Result of FASTA (omim) for
pFN21AE4212
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4212, 696 aa
1>>>pF1KE4212 696 - 696 aa - 696 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.2621+/-0.000308; mu= 12.7841+/- 0.019
mean_var=157.8845+/-32.228, 0's: 0 Z-trim(121.7): 97 B-trim: 0 in 0/53
Lambda= 0.102071
statistics sampled from 38551 (38673) to 38551 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.767), E-opt: 0.2 (0.453), width: 16
Scan time: 10.190
The best scores are: opt bits E(85289)
NP_699172 (OMIM: 610872) E3 ubiquitin-protein liga ( 732) 4448 667.0 7.1e-191
XP_006710419 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 732) 4448 667.0 7.1e-191
NP_001287755 (OMIM: 610872) E3 ubiquitin-protein l ( 731) 4431 664.5 4e-190
XP_006710421 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 588) 3418 515.2 2.8e-145
NP_001120833 (OMIM: 610872) E3 ubiquitin-protein l ( 587) 3401 512.7 1.6e-144
XP_006710420 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 688) 3160 477.3 8.5e-134
XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 2306 351.6 7e-96
XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 2306 351.6 7e-96
NP_001267468 (OMIM: 607119) E3 ubiquitin-protein l ( 838) 2306 351.6 7e-96
NP_056250 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 2306 351.6 7e-96
XP_016868791 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 2306 351.6 7e-96
NP_904355 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 2306 351.6 7e-96
XP_011515258 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 1907 292.8 3.3e-78
XP_016868793 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 1907 292.8 3.3e-78
XP_016868794 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 528) 1237 194.0 1.2e-48
XP_011512731 (OMIM: 607489) PREDICTED: cullin-9 is (1834) 327 60.5 6.7e-08
XP_016866079 (OMIM: 607489) PREDICTED: cullin-9 is (1909) 327 60.5 6.9e-08
XP_011512729 (OMIM: 607489) PREDICTED: cullin-9 is (2095) 327 60.5 7.4e-08
NP_055904 (OMIM: 607489) cullin-9 [Homo sapiens] (2517) 328 60.8 7.7e-08
XP_011512728 (OMIM: 607489) PREDICTED: cullin-9 is (2339) 327 60.6 8e-08
XP_011512727 (OMIM: 607489) PREDICTED: cullin-9 is (2456) 327 60.6 8.3e-08
XP_011512726 (OMIM: 607489) PREDICTED: cullin-9 is (2539) 327 60.6 8.5e-08
XP_016866078 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 327 60.6 8.6e-08
XP_011512725 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 327 60.6 8.6e-08
XP_011512724 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 327 60.6 8.6e-08
NP_006453 (OMIM: 610924,615895) ranBP-type and C3H ( 468) 276 52.5 4.4e-06
NP_112506 (OMIM: 610924,615895) ranBP-type and C3H ( 510) 276 52.5 4.7e-06
XP_005260702 (OMIM: 610924,615895) PREDICTED: ranB ( 527) 276 52.5 4.9e-06
XP_011527440 (OMIM: 610924,615895) PREDICTED: ranB ( 551) 276 52.5 5e-06
XP_011527439 (OMIM: 610924,615895) PREDICTED: ranB ( 568) 276 52.5 5.1e-06
XP_011519741 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 465) 260 50.1 2.3e-05
XP_011519740 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 498) 260 50.1 2.4e-05
NP_005735 (OMIM: 605624) E3 ubiquitin-protein liga ( 557) 260 50.2 2.6e-05
XP_011531575 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 432) 247 48.2 8.1e-05
XP_016861024 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05
XP_011531572 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05
XP_011531573 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05
XP_016861023 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05
XP_016861022 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 247 48.2 8.3e-05
XP_011531570 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05
XP_011531567 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05
XP_011531569 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05
XP_011531568 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 247 48.2 9.2e-05
NP_001297261 (OMIM: 612487) E3 ubiquitin-protein l ( 921) 241 47.6 0.00026
NP_060469 (OMIM: 612487) E3 ubiquitin-protein liga (1072) 241 47.6 0.00029
NP_054643 (OMIM: 167000,211980,600116,602544,60757 ( 316) 221 44.2 0.00091
XP_016866398 (OMIM: 167000,211980,600116,602544,60 ( 385) 221 44.3 0.0011
NP_054642 (OMIM: 167000,211980,600116,602544,60757 ( 437) 221 44.3 0.0012
XP_011534165 (OMIM: 167000,211980,600116,602544,60 ( 464) 221 44.4 0.0012
