Result of FASTA (omim) for
pFN21AE4203
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4203, 710 aa
1>>>pF1KE4203 710 - 710 aa - 710 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.6502+/-0.000353; mu= -7.4585+/- 0.022
mean_var=365.0365+/-74.812, 0's: 0 Z-trim(125.0): 102 B-trim: 0 in 0/62
Lambda= 0.067128
statistics sampled from 47544 (47664) to 47544 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.559), width: 16
Scan time: 15.140
The best scores are: opt bits E(85289)
NP_001030300 (OMIM: 616743) ral guanine nucleotide ( 710) 4755 474.4 6.5e-133
NP_001155088 (OMIM: 616743) ral guanine nucleotide ( 716) 4733 472.3 2.9e-132
NP_001035827 (OMIM: 601619) ral guanine nucleotide ( 859) 985 109.4 6.1e-23
NP_001258703 (OMIM: 601619) ral guanine nucleotide ( 885) 985 109.4 6.3e-23
NP_001258705 (OMIM: 601619) ral guanine nucleotide ( 902) 985 109.4 6.4e-23
NP_001258704 (OMIM: 601619) ral guanine nucleotide ( 913) 985 109.4 6.4e-23
NP_006257 (OMIM: 601619) ral guanine nucleotide di ( 914) 985 109.4 6.4e-23
NP_001230667 (OMIM: 602306) ral guanine nucleotide ( 695) 719 83.6 3e-15
NP_004752 (OMIM: 602306) ral guanine nucleotide di ( 777) 719 83.6 3.2e-15
XP_011513087 (OMIM: 602306) PREDICTED: ral guanine ( 496) 703 81.9 6.7e-15
XP_011513083 (OMIM: 602306) PREDICTED: ral guanine ( 670) 661 77.9 1.4e-13
NP_705843 (OMIM: 612214) ral-GDS-related protein i ( 473) 616 73.5 2.2e-12
XP_016856245 (OMIM: 605667) PREDICTED: ral guanine ( 683) 607 72.7 5.4e-12
XP_011507643 (OMIM: 605667) PREDICTED: ral guanine ( 718) 607 72.7 5.6e-12
NP_001316353 (OMIM: 612214) ral-GDS-related protei ( 580) 603 72.3 6.2e-12
XP_011507644 (OMIM: 605667) PREDICTED: ral guanine ( 620) 598 71.8 9.1e-12
NP_001284601 (OMIM: 605667) ral guanine nucleotide ( 739) 598 71.9 1e-11
NP_001284598 (OMIM: 605667) ral guanine nucleotide ( 766) 598 71.9 1.1e-11
NP_001284599 (OMIM: 605667) ral guanine nucleotide ( 766) 598 71.9 1.1e-11
NP_001284600 (OMIM: 605667) ral guanine nucleotide ( 768) 598 71.9 1.1e-11
NP_055964 (OMIM: 605667) ral guanine nucleotide di ( 803) 598 71.9 1.1e-11
XP_011507641 (OMIM: 605667) PREDICTED: ral guanine ( 803) 598 71.9 1.1e-11
NP_001177659 (OMIM: 614444) ras-specific guanine n ( 305) 306 43.3 0.0017
XP_016870839 (OMIM: 614444) PREDICTED: ras-specifi ( 384) 306 43.4 0.002
XP_011517540 (OMIM: 614444) PREDICTED: ras-specifi ( 474) 306 43.4 0.0024
NP_001309253 (OMIM: 614444) ras-specific guanine n ( 514) 306 43.5 0.0026
XP_011517538 (OMIM: 614444) PREDICTED: ras-specifi ( 515) 306 43.5 0.0026
XP_016870837 (OMIM: 614444) PREDICTED: ras-specifi ( 527) 306 43.5 0.0026
NP_001177657 (OMIM: 614444) ras-specific guanine n ( 529) 306 43.5 0.0026
NP_001177658 (OMIM: 614444) ras-specific guanine n ( 537) 306 43.5 0.0027
NP_001309249 (OMIM: 614444) ras-specific guanine n ( 537) 306 43.5 0.0027
XP_016870835 (OMIM: 614444) PREDICTED: ras-specifi ( 549) 306 43.5 0.0027
NP_055451 (OMIM: 614444) ras-specific guanine nucl ( 557) 306 43.5 0.0027
XP_016870836 (OMIM: 614444) PREDICTED: ras-specifi ( 557) 306 43.5 0.0027
XP_016870834 (OMIM: 614444) PREDICTED: ras-specifi ( 569) 306 43.5 0.0028
NP_001309251 (OMIM: 614444) ras-specific guanine n ( 576) 306 43.5 0.0028
NP_001309250 (OMIM: 614444) ras-specific guanine n ( 584) 306 43.5 0.0028
XP_011517535 (OMIM: 614444) PREDICTED: ras-specifi ( 585) 306 43.5 0.0028
XP_011517534 (OMIM: 614444) PREDICTED: ras-specifi ( 590) 306 43.5 0.0029
XP_011517533 (OMIM: 614444) PREDICTED: ras-specifi ( 591) 306 43.5 0.0029
NP_001309254 (OMIM: 614444) ras-specific guanine n ( 607) 306 43.5 0.0029
XP_016870831 (OMIM: 614444) PREDICTED: ras-specifi ( 638) 306 43.5 0.003
XP_011517530 (OMIM: 614444) PREDICTED: ras-specifi ( 639) 306 43.5 0.003
XP_011517528 (OMIM: 614444) PREDICTED: ras-specifi ( 653) 306 43.5 0.0031
XP_011517527 (OMIM: 614444) PREDICTED: ras-specifi ( 660) 306 43.5 0.0031
XP_011517537 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031
XP_011517532 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031
XP_016870832 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031
XP_006717391 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031
XP_011517531 (OMIM: 614444) PREDICTED: ras-specifi ( 661) 306 43.5 0.0031
>>NP_001030300 (OMIM: 616743) ral guanine nucleotide dis (710 aa)
initn: 4755 init1: 4755 opt: 4755 Z-score: 2507.2 bits: 474.4 E(85289): 6.5e-133
Smith-Waterman score: 4755; 99.7% identity (99.9% similar) in 710 aa overlap (1-710:1-710)
10 20 30 40 50 60
