Result of FASTA (omim) for
pFN21AE4089
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4089, 453 aa
1>>>pF1KE4089 453 - 453 aa - 453 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4535+/-0.000483; mu= 12.5369+/- 0.030
mean_var=174.8247+/-36.931, 0's: 0 Z-trim(116.0): 565 B-trim: 678 in 1/51
Lambda= 0.097000
statistics sampled from 26147 (26848) to 26147 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.668), E-opt: 0.2 (0.315), width: 16
Scan time: 8.290
The best scores are: opt bits E(85289)
NP_543139 (OMIM: 615056) ankyrin repeat and SOCS b ( 453) 3078 443.6 5e-124
NP_543147 (OMIM: 603383,615054) ankyrin repeat and ( 452) 736 115.9 2.3e-25
NP_001135932 (OMIM: 603383,615054) ankyrin repeat ( 429) 602 97.1 9.9e-20
NP_001135931 (OMIM: 603383,615054) ankyrin repeat ( 467) 602 97.1 1e-19
NP_057200 (OMIM: 605761) ankyrin repeat and SOCS b ( 426) 562 91.5 4.8e-18
XP_016867792 (OMIM: 605761) PREDICTED: ankyrin rep ( 368) 552 90.0 1.1e-17
NP_665879 (OMIM: 605761) ankyrin repeat and SOCS b ( 349) 496 82.1 2.5e-15
NP_001183959 (OMIM: 610500) ankyrin repeat and KH ( 581) 320 57.8 9e-08
NP_060448 (OMIM: 610500) ankyrin repeat and KH dom ( 616) 320 57.8 9.4e-08
NP_078944 (OMIM: 610500) ankyrin repeat and KH dom ( 627) 320 57.8 9.5e-08
XP_016863506 (OMIM: 615929) PREDICTED: ankyrin rep (1116) 318 57.9 1.7e-07
XP_016863505 (OMIM: 615929) PREDICTED: ankyrin rep (1229) 318 57.9 1.8e-07
XP_016863504 (OMIM: 615929) PREDICTED: ankyrin rep (1367) 318 58.0 1.9e-07
XP_016863503 (OMIM: 615929) PREDICTED: ankyrin rep (1479) 318 58.0 2e-07
XP_005265730 (OMIM: 615929) PREDICTED: ankyrin rep (1480) 318 58.0 2e-07
XP_005265729 (OMIM: 615929) PREDICTED: ankyrin rep (1543) 318 58.0 2e-07
XP_016861518 (OMIM: 611122) PREDICTED: serine/thre ( 681) 312 56.8 2.2e-07
XP_016861517 (OMIM: 611122) PREDICTED: serine/thre ( 687) 312 56.8 2.2e-07
NP_060217 (OMIM: 610500) ankyrin repeat and KH dom (2542) 320 58.6 2.3e-07
XP_016863502 (OMIM: 615929) PREDICTED: ankyrin rep (2238) 318 58.2 2.6e-07
XP_016863501 (OMIM: 615929) PREDICTED: ankyrin rep (2239) 318 58.2 2.6e-07
NP_001182027 (OMIM: 611122) serine/threonine-prote ( 899) 312 56.9 2.6e-07
NP_001182028 (OMIM: 611122) serine/threonine-prote ( 899) 312 56.9 2.6e-07
XP_016861515 (OMIM: 611122) PREDICTED: serine/thre ( 899) 312 56.9 2.6e-07
XP_016861516 (OMIM: 611122) PREDICTED: serine/thre ( 899) 312 56.9 2.6e-07
XP_005265728 (OMIM: 615929) PREDICTED: ankyrin rep (2351) 318 58.3 2.6e-07
NP_942592 (OMIM: 615929) ankyrin repeat domain-con (2352) 318 58.3 2.6e-07
XP_016863500 (OMIM: 615929) PREDICTED: ankyrin rep (2489) 318 58.3 2.7e-07
NP_001273700 (OMIM: 615929) ankyrin repeat domain- (2490) 318 58.3 2.7e-07
XP_011531849 (OMIM: 611122) PREDICTED: serine/thre ( 997) 312 57.0 2.8e-07
XP_011531847 (OMIM: 611122) PREDICTED: serine/thre ( 997) 312 57.0 2.8e-07
XP_011531848 (OMIM: 611122) PREDICTED: serine/thre ( 997) 312 57.0 2.8e-07
XP_011531845 (OMIM: 611122) PREDICTED: serine/thre (1019) 312 57.0 2.8e-07
XP_011531844 (OMIM: 611122) PREDICTED: serine/thre (1025) 312 57.0 2.8e-07
NP_056389 (OMIM: 615929) ankyrin repeat domain-con (2602) 318 58.3 2.8e-07