NP_004553 (OMIM: 167000,211980,600116,602544,60757 ( 465) 221 44.4 0.0012
>>NP_699172 (OMIM: 610872) E3 ubiquitin-protein ligase R (732 aa)
initn: 4448 init1: 4448 opt: 4448 Z-score: 3547.8 bits: 667.0 E(85289): 7.1e-191
Smith-Waterman score: 4730; 95.1% identity (95.1% similar) in 728 aa overlap (5-696:5-732)
10 20 30 40 50 60
pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
10 20 30 40 50 60
70 80
pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP
: :::::::::::::::::::::::
NP_699 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_699 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
670 680 690 700 710 720
690
pF1KE4 TVLKPEGGEARV
::::::::::::
NP_699 TVLKPEGGEARV
730
>>XP_006710419 (OMIM: 610872) PREDICTED: E3 ubiquitin-pr (732 aa)
initn: 4448 init1: 4448 opt: 4448 Z-score: 3547.8 bits: 667.0 E(85289): 7.1e-191
Smith-Waterman score: 4730; 95.1% identity (95.1% similar) in 728 aa overlap (5-696:5-732)
10 20 30 40 50 60
pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
10 20 30 40 50 60
70 80
pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP
: :::::::::::::::::::::::
XP_006 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
550 560 570 580 590 600
570 580 590 600 610 620
pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
610 620 630 640 650 660
630 640 650 660 670 680
pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
670 680 690 700 710 720
690
pF1KE4 TVLKPEGGEARV
::::::::::::
XP_006 TVLKPEGGEARV
730
>>NP_001287755 (OMIM: 610872) E3 ubiquitin-protein ligas (731 aa)
initn: 3505 init1: 3051 opt: 4431 Z-score: 3534.3 bits: 664.5 E(85289): 4e-190
Smith-Waterman score: 4719; 94.9% identity (94.9% similar) in 729 aa overlap (4-696:4-731)
10 20 30 40 50 60
pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
10 20 30 40 50 60
70 80
pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP
: :::::::::::::::::::::::
NP_001 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_001 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGP-DDIKPCPRCSAYIIKMNDG
250 260 270 280 290
270 280 290 300 310 320
pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
480 490 500 510 520 530
510 520 530 540 550 560
pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
540 550 560 570 580 590
570 580 590 600 610 620
pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
600 610 620 630 640 650
630 640 650 660 670 680
pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
660 670 680 690 700 710
690
pF1KE4 TVLKPEGGEARV
::::::::::::
NP_001 TVLKPEGGEARV
720 730
>>XP_006710421 (OMIM: 610872) PREDICTED: E3 ubiquitin-pr (588 aa)
initn: 3418 init1: 3418 opt: 3418 Z-score: 2729.3 bits: 515.2 E(85289): 2.8e-145
Smith-Waterman score: 3700; 93.8% identity (93.8% similar) in 578 aa overlap (5-546:5-582)
10 20 30 40 50 60
pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
10 20 30 40 50 60
70 80
pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP
: :::::::::::::::::::::::
XP_006 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
490 500 510 520 530 540
510 520 530 540 550 560
pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
::::::::::::::::::::::::::::::::::::::::::
XP_006 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRFSMIHA
550 560 570 580
570 580 590 600 610 620
pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
>>NP_001120833 (OMIM: 610872) E3 ubiquitin-protein ligas (587 aa)
initn: 2475 init1: 2021 opt: 3401 Z-score: 2715.8 bits: 512.7 E(85289): 1.6e-144
Smith-Waterman score: 3689; 93.6% identity (93.6% similar) in 579 aa overlap (4-546:4-581)
10 20 30 40 50 60
pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
10 20 30 40 50 60
70 80
pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP
: :::::::::::::::::::::::
NP_001 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
:::::::::::::::::::::::::::::::::::::::: :::::::::::::::::::
NP_001 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGP-DDIKPCPRCSAYIIKMNDG
250 260 270 280 290
270 280 290 300 310 320
pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
420 430 440 450 460 470
450 460 470 480 490 500
pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
480 490 500 510 520 530
510 520 530 540 550 560
pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
::::::::::::::::::::::::::::::::::::::::::