pF1KE4 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAP
::::::::::::::::::::::::::::::::::::::::: :.::::::::::::::::
NP_001 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDHPAHSDLGSVRTFLGWAAP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDPSSPTSSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLG
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE4 SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACD
610 620 630 640 650 660
670 680 690 700 710
pF1KE4 YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
670 680 690 700 710
>>NP_001155088 (OMIM: 616743) ral guanine nucleotide dis (716 aa)
initn: 3666 init1: 3666 opt: 4733 Z-score: 2495.6 bits: 472.3 E(85289): 2.9e-132
Smith-Waterman score: 4733; 98.9% identity (99.0% similar) in 716 aa overlap (1-710:1-716)
10 20 30 40 50 60
pF1KE4 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSPAEGPGGSQAPSPIANTFLH
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRTSKVRVLRAARLERLVGELVFGDREQDPSFMPAFLATYRTFVPTACLLGFLLPPMPPP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAP
::::::::::::::::::::::::::::::::::::::::: :.::::::::::::::::
NP_001 PPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQDFRDHPAHSDLGSVRTFLGWAAP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPPRVAQTSDPDSSEACAEEEEGLMPQG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKR
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGS
490 500 510 520 530 540
550 560 570 580 590
pF1KE4 PGDPSSPTSS------VSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP
:::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGDPSSPTSSLCISPSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRP
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE4 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FALPLGSPRIPLPAQQSSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVP
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE4 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
670 680 690 700 710
>>NP_001035827 (OMIM: 601619) ral guanine nucleotide dis (859 aa)
initn: 1554 init1: 617 opt: 985 Z-score: 532.8 bits: 109.4 E(85289): 6.1e-23
Smith-Waterman score: 1320; 37.1% identity (57.9% similar) in 776 aa overlap (61-696:53-826)
40 50 60 70 80 90
pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP
:.: :::...:. ::.:: .:: . . .:
NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL
30 40 50 60 70 80
100 110 120 130 140
pF1KE4 SFMPAFLATYRTFVPTACLLGFLLP------PMPPPPPPGVEIKKTAVQDLSFNKNLR-A
:.. :: :::.:. : .: .:. . : : . .: . . .:. :
NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGC-ILPYSDEDGGPQDQLKNA
90 100 110 120 130 140
150 160 170 180 190
pF1KE4 VVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EA
. :.::.::... .:: .:: : .. ... ::: ..:. :: .. . ::
NP_001 ISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEA
150 160 170 180 190 200
200 210
pF1KE4 EREQ-------------------------------EEEP-----------------PQVW
: : : :: :..
NP_001 EPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQ
210 220 230 240 250 260
220 230
pF1KE4 TGP-PRV--------------AQTSDPDSSEACAEE-------------------EEGLM
.: : : : .:: :.. : :.::
NP_001 QAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLS
270 280 290 300 310 320
240 250 260 270 280 290
pF1KE4 PQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQ
. :.:: : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.:
NP_001 EEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQ
330 340 350 360 370 380
300 310 320 330 340 350
pF1KE4 FNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYR
::.:..::. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.:
NP_001 FNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHR
390 400 410 420 430 440
360 370 380 390 400 410
pF1KE4 LKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPP
::..: :::. . :.:::.:::::::. :::.:..: ... . : : : ..:
NP_001 LKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPK
450 460 470 480 490 500
420 430 440 450 460 470
pF1KE4 P-----GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSY
: :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..:
NP_001 ETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY
510 520 530 540 550 560
480 490 500 510 520 530
pF1KE4 TLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLARE
...: . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . :
NP_001 SIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPS
570 580 590 600 610 620
540 550 560
pF1KE4 KSSSPSGS------------P----GDPSSPTSSVSPGSP------------PSSPRSRD
: ::: : :: .. : : :: : :: ...