XP_011531843 (OMIM: 611122) PREDICTED: serine/thre (1027) 312 57.0 2.8e-07
NP_115593 (OMIM: 615929) ankyrin repeat domain-con (2603) 318 58.3 2.8e-07
NP_056014 (OMIM: 611122) serine/threonine-protein (1053) 312 57.0 2.9e-07
XP_005265053 (OMIM: 611122) PREDICTED: serine/thre (1083) 312 57.0 2.9e-07
XP_011531842 (OMIM: 611122) PREDICTED: serine/thre (1086) 312 57.0 2.9e-07
NP_001306226 (OMIM: 615053) ankyrin repeat and SOC ( 288) 282 52.1 2.3e-06
NP_001306225 (OMIM: 615053) ankyrin repeat and SOC ( 288) 282 52.1 2.3e-06
NP_077000 (OMIM: 615053) ankyrin repeat and SOCS b ( 288) 282 52.1 2.3e-06
NP_001306228 (OMIM: 615053) ankyrin repeat and SOC ( 227) 274 50.8 4.4e-06
NP_001306227 (OMIM: 615053) ankyrin repeat and SOC ( 227) 274 50.8 4.4e-06
NP_004548 (OMIM: 164951) neurogenic locus notch ho (2003) 280 52.9 9.5e-06
NP_078977 (OMIM: 615055) ankyrin repeat and SOCS b ( 278) 262 49.3 1.6e-05
XP_011543762 (OMIM: 300890) PREDICTED: ankyrin rep ( 233) 245 46.8 7.4e-05
XP_011543760 (OMIM: 300890) PREDICTED: ankyrin rep ( 265) 245 46.9 8e-05
XP_016884773 (OMIM: 300890) PREDICTED: ankyrin rep ( 348) 245 47.0 9.5e-05
>>NP_543139 (OMIM: 615056) ankyrin repeat and SOCS box p (453 aa)
initn: 3078 init1: 3078 opt: 3078 Z-score: 2347.6 bits: 443.6 E(85289): 5e-124
Smith-Waterman score: 3078; 99.8% identity (100.0% similar) in 453 aa overlap (1-453:1-453)
10 20 30 40 50 60
pF1KE4 MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 MARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 VHHALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA
::.:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 VHQALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 RGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 RGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 HLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE4 SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 SQGETALNTACAGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLA
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE4 ELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 ELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCA
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE4 NFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_543 NFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVR
370 380 390 400 410 420
430 440 450
pF1KE4 ARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
:::::::::::::::::::::::::::::::::
NP_543 ARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
430 440 450
>>NP_543147 (OMIM: 603383,615054) ankyrin repeat and SOC (452 aa)
initn: 881 init1: 424 opt: 736 Z-score: 576.3 bits: 115.9 E(85289): 2.3e-25
Smith-Waterman score: 971; 40.5% identity (65.0% similar) in 432 aa overlap (32-452:20-451)
10 20 30 40 50 60
pF1KE4 ARETFPFTSSMLRSLRLQQEWLEWEDRRRAAAQQCRSRRCPSSPRARLTRPHRS-CRDPA
.: :: : : : . :: :.: :
NP_543 MPWGKNSSPHWGHHLGCLPSAPACRIWRPHSRPAWEPPRPSPLLCQDMA
10 20 30 40
70 80 90 100 110
pF1KE4 VHHALFSGNLQQVQALFQDEEAANMIVETVSNQLAWSAEQ-GFWVLTPKTKQTAPLAIAT
...::..:.: ..: :: . .:....:. . . ::..: :.: :: . . :.:: .:.
