Result of FASTA (omim) for
pFN21AE4152
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4152, 587 aa
1>>>pF1KE4152 587 - 587 aa - 587 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6960+/-0.000627; mu= 17.8489+/- 0.039
mean_var=210.2634+/-43.246, 0's: 0 Z-trim(110.4): 713 B-trim: 83 in 1/56
Lambda= 0.088449
statistics sampled from 17874 (18766) to 17874 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.576), E-opt: 0.2 (0.22), width: 16
Scan time: 9.620
The best scores are: opt bits E(85289)
XP_016876858 (OMIM: 605759) PREDICTED: ankyrin rep ( 600) 1153 161.6 6.6e-39
XP_011535137 (OMIM: 605759) PREDICTED: ankyrin rep ( 533) 1125 158.0 7.4e-38
NP_057234 (OMIM: 605759) ankyrin repeat and SOCS b ( 587) 1125 158.1 7.7e-38
XP_005267815 (OMIM: 605759) PREDICTED: ankyrin rep ( 635) 1125 158.1 8.1e-38
NP_001189358 (OMIM: 605759) ankyrin repeat and SOC ( 635) 1125 158.1 8.1e-38
XP_011535136 (OMIM: 605759) PREDICTED: ankyrin rep ( 583) 969 138.1 7.6e-32
NP_057199 (OMIM: 605760) ankyrin repeat and SOCS b ( 518) 544 83.8 1.5e-15
XP_016861517 (OMIM: 611122) PREDICTED: serine/thre ( 687) 493 77.5 1.6e-13
XP_011531843 (OMIM: 611122) PREDICTED: serine/thre (1027) 493 77.8 1.9e-13
XP_011531842 (OMIM: 611122) PREDICTED: serine/thre (1086) 493 77.8 2e-13
XP_005265053 (OMIM: 611122) PREDICTED: serine/thre (1083) 490 77.5 2.6e-13
NP_001188894 (OMIM: 605760) ankyrin repeat and SOC ( 445) 469 74.1 1.1e-12
NP_665862 (OMIM: 605760) ankyrin repeat and SOCS b ( 445) 469 74.1 1.1e-12
NP_056014 (OMIM: 611122) serine/threonine-protein (1053) 472 75.1 1.3e-12
NP_065210 (OMIM: 182900,612641) ankyrin-1 isoform (1719) 466 74.7 2.7e-12
XP_011542807 (OMIM: 182900,612641) PREDICTED: anky (1751) 466 74.7 2.8e-12
XP_011542806 (OMIM: 182900,612641) PREDICTED: anky (1752) 466 74.7 2.8e-12
XP_016868818 (OMIM: 182900,612641) PREDICTED: anky (1759) 466 74.7 2.8e-12
XP_011542805 (OMIM: 182900,612641) PREDICTED: anky (1791) 466 74.8 2.8e-12
XP_016868817 (OMIM: 182900,612641) PREDICTED: anky (1792) 466 74.8 2.8e-12
XP_016868816 (OMIM: 182900,612641) PREDICTED: anky (1807) 466 74.8 2.8e-12
NP_065208 (OMIM: 182900,612641) ankyrin-1 isoform (1856) 466 74.8 2.8e-12
NP_000028 (OMIM: 182900,612641) ankyrin-1 isoform (1880) 466 74.8 2.9e-12
NP_065209 (OMIM: 182900,612641) ankyrin-1 isoform (1881) 466 74.8 2.9e-12
XP_011542804 (OMIM: 182900,612641) PREDICTED: anky (1889) 466 74.8 2.9e-12
XP_016868815 (OMIM: 182900,612641) PREDICTED: anky (1892) 466 74.8 2.9e-12
NP_001135918 (OMIM: 182900,612641) ankyrin-1 isofo (1897) 466 74.8 2.9e-12
XP_016868814 (OMIM: 182900,612641) PREDICTED: anky (1908) 466 74.8 2.9e-12
XP_011542803 (OMIM: 182900,612641) PREDICTED: anky (1913) 466 74.8 2.9e-12
XP_011542802 (OMIM: 182900,612641) PREDICTED: anky (1914) 466 74.8 2.9e-12
XP_005273533 (OMIM: 182900,612641) PREDICTED: anky (1921) 466 74.8 2.9e-12
XP_016868813 (OMIM: 182900,612641) PREDICTED: anky (1922) 466 74.8 2.9e-12
XP_016868812 (OMIM: 182900,612641) PREDICTED: anky (1936) 466 74.8 2.9e-12
XP_016868811 (OMIM: 182900,612641) PREDICTED: anky (1937) 466 74.8 2.9e-12
XP_016868810 (OMIM: 182900,612641) PREDICTED: anky (1940) 466 74.8 2.9e-12
XP_011542798 (OMIM: 182900,612641) PREDICTED: anky (1944) 466 74.8 2.9e-12
XP_016868809 (OMIM: 182900,612641) PREDICTED: anky (1946) 466 74.8 2.9e-12
XP_011542797 (OMIM: 182900,612641) PREDICTED: anky (1953) 466 74.8 2.9e-12
XP_011542796 (OMIM: 182900,612641) PREDICTED: anky (1954) 466 74.8 2.9e-12
XP_016868808 (OMIM: 182900,612641) PREDICTED: anky (1961) 466 74.8 2.9e-12
XP_011542793 (OMIM: 182900,612641) PREDICTED: anky (1968) 466 74.8 2.9e-12
XP_011542792 (OMIM: 182900,612641) PREDICTED: anky (1969) 466 74.8 2.9e-12
XP_011531844 (OMIM: 611122) PREDICTED: serine/thre (1025) 456 73.1 5.1e-12
XP_016871638 (OMIM: 600465,615493) PREDICTED: anky (1720) 432 70.4 5.5e-11