NP_001 TELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQE
630 640 650 660 670 680
570 580 590 600 610
pF1KE4 -----APAGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQ
. . : : . : .. :.. : .: : . : .: .:: ::
NP_001 KKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQ
690 700 710 720 730 740
620 630 640 650 660 670
pF1KE4 SSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGD
.. .::::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: :
NP_001 VGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDD
750 760 770 780 790 800
680 690 700 710
pF1KE4 RVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
: : ::.::::::::. .: ::.:.
NP_001 RKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF
810 820 830 840 850
>>NP_001258703 (OMIM: 601619) ral guanine nucleotide dis (885 aa)
initn: 1566 init1: 617 opt: 985 Z-score: 532.6 bits: 109.4 E(85289): 6.3e-23
Smith-Waterman score: 1330; 37.7% identity (58.1% similar) in 769 aa overlap (61-696:91-852)
40 50 60 70 80 90
pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP
:.: :::...:. ::.:: .:: . . .:
NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE4 SFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGS
:.. :: :::.:. : .: .:. . : . : . :: :: :. :.::.
NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGCILPYSDE--DGGPQDQL--KN--AISSILGT
130 140 150 160 170
160 170 180 190 200
pF1KE4 WLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EAEREQ---
::... .:: .:: : .. ... ::: ..:. :: .. . ::: :
NP_001 WLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSP
180 190 200 210 220 230
210
pF1KE4 ----------------------------EEEP-----------------PQVWTGP-PRV
: :: :.. .: : :
NP_001 VPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAV
240 250 260 270 280 290
220 230 240
pF1KE4 --------------AQTSDPDSSEACAEE-------------------EEGLMPQGPQLL
: .:: :.. : :.:: . :.::
NP_001 GLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLL
300 310 320 330 340 350
250 260 270 280 290 300
pF1KE4 DFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGC
: : ::::.::.: :::.:: :.::::.:::::. : .::.::::.:::.:..:
NP_001 VFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANC
360 370 380 390 400 410
310 320 330 340 350 360
pF1KE4 VLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGA
:. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.:::..:
NP_001 VITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWED
420 430 440 450 460 470
370 380 390 400 410
pF1KE4 VSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----G
:::. . :.:::.:::::::. :::.:..: ... . : : : ..: :
NP_001 VSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQG
480 490 500 510 520 530
420 430 440 450 460 470
pF1KE4 PVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPP
:::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..:...:
NP_001 TVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQ
540 550 560 570 580 590
480 490 500 510 520 530
pF1KE4 ILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSG
. : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . : : ::
NP_001 FGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSG
600 610 620 630 640 650
540 550 560
pF1KE4 S------------P----GDPSSPTSSVSPGSP------------PSSPRSRD-----AP
: : :: .. : : :: : :: ... .
NP_001 SSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESA
660 670 680 690 700 710
570 580 590 600 610
pF1KE4 AGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQSSEARVI
. : : . : .. :.. : .: : . : .: .:: :: .. .:
NP_001 SQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCII
720 730 740 750 760 770
620 630 640 650 660 670
pF1KE4 RVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPD
:::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: :: : ::.
NP_001 RVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPE
780 790 800 810 820 830
680 690 700 710
pF1KE4 NANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
::::::::. .: ::.:.
NP_001 NANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF
840 850 860 870 880
>>NP_001258705 (OMIM: 601619) ral guanine nucleotide dis (902 aa)
initn: 1566 init1: 617 opt: 985 Z-score: 532.5 bits: 109.4 E(85289): 6.4e-23
Smith-Waterman score: 1330; 37.7% identity (58.1% similar) in 769 aa overlap (61-696:108-869)
40 50 60 70 80 90
pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP
:.: :::...:. ::.:: .:: . . .:
NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE4 SFMPAFLATYRTFVPTACLLGFLLPPMPPPPPPGVEIKKTAVQDLSFNKNLRAVVSVLGS
:.. :: :::.:. : .: .:. . : . : . :: :: :. :.::.
NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGCILPYSDE--DGGPQDQL--KN--AISSILGT
140 150 160 170 180 190
160 170 180 190 200
pF1KE4 WLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EAEREQ---
::... .:: .:: : .. ... ::: ..:. :: .. . ::: :
NP_001 WLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEAEPEALSP
200 210 220 230 240 250
210
pF1KE4 ----------------------------EEEP-----------------PQVWTGP-PRV
: :: :.. .: : :
NP_001 VPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQQAPEPAV
260 270 280 290 300 310
220 230 240
pF1KE4 --------------AQTSDPDSSEACAEE-------------------EEGLMPQGPQLL
: .:: :.. : :.:: . :.::
NP_001 GLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLSEEKPHLL
320 330 340 350 360 370
250 260 270 280 290 300
pF1KE4 DFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGC
: : ::::.::.: :::.:: :.::::.:::::. : .::.::::.:::.:..:
NP_001 VFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQFNSVANC
380 390 400 410 420 430
310 320 330 340 350 360
pF1KE4 VLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGA
:. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.:::..:
NP_001 VITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHRLKKTWED
440 450 460 470 480 490
370 380 390 400 410
pF1KE4 VSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPP-----G
:::. . :.:::.:::::::. :::.:..: ... . : : : ..: :
NP_001 VSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPKETGIIQG
500 510 520 530 540 550
420 430 440 450 460 470
pF1KE4 PVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPP
:::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..:...:
NP_001 TVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNYSIAPDEQ
560 570 580 590 600 610
480 490 500 510 520 530
pF1KE4 ILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSG
. : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . : : ::
NP_001 FGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPSTELSTSG
620 630 640 650 660 670
540 550 560
pF1KE4 S------------P----GDPSSPTSSVSPGSP------------PSSPRSRD-----AP
: : :: .. : : :: : :: ... .
NP_001 SSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQEKKFWESA
680 690 700 710 720 730
570 580 590 600 610
pF1KE4 AGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQSSEARVI
. : : . : .. :.. : .: : . : .: .:: :: .. .:
NP_001 SQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQVGDCCII
740 750 760 770 780 790
620 630 640 650 660 670
pF1KE4 RVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGDRVLLIPD
:::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: :: : ::.
NP_001 RVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDDRKLKIPE
800 810 820 830 840 850
680 690 700 710
pF1KE4 NANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
::::::::. .: ::.:.
NP_001 NANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF
860 870 880 890 900
>>NP_001258704 (OMIM: 601619) ral guanine nucleotide dis (913 aa)
initn: 1554 init1: 617 opt: 985 Z-score: 532.4 bits: 109.4 E(85289): 6.4e-23
Smith-Waterman score: 1320; 37.1% identity (57.9% similar) in 776 aa overlap (61-696:107-880)
40 50 60 70 80 90
pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP
:.: :::...:. ::.:: .:: . . .:
NP_001 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL
80 90 100 110 120 130
100 110 120 130 140
pF1KE4 SFMPAFLATYRTFVPTACLLGFLLP------PMPPPPPPGVEIKKTAVQDLSFNKNLR-A
:.. :: :::.:. : .: .:. . : : . .: . . .:. :
NP_001 SYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGC-ILPYSDEDGGPQDQLKNA
140 150 160 170 180 190
150 160 170 180 190
pF1KE4 VVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EA
. :.::.::... .:: .:: : .. ... ::: ..:. :: .. . ::
NP_001 ISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEA
200 210 220 230 240 250
200 210
pF1KE4 EREQ-------------------------------EEEP-----------------PQVW
: : : :: :..
NP_001 EPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQ
260 270 280 290 300 310
220 230
pF1KE4 TGP-PRV--------------AQTSDPDSSEACAEE-------------------EEGLM
.: : : : .:: :.. : :.::
NP_001 QAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLS
320 330 340 350 360 370
240 250 260 270 280 290
pF1KE4 PQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQ
. :.:: : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.:
NP_001 EEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQ
380 390 400 410 420 430
300 310 320 330 340 350
pF1KE4 FNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYR
::.:..::. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.:
NP_001 FNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHR
440 450 460 470 480 490
360 370 380 390 400 410
pF1KE4 LKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPP
::..: :::. . :.:::.:::::::. :::.:..: ... . : : : ..:
NP_001 LKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPK
500 510 520 530 540 550
420 430 440 450 460 470
pF1KE4 P-----GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSY
: :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..:
NP_001 ETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY
560 570 580 590 600 610
480 490 500 510 520 530
pF1KE4 TLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLARE
...: . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . :
NP_001 SIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPS
620 630 640 650 660 670
540 550 560
pF1KE4 KSSSPSGS------------P----GDPSSPTSSVSPGSP------------PSSPRSRD
: ::: : :: .. : : :: : :: ...
NP_001 TELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQE
680 690 700 710 720 730
570 580 590 600 610
pF1KE4 -----APAGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQ
. . : : . : .. :.. : .: : . : .: .:: ::
NP_001 KKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQ
740 750 760 770 780 790
620 630 640 650 660 670
pF1KE4 SSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGD
.. .::::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: :
NP_001 VGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDD
800 810 820 830 840 850
680 690 700 710
pF1KE4 RVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
: : ::.::::::::. .: ::.:.
