Result of FASTA (omim) for
pFN21AE4220
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4220, 759 aa
1>>>pF1KE4220 759 - 759 aa - 759 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4569+/-0.000338; mu= 16.4210+/- 0.021
mean_var=135.5056+/-28.025, 0's: 0 Z-trim(119.3): 187 B-trim: 804 in 1/58
Lambda= 0.110178
statistics sampled from 32943 (33155) to 32943 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.389), width: 16
Scan time: 10.360
The best scores are: opt bits E(85289)
NP_079334 (OMIM: 600986) tripartite motif-containi ( 759) 5215 840.9 0
XP_011508304 (OMIM: 600986) PREDICTED: tripartite ( 788) 5098 822.3 0
NP_001243530 (OMIM: 600986) tripartite motif-conta ( 746) 5086 820.3 0
XP_016857882 (OMIM: 600986) PREDICTED: tripartite ( 746) 5086 820.3 0
NP_001243528 (OMIM: 600986) tripartite motif-conta ( 736) 5076 818.8 0
NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 4347 702.8 1.1e-201
NP_001269308 (OMIM: 600986) tripartite motif-conta ( 551) 3649 591.8 2.5e-168
NP_001243529 (OMIM: 600986) tripartite motif-conta ( 717) 2974 484.6 6.1e-136
XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 745) 1972 325.4 5.5e-88
XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 733) 1936 319.6 2.9e-86
NP_001287688 (OMIM: 609317) E3 ubiquitin-protein l ( 716) 1786 295.8 4.2e-79
NP_061170 (OMIM: 609317) E3 ubiquitin-protein liga ( 728) 1779 294.7 9.3e-79
XP_016865112 (OMIM: 609317) PREDICTED: E3 ubiquiti ( 529) 1558 259.4 2.8e-68
NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 1500 250.2 1.8e-65
NP_001092094 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 591 105.8 6.1e-22
NP_001180206 (OMIM: 189960,300000,300552) E3 ubiqu ( 667) 591 105.8 6.1e-22
NP_150632 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 591 105.8 6.1e-22
XP_016885025 (OMIM: 189960,300000,300552) PREDICTE ( 667) 591 105.8 6.1e-22
NP_000372 (OMIM: 189960,300000,300552) E3 ubiquiti ( 667) 591 105.8 6.1e-22
XP_016885029 (OMIM: 189960,300000,300552) PREDICTE ( 552) 584 104.6 1.2e-21
XP_016885031 (OMIM: 189960,300000,300552) PREDICTE ( 489) 514 93.4 2.4e-18
NP_001180208 (OMIM: 189960,300000,300552) E3 ubiqu ( 489) 514 93.4 2.4e-18
XP_016870672 (OMIM: 609829) PREDICTED: FSD1-like p ( 498) 400 75.3 6.8e-13
NP_001317668 (OMIM: 609829) FSD1-like protein isof ( 509) 399 75.2 7.7e-13
NP_001274121 (OMIM: 609829) FSD1-like protein isof ( 497) 397 74.8 9.5e-13
NP_001138785 (OMIM: 609829) FSD1-like protein isof ( 530) 396 74.7 1.1e-12
XP_011517380 (OMIM: 609829) PREDICTED: FSD1-like p ( 543) 396 74.7 1.1e-12
XP_005252311 (OMIM: 609829) PREDICTED: FSD1-like p ( 541) 395 74.6 1.3e-12
XP_011517379 (OMIM: 609829) PREDICTED: FSD1-like p ( 547) 395 74.6 1.3e-12
XP_016870671 (OMIM: 609829) PREDICTED: FSD1-like p ( 529) 393 74.2 1.5e-12
XP_011517381 (OMIM: 609829) PREDICTED: FSD1-like p ( 542) 393 74.2 1.6e-12
NP_001274120 (OMIM: 609829) FSD1-like protein isof ( 508) 392 74.1 1.7e-12
NP_077309 (OMIM: 609828) fibronectin type III and ( 496) 389 73.6 2.3e-12
NP_001317358 (OMIM: 609828) fibronectin type III a ( 437) 387 73.2 2.6e-12
XP_016870676 (OMIM: 609829) PREDICTED: FSD1-like p ( 317) 382 72.3 3.6e-12
XP_016870674 (OMIM: 609829) PREDICTED: FSD1-like p ( 362) 378 71.7 6.1e-12
NP_115977 (OMIM: 606131) E3 ubiquitin-protein liga ( 353) 363 69.3 3.2e-11
XP_016858048 (OMIM: 606131) PREDICTED: E3 ubiquiti ( 379) 363 69.3 3.3e-11
XP_011515919 (OMIM: 606469) PREDICTED: tripartite ( 426) 358 68.6 6.3e-11
XP_016869398 (OMIM: 606469) PREDICTED: tripartite ( 426) 358 68.6 6.3e-11
XP_011515918 (OMIM: 606469) PREDICTED: tripartite ( 452) 358 68.6 6.5e-11
NP_908974 (OMIM: 606469) tripartite motif-containi ( 452) 358 68.6 6.5e-11
XP_016869397 (OMIM: 606469) PREDICTED: tripartite ( 479) 358 68.6 6.8e-11
NP_912730 (OMIM: 606474) tripartite motif-containi ( 358) 356 68.2 6.9e-11
XP_011515917 (OMIM: 606469) PREDICTED: tripartite ( 540) 358 68.7 7.4e-11
NP_149047 (OMIM: 606469) tripartite motif-containi ( 540) 358 68.7 7.4e-11
XP_011515916 (OMIM: 606469) PREDICTED: tripartite ( 548) 358 68.7 7.5e-11
XP_011515915 (OMIM: 606469) PREDICTED: tripartite ( 548) 358 68.7 7.5e-11
NP_908973 (OMIM: 606469) tripartite motif-containi ( 548) 358 68.7 7.5e-11
XP_005251373 (OMIM: 606469) PREDICTED: tripartite ( 547) 356 68.4 9.3e-11
>>NP_079334 (OMIM: 600986) tripartite motif-containing p (759 aa)
initn: 5215 init1: 5215 opt: 5215 Z-score: 4486.5 bits: 840.9 E(85289): 0
Smith-Waterman score: 5215; 100.0% identity (100.0% similar) in 759 aa overlap (1-759:1-759)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
670 680 690 700 710 720
730 740 750
pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