XP_016871637 (OMIM: 600465,615493) PREDICTED: anky (1725) 432 70.4 5.6e-11
XP_016871636 (OMIM: 600465,615493) PREDICTED: anky (1735) 432 70.4 5.6e-11
XP_016871635 (OMIM: 600465,615493) PREDICTED: anky (1737) 432 70.4 5.6e-11
XP_016871634 (OMIM: 600465,615493) PREDICTED: anky (1738) 432 70.4 5.6e-11
XP_016871633 (OMIM: 600465,615493) PREDICTED: anky (1741) 432 70.4 5.6e-11
XP_016871632 (OMIM: 600465,615493) PREDICTED: anky (1742) 432 70.4 5.6e-11
>>XP_016876858 (OMIM: 605759) PREDICTED: ankyrin repeat (600 aa)
initn: 1096 init1: 819 opt: 1153 Z-score: 819.5 bits: 161.6 E(85289): 6.6e-39
Smith-Waterman score: 1153; 33.8% identity (66.2% similar) in 585 aa overlap (2-573:17-597)
10 20 30 40
pF1KE4 MDNYTSDEDIDEDFDTQLIIQQSLQDIYK-PGTAQHAPKD----E
..:. ...:: .:. :.::: : . : ::. . . .
XP_016 MATQISTRGSQCTIGQEEYSLYSSLSEDELVQMAIEQSLADKTRGPTTAEATASACTNRQ
10 20 30 40 50 60
50 60 70 80 90
pF1KE4 SLHSF-LSADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILE
: . . ....:. : :.::. . : . ..: .. ::.:::.:: . :.
XP_016 PAHFYPWTRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE4 ITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVL
. :. . :. .: : . :: ..::. :. :: : .:. .: ..:: :
XP_016 V-LQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACE
130 140 150 160 170
160 170 180 190 200 210
pF1KE4 RDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTP
: . . .:....::.: :: :::::... . ....... .::. . ...::.::
XP_016 RKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITP
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE4 LALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPK
: .:::::. : ...: . ::. . ::::..: : :: .. . ..: .:: ::::: .
XP_016 LFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTN
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE4 NSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFD
..: ::.:.:. .:. ...:.:::. . :..::.::.: :: : . :: :..: ::
XP_016 KDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFD
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 VNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNY
:: : . . :.:.:.::::::: :... ...:::. :: ::.: .. : .:.: :
XP_016 VNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCL
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE4 ELISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKV
. ..::: ::::.. . ..: ::.......: .:..:.. : : : ::.: .:.
XP_016 RTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGP
420 430 440 450 460 470
460 470 480 490 500 510
pF1KE4 HPSYTVEG--WTSTVIKD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLK
:: . .... : ..::: .. ... .: .. :.:::: .:..::.::
XP_016 HPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLK
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE4 AVLQKQGIWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLY
... :. :. :: : :::::..:: .:. ... ... ::::.:: :. :
XP_016 EHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKY
540 550 560 570 580 590
580
pF1KE4 KEYDLYGQGIFTGTW
.
XP_016 ENTQ
600
>>XP_011535137 (OMIM: 605759) PREDICTED: ankyrin repeat (533 aa)
initn: 1096 init1: 819 opt: 1125 Z-score: 800.7 bits: 158.0 E(85289): 7.4e-38
Smith-Waterman score: 1125; 35.0% identity (67.8% similar) in 528 aa overlap (53-573:7-530)
30 40 50 60 70 80
pF1KE4 SLQDIYKPGTAQHAPKDESLHSFLSADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIG
....:. : :.::. . : . ..: .. :
XP_011 MRPADPLIKAIKDGDEEALKTMIKEGKNLAEPNKEG
10 20 30
90 100 110 120 130 140
pF1KE4 WIPLHKAAVQLNRKILEITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCN
:.:::.:: . :.. :. . :. .: : . :: ..::. :. :: : .
XP_011 WLPLHEAAYYGQVGCLKV-LQRAYPGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAE
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE4 PNAKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLRCANERTALHEAAKLGREDMVKLM
:. .: ..:: : : . . .:....::.: :: :::::... . ......
