN domain-containing ( 775) 1635 185.7 6.8e-46
XP_011507550 (OMIM: 613292) PREDICTED: DENN domain ( 788) 1625 184.6 1.4e-45
XP_011507548 (OMIM: 613292) PREDICTED: DENN domain ( 823) 1623 184.4 1.7e-45
XP_006711255 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44
XP_011507551 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44
XP_006711256 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44
XP_016855959 (OMIM: 613292) PREDICTED: DENN domain ( 765) 1583 180.2 2.9e-44
NP_659414 (OMIM: 613292) DENN domain-containing pr ( 426) 1503 171.7 6.1e-42
XP_011507553 (OMIM: 613292) PREDICTED: DENN domain ( 447) 1373 158.0 8.1e-38
NP_079096 (OMIM: 613633) DENN domain-containing pr ( 559) 1153 135.0 8.6e-31
XP_011517185 (OMIM: 613633) PREDICTED: DENN domain (1066) 1160 135.9 8.7e-31
XP_005252170 (OMIM: 613633) PREDICTED: DENN domain ( 574) 1153 135.0 8.7e-31
NP_065997 (OMIM: 613633) DENN domain-containing pr (1009) 1153 135.2 1.4e-30
XP_016870440 (OMIM: 613633) PREDICTED: DENN domain (1020) 1153 135.2 1.4e-30
XP_005252168 (OMIM: 613633) PREDICTED: DENN domain (1024) 1153 135.2 1.4e-30
XP_016870437 (OMIM: 613633) PREDICTED: DENN domain (1052) 1153 135.2 1.4e-30
XP_006717258 (OMIM: 613633) PREDICTED: DENN domain (1067) 1153 135.2 1.5e-30
XP_011517189 (OMIM: 613633) PREDICTED: DENN domain ( 592) 1146 134.3 1.5e-30
XP_011517188 (OMIM: 613633) PREDICTED: DENN domain (1042) 1146 134.5 2.4e-30
XP_011517187 (OMIM: 613633) PREDICTED: DENN domain (1049) 1146 134.5 2.4e-30
XP_011517186 (OMIM: 613633) PREDICTED: DENN domain (1056) 1146 134.5 2.4e-30
XP_016870436 (OMIM: 613633) PREDICTED: DENN domain (1058) 1146 134.5 2.4e-30
XP_005252166 (OMIM: 613633) PREDICTED: DENN domain (1070) 1146 134.5 2.4e-30
XP_011517184 (OMIM: 613633) PREDICTED: DENN domain (1085) 1146 134.5 2.4e-30
XP_016855960 (OMIM: 613292) PREDICTED: DENN domain ( 745) 1134 133.1 4.3e-30
XP_005244988 (OMIM: 613292) PREDICTED: DENN domain ( 755) 1134 133.1 4.4e-30
XP_011507549 (OMIM: 613292) PREDICTED: DENN domain ( 803) 1134 133.1 4.6e-30
NP_001287787 (OMIM: 613292) DENN domain-containing ( 396) 1002 119.1 3.8e-26
XP_016870439 (OMIM: 613633) PREDICTED: DENN domain (1025) 680 85.6 1.2e-15
XP_016870438 (OMIM: 613633) PREDICTED: DENN domain (1043) 680 85.6 1.2e-15
XP_016870441 (OMIM: 613633) PREDICTED: DENN domain ( 811) 628 80.1 4.3e-14
XP_016855961 (OMIM: 613292) PREDICTED: DENN domain ( 491) 593 76.3 3.7e-13
XP_006711257 (OMIM: 613292) PREDICTED: DENN domain ( 469) 500 66.5 3.1e-10
XP_011518627 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06
XP_011518629 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06
XP_016873676 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06
XP_011518630 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06
XP_011518628 (OMIM: 140750) PREDICTED: suppression ( 737) 385 54.6 1.9e-06
XP_011518625 (OMIM: 140750) PREDICTED: suppression ( 767) 385 54.6 1.9e-06
XP_011518621 (OMIM: 140750) PREDICTED: suppression ( 977) 385 54.6 2.4e-06
XP_016873674 (OMIM: 140750) PREDICTED: suppression ( 977) 385 54.6 2.4e-06
XP_016873673 (OMIM: 140750) PREDICTED: suppression ( 977) 385 54.6 2.4e-06
XP_016873672 (OMIM: 140750) PREDICTED: suppression (1157) 385 54.7 2.7e-06
XP_011518613 (OMIM: 140750) PREDICTED: suppression (1157) 385 54.7 2.7e-06
XP_016873671 (OMIM: 140750) PREDICTED: suppression (1157) 385 54.7 2.7e-06
>>NP_079174 (OMIM: 613634) DENN domain-containing protei (801 aa)
initn: 5423 init1: 5423 opt: 5423 Z-score: 3091.6 bits: 582.9 E(85289): 1.8e-165