NP_001 RKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF
860 870 880 890 900 910
>>NP_006257 (OMIM: 601619) ral guanine nucleotide dissoc (914 aa)
initn: 1554 init1: 617 opt: 985 Z-score: 532.4 bits: 109.4 E(85289): 6.4e-23
Smith-Waterman score: 1320; 37.1% identity (57.9% similar) in 776 aa overlap (61-696:108-881)
40 50 60 70 80 90
pF1KE4 LRRQRSQRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQDP
:.: :::...:. ::.:: .:: . . .:
NP_006 SISLRKVQLHHGGNKGQRWLGYENESALNLYETCKVRTVKAGTLEKLVEHLVPAFQGSDL
80 90 100 110 120 130
100 110 120 130 140
pF1KE4 SFMPAFLATYRTFVPTACLLGFLLP------PMPPPPPPGVEIKKTAVQDLSFNKNLR-A
:.. :: :::.:. : .: .:. . : : . .: . . .:. :
NP_006 SYVTIFLCTYRAFTTTQQVLDLLFKRYGRCDALTASSRYGC-ILPYSDEDGGPQDQLKNA
140 150 160 170 180 190
150 160 170 180 190
pF1KE4 VVSVLGSWLQDHPQDFRDPPVHSDLGSVRTFLGWAAPGSAEAQKAEKLLEDFLE----EA
. :.::.::... .:: .:: : .. ... ::: ..:. :: .. . ::
NP_006 ISSILGTWLDQYSEDFCQPPDFPCLKQLVAYVQLNMPGSDLERRAHLLLAQLEHSEPIEA
200 210 220 230 240 250
200 210
pF1KE4 EREQ-------------------------------EEEP-----------------PQVW
: : : :: :..
NP_006 EPEALSPVPALKPTPELELALTPARAPSPVPAPAPEPEPAPTPAPGSELEVAPAPAPELQ
260 270 280 290 300 310
220 230
pF1KE4 TGP-PRV--------------AQTSDPDSSEACAEE-------------------EEGLM
.: : : : .:: :.. : :.::
NP_006 QAPEPAVGLESAPAPALELEPAPEQDPAPSQTLELEPAPAPVPSLQPSWPSPVVAENGLS
320 330 340 350 360 370
240 250 260 270 280 290
pF1KE4 PQGPQLLDFSVDEVAEQLTLIDLELFSKVRLYECLGSVWSQRDRPGAAGASPTVRATVAQ
. :.:: : : ::::.::.: :::.:: :.::::.:::::. : .::.::::.:
NP_006 EEKPHLLVFPPDLVAEQFTLMDAELFKKVVPYHCLGSIWSQRDKKGKEHLAPTIRATVTQ
380 390 400 410 420 430
300 310 320 330 340 350
pF1KE4 FNTVTGCVLGSVLGAPGLAAPQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYR
::.:..::. . :: . ::.::. .:.::..:..:: :.::::: ::::::::: :.:
NP_006 FNSVANCVITTCLGNRSTKAPDRARVVEHWIEVARECRILKNFSSLYAILSALQSNSIHR
440 450 460 470 480 490
360 370 380 390 400 410
pF1KE4 LKRSWGAVSREPLSTFRKLSQIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPP
::..: :::. . :.:::.:::::::. :::.:..: ... . : : : ..:
NP_006 LKKTWEDVSRDSFRIFQKLSEIFSDENNYSLSRELLIKEGTSKFATLEMN-PKRAQKRPK
500 510 520 530 540 550
420 430 440 450 460 470
pF1KE4 P-----GPVPYLGTFLTDLVMLDTALPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSY
: :::::::::::::::::. :.: : ::::::::::.:..:.:. :: :..:
NP_006 ETGIIQGTVPYLGTFLTDLVMLDTAMKDYLYGRLINFEKRRKEFEVIAQIKLLQSACNNY
560 570 580 590 600 610
480 490 500 510 520 530
pF1KE4 TLSPHPPILAALHAQNQLTEEQSYRLSRVIEPPAASCPSSPRIRRRISLTKRLSAKLARE
...: . : ..: ..:.: .:: :: .:::. : .. : .. ...:: : . :
NP_006 SIAPDEQFGAWFRAVERLSETESYNLSCELEPPSESASNTLRTKKNTAIVKRWSDRQAPS
620 630 640 650 660 670
540 550 560
pF1KE4 KSSSPSGS------------P----GDPSSPTSSVSPGSP------------PSSPRSRD
: ::: : :: .. : : :: : :: ...