XP_011 PDISNKSRETPLYKACERKNAEAVKILVQHNADTNHRCNRGWTALHESVSRNDLEVMQIL
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE4 LVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNP
. .::. . ...::.::: .:::::. : ...: . ::. . ::::..: : :: .. .
XP_011 VSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADINTQASDNASALYEACKNEHE
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE4 DAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAA
..: .:: ::::: ...: ::.:.:. .:. ...:.:::. . :..::.::.: ::
XP_011 EVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAA
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE4 AGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALP
: . :: :..: :::: : . . :.:.:.::::::: :... ...:::. :: :
XP_011 ERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYFAVVNNNVYATELLLQHGADP
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE4 NQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLN
:.: .. : .:.: : . ..::: ::::.. . ..: ::.......: .:..:..
XP_011 NRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMD
340 350 360 370 380 390
450 460 470 480 490
pF1KE4 YGYDTERCFDCPHGDKVHPSYTVEG--WTSTVIKD-----TKFCEVITLSWLQHLSGKVV
: : : ::.: .:. :: . .... : ..::: .. ... .: ..
XP_011 LGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPII
400 410 420 430 440 450
500 510 520 530 540 550
pF1KE4 RVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPV
:.:::: .:..::.:: ... :. :. :: : :::::..:: .:. ...
XP_011 DVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---
460 470 480 490 500 510
560 570 580
pF1KE4 FMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW
... ::::.:: :. :.
XP_011 LLDTLPLPGRLIRYLKYENTQ
520 530
>>NP_057234 (OMIM: 605759) ankyrin repeat and SOCS box p (587 aa)
initn: 1096 init1: 819 opt: 1125 Z-score: 800.3 bits: 158.1 E(85289): 7.7e-38
Smith-Waterman score: 1133; 34.2% identity (66.3% similar) in 564 aa overlap (17-573:39-584)
10 20 30 40
pF1KE4 MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKDESLHSFL
: ..:. ....: :.: :: :
NP_057 YFSLFHSCSAPSRSTAPPESSPARAPMGLFQGVMQKYSSSLFK--TSQLAPADP------
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE4 SADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITLSASD
....:. : :.::. . : . ..: .. ::.:::.:: . :.. :. .
NP_057 ------LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKV-LQRAY
70 80 90 100 110
110 120 130 140 150 160
pF1KE4 PSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMA
:. .: : . :: ..::. :. :: : .:. .: ..:: : : . .
NP_057 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQS
.:....::.: :: :::::... . ....... .::. . ...::.::: .::::
NP_057 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE4 GHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPI
:. : ...: . ::. . ::::..: : :: .. . ..: .:: ::::: ...: ::.
NP_057 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE4 HVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ
:.:. .:. ...:.:::. . :..::.::.: :: : . :: :..: :::: :
NP_057 HIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLL
. . :.:.:.::::::: :... ...:::. :: ::.: .. : .:.: : . ..:::
NP_057 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLL
360 370 380 390 400 410
410 420 430 440 450 460
pF1KE4 RHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVE
::::.. . ..: ::.......: .:..:.. : : : ::.: .:. ::
NP_057 DHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQP
420 430 440 450 460 470
470 480 490 500 510
pF1KE4 G--WTSTVIKD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQG
. .... : ..::: .. ... .: .. :.:::: .:..::.:: ...
NP_057 SSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFE
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE4 IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYG
:. :. :: : :::::..:: .:. ... ... ::::.:: :. :.
NP_057 DWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
540 550 560 570 580
580
pF1KE4 QGIFTGTW
>>XP_005267815 (OMIM: 605759) PREDICTED: ankyrin repeat (635 aa)
initn: 1096 init1: 819 opt: 1125 Z-score: 800.0 bits: 158.1 E(85289): 8.1e-38
Smith-Waterman score: 1133; 34.2% identity (66.3% similar) in 564 aa overlap (17-573:87-632)
10 20 30 40
pF1KE4 MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKDESLHSFL
: ..:. ....: :.: :: :
XP_005 TNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSLFK--TSQLAPADP------
60 70 80 90 100
50 60 70 80 90 100
pF1KE4 SADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITLSASD
....:. : :.::. . : . ..: .. ::.:::.:: . :.. :. .
XP_005 ------LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKV-LQRAY
110 120 130 140 150 160
110 120 130 140 150 160
pF1KE4 PSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMA
:. .: : . :: ..::. :. :: : .:. .: ..:: : : . .
XP_005 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE4 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQS
.:....::.: :: :::::... . ....... .::. . ...::.::: .::::
XP_005 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS
230 240 250 260 270 280
230 240 250 260 270 280
pF1KE4 GHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPI
:. : ...: . ::. . ::::..: : :: .. . ..: .:: ::::: ...: ::.
