Result of FASTA (omim) for
pFN21AE4140
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4140, 557 aa
1>>>pF1KE4140 557 - 557 aa - 557 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.6231+/-0.000423; mu= 5.3443+/- 0.027
mean_var=263.3897+/-52.845, 0's: 0 Z-trim(120.0): 102 B-trim: 57 in 1/52
Lambda= 0.079027
statistics sampled from 34608 (34714) to 34608 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.722), E-opt: 0.2 (0.407), width: 16
Scan time: 9.750
The best scores are: opt bits E(85289)
NP_005735 (OMIM: 605624) E3 ubiquitin-protein liga ( 557) 4005 470.2 7.7e-132
XP_011519741 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 465) 3130 370.3 7.4e-102
XP_011519740 (OMIM: 605624) PREDICTED: E3 ubiquiti ( 498) 2980 353.3 1.1e-96
XP_016861020 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 493) 1135 142.9 2.3e-33
NP_001304262 (OMIM: 605615) E3 ubiquitin-protein l ( 493) 1135 142.9 2.3e-33
XP_016861021 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 493) 1135 142.9 2.3e-33
NP_006312 (OMIM: 605615) E3 ubiquitin-protein liga ( 493) 1135 142.9 2.3e-33
XP_016861030 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 409) 1110 140.0 1.4e-32
XP_016861029 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 409) 1110 140.0 1.4e-32
XP_016861026 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32
XP_016861028 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32
XP_011531577 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32
XP_016861025 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32
XP_016861027 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 421) 1110 140.0 1.5e-32
NP_001304263 (OMIM: 605615) E3 ubiquitin-protein l ( 351) 1039 131.8 3.5e-30
XP_011531567 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17
XP_011531568 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17
XP_011531570 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17
XP_011531569 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 516) 676 90.6 1.3e-17
XP_011531575 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 432) 651 87.7 8.4e-17
XP_016861022 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17
XP_011531573 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17
XP_016861024 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17
XP_011531572 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17
XP_016861023 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 444) 651 87.7 8.6e-17
XP_011512731 (OMIM: 607489) PREDICTED: cullin-9 is (1834) 517 73.0 9e-12
XP_016866079 (OMIM: 607489) PREDICTED: cullin-9 is (1909) 517 73.1 9.2e-12
XP_011512729 (OMIM: 607489) PREDICTED: cullin-9 is (2095) 517 73.1 9.8e-12
XP_011512727 (OMIM: 607489) PREDICTED: cullin-9 is (2456) 517 73.2 1.1e-11
NP_055904 (OMIM: 607489) cullin-9 [Homo sapiens] (2517) 517 73.2 1.1e-11
XP_011512726 (OMIM: 607489) PREDICTED: cullin-9 is (2539) 517 73.2 1.1e-11
XP_011512725 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 517 73.2 1.1e-11
XP_011512724 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 517 73.2 1.1e-11
XP_016866078 (OMIM: 607489) PREDICTED: cullin-9 is (2566) 517 73.2 1.1e-11
XP_011512728 (OMIM: 607489) PREDICTED: cullin-9 is (2339) 493 70.4 7.1e-11
XP_011531578 (OMIM: 605615) PREDICTED: E3 ubiquiti ( 254) 286 45.8 0.0002
NP_001120833 (OMIM: 610872) E3 ubiquitin-protein l ( 587) 262 43.4 0.0023
XP_016868793 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 263 43.7 0.0026
XP_011515258 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 784) 263 43.7 0.0026
NP_001287755 (OMIM: 610872) E3 ubiquitin-protein l ( 731) 262 43.5 0.0027
XP_006710421 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 588) 260 43.2 0.0027
NP_056250 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 263 43.7 0.0027
NP_904355 (OMIM: 607119) E3 ubiquitin-protein liga ( 838) 263 43.7 0.0027
NP_001267468 (OMIM: 607119) E3 ubiquitin-protein l ( 838) 263 43.7 0.0027
XP_016868791 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 263 43.7 0.0027
XP_005250910 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 263 43.7 0.0027
XP_016868792 (OMIM: 607119) PREDICTED: E3 ubiquiti ( 838) 263 43.7 0.0027
XP_006710420 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 688) 260 43.3 0.003
XP_006710419 (OMIM: 610872) PREDICTED: E3 ubiquiti ( 732) 260 43.3 0.0032
NP_699172 (OMIM: 610872) E3 ubiquitin-protein liga ( 732) 260 43.3 0.0032
>>NP_005735 (OMIM: 605624) E3 ubiquitin-protein ligase A (557 aa)
initn: 4005 init1: 4005 opt: 4005 Z-score: 2487.9 bits: 470.2 E(85289): 7.7e-132
Smith-Waterman score: 4005; 100.0% identity (100.0% similar) in 557 aa overlap (1-557:1-557)
10 20 30 40 50 60
pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNTRSS
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 AQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 AQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILV
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 DDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 DDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRCKCG
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHM
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 VCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNR
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE4 YMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYVFAF
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE4 YLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 YLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLL
490 500 510 520 530 540
550
pF1KE4 QHVHEGYEKDLWEYIED
:::::::::::::::::
NP_005 QHVHEGYEKDLWEYIED
550
>>XP_011519741 (OMIM: 605624) PREDICTED: E3 ubiquitin-pr (465 aa)
initn: 3130 init1: 3130 opt: 3130 Z-score: 1949.7 bits: 370.3 E(85289): 7.4e-102
Smith-Waterman score: 3130; 99.8% identity (100.0% similar) in 433 aa overlap (125-557:33-465)
100 110 120 130 140 150
pF1KE4 QEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNL
.:::::::::::::::::::::::::::::
XP_011 PGGQRGHPVHIGYFQKYEFSDAKDRRAAAAKNPATITRILLSHFNWDKEKLMERYFDGNL
10 20 30 40 50 60
160 170 180 190 200 210
pF1KE4 EKLFAECHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EKLFAECHVINPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSE
70 80 90 100 110 120
220 230 240 250 260 270
pF1KE4 YLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLK
130 140 150 160 170 180
280 290 300 310 320 330
pF1KE4 WCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WCPAPDCHHVVKVQYPDAKPVRCKCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETS
190 200 210 220 230 240
340 350 360 370 380 390
pF1KE4 NWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNE
250 260 270 280 290 300
400 410 420 430 440 450
pF1KE4 DDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIE
310 320 330 340 350 360
460 470 480 490 500 510
pF1KE4 VQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDIS
370 380 390 400 410 420
520 530 540 550
pF1KE4 QDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED
:::::::::::::::::::::::::::::::::::::::::::
XP_011 QDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED
430 440 450 460
>>XP_011519740 (OMIM: 605624) PREDICTED: E3 ubiquitin-pr (498 aa)
initn: 2980 init1: 2980 opt: 2980 Z-score: 1856.9 bits: 353.3 E(85289): 1.1e-96
Smith-Waterman score: 2980; 100.0% identity (100.0% similar) in 410 aa overlap (148-557:89-498)
120 130 140 150 160 170
pF1KE4 REVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVINPSKKSRTRQMNT
::::::::::::::::::::::::::::::
XP_011 RRRITATRCSRPSRFYNTWWNVSGRSTRSSRYFDGNLEKLFAECHVINPSKKSRTRQMNT
60 70 80 90 100 110
180 190 200 210 220 230
pF1KE4 RSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCD
120 130 140 150 160 170
240 250 260 270 280 290
pF1KE4 ILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC
180 190 200 210 220 230
300 310 320 330 340 350
pF1KE4 KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGC
240 250 260 270 280 290
360 370 380 390 400 410
pF1KE4 NHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFY
300 310 320 330 340 350
420 430 440 450 460 470
pF1KE4 CNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNMSWIEVQFLKKAVDVLCQCRATLMYTYV
360 370 380 390 400 410
480 490 500 510 520 530
pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR
420 430 440 450 460 470
540 550
pF1KE4 VLLQHVHEGYEKDLWEYIED
::::::::::::::::::::
XP_011 VLLQHVHEGYEKDLWEYIED
480 490
>>XP_016861020 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (493 aa)
initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33
Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492)
10 20 30 40 50 60
pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
: .:: . : . ::::.:..:.: :..: :.. :..:
XP_016 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
..:. : :.:.. :: .. . : . .
XP_016 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL
60 70 80
130 140 150 160 170
pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS
:.. ......: .:.:. ....:: .: .:..: .: :::: .. .
XP_016 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT
90 100 110 120 130
180 190 200 210 220 230
pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL
: : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : .
XP_016 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K
. .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: .
XP_016 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN
:.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.::::
XP_016 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC
:: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..::::
XP_016 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF
320 330 340 350 360
420 430 440 450 460 470
pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV
.:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.:::
XP_016 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP
370 380 390 400 410 420
480 490 500 510 520 530
pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR
.:.:.... .. .:: .::.:: : :: .:: : : . ...... :.:::
XP_016 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR
430 440 450 460 470 480
540 550
pF1KE4 VLLQHVHEGYEKDLWEYIED
.::. :.