NP_006 TELSTSGSSHSKSCDQLRCGPYLSSGDIADALSVHSAGSSSSDVEEINISFVPESPDGQE
680 690 700 710 720 730
570 580 590 600 610
pF1KE4 -----APAGSPPASPGPQGPSTKLPLSLDLPSP--------RPFA-LPLGSPRIPLPAQQ
. . : : . : .. :.. : .: : . : .: .:: ::
NP_006 KKFWESASQSSPETSGISSASSSTSSSSASTTPVAATRTHKRSVSGLCNSSSALPLYNQQ
740 750 760 770 780 790
620 630 640 650 660 670
pF1KE4 SSEARVIRVSIDNDHGNLYRSILLTSQDKAPSVVRRALQKHNVPQPWACDYQLFQVLPGD
.. .::::.: :.::.:.:::.:::::::.:.:.:..:::. . ::.:.:.: :
NP_006 VGDCCIIRVSLDVDNGNMYKSILVTSQDKAPAVIRKAMDKHNLEEEEPEDYELLQILSDD
800 810 820 830 840 850
680 690 700 710
pF1KE4 RVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
: : ::.::::::::. .: ::.:.
NP_006 RKLKIPENANVFYAMNSTANYDFVLKKRTFTKGVKVKHGASSTLPRMKQKGLKIAKGIF
860 870 880 890 900 910
>>NP_001230667 (OMIM: 602306) ral guanine nucleotide dis (695 aa)
initn: 1285 init1: 649 opt: 719 Z-score: 394.9 bits: 83.6 E(85289): 3e-15
Smith-Waterman score: 1283; 38.4% identity (61.9% similar) in 693 aa overlap (67-709:8-659)
40 50 60 70 80 90
pF1KE4 QRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQ--DPSFMP
: :::. :: :: .:. : . : :::
NP_001 MPPPRSSRRLRAGTLEALVRHLL-DTRTSGTDVSFMS
10 20 30
100 110 120 130 140 150
pF1KE4 AFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQ
:::::.:.:. : :::.. . : :...:. ....:::..::
NP_001 AFLATHRAFTSTPALLGLMADRLEALESHPTDELERTT----------EVAISVLSTWLA
40 50 60 70 80
160 170 180 190 200 210
pF1KE4 DHPQDFRDPPVHSDLGSVRTFL---GWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQV
.::.:: ....: ...:: :.:: :.. . . :.... ... ::.
NP_001 SHPEDF-GSEAKGQLDRLESFLLQTGYAA-GKGVGGGSADLIRNLRSRVD-------PQA
90 100 110 120 130
220 230 240 250 260
pF1KE4 WTGPPRVAQTSDPDSSEACAEEEEGLMPQGP-QLLDFSVDEVAEQLTLIDLELFSKVRLY
: .: .:: : : ..: : .:..::::::.: ::: ..
NP_001 PDLPKPLALPGDP--------------PADPTDVLVFLADHLAEQLTLLDAELFLNLIPS
140 150 160 170 180
270 280 290 300 310
pF1KE4 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGA------PG------LAA
.:::..:..::::: . :.:::::.::: :.: :..::::: :: :
NP_001 QCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRP
190 200 210 220 230 240
320 330 340 350 360 370
pF1KE4 PQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLS
::::. ::::::.:..:: ::::::. :..:::::.::.::. .:: ..:. : .: .:
NP_001 PQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLC
250 260 270 280 290 300
380 390 400 410 420 430
pF1KE4 QIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTA
::::.:.:. .:::.: :: .. : . . .. : :::::::: ::::::.:
NP_001 QIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAA
310 320 330 340 350 360
440 450 460 470 480 490
pF1KE4 LPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYR
: ::. :::.:::::. .:.....:: .:..:.:.: : :.. ::: ::.:
NP_001 SKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHR
370 380 390 400 410 420
500 510 520 530 540
pF1KE4 LSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSP------SGSPGD--PSSPT-
.: .:::..: : .::. : . .. . :. .: .. :: :..:.
NP_001 VSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAP
430 440 450 460 470 480
550 560 570 580 590 600
pF1KE4 --SSVSPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPF-----ALPLGS
. .. : : :. : :. .: :: :: :::: . ::
NP_001 LLTRLAQHMKWPSVSSLDSALESSPSLHSPADPS---HLSPPASSPRPSRGHRRSASCGS
490 500 510 520 530 540
610 620 630 640
pF1KE4 PRIPLPAQQS--------------SEARVIRVSID-NDHGNLYRSILLTSQDKAPSVVRR
: . : :. :.:::... .. :..:.:::.:::::::::. :
NP_001 PLSGGAEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISR
550 560 570 580 590 600
650 660 670 680 690 700
pF1KE4 ALQKHNVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLS
.:.:.: . : .:.: :.:::.: : :: .:::::::. : .::.::.. : . .