XP_005 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL
290 300 310 320 330 340
290 300 310 320 330 340
pF1KE4 HVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ
:.:. .:. ...:.:::. . :..::.::.: :: : . :: :..: :::: :
XP_005 HIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP
350 360 370 380 390 400
350 360 370 380 390 400
pF1KE4 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLL
. . :.:.:.::::::: :... ...:::. :: ::.: .. : .:.: : . ..:::
XP_005 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLL
410 420 430 440 450 460
410 420 430 440 450 460
pF1KE4 RHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVE
::::.. . ..: ::.......: .:..:.. : : : ::.: .:. ::
XP_005 DHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQP
470 480 490 500 510 520
470 480 490 500 510
pF1KE4 G--WTSTVIKD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQG
. .... : ..::: .. ... .: .. :.:::: .:..::.:: ...
XP_005 SSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFE
530 540 550 560 570 580
520 530 540 550 560 570
pF1KE4 IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYG
:. :. :: : :::::..:: .:. ... ... ::::.:: :. :.
XP_005 DWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
590 600 610 620 630
580
pF1KE4 QGIFTGTW
>>NP_001189358 (OMIM: 605759) ankyrin repeat and SOCS bo (635 aa)
initn: 1096 init1: 819 opt: 1125 Z-score: 800.0 bits: 158.1 E(85289): 8.1e-38
Smith-Waterman score: 1133; 34.2% identity (66.3% similar) in 564 aa overlap (17-573:87-632)
10 20 30 40
pF1KE4 MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKDESLHSFL
: ..:. ....: :.: :: :
NP_001 TNRQPAHFYPWTRSTAPPESSPARAPMGLFQGVMQKYSSSLFK--TSQLAPADP------
60 70 80 90 100
50 60 70 80 90 100
pF1KE4 SADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITLSASD
....:. : :.::. . : . ..: .. ::.:::.:: . :.. :. .
NP_001 ------LIKAIKDGDEEALKTMIKEGKNLAEPNKEGWLPLHEAAYYGQVGCLKV-LQRAY
110 120 130 140 150 160
110 120 130 140 150 160
pF1KE4 PSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMA
:. .: : . :: ..::. :. :: : .:. .: ..:: : : . .
NP_001 PGTIDQRTLQEETAVYLATCRGHLDCLLSLLQAGAEPDISNKSRETPLYKACERKNAEAV
170 180 190 200 210 220
170 180 190 200 210 220
pF1KE4 ALLINYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQS
.:....::.: :: :::::... . ....... .::. . ...::.::: .::::
NP_001 KILVQHNADTNHRCNRGWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQS
230 240 250 260 270 280
230 240 250 260 270 280
pF1KE4 GHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPI
:. : ...: . ::. . ::::..: : :: .. . ..: .:: ::::: ...: ::.
NP_001 GQLEALRFLAKYGADINTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPL
290 300 310 320 330 340
290 300 310 320 330 340
pF1KE4 HVAADRGHLLALKILIPVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQ
:.:. .:. ...:.:::. . :..::.::.: :: : . :: :..: :::: :
NP_001 HIASKKGNYRIVQMLLPVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAP
350 360 370 380 390 400
350 360 370 380 390 400
pF1KE4 RINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLL
. . :.:.:.::::::: :... ...:::. :: ::.: .. : .:.: : . ..:::
NP_001 ERARLYEDRRSSALYFAVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLL
410 420 430 440 450 460
410 420 430 440 450 460
pF1KE4 RHGANVNYFCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVE
::::.. . ..: ::.......: .:..:.. : : : ::.: .:. ::
NP_001 DHGANIDAYIATHPTAFPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQP
470 480 490 500 510 520
470 480 490 500 510
pF1KE4 G--WTSTVIKD-----TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQG
. .... : ..::: .. ... .: .. :.:::: .:..::.:: ...
NP_001 SSRFNDAPAADKEPSVVQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFE
530 540 550 560 570 580
520 530 540 550 560 570
pF1KE4 IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYG
:. :. :: : :::::..:: .:. ... ... ::::.:: :. :.
NP_001 DWAVIKEKAEPPRPLAHLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
590 600 610 620 630
580
pF1KE4 QGIFTGTW
>>XP_011535136 (OMIM: 605759) PREDICTED: ankyrin repeat (583 aa)
initn: 1038 init1: 761 opt: 969 Z-score: 692.7 bits: 138.1 E(85289): 7.6e-32
Smith-Waterman score: 980; 34.6% identity (65.6% similar) in 488 aa overlap (108-573:96-580)
80 90 100 110 120 130
pF1KE4 ADEIGWIPLHKAAVQLNRKILEITLSASDPSLWEQTTHNGETPLFLAVSSCLLENATFLL
::.. . ::. :... : ..