Smith-Waterman score: 5423; 99.9% identity (100.0% similar) in 801 aa overlap (1-801:1-801)
10 20 30 40 50 60
pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGS
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LRAPALPSRSDRLQQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCP
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 WAEEALDSSFLGSGEELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI
::::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::
NP_079 WAEEALDSSFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNI
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTA
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 SADPSIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE4 PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 PTKPNFDIAWTSQPLDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSN
730 740 750 760 770 780
790 800
pF1KE4 CQKSQPSSRPRVADLKKCFEG
:::::::::::::::::::::
NP_079 CQKSQPSSRPRVADLKKCFEG
790 800
>>NP_001277260 (OMIM: 613634) DENN domain-containing pro (757 aa)
initn: 5103 init1: 5103 opt: 5103 Z-score: 2910.6 bits: 549.3 E(85289): 2.2e-155
Smith-Waterman score: 5103; 99.9% identity (100.0% similar) in 757 aa overlap (45-801:1-757)
20 30 40 50 60 70
pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT
::::::::::::::::::::::::::::::
NP_001 MQMVPKFCFPFDVEREPPSPAVQHFTFALT
10 20 30
80 90 100 110 120 130
pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
NP_001 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
700 710 720 730 740 750
800
pF1KE4 LKKCFEG
:::::::
NP_001 LKKCFEG
>>XP_011526620 (OMIM: 613634) PREDICTED: DENN domain-con (757 aa)
initn: 5103 init1: 5103 opt: 5103 Z-score: 2910.6 bits: 549.3 E(85289): 2.2e-155
Smith-Waterman score: 5103; 99.9% identity (100.0% similar) in 757 aa overlap (45-801:1-757)
20 30 40 50 60 70
pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT
::::::::::::::::::::::::::::::
XP_011 MQMVPKFCFPFDVEREPPSPAVQHFTFALT
10 20 30
80 90 100 110 120 130
pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_011 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
700 710 720 730 740 750
800
pF1KE4 LKKCFEG
:::::::
XP_011 LKKCFEG
>>XP_006722969 (OMIM: 613634) PREDICTED: DENN domain-con (757 aa)
initn: 5103 init1: 5103 opt: 5103 Z-score: 2910.6 bits: 549.3 E(85289): 2.2e-155
Smith-Waterman score: 5103; 99.9% identity (100.0% similar) in 757 aa overlap (45-801:1-757)
20 30 40 50 60 70
pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT
::::::::::::::::::::::::::::::
XP_006 MQMVPKFCFPFDVEREPPSPAVQHFTFALT
10 20 30
80 90 100 110 120 130
pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR
220 230 240 250 260 270
320 330 340 350 360 370
pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF
280 290 300 310 320 330
380 390 400 410 420 430
pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
340 350 360 370 380 390
440 450 460 470 480 490
pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
460 470 480 490 500 510
560 570 580 590 600 610
pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_006 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
520 530 540 550 560 570
620 630 640 650 660 670
pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
700 710 720 730 740 750
800
pF1KE4 LKKCFEG
:::::::
XP_006 LKKCFEG
>>XP_006722968 (OMIM: 613634) PREDICTED: DENN domain-con (715 aa)
initn: 3056 init1: 3056 opt: 3064 Z-score: 1755.3 bits: 335.5 E(85289): 4.9e-91
Smith-Waterman score: 4742; 94.3% identity (94.5% similar) in 757 aa overlap (45-801:1-715)