:::::::::::::::::::::::::::::::::::::::
NP_079 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
730 740 750
>>XP_011508304 (OMIM: 600986) PREDICTED: tripartite moti (788 aa)
initn: 5098 init1: 5098 opt: 5098 Z-score: 4385.7 bits: 822.3 E(85289): 0
Smith-Waterman score: 5147; 96.3% identity (96.3% similar) in 788 aa overlap (1-759:1-788)
10 20 30
pF1KE4 MAEGEDMQTFTSIMDALVRIS-----------------------------TSMKNMEKEL
::::::::::::::::::::: ::::::::::
XP_011 MAEGEDMQTFTSIMDALVRISLCSGEREARDRGLGRSVNQPKAGALEKLQTSMKNMEKEL
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE4 LCPVCQEMYKQPLVLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LCPVCQEMYKQPLVLPCTHNVCQACAREVLGQQGYIGHGGDPSSEPTSPASTPSTRSPRL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE4 SRRTLPKPDRLDRLLKSGFGTYPGRKRGALHPQVIMFPCPACQGDVELGERGLAGLFRNL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRRTLPKPDRLDRLLKSGFGTYPGRKRGALHPQVIMFPCPACQGDVELGERGLAGLFRNL
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE4 TLERVVERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLERVVERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQH
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE4 EPTLPTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPTLPTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALK
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE4 DKLTKSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DKLTKSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE4 LQAIEECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LQAIEECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIAR
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE4 ATEALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ATEALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWR
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE4 LPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LPPHSPPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNK
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE4 AGYGEYSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGYGEYSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLL
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE4 TGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TGCHLSVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYD
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE4 PDSGHDSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PDSGHDSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRL
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE4 GICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GICLDYERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVT
730 740 750 760 770 780
pF1KE4 IGGFAKLD
::::::::
XP_011 IGGFAKLD
>>NP_001243530 (OMIM: 600986) tripartite motif-containin (746 aa)
initn: 5086 init1: 5086 opt: 5086 Z-score: 4375.7 bits: 820.3 E(85289): 0
Smith-Waterman score: 5086; 100.0% identity (100.0% similar) in 738 aa overlap (22-759:9-746)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
:::::::::::::::::::::::::::::::::::::::
NP_001 MGAKGNGLTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40
70 80 90 100 110 120
pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
650 660 670 680 690 700
730 740 750
pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
:::::::::::::::::::::::::::::::::::::::
NP_001 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
710 720 730 740
>>XP_016857882 (OMIM: 600986) PREDICTED: tripartite moti (746 aa)
initn: 5086 init1: 5086 opt: 5086 Z-score: 4375.7 bits: 820.3 E(85289): 0
Smith-Waterman score: 5086; 100.0% identity (100.0% similar) in 738 aa overlap (22-759:9-746)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
:::::::::::::::::::::::::::::::::::::::
XP_016 MAAKRGTKTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40
70 80 90 100 110 120
pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
290 300 310 320 330 340
370 380 390 400 410 420
pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
350 360 370 380 390 400
430 440 450 460 470 480
pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
410 420 430 440 450 460
490 500 510 520 530 540
pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
470 480 490 500 510 520
550 560 570 580 590 600
pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
530 540 550 560 570 580
610 620 630 640 650 660
pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
590 600 610 620 630 640
670 680 690 700 710 720
pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
650 660 670 680 690 700
730 740 750
pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
:::::::::::::::::::::::::::::::::::::::
XP_016 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