XP_011 PWTRSTAPPESSPARAPMGLFQGVMQKYSSSLFKTSQLAPADPLIKAIKDGDEEALKTMI
70 80 90 100 110 120
140 150 160 170 180
pF1KE4 LNGCNPNAKNFEGNSPL-----------LAAVLRDCYDMAA----LLINYGADVNLRCAN
.: : : :: :: : .. : : : .:....::.: ::
XP_011 KEGKNLAEPNKEGWLPLHEAAYYGQVGCLKVLQRACERKNAEAVKILVQHNADTNHRCNR
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 ERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANA
:::::... . ....... .::. . ...::.::: .:::::. : ...: . ::.
XP_011 GWTALHESVSRNDLEVMQILVSGGAKVESKNAYGITPLFVAAQSGQLEALRFLAKYGADI
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 HGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILI
. ::::..: : :: .. . ..: .:: ::::: ...: ::.:.:. .:. ...:.
XP_011 NTQASDNASALYEACKNEHEEVVEFLLSQGADANKTNKDGLLPLHIASKKGNYRIVQMLL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 PVTDLAAIKQSGISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYF
:::. . :..::.::.: :: : . :: :..: :::: : . . :.:.:.:::::
XP_011 PVTSRTRIRRSGVSPLHLAAERNHDEVLEALLSARFDVNTPLAPERARLYEDRRSSALYF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 AVSNSDLSSVKLLLSAGALPNQDPVNCLQIALRMGNYELISLLLRHGANVNYFCRVNPLH
:: :... ...:::. :: ::.: .. : .:.: : . ..::: ::::.. . ..:
XP_011 AVVNNNVYATELLLQHGADPNRDVISPLLVAIRHGCLRTMQLLLDHGANIDAYIATHPTA
370 380 390 400 410 420
430 440 450 460 470
pF1KE4 FPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEG--WTSTVIKD-----
::.......: .:..:.. : : : ::.: .:. :: . .... :
XP_011 FPATIMFAMKCLSLLKFLMDLGCDGEPCFSCLYGNGPHPPAPQPSSRFNDAPAADKEPSV
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE4 TKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWSEIHFILTNPRSLK
..::: .. ... .: .. :.:::: .:..::.:: ... :. :. :: :
XP_011 VQFCEFVSAPEVSRWAGPIIDVLLDYVGNVQLCSRLKEHIDSFEDWAVIKEKAEPPRPLA
490 500 510 520 530 540
540 550 560 570 580
pF1KE4 HLCRLKIRKCMGRLHLRCPVFMSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW
:::::..:: .:. ... ... ::::.:: :. :.
XP_011 HLCRLRVRKAIGKYRIK---LLDTLPLPGRLIRYLKYENTQ
550 560 570 580
>>NP_057199 (OMIM: 605760) ankyrin repeat and SOCS box p (518 aa)
initn: 497 init1: 211 opt: 544 Z-score: 400.1 bits: 83.8 E(85289): 1.5e-15
Smith-Waterman score: 641; 29.5% identity (57.6% similar) in 528 aa overlap (59-574:20-502)
30 40 50 60 70 80
pF1KE4 KPGTAQHAPKDESLHSFLSADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHK
.:. .: .: : . ::. ::.:.:.
NP_057 MDFTEAYADTCSTVGLAAREGNVKVLRKLLKKGRSVDVADNRGWMPIHE
10 20 30 40
90 100 110 120 130 140
pF1KE4 AAVQLNRKILEITLSA-SDPSLWEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKN
:: . . . :.. ..: :. . .. : .: : ::.:. . . .:: : .::: .
NP_057 AAYHNSVECLQMLINADSSENYIKMKTFEGFCALHLAASQGHWKIVQILLEAGADPNATT
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE4 FEGNSPLLAAVLRDCYDMAALLINYGADVNLR---CANERTALHEAAKLGREDMVKLMLV
.: ..::. :: :. ::...::.:: :. ..::.:. ...::.:
NP_057 LEETTPLFLAVENGQIDVLRLLLQHGANVNGSHSMCG--WNSLHQASFQENAEIIKLLLR
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE4 SGAHPDPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASGGNPDA
.::. . :. .:.::: .::: :. : . .:. .:::.. :: :... :. ::. :.
NP_057 KGANKECQDDFGITPLFVAAQYGKLESLSILISSGANVNCQALDKATPLFIAAQEGHTKC
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE4 VALLLEYGADANIPKN--SGHLPIHVAADRGHLLALKILIPVTDLAA-IKQSGISPVHCA
: ::: ::: .. : : .::::.::. :: : .:::.:. : . .:::. :
NP_057 VELLLSSGADPDLYCNEDSWQLPIHAAAQMGHTKILDLLIPLTNRACDTGLNKVSPVYSA
230 240 250 260 270 280
330 340 350 360 370 380
pF1KE4 AAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKLLLSAGAL
. :.: .:::.:.. :.. : . . . : . .. :..::. ::
NP_057 VFGGHEDCLEILLRNGYSP----DAQACLVFGFSSPVCMAFQKDCEFFGIVNILLKYGA-
290 300 310 320 330 340
390 400 410 420 430
pF1KE4 PNQDPVNCLQIA--LRMGNYELISLLLRHGANVNYFCRVNPL-HFPSALQYTLKDEVMLR
.: :..: :.. .. .. .::.: : ..: :. .....: .. .