20 30 40 50 60 70
pF1KE4 WFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALT
::::::::::::::::::::::::::::::
XP_006 MQMVPKFCFPFDVEREPPSPAVQHFTFALT
10 20 30
80 90 100 110 120 130
pF1KE4 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQDQVTEAEELLQNLF
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE4 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTE
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE4 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYPMRWEHVLIPTLPPH
160 170 180 190 200 210
260 270 280 290 300 310
pF1KE4 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLLR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFNDVQALPPDV-----
220 230 240 250 260
320 330 340 350 360 370
pF1KE4 LRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEEVFLAQKPGAPLQAF
:::::::::::::::::::::::
XP_006 -------------------------------------GQPVTFSEEVFLAQKPGAPLQAF
270 280
380 390 400 410 420 430
pF1KE4 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLKKGGG
290 300 310 320 330 340
440 450 460 470 480 490
pF1KE4 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYKDGDSVLQRGGSLRAPALPSRSDRLQ
350 360 370 380 390 400
500 510 520 530 540 550
pF1KE4 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALDSSFLGSG
410 420 430 440 450 460
560 570 580 590 600 610
pF1KE4 EELDLLSEILDSLSVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::
XP_006 EELDLLSEILDSLSMGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPE
470 480 490 500 510 520
620 630 640 650 660 670
pF1KE4 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PQPLSLPSLQNASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADPSIWGDPKPSP
530 540 550 560 570 580
680 690 700 710 720 730
pF1KE4 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LTEPLILHLTPSHKAAEDSTAQENPTPWLSTAPTEPSPPESPQILAPTKPNFDIAWTSQP
590 600 610 620 630 640
740 750 760 770 780 790
pF1KE4 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDPSSDPSSLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNCQKSQPSSRPRVAD
650 660 670 680 690 700
800
pF1KE4 LKKCFEG
:::::::
XP_006 LKKCFEG
710
>>NP_001182144 (OMIM: 613292) DENN domain-containing pro (775 aa)
initn: 1718 init1: 848 opt: 1635 Z-score: 944.9 bits: 185.7 E(85289): 6.8e-46
Smith-Waterman score: 1692; 46.9% identity (72.3% similar) in 599 aa overlap (1-584:1-592)
10 20 30 40 50 60
pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE
:. :.... .:: ... : :: .::: .: .:: :: ::: .: ::::::::::::
NP_001 MDCRTKANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ
. . :::::.:::. ...::::::: .: ::::::.::::::.::::::..: ::.
NP_001 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS
. .. .: :..:... . .. :.: ... . .. : . . : : :.:::
NP_001 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLK--DQPALVPHSYFIAPDV
130 140 150 160 170
190 200 210 220 230 240
pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP
::.:::.::::: ::: .:.. :.:..: :::... .:::::::.:.:.: :::::
NP_001 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN
: :.:. ::.::::::::::::::::::.:.:: :::..:.:::::.::::.::::. :.
NP_001 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE
:.. :: :::: :. .:.: . : :.::.: ::.::: :::.::::: .::.:.:: ::
NP_001 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR
:. .. .. .. : . :..::::::::..:: ::: :.:::: ::.:::. : .: :
NP_001 SFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR
360 370 380 390 400 410
430 440 450 460 470
pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ
::: :. ..:::: ::.... .:. :::.. :. ::. ::: :.: : .:...