NP_001 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRFSMIHA
540 550 560 570 580
570 580 590 600 610 620
pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
>>XP_006710420 (OMIM: 610872) PREDICTED: E3 ubiquitin-pr (688 aa)
initn: 3144 init1: 3144 opt: 3160 Z-score: 2523.1 bits: 477.3 E(85289): 8.5e-134
Smith-Waterman score: 4358; 89.0% identity (89.0% similar) in 728 aa overlap (5-696:5-688)
10 20 30 40 50 60
pF1KE4 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGSEKDSESPRSTSLHAAAPDPKCRSGGRRRRLTLHSVFSASARGRRARAKPQAEPPPPA
10 20 30 40 50 60
70 80
pF1KE4 A------------------------------------EPGFDDEEAAEGGGPGAEEVECP
: :::::::::::::::::::::::
XP_006 AQPPPAPAPAAAQGPPPEALPAEPAAEAEAEAAAAAAEPGFDDEEAAEGGGPGAEEVECP
70 80 90 100 110 120
90 100 110 120 130 140
pF1KE4 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSERLNPHDIRLLLA
130 140 150 160 170 180
150 160 170 180 190 200
pF1KE4 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTCEREGCQTEFCYH
190 200 210 220 230 240
210 220 230 240 250 260
pF1KE4 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPADDIKPCPRCSAYIIKMNDG
250 260 270 280 290 300
270 280 290 300 310 320
pF1KE4 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKILWQLGTLIGAPVG
310 320 330 340 350 360
330 340 350 360 370 380
pF1KE4 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVTLSVIASPVIAAVS
370 380 390 400 410 420
390 400 410 420 430 440
pF1KE4 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDDGPITVADAWRALKNPS
430 440 450 460 470 480
450 460 470 480 490 500
pF1KE4 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSRLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 IGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAALSGGTLSGGILSSGKGKYSR--
490 500 510 520 530
510 520 530 540 550 560
pF1KE4 VQADVQKEIFPKDTASLGAISDNASTRAMAGSIISSYNPQDRECNNMEIQVDIEAKPSHY
::::::::::::::::::
XP_006 ------------------------------------------ECNNMEIQVDIEAKPSHY
540 550
570 580 590 600 610 620
pF1KE4 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEEDPPCRHQSCEQKDCLASKPWDISLAQP
560 570 580 590 600 610
630 640 650 660 670 680
pF1KE4 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESIRSDLESSDAQSDDVPDITSDECGSPRSHTAACPSTPRAQGAPSPSAHMNLSALAEGQ
620 630 640 650 660 670
690
pF1KE4 TVLKPEGGEARV
::::::::::::
XP_006 TVLKPEGGEARV
680
>>XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (838 aa)
initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96
Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729)
10 20
pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR
:::..: .: :. :: :. ... .
XP_005 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK
10 20 30 40 50 60
30 40 50 60 70
pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG
.::... :.: . ..: . .. :. . :. . ....: .
XP_005 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS
70 80 90 100 110 120
80 90 100 110 120 130
pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE
. .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.:
XP_005 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC
:.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.::::::::::
XP_005 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC
:::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : ::::::
XP_005 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT
:::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.::::
XP_005 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT
370 380 390 400 410 420
380 390 400 410 420
pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD---
::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::...
XP_005 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN
430 440 450 460 470 480
430 440 450 460 470 480
pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL
: :..:. .: .::::::.:. :::. ::.::: : ..... ::::: ::
XP_005 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL
490 500 510 520 530 540
490 500 510 520 530
pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII
.:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::.
XP_005 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED
.:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: :
XP_005 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK
610 620 630 640 650
600 610 620 630 640 650
pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA
. : : :: . .: :. ::: . . .:.: .: : . .