NP_057 ----QINELHLAYCLKYEKFSIFRYFLRKG------CSLGPWNHIYEFVNHAIKAQAKYK
350 360 370 380 390
440 450 460 470 480 490
pF1KE4 MLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVM
: :: : :. .. .:. ::.. .: ..
NP_057 EWL------------PH-------LLVAGFDPLIL----LCN----SWIDSVSIDTLIFT
400 410 420
500 510 520 530 540 550
pF1KE4 LDYVDQVRICSKLKAVLQKQG--IWSEIHFILTNPRSLKHLCRLKIRKCMGRLHLRCPVF
:.... . .. .:. .. : . : : : :: :::::.::. . .:: .
NP_057 LEFTNWKTLAPAVERMLSARASNAWILQQHIATVP-SLTHLCRLEIRSSLKSERLRSDSY
430 440 450 460 470 480
560 570 580
pF1KE4 MSFLPLPNRLKAYVLYKEYDLYGQGIFTGTW
.: :::: :. :.::..
NP_057 ISQLPLPRSLHNYLLYEDVLRMYEVPELAAIQDG
490 500 510
>>XP_016861517 (OMIM: 611122) PREDICTED: serine/threonin (687 aa)
initn: 302 init1: 302 opt: 493 Z-score: 363.8 bits: 77.5 E(85289): 1.6e-13
Smith-Waterman score: 493; 30.1% identity (57.2% similar) in 449 aa overlap (18-448:6-432)
10 20 30 40 50
pF1KE4 MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKD-ESLHSFLSAD----YKKIVE
... . ..: .:. .. :.. .:::: :.. : ..:.
XP_016 MSRVCIVVLEEVED-ESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQ
10 20 30 40
60 70 80 90 100
pF1KE4 TIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITL------SASDPSL
.: .: : . : . . :. ::: :: . .:.:. . .:.: :
XP_016 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD-SK
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE4 WEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALL
: ::: ::.:: : . :: .. . ::.. . ..:: :. : :
XP_016 W-------LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL
110 120 130 140 150
170 180 190 200 210 220
pF1KE4 INYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT
. ..::. :::::.:: :. .::::.: ::. . . . :: ::
XP_016 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 EIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVA
:....:. .::.. . . : . : :::.: ..: ::. :.: : :. :. :.:::
XP_016 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE4 ADRGHLLALKILIPVTDLAAIK-QSGISPVHCAAAGAHPQ-CLELLIQAGFDVNFMLDQR
:. .... :: .. : ..:..:.: :::..: :::::. : :::.
XP_016 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM-----
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMGNYELISL
: : :. :.... .. .: . ....::. . . : :.:: :.:. ::.
XP_016 --KSKDG--KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE4 LLRHGANVNY--FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPS
:. ::.. . . :::. .::. ..: : ::. :.: .
XP_016 LITSGADTAKRGIHGMFPLHL-AALS-GFSDCC--RKLLSSGFDIDTPDDFGRTCLHAAA
400 410 420 430 440
470 480 490 500 510 520
pF1KE4 YTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWS
XP_016 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT
450 460 470 480 490 500
>>XP_011531843 (OMIM: 611122) PREDICTED: serine/threonin (1027 aa)
initn: 420 init1: 302 opt: 493 Z-score: 362.2 bits: 77.8 E(85289): 1.9e-13
Smith-Waterman score: 493; 30.1% identity (57.2% similar) in 449 aa overlap (18-448:6-432)
10 20 30 40 50
pF1KE4 MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKD-ESLHSFLSAD----YKKIVE
... . ..: .:. .. :.. .:::: :.. : ..:.
XP_011 MSRVCIVVLEEVED-ESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQ
10 20 30 40
60 70 80 90 100
pF1KE4 TIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITL------SASDPSL
.: .: : . : . . :. ::: :: . .:.:. . .:.: :
XP_011 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD-SK
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE4 WEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALL
: ::: ::.:: : . :: .. . ::.. . ..:: :. : :
XP_011 W-------LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL
110 120 130 140 150
170 180 190 200 210 220
pF1KE4 INYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT
. ..::. :::::.:: :. .::::.: ::. . . . :: ::
XP_011 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 EIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVA
:....:. .::.. . . : . : :::.: ..: ::. :.: : :. :. :.:::
XP_011 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE4 ADRGHLLALKILIPVTDLAAIK-QSGISPVHCAAAGAHPQ-CLELLIQAGFDVNFMLDQR
:. .... :: .. : ..:..:.: :::..: :::::. : :::.
XP_011 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM-----
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMGNYELISL
: : :. :.... .. .: . ....::. . . : :.:: :.:. ::.