NP_001 SYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE4 RGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL
.: .:. .... ... ..: : :::. : : . .. . :
NP_001 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL
480 490 500 510 520 530
540 550 560 570 580
pF1KE4 SPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAKSAGSLRPSQSLDC
: :: :. . :. :: ::: .:::.::::.::. ... :.: ..:::
NP_001 SSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSSDQGKLAAAKSLDF
540 550 560 570 580 590
590 600 610 620 630 640
pF1KE4 CHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPS
NP_001 FRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSS
600 610 620 630 640 650
>>XP_011507550 (OMIM: 613292) PREDICTED: DENN domain-con (788 aa)
initn: 1706 init1: 848 opt: 1625 Z-score: 939.2 bits: 184.6 E(85289): 1.4e-45
Smith-Waterman score: 1682; 47.2% identity (72.0% similar) in 600 aa overlap (4-584:13-605)
10 20 30 40
pF1KE4 MESRAEGGSPA----VFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQM
.:: :. : .:: ... : :: .::: .: .:: :: ::: .:
XP_011 MSGRLRNKDKGEQAETGQRANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQEILQS
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 VPKFCFPFDVEREPPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVF
:::::::::::: . . :::::.:::. ...::::::: .: ::::::.::::::.
XP_011 VPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVY
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 YKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRG
::::::..: ::.. .. .: :..:... . .. :.: ... . .. : . .
XP_011 YKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKD--QP
130 140 150 160 170
170 180 190 200 210 220
pF1KE4 NSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTL
: : :.::: ::.:::.::::: ::: .:.. :.:..: :::... .::::::
XP_011 ALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTL
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 TSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVV
:.:.:.: :::::: :.:. ::.::::::::::::::::::.:.:: :::..:.:::::.
XP_011 TACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVM
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 LNVDANTLETTFNDVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDAL
::::.::::. :.:.. :: :::: :. .:.: . : :.::.: ::.::: :::.:::::
XP_011 LNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDAL
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 VCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQ
.::.:.:: :: :. .. .. .. : . :..::::::::..:: ::: :.:::: ::.
XP_011 RYKPGEPITFCEESFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEE
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 EITGCGASSGALRSYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQ
:::. : .: :::: :. ..:::: ::.... .:. :::.. :. ::. ::: :.
XP_011 EITSGGFCGGNPRSYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVK
420 430 440 450 460 470
470 480 490 500 510
pF1KE4 SLLMYKDGDSVLQRGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEE
: : .:... .: .:. .... ... ..: : :::. : : .
XP_011 SKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYD
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE4 GTSEPPGAGTPPLSPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAK
.. . :: :: :. . :. :: ::: .:::.::::.::. ..
XP_011 DEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSS
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE4 SAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDAT
. :.: ..:::
XP_011 DQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHG
600 610 620 630 640 650
>>XP_011507548 (OMIM: 613292) PREDICTED: DENN domain-con (823 aa)
initn: 1706 init1: 848 opt: 1623 Z-score: 937.7 bits: 184.4 E(85289): 1.7e-45
Smith-Waterman score: 1680; 47.5% identity (72.4% similar) in 587 aa overlap (13-584:61-640)
10 20 30 40
pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQ
:: ... : :: .::: .: .:: :: ::
XP_011 YPIRGYFYVCAKVFINDYFAQEIRANPDRTFDLVLKVKCHASENEDPVVLWKFPEDFGDQ
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE4 EAMQMVPKFCFPFDVEREPPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLP
: .: :::::::::::: . . :::::.:::. ...::::::: .: ::::::.::
XP_011 EILQSVPKFCFPFDVERVSQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLP
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE4 WFEVFYKLLNTVGDLLAQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIP
::::.::::::..: ::.. .. .: :..:... . .. :.: ... . .. : .
XP_011 WFEVYYKLLNTLADYLAKELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLK
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE4 PPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTAS
. : : :.::: ::.:::.::::: ::: .:.. :.:..: :::... .:
XP_011 D--QPALVPHSYFIAPDVTGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISS
220 230 240 250 260
230 240 250 260 270 280
pF1KE4 KLSTLTSCVHASCALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKAL
::::::.:.:.: :::::: :.:. ::.::::::::::::::::::.:.:: :::..:.:
XP_011 KLSTLTACIHGSAALLYPMYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSL
270 280 290 300 310 320
290 300 310 320 330 340
pF1KE4 EDVVVLNVDANTLETTFNDVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGG
::::.::::.::::. :.:.. :: :::: :. .:.: . : :.::.: ::.::: :::.