XP_005 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS
660 670 680 690 700 710
660 670 680 690
pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV
::. : : :.:..
XP_005 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS
720 730 740 750 760 770
>>XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquitin-pr (838 aa)
initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96
Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729)
10 20
pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR
:::..: .: :. :: :. ... .
XP_016 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK
10 20 30 40 50 60
30 40 50 60 70
pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG
.::... :.: . ..: . .. :. . :. . ....: .
XP_016 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS
70 80 90 100 110 120
80 90 100 110 120 130
pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE
. .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.:
XP_016 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC
:.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.::::::::::
XP_016 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC
:::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : ::::::
XP_016 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT
:::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.::::
XP_016 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT
370 380 390 400 410 420
380 390 400 410 420
pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD---
::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::...
XP_016 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN
430 440 450 460 470 480
430 440 450 460 470 480
pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL
: :..:. .: .::::::.:. :::. ::.::: : ..... ::::: ::
XP_016 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL
490 500 510 520 530 540
490 500 510 520 530
pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII
.:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::.
XP_016 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED
.:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: :
XP_016 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK
610 620 630 640 650
600 610 620 630 640 650
pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA
. : : :: . .: :. ::: . . .:.: .: : . .
XP_016 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS
660 670 680 690 700 710
660 670 680 690
pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV
::. : : :.:..
XP_016 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS
720 730 740 750 760 770
>>NP_001267468 (OMIM: 607119) E3 ubiquitin-protein ligas (838 aa)
initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96
Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729)
10 20
pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR
:::..: .: :. :: :. ... .
NP_001 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK
10 20 30 40 50 60
30 40 50 60 70
pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG
.::... :.: . ..: . .. :. . :. . ....: .
NP_001 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS
70 80 90 100 110 120
80 90 100 110 120 130
pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE
. .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.:
NP_001 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC
:.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.::::::::::
NP_001 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC
:::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : ::::::
NP_001 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT
:::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.::::
NP_001 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT
370 380 390 400 410 420
380 390 400 410 420
pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD---
::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::...
NP_001 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN
430 440 450 460 470 480
430 440 450 460 470 480
pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL
: :..:. .: .::::::.:. :::. ::.::: : ..... ::::: ::
NP_001 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL
490 500 510 520 530 540
490 500 510 520 530
pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII
.:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::.
NP_001 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED
.:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: :
NP_001 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK
610 620 630 640 650
600 610 620 630 640 650
pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA
. : : :: . .: :. ::: . . .:.: .: : . .
NP_001 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS
660 670 680 690 700 710
660 670 680 690
pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV
::. : : :.:..
NP_001 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS
720 730 740 750 760 770
>>NP_056250 (OMIM: 607119) E3 ubiquitin-protein ligase R (838 aa)
initn: 1630 init1: 1204 opt: 2306 Z-score: 1842.3 bits: 351.6 E(85289): 7e-96
Smith-Waterman score: 2601; 57.5% identity (77.1% similar) in 708 aa overlap (1-676:38-729)
10 20
pF1KE4 MGSEKDSESPRST-SLHAAAPDPKCRSGGR
:::..: .: :. :: :. ... .
NP_056 FISKYNEGLCVNTDPVSILTSILDMSLHRQMGSDRDLQSSASSVSL------PSVKKAPK
10 20 30 40 50 60
30 40 50 60 70
pF1KE4 RRRLTLHSVFSASARGRRARAKPQAEPPPPAAEPG------------FDDEEAAEGGGPG
.::... :.: . ..: . .. :. . :. . ....: .