XP_011 --KSKDG--KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE4 LLRHGANVNY--FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPS
:. ::.. . . :::. .::. ..: : ::. :.: .
XP_011 LITSGADTAKRGIHGMFPLHL-AALS-GFSDCC--RKLLSSGFDIDTPDDFGRTCLHAAA
400 410 420 430 440
470 480 490 500 510 520
pF1KE4 YTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWS
XP_011 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT
450 460 470 480 490 500
>--
initn: 374 init1: 175 opt: 343 Z-score: 258.8 bits: 58.7 E(85289): 1.1e-07
Smith-Waterman score: 343; 26.5% identity (55.1% similar) in 374 aa overlap (65-413:521-883)
40 50 60 70 80 90
pF1KE4 HAPKDESLHSFLSADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLN
: .: . . : :. :. .: .:. .
XP_011 VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH
500 510 520 530 540 550
100 110 120 130 140
pF1KE4 RKILEITLSASDPSLWEQTTHNGE----------TPLFLAVSSCLLENATFLLLNGCNPN
: :.. : . .. .:. . .:: ::. . :. . . .
XP_011 RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD
560 570 580 590 600 610
150 160 170 180 190 200
pF1KE4 AKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLR-CANERTALHEAAKLGREDMVKLML
..: : .:: :... . . .::: ::.. .. .:: .: :: :. . ..: :
XP_011 VRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL-L
620 630 640 650 660
210 220 230 240 250
pF1KE4 VSGAHP----DPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASG
...:.: : :. : ::: :.. .:::. . :: ::::. .. . . . : ..:
XP_011 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT
670 680 690 700 710 720
260 270 280 290 300 310
pF1KE4 GNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVT-----DLAAIKQSG
:. . : ::..:: . . :. :::..: ::. .: :. . . :. . :
XP_011 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG
730 740 750 760 770 780
320 330 340 350 360 370
pF1KE4 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL
. .: : ..: :.::: :.:.. .. . . : :. :: :.. .....
XP_011 YTALHWACYNGHETCVELL----------LEQEVFQKTEGNAFSPLHCAVINDNEGAAEM
790 800 810 820 830
380 390 400 410 420
pF1KE4 L---LSAGALPNQDPVNC--LQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQY
: :.:. . : . :. : . : ..::: :.:.::
XP_011 LIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAEN
840 850 860 870 880 890
430 440 450 460 470 480
pF1KE4 TLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQH
XP_011 GQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAAL
900 910 920 930 940 950
>>XP_011531842 (OMIM: 611122) PREDICTED: serine/threonin (1086 aa)
initn: 420 init1: 302 opt: 493 Z-score: 362.0 bits: 77.8 E(85289): 2e-13
Smith-Waterman score: 493; 30.1% identity (57.2% similar) in 449 aa overlap (18-448:6-432)
10 20 30 40 50
pF1KE4 MDNYTSDEDIDEDFDTQLIIQQSLQDIYKPGTAQHAPKD-ESLHSFLSAD----YKKIVE
... . ..: .:. .. :.. .:::: :.. : ..:.
XP_011 MSRVCIVVLEEVED-ESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQ
10 20 30 40
60 70 80 90 100
pF1KE4 TIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLNRKILEITL------SASDPSL
.: .: : . : . . :. ::: :: . .:.:. . .:.: :
XP_011 AIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKD-SK
50 60 70 80 90 100
110 120 130 140 150 160
pF1KE4 WEQTTHNGETPLFLAVSSCLLENATFLLLNGCNPNAKNFEGNSPLLAAVLRDCYDMAALL
: ::: ::.:: : . :: .. . ::.. . ..:: :. : :
XP_011 W-------LTPLHRAVASCSEEAVQVLLKHSADVNARDKNWQTPLHIAAANKAVKCAEAL
110 120 130 140 150
170 180 190 200 210 220
pF1KE4 INYGADVNLRCANERTALHEAAKLGREDMVKLMLVSGAHPDPQSTYGFTPLALAAQSGHT
. ..::. :::::.:: :. .::::.: ::. . . . :: ::
XP_011 VPLLSNVNVSDRAGRTALHHAAFSGHGEMVKLLLSRGANINAFDKKDRRAIHWAAYMGHI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE4 EIMEMLLRKGANAHGQASDSSSILLEAASGGNPDAVALLLEYGADANIPKNSGHLPIHVA
:....:. .::.. . . : . : :::.: ..: ::. :.: : :. :. :.:::
XP_011 EVVKLLVSHGAEVTCKDKKSYTPLHAAASSGMISVVKYLLDLGVDMNEPNAYGNTPLHVA
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE4 ADRGHLLALKILIPVTDLAAIK-QSGISPVHCAAAGAHPQ-CLELLIQAGFDVNFMLDQR
:. .... :: .. : ..:..:.: :::..: :::::. : :::.