NP_001 VLKKNNRDSAVASEYELVQLLPGERELTIPASANVFYAMDG-ASHDFLLRQR---RRSST
610 620 630 640 650
710
pF1KE4 VSPS
..:
NP_001 ATPGVTSGPSASGTPPSEGGGGSFPRIKATGRKIARALF
660 670 680 690
>>NP_004752 (OMIM: 602306) ral guanine nucleotide dissoc (777 aa)
initn: 1285 init1: 649 opt: 719 Z-score: 394.2 bits: 83.6 E(85289): 3.2e-15
Smith-Waterman score: 1331; 38.0% identity (60.8% similar) in 748 aa overlap (12-709:53-741)
10 20 30 40
pF1KE4 MERTAGKELALAPLQDWGEETEDGAVYSVSLRRQRSQRRSP
::.. : :: :::::..:. :. :
NP_004 FRSRDPEEGGGPGGLVVGGGQEEEEEEEEEAPVSVWDEE-EDGAVFTVTSRQYR------
30 40 50 60 70
50 60 70 80 90
pF1KE4 AEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQ--DPSFMPAFLAT
: .: : :.: : :::. :: :: .:. : . : ::: :::::
NP_004 ---PLDPLVPMPPP------RSS--RRLRAGTLEALVRHLL-DTRTSGTDVSFMSAFLAT
80 90 100 110 120
100 110 120 130 140 150
pF1KE4 YRTFVPTACLLGFLLPPMPP-PPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQDHPQD
.:.:. : :::.. . : :...:. ....:::..:: .::.:
NP_004 HRAFTSTPALLGLMADRLEALESHPTDELERTT----------EVAISVLSTWLASHPED
130 140 150 160 170
160 170 180 190 200 210
pF1KE4 FRDPPVHSDLGSVRTFL---GWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQVWTGPP
: ....: ...:: :.:: :.. . . :.... ... ::. :
NP_004 F-GSEAKGQLDRLESFLLQTGYAA-GKGVGGGSADLIRNLRSRVD-------PQAPDLPK
180 190 200 210 220
220 230 240 250 260 270
pF1KE4 RVAQTSDPDSSEACAEEEEGLMPQGP-QLLDFSVDEVAEQLTLIDLELFSKVRLYECLGS
.: .:: : : ..: : .:..::::::.: ::: .. .:::.
NP_004 PLALPGDP--------------PADPTDVLVFLADHLAEQLTLLDAELFLNLIPSQCLGG
230 240 250 260 270
280 290 300 310 320
pF1KE4 VWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGA------PG------LAAPQRAQ
.:..::::: . :.:::::.::: :.: :..::::: :: : ::::.
NP_004 LWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRPPQRAR
280 290 300 310 320 330
330 340 350 360 370 380
pF1KE4 RLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLSQIFSD
::::::.:..:: ::::::. :..:::::.::.::. .:: ..:. : .: .: ::::.
NP_004 LLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLCQIFSE
340 350 360 370 380 390
390 400 410 420 430 440
pF1KE4 ENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTALPDML
:.:. .:::.: :: .. : . . .. : :::::::: ::::::.: : :
NP_004 EDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAASKDEL
400 410 420 430 440 450
450 460 470 480 490 500
pF1KE4 EGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYRLSRVI
:. :::.:::::. .:.....:: .:..:.:.: : :.. ::: ::.:.: .
NP_004 ENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHRVSCEV
460 470 480 490 500 510
510 520 530 540 550
pF1KE4 EPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSP------SGSPGD--PSSPT---SSV
:::..: : .::. : . .. . :. .: .. :: :..:. . .
NP_004 EPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTGGDEAPTTPAPLLTRL
520 530 540 550 560 570
560 570 580 590 600
pF1KE4 SPGSPPSSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPF-----ALPLGSPRIPL
. : : :. : :. .: :: :: :::: . :::
NP_004 AQHMKWPSVSSLDSALESSPSLHSPADPSH---LSPPASSPRPSRGHRRSASCGSPLSGG
580 590 600 610 620
610 620 630 640 650
pF1KE4 PAQQS--------------SEARVIRVSID-NDHGNLYRSILLTSQDKAPSVVRRALQKH
. : :. :.:::... .. :..:.:::.:::::::::. :.:.:.