XP_016 TLLKDFHDT
490
>>NP_001304262 (OMIM: 605615) E3 ubiquitin-protein ligas (493 aa)
initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33
Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492)
10 20 30 40 50 60
pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
: .:: . : . ::::.:..:.: :..: :.. :..:
NP_001 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
..:. : :.:.. :: .. . : . .
NP_001 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL
60 70 80
130 140 150 160 170
pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS
:.. ......: .:.:. ....:: .: .:..: .: :::: .. .
NP_001 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT
90 100 110 120 130
180 190 200 210 220 230
pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL
: : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : .
NP_001 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K
. .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: .
NP_001 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN
:.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.::::
NP_001 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC
:: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..::::
NP_001 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF
320 330 340 350 360
420 430 440 450 460 470
pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV
.:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.:::
NP_001 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP
370 380 390 400 410 420
480 490 500 510 520 530
pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR
.:.:.... .. .:: .::.:: : :: .:: : : . ...... :.:::
NP_001 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR
430 440 450 460 470 480
540 550
pF1KE4 VLLQHVHEGYEKDLWEYIED
.::. :.
NP_001 TLLKDFHDT
490
>>XP_016861021 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (493 aa)
initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33
Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492)
10 20 30 40 50 60
pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
: .:: . : . ::::.:..:.: :..: :.. :..:
XP_016 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
..:. : :.:.. :: .. . : . .
XP_016 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL
60 70 80
130 140 150 160 170
pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS
:.. ......: .:.:. ....:: .: .:..: .: :::: .. .
XP_016 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT
90 100 110 120 130
180 190 200 210 220 230
pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL
: : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : .
XP_016 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K
. .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: .
XP_016 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN
:.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.::::
XP_016 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC
:: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..::::
XP_016 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF
320 330 340 350 360
420 430 440 450 460 470
pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV
.:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.:::
XP_016 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP
370 380 390 400 410 420
480 490 500 510 520 530
pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR
.:.:.... .. .:: .::.:: : :: .:: : : . ...... :.:::
XP_016 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR
430 440 450 460 470 480
540 550
pF1KE4 VLLQHVHEGYEKDLWEYIED
.::. :.
XP_016 TLLKDFHDT
490
>>NP_006312 (OMIM: 605615) E3 ubiquitin-protein ligase A (493 aa)
initn: 950 init1: 319 opt: 1135 Z-score: 720.1 bits: 142.9 E(85289): 2.3e-33
Smith-Waterman score: 1142; 33.0% identity (64.4% similar) in 537 aa overlap (12-545:11-492)
10 20 30 40 50 60
pF1KE4 MDSDEGYNYEFDEDEECSEEDSGAEEEEDEDDDEPDDDTLDLGEVELVEPGLGVGGERDG
: .:: . : . ::::.:..:.: :..: :.. :..:
NP_006 MSVDMNSQGSDSNEE--DYDPNCEEEEEEEEDDP-------GDIEDYYVGVASDVEQQG
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 LLCGETGGGGGSALGPGGGGGGGGGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREV
..:. : :.:.. :: .. . : . .
NP_006 ----------ADAFDP--------------------EEYQFTCLTYKESEGALNEHMTSL
60 70 80
130 140 150 160 170
pF1KE4 NEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRS
:.. ......: .:.:. ....:: .: .:..: .: :::: .. .
NP_006 ASVLKVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLLVEARVQPNPSK-------HVPT
90 100 110 120 130
180 190 200 210 220 230
pF1KE4 SAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDIL
: : .:. . . .: : :.:: .:: .. .. ....:.: .:: :. : .
NP_006 SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLR
140 150 160 170 180 190
240 250 260 270 280 290
pF1KE4 VDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-K
. .. :. :. . ... ::.. . ..:: . :. ::. :: :..:: : :. :.: .