XP_011 CYNGQDVVVNELIDCGAIVNQKNEKGFTPLHFAAASTHGALCLELLVGNGADVNM-----
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE4 INKHYDDHRKSALYFAVSNSDLSSVKLLLSAGALPNQDPVNC---LQIALRMGNYELISL
: : :. :.... .. .: . ....::. . . : :.:: :.:. ::.
XP_011 --KSKDG--KTPLHMTALHGRFSRSQTIIQSGAVIDCEDKNGNTPLHIAARYGHELLINT
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE4 LLRHGANVNY--FCRVNPLHFPSALQYTLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPS
:. ::.. . . :::. .::. ..: : ::. :.: .
XP_011 LITSGADTAKRGIHGMFPLHL-AALS-GFSDCC--RKLLSSGFDIDTPDDFGRTCLHAAA
400 410 420 430 440
470 480 490 500 510 520
pF1KE4 YTVEGWTSTVIKDTKFCEVITLSWLQHLSGKVVRVMLDYVDQVRICSKLKAVLQKQGIWS
XP_011 AGGNLECLNLLLNTGADFNKKDKFGRSPLHYAAANCNYQCLFALVGSGASVNDLDERGCT
450 460 470 480 490 500
>--
initn: 374 init1: 175 opt: 343 Z-score: 258.6 bits: 58.7 E(85289): 1.2e-07
Smith-Waterman score: 343; 26.5% identity (55.1% similar) in 374 aa overlap (65-413:521-883)
40 50 60 70 80 90
pF1KE4 HAPKDESLHSFLSADYKKIVETIEKGKEDALSHLTKYHSAFGEADEIGWIPLHKAAVQLN
: .: . . : :. :. .: .:. .
XP_011 VGSGASVNDLDERGCTPLHYAATSDTDGKCLEYLLRNDANPGIRDKQGYNAVHYSAAYGH
500 510 520 530 540 550
100 110 120 130 140
pF1KE4 RKILEITLSASDPSLWEQTTHNGE----------TPLFLAVSSCLLENATFLLLNGCNPN
: :.. : . .. .:. . .:: ::. . :. . . .
XP_011 RLCLQLIASETPLDVLMETSGTDMLSDSDNRATISPLHLAAYHGHHQALEVLVQSLLDLD
560 570 580 590 600 610
150 160 170 180 190 200
pF1KE4 AKNFEGNSPLLAAVLRDCYDMAALLINYGADVNLR-CANERTALHEAAKLGREDMVKLML
..: : .:: :... . . .::: ::.. .. .:: .: :: :. . ..: :
XP_011 VRNSSGRTPLDLAAFKGHVECVDVLINQGASILVKDYILKRTPIHAAATNGHSECLRL-L
620 630 640 650 660
210 220 230 240 250
pF1KE4 VSGAHP----DPQSTYGFTPLALAAQSGHTEIMEMLLRKGANAHGQASDSSSILLEAASG
...:.: : :. : ::: :.. .:::. . :: ::::. .. . . . : ..:
XP_011 IGNAEPQNAVDIQDGNGQTPLMLSVLNGHTDCVYSLLNKGANVDAKDKWGRTALHRGAVT
670 680 690 700 710 720
260 270 280 290 300 310
pF1KE4 GNPDAVALLLEYGADANIPKNSGHLPIHVAADRGHLLALKILIPVT-----DLAAIKQSG
:. . : ::..:: . . :. :::..: ::. .: :. . . :. . :
XP_011 GHEECVDALLQHGAKCLLRDSRGRTPIHLSAACGHIGVLGALLQSAASMDANPATADNHG
730 740 750 760 770 780
320 330 340 350 360 370
pF1KE4 ISPVHCAAAGAHPQCLELLIQAGFDVNFMLDQRINKHYDDHRKSALYFAVSNSDLSSVKL
. .: : ..: :.::: :.:.. .. . . : :. :: :.. .....
XP_011 YTALHWACYNGHETCVELL----------LEQEVFQKTEGNAFSPLHCAVINDNEGAAEM
790 800 810 820 830
380 390 400 410 420
pF1KE4 L---LSAGALPNQDPVNC--LQIALRMGNYELISLLLRHGANVNYFCRVNPLHFPSALQY
: :.:. . : . :. : . : ..::: :.:.::
XP_011 LIDTLGASIVNATDSKGRTPLHAAAFTDHVECLQLLLSHNAQVNSVDSTGKTPLMMAAEN
840 850 860 870 880 890
430 440 450 460 470 480
pF1KE4 TLKDEVMLRMLLNYGYDTERCFDCPHGDKVHPSYTVEGWTSTVIKDTKFCEVITLSWLQH
XP_011 GQTNTVEMLVSSASAELTLQDNSKNTALHLACSKGHETSALLILEKITDRNLINATNAAL
900 910 920 930 940 950
587 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:23:23 2016 done: Sun Nov 6 03:23:24 2016
Total Scan time: 9.620 Total Display time: 0.150
Function used was FASTA [36.3.4 Apr, 2011]