710 720 730 740
>>NP_001243528 (OMIM: 600986) tripartite motif-containin (736 aa)
initn: 5076 init1: 5076 opt: 5076 Z-score: 4367.2 bits: 818.8 E(85289): 0
Smith-Waterman score: 5076; 100.0% identity (100.0% similar) in 736 aa overlap (24-759:1-736)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
:::::::::::::::::::::::::::::::::::::
NP_001 MKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30
70 80 90 100 110 120
pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
640 650 660 670 680 690
730 740 750
pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
:::::::::::::::::::::::::::::::::::::::
NP_001 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
700 710 720 730
>>NP_001269307 (OMIM: 600986) tripartite motif-containin (633 aa)
initn: 4347 init1: 4347 opt: 4347 Z-score: 3741.8 bits: 702.8 E(85289): 1.1e-201
Smith-Waterman score: 4347; 100.0% identity (100.0% similar) in 633 aa overlap (127-759:1-633)
100 110 120 130 140 150
pF1KE4 PKPDRLDRLLKSGFGTYPGRKRGALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERV
::::::::::::::::::::::::::::::
NP_001 MFPCPACQGDVELGERGLAGLFRNLTLERV
10 20 30
160 170 180 190 200 210
pF1KE4 VERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VERYRQSVSVGGAILCQLCKPPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLP
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE4 TLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTK
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE4 SLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIE
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE4 ECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ECQQERLARLSAQIQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEAL
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE4 QTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHS
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE4 PPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPAWHYTVEFRRTDVPAQPGPTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGE
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE4 YSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSEDVHLHTPPAPVLHFFLDSRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHL
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE4 SVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVDVVLGDVAVTQGRSYWACAVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGH
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE4 DSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSGAEDATVEASPPFAFLTIGMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLD
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE4 YERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YERGRVSFLDAVSFRGLLECPLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFA
580 590 600 610 620 630
pF1KE4 KLD
:::
NP_001 KLD
>>NP_001269308 (OMIM: 600986) tripartite motif-containin (551 aa)
initn: 3647 init1: 3647 opt: 3649 Z-score: 3142.9 bits: 591.8 E(85289): 2.5e-168
Smith-Waterman score: 3649; 98.5% identity (98.9% similar) in 541 aa overlap (1-541:1-540)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
::::::::::::::::::::::::::::::::::::::::::::::::: .. : : :
NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPGIQN-LARRGG
490 500 510 520 530
550 560 570 580 590 600
pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
:
NP_001 ACLQFQLLGRLR
540 550
>>NP_001243529 (OMIM: 600986) tripartite motif-containin (717 aa)
initn: 2974 init1: 2974 opt: 2974 Z-score: 2561.6 bits: 484.6 E(85289): 6.1e-136
Smith-Waterman score: 4843; 96.1% identity (96.1% similar) in 738 aa overlap (22-759:9-717)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
:::::::::::::::::::::::::::::::::::::::
NP_001 MAAKRGTKTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
10 20 30 40
70 80 90 100 110 120
pF1KE4 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGQQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKRGA
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE4 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPPPL
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE4 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHKEEVTHYCKT
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE4 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEEAVR
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE---
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE4 HTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
::::::::::::::::::::::::::::::::::
NP_001 --------------------------KRASLLQAIEECQQERLARLSAQIQEHRSLLDGS
290 300 310
370 380 390 400 410 420
pF1KE4 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGREMKL
320 330 340 350 360 370
430 440 450 460 470 480
pF1KE4 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPGPTRW
380 390 400 410 420 430
490 500 510 520 530 540
pF1KE4 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLDSRWG
440 450 460 470 480 490
550 560 570 580 590 600
pF1KE4 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWACAVDP
500 510 520 530 540 550
610 620 630 640 650 660
pF1KE4 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTIGMGK
560 570 580 590 600 610
670 680 690 700 710 720
pF1KE4 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLECPLDC
620 630 640 650 660 670
730 740 750
pF1KE4 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
:::::::::::::::::::::::::::::::::::::::
NP_001 SGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
680 690 700 710
>>XP_016865110 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (745 aa)
initn: 1473 init1: 626 opt: 1972 Z-score: 1700.6 bits: 325.4 E(85289): 5.5e-88
Smith-Waterman score: 2131; 41.8% identity (75.2% similar) in 749 aa overlap (1-745:1-737)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
:.:. .:. : ::. ... ....::.:.::.::.:.:.. .::.::: :..:. :..:.
XP_016 MSESGEMSEFGYIMELIAKGKVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
10 20 30 40 50 60
70 80 90 100 110
pF1KE4 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR
: .... :.: :.. . :: ...: . : .: . .. : ::
XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP
..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.:::::
XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY
: :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... :
XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE
:. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::.
XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL
...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...::
XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE
...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ......
XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE4 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG
.:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . .
XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD
430 440 450 460 470
480 490 500 510 520 530
pF1KE4 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD
:.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..:
XP_016 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD
480 490 500 510 520 530
540 550 560 570 580 590
pF1KE4 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC
. : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .::
XP_016 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF
540 550 560 570 580 590
600 610 620 630 640 650
pF1KE4 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI
:.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...::
XP_016 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI
600 610 620 630 640 650
660 670 680 690 700 710
pF1KE4 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC
:: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : :
XP_016 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYER
660 670 680 690 700
720 730 740 750
pF1KE4 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
.::: . ::: ..:.:..::.::. .:
XP_016 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
710 720 730 740
>>XP_016865111 (OMIM: 609317) PREDICTED: E3 ubiquitin-pr (733 aa)
initn: 1456 init1: 626 opt: 1936 Z-score: 1669.8 bits: 319.6 E(85289): 2.9e-86
Smith-Waterman score: 2095; 42.2% identity (75.2% similar) in 727 aa overlap (23-745:11-725)
10 20 30 40 50 60
pF1KE4 MAEGEDMQTFTSIMDALVRISTSMKNMEKELLCPVCQEMYKQPLVLPCTHNVCQACAREV
..::.:.::.::.:.:.. .::.::: :..:. :..:.
XP_016 MEGDGSDSPVTIKNIERELICPACKELFTHPLILPCQHSICHKCVKEL
10 20 30 40
70 80 90 100 110
pF1KE4 LG--QQGYIGHGGDPSSEPTSPASTPSTRSPRLSRRTLPKPDRLDRLLKSGFGTYPGRKR
: .... :.: :.. . :: ...: . : .: . .. : ::
XP_016 LLTLDDSFNDVGSDNSNQSSPRLRLPSPSMDKIDRINRPASQRRSVGWRGHKKLLNGWKR
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 GALHPQVIMFPCPACQGDVELGERGLAGLFRNLTLERVVERYRQSVSVGGAILCQLCKPP
..: :.. .::::.:. ::.:::::. :::::.::: .::::::.. .. ::.:.:::::
XP_016 NSLTPRTTVFPCPGCEHDVDLGERGINGLFRNFTLETIVERYRQAARAATAIMCDLCKPP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 PLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTLPTLSFRPKGLMCPDHK-EEVTHY
: :.::.: .: :..::::::. ::::: ::::: . :: .:::: ::::.:. :... :
XP_016 PQESTKSCMDCSASYCNECFKIHHPWGTIKAQHEYVGPTTNFRPKILMCPEHETERINMY
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE4 CKTCQRLVCQLCRVRRTHSGHKITPVLSAYQALKDKLTKSLTYILGNQDTVQTQICELEE
:. :.: ::.::.. .:..:..: . :::..::.::.:.. :..:... :..:: ::.