NP_006 TPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNR
200 210 220 230 240 250
300 310 320 330 340 350
pF1KE4 CGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCN
:.. :::.: . .: :. : ..::. :: :::::.:.:.:.::.::::.. :::.::::
NP_006 CNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCN
260 270 280 290 300 310
360 370 380 390 400 410
pF1KE4 HMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYC
:: : ..:: .:::.::: :. ::: .:.:.::.:. . .. : ..: ::..::::
NP_006 HMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYF
320 330 340 350 360
420 430 440 450 460 470
pF1KE4 NRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYV
.:. :: .::..: . : ....:..: ..:. .::. :.:..:. .: .:: ::.:::
NP_006 ERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYP
370 380 390 400 410 420
480 490 500 510 520 530
pF1KE4 FAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRR
.:.:.... .. .:: .::.:: : :: .:: : : . ...... :.:::
NP_006 YAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYD-----RGDLENQMHIAEQRRR
430 440 450 460 470 480
540 550
pF1KE4 VLLQHVHEGYEKDLWEYIED
.::. :.
NP_006 TLLKDFHDT
490
>>XP_016861030 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (409 aa)
initn: 927 init1: 319 opt: 1110 Z-score: 705.7 bits: 140.0 E(85289): 1.4e-32
Smith-Waterman score: 1110; 36.7% identity (70.2% similar) in 420 aa overlap (129-545:5-408)
100 110 120 130 140 150
pF1KE4 YRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLF
......: .:.:. ....:: .: .:.
XP_016 MVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLL
10 20 30
160 170 180 190 200 210
pF1KE4 AECHVI-NPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLT
.: .: ::::. : : : .:. . . .: : :.:: .:: .. .
XP_016 VEARVQPNPSKHVPT-------SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCS
40 50 60 70 80
220 230 240 250 260 270
pF1KE4 TKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCP
. ....:.: .:: :. : . . .. :. :. . ... ::.. . ..:: . :. ::
XP_016 V-LVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCP
90 100 110 120 130 140
280 290 300 310 320 330
pF1KE4 APDCHHVVKVQYPDAKPVRC-KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNW
. :: :..:: : :. :.: .:.. :::.: . .: :. : ..::. :: :::::.:.
XP_016 GADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANY
150 160 170 180 190 200
340 350 360 370 380 390
pF1KE4 IAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDD
:.:.::.::::.. :::.:::::: : ..:: .:::.::: :. ::: .:.:.::.:.
XP_016 ISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENP
210 220 230 240 250 260
400 410 420 430 440 450
pF1KE4 AKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEV
. .. : ..: ::..:::: .:. :: .::..: . : ....:..: ..:. .::.
XP_016 DIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDW
270 280 290 300 310 320
460 470 480 490 500 510
pF1KE4 QFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQ
:.:..:. .: .:: ::.::: .:.:.... .. .:: .::.:: : :: .:: :
XP_016 QYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSY
330 340 350 360 370 380
520 530 540 550
pF1KE4 DSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED
: . ...... :.:::.::. :.
XP_016 D-----RGDLENQMHIAEQRRRTLLKDFHDT
390 400
>>XP_016861029 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (409 aa)
initn: 927 init1: 319 opt: 1110 Z-score: 705.7 bits: 140.0 E(85289): 1.4e-32
Smith-Waterman score: 1110; 36.7% identity (70.2% similar) in 420 aa overlap (129-545:5-408)
100 110 120 130 140 150
pF1KE4 YRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKEKLMERYFDGNLEKLF
......: .:.:. ....:: .: .:.
XP_016 MVSHSVAKLILVNFHWQVSEILDRY-KSNSAQLL
10 20 30
160 170 180 190 200 210
pF1KE4 AECHVI-NPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLECGHKFCMQCWSEYLT
.: .: ::::. : : : .:. . . .: : :.:: .:: .. .
XP_016 VEARVQPNPSKHVPT-------SHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCS
40 50 60 70 80
220 230 240 250 260 270
pF1KE4 TKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLITNSFVECNRLLKWCP
. ....:.: .:: :. : . . .. :. :. . ... ::.. . ..:: . :. ::
XP_016 V-LVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYLFRDYVESHYQLQLCP
90 100 110 120 130 140
280 290 300 310 320 330
pF1KE4 APDCHHVVKVQYPDAKPVRC-KCGRQFCFNCGENWHDPVKCKWLKKWIKKCDDDSETSNW
. :: :..:: : :. :.: .:.. :::.: . .: :. : ..::. :: :::::.:.
XP_016 GADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANY
150 160 170 180 190 200
340 350 360 370 380 390
pF1KE4 IAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEPHGSAWYNCNRYNEDD
:.:.::.::::.. :::.:::::: : ..:: .:::.::: :. ::: .:.:.::.:.