NP_004 AEEASGGTGYGGEGSGPGASDCRIIRVQMELGEDGSVYKSILVTSQDKAPSVISRVLKKN
630 640 650 660 670 680
660 670 680 690 700 710
pF1KE4 NVPQPWACDYQLFQVLPGDRVLLIPDNANVFYAMSPVAPRDFMLRRKEGTRNTLSVSPS
: . : .:.: :.:::.: : :: .:::::::. : .::.::.. : . ...:
NP_004 NRDSAVASEYELVQLLPGERELTIPASANVFYAMDG-ASHDFLLRQR---RRSSTATPGV
690 700 710 720 730 740
NP_004 TSGPSASGTPPSEGGGGSFPRIKATGRKIARALF
750 760 770
>>XP_011513087 (OMIM: 602306) PREDICTED: ral guanine nuc (496 aa)
initn: 1023 init1: 647 opt: 703 Z-score: 388.5 bits: 81.9 E(85289): 6.7e-15
Smith-Waterman score: 1020; 39.5% identity (64.0% similar) in 509 aa overlap (67-556:8-481)
40 50 60 70 80 90
pF1KE4 QRRSPAEGPGGSQAPSPIANTFLHYRTSKVRVLRAARLERLVGELVFGDREQ--DPSFMP
: :::. :: :: .:. : . : :::
XP_011 MPPPRSSRRLRAGTLEALVRHLL-DTRTSGTDVSFMS
10 20 30
100 110 120 130 140 150
pF1KE4 AFLATYRTFVPTACLLGFLLPPMPP-PPPPGVEIKKTAVQDLSFNKNLRAVVSVLGSWLQ
:::::.:.:. : :::.. . : :...:. ....:::..::
XP_011 AFLATHRAFTSTPALLGLMADRLEALESHPTDELERTT----------EVAISVLSTWLA
40 50 60 70 80
160 170 180 190 200 210
pF1KE4 DHPQDFRDPPVHSDLGSVRTFL---GWAAPGSAEAQKAEKLLEDFLEEAEREQEEEPPQV
.::.:: ....: ...:: :.:: :.. . . :.... ... ::.
XP_011 SHPEDF-GSEAKGQLDRLESFLLQTGYAA-GKGVGGGSADLIRNLRSRVD-------PQA
90 100 110 120 130
220 230 240 250 260
pF1KE4 WTGPPRVAQTSDPDSSEACAEEEEGLMPQGP-QLLDFSVDEVAEQLTLIDLELFSKVRLY
: .: .:: : : ..: : .:..::::::.: ::: ..
XP_011 PDLPKPLALPGDP--------------PADPTDVLVFLADHLAEQLTLLDAELFLNLIPS
140 150 160 170 180
270 280 290 300 310
pF1KE4 ECLGSVWSQRDRPGAAGASPTVRATVAQFNTVTGCVLGSVLGA------PG------LAA
.:::..:..::::: . :.:::::.::: :.: :..::::: :: :
XP_011 QCLGGLWGHRDRPGHSHLCPSVRATVTQFNKVAGAVVSSVLGATSTGEGPGEVTIRPLRP
190 200 210 220 230 240
320 330 340 350 360 370
pF1KE4 PQRAQRLEKWIRIAQRCRELRNFSSLRAILSALQSNPIYRLKRSWGAVSREPLSTFRKLS
::::. ::::::.:..:: ::::::. :..:::::.::.::. .:: ..:. : .: .:
XP_011 PQRARLLEKWIRVAEECRLLRNFSSVYAVVSALQSSPIHRLRAAWGEATRDSLRVFSSLC
250 260 270 280 290 300
380 390 400 410 420 430
pF1KE4 QIFSDENNHLSSREILFQEEATEGSQEEDNTPGSLPSKPPPGPVPYLGTFLTDLVMLDTA
::::.:.:. .:::.: :: .. : . . .. : :::::::: ::::::.:
XP_011 QIFSEEDNYSQSRELLVQEVKLQSPLEPHSKKAPRSGSRGGGVVPYLGTFLKDLVMLDAA
310 320 330 340 350 360
440 450 460 470 480 490
pF1KE4 LPDMLEGDLINFEKRRKEWEILARIQQLQRRCQSYTLSPHPPILAALHAQNQLTEEQSYR
: ::. :::.:::::. .:.....:: .:..:.:.: : :.. ::: ::.:
XP_011 SKDELENGYINFDKRRKEFAVLSELRRLQNECRGYNLQPDHDIQRWLQGLRPLTEAQSHR
370 380 390 400 410 420
500 510 520 530 540 550
pF1KE4 LSRVIEPPAASCPSSPRIRRRISLTKRLSAKLAREKSSSPSGSPGDPSSPTSSVSPGSPP
.: .:::..: : .::. : . .. . :. .: : ::. .. .: .:
XP_011 VSCEVEPPGSSDPPAPRVLRPTLVISQWTEVLGSVGVPTPLVSCDRPSTG-GDEAPTTPA
430 440 450 460 470 480
560 570 580 590 600 610
pF1KE4 SSPRSRDAPAGSPPASPGPQGPSTKLPLSLDLPSPRPFALPLGSPRIPLPAQQSSEARVI
XP_011 PLLTRLAQSHVVCS
490
710 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:29:11 2016 done: Sun Nov 6 03:29:13 2016
Total Scan time: 15.140 Total Display time: 0.230
Function used was FASTA [36.3.4 Apr, 2011]