XP_016 CELCRRPVCHLCKLGGNHANHRVTTMSSAYKTLKEKLSKDIDYLIGKESQVKSQISELNL
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE4 AVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQAIEECQQERLARLSAQIQEHRSLL
...:: .:..::::. . : ::::...:.:.::. .. :: ....:..:...::
XP_016 LMKETECNGERAKEEAITHFEKLFEVLEERKSSVLKAIDSSKKLRLDKFQTQMEEYQGLL
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 DGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARATEALQTFRPAASSSFRHCQLDVGRE
...::::::::::::::: ::::.::::: :: .:::.:..:::::..::. ......
XP_016 ENNGLVGYAQEVLKETDQSCFVQTAKQLHLRIQKATESLKSFRPAAQTSFEDYVVNTSKQ
350 360 370 380 390 400
420 430 440 450 460 470
pF1KE4 MKLLTELNFLRVP-EAPVIDTQRTFAYDQIFLCWRLPPHSPPAWHYTVEFRRTDVPAQPG
.:: ::.:. ..: :. ... .:.. .. :. :.. : :..:.:. . .
XP_016 TELLGELSFFSSGIDVPEINEEQSKVYNNALINWH-HPEKDKADSYVLEYRKIN---RDD
410 420 430 440 450 460
480 490 500 510 520 530
pF1KE4 PTRWQRREEVRGTSALLENPDTGSVYVLRVRGCNKAGYGEYSEDVHLHTPPAPVLHFFLD
:.. : : ::: .... ...:.:..:::. . . . :... ::::::::. :..:
XP_016 EMSWNEIE-VCGTSKIIQDLENSSTYAFRVRAYKGSICSPCSRELILHTPPAPVFSFLFD
470 480 490 500 510 520
540 550 560 570 580 590
pF1KE4 SRWGASRERLAISKDQRAVRSVPGLPLLLAADRLLTGCHLSVDVVLGDVAVTQGRSYWAC
. : . :.: .. . :.: :. :::::.:. .: . :.: ..::...:.:. .::
XP_016 EKCGYNNEHLLLNLKRDRVESRAGFNLLLAAERIQVGYYTSLDYIIGDTGITKGKHFWAF
530 540 550 560 570 580
600 610 620 630 640 650
pF1KE4 AVDPASYLVKVGVGLESKLQESFQGAPDVISPRYDPDSGHDSGAEDATVEASPPFAFLTI
:.: ::::::::. .:::: ... :..::::. :::::::.::: ..: ::...::
XP_016 RVEPYSYLVKVGVASSDKLQEWLRSPRDAVSPRYEQDSGHDSGSEDACFDSSQPFTLVTI
590 600 610 620 630 640
660 670 680 690 700 710
pF1KE4 GMGKILLGSGASSNAGLTGRDGPTAGCTVPLPPRLGICLDYERGRVSFLDAVSFRGLLEC
:: :... .. .:. .: ..:.: .:: :: ..:.:.: : ... : :
XP_016 GMQKFFIPKSPTSSNEPENR-------VLPMPTSIGIFLDCDKGKVDFYDMDQMKCLYER
650 660 670 680 690
720 730 740 750
pF1KE4 PLDCSGPVCPAFCFIGGGAVQLQEPVGTKPERKVTIGGFAKLD
.::: . ::: ..:.:..::.::. .:
XP_016 QVDCSHTLYPAFALMGSGGIQLEEPITAKYLEYQEDM
700 710 720 730
759 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:51:20 2016 done: Mon Nov 7 16:51:22 2016
Total Scan time: 10.360 Total Display time: 0.170
Function used was FASTA [36.3.4 Apr, 2011]