XP_016 ISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGDWKTHGSEYYECSRYKENP
210 220 230 240 250 260
400 410 420 430 440 450
pF1KE4 AKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQKMEEMQQHNM-SWIEV
. .. : ..: ::..:::: .:. :: .::..: . : ....:..: ..:. .::.
XP_016 DIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEKIQERVMNNLGTWIDW
270 280 290 300 310 320
460 470 480 490 500 510
pF1KE4 QFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLENATEVLSGYLERDISQ
:.:..:. .: .:: ::.::: .:.:.... .. .:: .::.:: : :: .:: :
XP_016 QYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSY
330 340 350 360 370 380
520 530 540 550
pF1KE4 DSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED
: . ...... :.:::.::. :.
XP_016 D-----RGDLENQMHIAEQRRRTLLKDFHDT
390 400
>>XP_016861026 (OMIM: 605615) PREDICTED: E3 ubiquitin-pr (421 aa)
initn: 927 init1: 319 opt: 1110 Z-score: 705.6 bits: 140.0 E(85289): 1.5e-32
Smith-Waterman score: 1111; 36.1% identity (69.2% similar) in 435 aa overlap (114-545:5-420)
90 100 110 120 130 140
pF1KE4 GGGGGGGPGHEQEEDYRYEVLTAEQILQHMVECIREVNEVIQNPATITRILLSHFNWDKE
. :: . : . ......: .:.:.
XP_016 MLTAISCILPMALVSH---SVAKLILVNFHWQVS
10 20 30
150 160 170 180 190 200
pF1KE4 KLMERYFDGNLEKLFAECHVI-NPSKKSRTRQMNTRSSAQDMPCQICYLNYPNSYFTGLE
....:: .: .:..: .: ::::. : : : .:. . . .:
XP_016 EILDRY-KSNSAQLLVEARVQPNPSKHVPT-------SHPPHHCAVCMQFVRKENLLSLA
40 50 60 70 80
210 220 230 240 250 260
pF1KE4 CGHKFCMQCWSEYLTTKIMEEGMGQTISCPAHGCDILVDDNTVMRLITDSKVKLKYQHLI
: :.:: .:: .. .. ....:.: .:: :. : . . .. :. :. . ... ::.. .
XP_016 CQHQFCRSCWEQHCSV-LVKDGVGVGVSCMAQDCPLRTPEDFVFPLLPNEELREKYRRYL
90 100 110 120 130 140
270 280 290 300 310 320
pF1KE4 TNSFVECNRLLKWCPAPDCHHVVKVQYPDAKPVRC-KCGRQFCFNCGENWHDPVKCKWLK
..:: . :. ::. :: :..:: : :. :.: .:.. :::.: . .: :. : ..
XP_016 FRDYVESHYQLQLCPGADCPMVIRVQEPRARRVQCNRCNEVFCFKCRQMYHAPTDCATIR
150 160 170 180 190 200
330 340 350 360 370 380
pF1KE4 KWIKKCDDDSETSNWIAANTKECPKCHVTIEKDGGCNHMVCRNQNCKAEFCWVCLGPWEP
::. :: :::::.:.:.:.::.::::.. :::.:::::: : ..:: .:::.::: :.
XP_016 KWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQC--SKCKHDFCWMCLGDWKT
210 220 230 240 250 260
390 400 410 420 430 440
pF1KE4 HGSAWYNCNRYNEDDAKAARDAQERSRAALQRYLFYCNRYMNHMQSLRFEHKLYAQVKQK
::: .:.:.::.:. . .. : ..: ::..:::: .:. :: .::..: . : ....:
XP_016 HGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYQRIHEK
270 280 290 300 310 320
450 460 470 480 490 500
pF1KE4 MEEMQQHNM-SWIEVQFLKKAVDVLCQCRATLMYTYVFAFYLKKNNQSIIFENNQADLEN
..: ..:. .::. :.:..:. .: .:: ::.::: .:.:.... .. .:: .::.::
XP_016 IQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEA
330 340 350 360 370 380
510 520 530 540 550
pF1KE4 ATEVLSGYLERDISQDSLQDIKQKVQDKYRYCESRRRVLLQHVHEGYEKDLWEYIED
: :: .:: : : . ...... :.:::.::. :.
XP_016 EIENLSWKVERADSYD-----RGDLENQMHIAEQRRRTLLKDFHDT
390 400 410 420
557 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:50:28 2016 done: Sun Nov 6 01:50:29 2016
Total Scan time: 9.750 Total Display time: 0.120
Function used was FASTA [36.3.4 Apr, 2011]