XP_011 EDVVMLNVDTNTLESPFSDLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGS
330 340 350 360 370 380
350 360 370 380 390 400
pF1KE4 YRDALVCSPGQPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFS
::::: .::.:.:: :: :. .. .. .. : . :..::::::::..:: ::: :.:::
XP_011 YRDALRYKPGEPITFCEESFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFS
390 400 410 420 430 440
410 420 430 440 450
pF1KE4 DQFEQEITGCGASSGALRSYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----G
: ::.:::. : .: :::: :. ..:::: ::.... .:. :::.. :. ::. :
XP_011 DVFEEEITSGGFCGGNPRSYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLG
450 460 470 480 490 500
460 470 480 490 500 510
pF1KE4 LKGVQSLLMYKDGDSVLQRGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRR
:: :.: : .:... .: .:. .... ... ..: : :::. :
XP_011 LKEVKSKLKHKENEEDYGTCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLD
510 520 530 540 550 560
520 530 540 550 560
pF1KE4 RQLEEGTSEPPGAGTPPLSPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSL
: . .. . :: :: :. . :. :: ::: .:::.::::.:
XP_011 GALYDDEDDDDIERASKLSSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTL
570 580 590 600 610 620
570 580 590 600 610 620
pF1KE4 SVGAKSAGSLRPSQSLDCCHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNAS
:. ... :.: ..:::
XP_011 STHSSDQGKLAAAKSLDFFRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDD
630 640 650 660 670 680
>>XP_006711255 (OMIM: 613292) PREDICTED: DENN domain-con (765 aa)
initn: 1662 init1: 848 opt: 1583 Z-score: 915.5 bits: 180.2 E(85289): 2.9e-44
Smith-Waterman score: 1640; 47.2% identity (72.1% similar) in 578 aa overlap (22-584:12-582)
10 20 30 40 50 60
pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE
: . .: .: .:: :: ::: .: ::::::::::::
XP_006 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ
. . :::::.:::. ...::::::: .: ::::::.::::::.::::::..: ::.
XP_006 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS
. .. .: :..:... . .. :.: ... . .. : . . : : :.:::
XP_006 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKD--QPALVPHSYFIAPDV
120 130 140 150 160
190 200 210 220 230 240
pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP
::.:::.::::: ::: .:.. :.:..: :::... .:::::::.:.:.: :::::
XP_006 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN
: :.:. ::.::::::::::::::::::.:.:: :::..:.:::::.::::.::::. :.
XP_006 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE
:.. :: :::: :. .:.: . : :.::.: ::.::: :::.::::: .::.:.:: ::
XP_006 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR
:. .. .. .. : . :..::::::::..:: ::: :.:::: ::.:::. : .: :
XP_006 SFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR
350 360 370 380 390 400
430 440 450 460 470
pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ
::: :. ..:::: ::.... .:. :::.. :. ::. ::: :.: : .:...
XP_006 SYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE4 RGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL
.: .:. .... ... ..: : :::. : : . .. . :
XP_006 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL
470 480 490 500 510 520
540 550 560 570 580
pF1KE4 SPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAKSAGSLRPSQSLDC
: :: :. . :. :: ::: .:::.::::.::. ... :.: ..:::
XP_006 SSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSSDQGKLAAAKSLDF
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE4 CHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPS
XP_006 FRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSS
590 600 610 620 630 640
>>XP_011507551 (OMIM: 613292) PREDICTED: DENN domain-con (765 aa)
initn: 1662 init1: 848 opt: 1583 Z-score: 915.5 bits: 180.2 E(85289): 2.9e-44
Smith-Waterman score: 1640; 47.2% identity (72.1% similar) in 578 aa overlap (22-584:12-582)
10 20 30 40 50 60
pF1KE4 MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFRDQEAMQMVPKFCFPFDVERE
: . .: .: .:: :: ::: .: ::::::::::::
XP_011 MAAAPREEKRWPQPVFSNPVVLWKFPEDFGDQEILQSVPKFCFPFDVERV
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 PPSPAVQHFTFALTDLAGNRRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLLAQ
. . :::::.:::. ...::::::: .: ::::::.::::::.::::::..: ::.