NP_056 KRRISIGSLFRRKKDNKRKSRELNGGVDGIASIESIHSEMCTDKNSIFSTNTSSDNGLTS
70 80 90 100 110 120
80 90 100 110 120 130
pF1KE4 AEE-----VECPLCLVRLPPERAPRLLSCPHRSCRDCLRHYLRLEISESRVPISCPECSE
. .::::::.: .: : ...: :::: ::::.:::.::::::: ::::::.:
NP_056 ISKQIGDFIECPLCLLRHSKDRFPDIMTCHHRSCVDCLRQYLRIEISESRVNISCPECTE
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE4 RLNPHDIRLLLADPPLMHKYEEFMLRRYLASDPDCRWCPAPDCGYAVIAYGCASCPKLTC
:.:::::::.:.: ::.:::::::::.:..::::::::::::::::::.::::::::::
NP_056 RFNPHDIRLILSDDVLMEKYEEFMLRRWLVADPDCRWCPAPDCGYAVIAFGCASCPKLTC
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE4 EREGCQTEFCYHCKQIWHPNQTCDMARQQRAQTLRVRTKHTSGLSYGQESGPA-DDIKPC
:::: :::::::::::::::::: :::.:::.::.:: ..:..::.:::: : ::::::
NP_056 GREGCGTEFCYHCKQIWHPNQTCDAARQERAQSLRLRTIRSSSISYSQESGAAADDIKPC
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE4 PRCSAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
:::.::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_056 PRCAAYIIKMNDGSCNHMTCAVCGCEFCWLCMKEISDLHYLSPSGCTFWGKKPWSRKKKI
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE4 LWQLGTLIGAPVGISLIAGIAIPAMVIGIPVYVGRKIHSRYEGRKTSKHKRNLAITGGVT
:::::::.::::::.::::::::::.::::::::::::.::::. .:::::::::.::::
NP_056 LWQLGTLVGAPVGIALIAGIAIPAMIIGIPVYVGRKIHNRYEGKDVSKHKRNLAIAGGVT
370 380 390 400 410 420
380 390 400 410 420
pF1KE4 LSVIASPVIAAVSVGIGVPIMLAYVYGVVPISLCRGGGCGVSTANGKGVKIEFDEDD---
::::.:::.:::.::::::::::::::::::::::.::::::..:::::.::::...
NP_056 LSVIVSPVVAAVTVGIGVPIMLAYVYGVVPISLCRSGGCGVSAGNGKGVRIEFDDENDIN
430 440 450 460 470 480
430 440 450 460 470 480
pF1KE4 --GPITVADAW---RALKNPSIGESSIEGLTSVLSTSGSPTDGLSVMQGPYSETASFAAL
: :..:. .: .::::::.:. :::. ::.::: : ..... ::::: ::
NP_056 VGGTNTAVDTTSVAEARHNPSIGEGSVGGLTGSLSASGSHMDRIGAIRDNLSETASTMAL
490 500 510 520 530 540
490 500 510 520 530
pF1KE4 SGGTLSGGILSSGK-GKYSRLEVQADVQKEIFP----KDTASLGAISDNASTRAMAGSII
.:....:.. .:. . ..::::::::::: . . :.:::..::::::.::::::.
NP_056 AGASITGSLSGSAMVNCFNRLEVQADVQKERYSLSGESGTVSLGTVSDNASTKAMAGSIL
550 560 570 580 590 600
540 550 560 570 580 590
pF1KE4 SSYNPQDRECNNMEIQVDIEAKPSHYQLVSGSSTEDSLHVHAQMAENEEEGSGGGGSEED
.:: : :.: :.::.:::::.:::... ::::. :. .. .... ::..: :
NP_056 NSYIPLDKEGNSMEVQVDIESKPSKFRHNSGSSSVDD----GSATRSHAGGSSSGLPEGK
610 620 630 640 650
600 610 620 630 640 650
pF1KE4 PPCRHQSCEQKDCLASKPWDISLAQPESIRSDLESSDAQSDDVPDITSDECGSPRSHTAA
. : : :: . .: :. ::: . . .:.: .: : . .
NP_056 SSATKWSKEATAGKKSKSGKLRKKGNMKINETREDMDAQLLEQQSTNSSEFEAP-SLSDS
660 670 680 690 700 710
660 670 680 690
pF1KE4 CPSTPRAQGAPSPSAHMNLSALAEGQTVLKPEGGEARV
::. : : :.:..
NP_056 MPSV-----ADSHSSHFSEFSCSDLESMKTSCSHGSSDYHTRFATVNILPEVENDRLENS
720 730 740 750 760 770
696 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 17:13:29 2016 done: Mon Nov 7 17:13:30 2016
Total Scan time: 10.190 Total Display time: 0.160
Function used was FASTA [36.3.4 Apr, 2011]