Result of FASTA (omim) for
pFN21AE4180
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4180, 647 aa
1>>>pF1KE4180 647 - 647 aa - 647 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.1109+/-0.000402; mu= 11.2082+/- 0.025
mean_var=142.1009+/-30.096, 0's: 0 Z-trim(116.3): 61 B-trim: 1137 in 1/54
Lambda= 0.107591
statistics sampled from 27274 (27340) to 27274 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.321), width: 16
Scan time: 11.580
The best scores are: opt bits E(85289)
NP_690852 (OMIM: 615167) leucine-rich repeat and W ( 647) 4366 690.0 7.1e-198
NP_001304650 (OMIM: 615167) leucine-rich repeat an ( 495) 3376 536.2 1.1e-151
XP_016867334 (OMIM: 615167) PREDICTED: leucine-ric ( 454) 3108 494.6 3.3e-139
>>NP_690852 (OMIM: 615167) leucine-rich repeat and WD re (647 aa)
initn: 4366 init1: 4366 opt: 4366 Z-score: 3673.4 bits: 690.0 E(85289): 7.1e-198
Smith-Waterman score: 4366; 99.8% identity (100.0% similar) in 647 aa overlap (1-647:1-647)
10 20 30 40 50 60
pF1KE4 MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 MGPLSARLLMQRGRPKSDRLGKIRSLDLSGLELLSEHLDPKLLCRLTQLQELDLSNNHLE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 TLPDNLGLSHLRVLRCANNQLGDVTALCQFPKLEELSLEGNPFLTVNDNLKVSFLLPTLR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 KVNGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHRPRARLAALKRPDDVPL
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
NP_690 PESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 SLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAF
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 EPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKK
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 RWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILW
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 DIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKR
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 RVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVA
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE4 VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_690 VVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPT
550 560 570 580 590 600
610 620 630 640
pF1KE4 QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM
:::::::::::::::::::::::::::::::::::::::::::::::
NP_690 QILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM
610 620 630 640
>>NP_001304650 (OMIM: 615167) leucine-rich repeat and WD (495 aa)
initn: 3376 init1: 3376 opt: 3376 Z-score: 2844.5 bits: 536.2 E(85289): 1.1e-151
Smith-Waterman score: 3376; 99.8% identity (100.0% similar) in 495 aa overlap (153-647:1-495)
130 140 150 160 170 180
pF1KE4 NGKDASSTYSQVENLNRELTSRVTAHWEKFMATLGPEEEAEKAQADFVKSAVRDVRYGPE
::::::::::::::::::::::::::::::
NP_001 MATLGPEEEAEKAQADFVKSAVRDVRYGPE
10 20 30
190 200 210 220 230 240
pF1KE4 SLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHRPRARLAALKRPDDVPLSL
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_001 SLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAHKPRARLAALKRPDDVPLSL
40 50 60 70 80 90
250 260 270 280 290 300
pF1KE4 SPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHSKNNSPQDLETQLWACAFEP
100 110 120 130 140 150
310 320 330 340 350 360
pF1KE4 AWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFFSVAWTALMVVTQAGHKKRW
160 170 180 190 200 210
370 380 390 400 410 420
pF1KE4 SVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPAHETHLFTASYDKRIILWDI
220 230 240 250 260 270
430 440 450 460 470 480
pF1KE4 GVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKRRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGCEGGCCCWDVRLDQPQKRRV
280 290 300 310 320 330
490 500 510 520 530 540
pF1KE4 CEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVAVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICLWSWRQTWGGRGSQSTVAVV
340 350 360 370 380 390
550 560 570 580 590 600
pF1KE4 VLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPTQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVSNILKQPPLLPAALQAPTQI
400 410 420 430 440 450
610 620 630 640
pF1KE4 LKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAIWGRM
460 470 480 490
>>XP_016867334 (OMIM: 615167) PREDICTED: leucine-rich re (454 aa)
initn: 3108 init1: 3108 opt: 3108 Z-score: 2620.2 bits: 494.6 E(85289): 3.3e-139
Smith-Waterman score: 3108; 99.8% identity (100.0% similar) in 454 aa overlap (194-647:1-454)
170 180 190 200 210 220
pF1KE4 KAQADFVKSAVRDVRYGPESLSEFTQWRVRMISEELVAASRTQVQKANSPEKPPEAGAAH
::::::::::::::::::::::::::::::
XP_016 MISEELVAASRTQVQKANSPEKPPEAGAAH
10 20 30
230 240 250 260 270 280
pF1KE4 RPRARLAALKRPDDVPLSLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHS
.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPRARLAALKRPDDVPLSLSPSKRACASPSAQVEGSPVAGSDGSQPAVKLEPLHFLQCHS
40 50 60 70 80 90
290 300 310 320 330 340
pF1KE4 KNNSPQDLETQLWACAFEPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KNNSPQDLETQLWACAFEPAWEEGATSQTVATCGGEAVCVIDCQTGIVLHKYKAPGEEFF
100 110 120 130 140 150
350 360 370 380 390 400
pF1KE4 SVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVAWTALMVVTQAGHKKRWSVLAAAGLRGLVRLLHVRAGFCCGVIRAHKKAIATLCFSPA
160 170 180 190 200 210
410 420 430 440 450 460
pF1KE4 HETHLFTASYDKRIILWDIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HETHLFTASYDKRIILWDIGVPNQDYEFQASQLLTLDTTSIPLRLCPVASCPDARLLAGC
220 230 240 250 260 270
470 480 490 500 510 520
pF1KE4 EGGCCCWDVRLDQPQKRRVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EGGCCCWDVRLDQPQKRRVCEVEFVFSEGSEASGRRVDGLAFVNEDIVASKGSGLGTICL
280 290 300 310 320 330
530 540 550 560 570 580
pF1KE4 WSWRQTWGGRGSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 WSWRQTWGGRGSQSTVAVVVLARLQWSSTELAYFSLSACPDKGIVLCGDEEGNVWLYDVS
340 350 360 370 380 390
590 600 610 620 630 640
pF1KE4 NILKQPPLLPAALQAPTQILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NILKQPPLLPAALQAPTQILKWPQPWALGQVVTKTMVNTVVANASFTYLTALTDSNIVAI
400 410 420 430 440 450
pF1KE4 WGRM
::::
XP_016 WGRM
647 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:09:15 2016 done: Sun Nov 6 04:09:17 2016
Total Scan time: 11.580 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]