XP_011 SQNQVGQHFTFVLTDIESKQRFGFCRLTSGGTICLCILSYLPWFEVYYKLLNTLADYLAK
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 DQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSSGQGIPPPTRGNSKPLSCFVAPDS
. .. .: :..:... . .. :.: ... . .. : . . : : :.:::
XP_011 ELENDLNETLRSLYNHPVPKANTPVNLSVNQEIFIACEQVLKD--QPALVPHSYFIAPDV
120 130 140 150 160
190 200 210 220 230 240
pF1KE4 GRLPSIPENRNLTELVVAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASCALLYP
::.:::.::::: ::: .:.. :.:..: :::... .:::::::.:.:.: :::::
XP_011 TGLPTIPESRNLTEYFVAVDVNNMLQLYASMLHERRIVIISSKLSTLTACIHGSAALLYP
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 MRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLAERVREKALEDVVVLNVDANTLETTFN
: :.:. ::.::::::::::::::::::.:.:: :::..:.:::::.::::.::::. :.
XP_011 MYWQHIYIPVLPPHLLDYCCAPMPYLIGIHSSLIERVKNKSLEDVVMLNVDTNTLESPFS
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 DVQALPPDVVSLLRLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPGQPVTFSEE
:.. :: :::: :. .:.: . : :.::.: ::.::: :::.::::: .::.:.:: ::
XP_011 DLNNLPSDVVSALKNKLKKQSTATGDGVARAFLRAQAALFGSYRDALRYKPGEPITFCEE
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 VFLAQKPGAPLQAFHRRAVHLQLFKQFIEARLEKLNKGEGFSDQFEQEITGCGASSGALR
:. .. .. .. : . :..::::::::..:: ::: :.:::: ::.:::. : .: :
XP_011 SFVKHRSSV-MKQFLETAINLQLFKQFIDGRLAKLNAGRGFSDVFEEEITSGGFCGGNPR
350 360 370 380 390 400
430 440 450 460 470
pF1KE4 SYQLWADNLKKGGGALLHSVKAKTQPAVKNMYRSAKS----GLKGVQSLLMYKDGDSVLQ
::: :. ..:::: ::.... .:. :::.. :. ::. ::: :.: : .:...
XP_011 SYQQWVHTVKKGG-ALFNTAMTKATPAVRTAYKFAKNHAKLGLKEVKSKLKHKENEEDYG
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE4 RGGS--LRAPALPSRSDRL--QQRLPITQHFGKNRPLRPSRRRQLEEGTSEPPGAGTPPL
.: .:. .... ... ..: : :::. : : . .. . :
XP_011 TCSSSVQYTPVYKLHNEKGGNSEKRKLAQARLK-RPLK-SLDGALYDDEDDDDIERASKL
470 480 490 500 510 520
540 550 560 570 580
pF1KE4 SPED--EGCPWAEEALDSSFLG-----SGEELDLLSEILDSLSVGAKSAGSLRPSQSLDC
: :: :. . :. :: ::: .:::.::::.::. ... :.: ..:::
XP_011 SSEDGEEASAYLYESDDSVETRVKTPYSGE-MDLLGEILDTLSTHSSDQGKLAAAKSLDF
530 540 550 560 570 580
590 600 610 620 630 640
pF1KE4 CHRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQNASSLDATSSSKDSRSQLIPS
XP_011 FRSMDDIDYKPTNKSNAPSENNLAFLCGGSGDQAEWNLGQDDSALHGKHLPPSPRKRVSS
590 600 610 620 630 640
801 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:19:10 2016 done: Sun Nov 6 03:19:12 2016
Total Scan time: 15.990 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]