NP_543 LQNALYTGDLARLQELFPPHSTADLLLESRAAEPRWSSHQRGLWSLTYEEELTTPLHVAA
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 ARGYTDCARHLIRQGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTP
.::.:. : :.:. :. :. :::.::::::: .. ::..::. :: :. ..: :
NP_543 SRGHTEVLRLLLRRRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRP
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 LHLCTIPESLQCAKLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLR
:::: : .:.::.:::. :: :. . : .:::::::: : . . : :..:: :
NP_543 LHLCRGPGTLECAELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDAR
170 180 190 200 210 220
240 250 260 270 280 290
pF1KE4 TSQGETALNTAC-----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACAN
...: : : .:: . ... .. : :: ::::: :: . .. ::: ::
NP_543 NAEGWTPLLAACDVRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRR
230 240 250 260 270 280
300 310 320 330 340 350
pF1KE4 GCGGLAELLLRYGARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP-
: ....:::: :. :.. . .::::. ::::. . :: . :::..:: : :
NP_543 GHAAVVELLLSCGVSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPG
290 300 310 320 330 340
360 370 380 390 400 410
pF1KE4 ---EMLKHCANFPRALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQ
..:.. .. ::..:::.:.: : : : : :: ..:. :::: . .: :::.
NP_543 ALPKVLERWSTCPRTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRS
350 360 370 380 390 400
420 430 440 450
pF1KE4 LQHLARLAVRARLGSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
::::.: :.:..: . :. :::::: : :: : :: .
NP_543 LQHLSRCALRSHLEGSLPQALPRLPLPPRLLRYLQLDFEGVLY
410 420 430 440 450
>>NP_001135932 (OMIM: 603383,615054) ankyrin repeat and (429 aa)
initn: 768 init1: 410 opt: 602 Z-score: 475.2 bits: 97.1 E(85289): 9.9e-20
Smith-Waterman score: 721; 36.6% identity (58.8% similar) in 415 aa overlap (54-452:49-428)
30 40 50 60 70 80
pF1KE4 EWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVH--HALFSGNLQQVQALFQDEE
:. ::. .:...:.. :. .. :
NP_001 DRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSS
20 30 40 50 60 70
90 100 110 120 130
pF1KE4 ---AANMIVETVSNQLAWSAEQ------GFWVLTPKTKQTAPLAIATARGYTDCARHLIR
: . . .: :. : . .: :: . . :.:: .:..::.:. : :.:
NP_001 TGLAPDSVFDT-SDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLR
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE4 QGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA
. :. :. :::.::::::: .. ::..::. :: :. ..: ::::: : .:.::
NP_001 RRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECA
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE4 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-
.:::. :: :. . : .:::::::: : . . : :..:: :...: : : .::
NP_001 ELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACD
200 210 220 230 240 250
260 270 280 290 300
pF1KE4 ----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYG
. ... .. : :: ::::: :: . .. ::: :: : ....:::: :
NP_001 VRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCG
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE4 ARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKHCANFPRALE
. :.. . .::::. ::::. . :: . :::..:: ::
NP_001 VSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGA--VR---------------
320 330 340 350 360
370 380 390 400 410 420
pF1KE4 VLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRC
.: ..:: :.:. :::: . .: :::.::::.: :.:..: .
NP_001 -------------VW-PGALP---KKHQRFYSSLFALVRQPRSLQHLSRCALRSHLEGSL
370 380 390 400
430 440 450
pF1KE4 RQGATRLPLPPLLRDYLLLRVEGCIQ
:. :::::: : :: : :: .
NP_001 PQALPRLPLPPRLLRYLQLDFEGVLY
410 420
>>NP_001135931 (OMIM: 603383,615054) ankyrin repeat and (467 aa)
initn: 867 init1: 410 opt: 602 Z-score: 474.8 bits: 97.1 E(85289): 1e-19
Smith-Waterman score: 841; 38.7% identity (62.5% similar) in 419 aa overlap (54-452:49-466)
30 40 50 60 70 80
pF1KE4 EWEDRRRAAAQQCRSRRCPSSPRARLTRPHRSCRDPAVH--HALFSGNLQQVQALFQDEE
:. ::. .:...:.. :. .. :
NP_001 DRHPLCARLVEKPSRGSEEHLKSGPGPIVTRTASGPALAFWQAVLAGDVGCVSRILADSS
20 30 40 50 60 70
90 100 110 120 130
pF1KE4 ---AANMIVETVSNQLAWSAEQ------GFWVLTPKTKQTAPLAIATARGYTDCARHLIR
: . . .: :. : . .: :: . . :.:: .:..::.:. : :.:
NP_001 TGLAPDSVFDT-SDPERWRDFRFNIRALRLWSLTYEEELTTPLHVAASRGHTEVLRLLLR
80 90 100 110 120 130
140 150 160 170 180 190
pF1KE4 QGAELDARVGGRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCA
. :. :. :::.::::::: .. ::..::. :: :. ..: ::::: : .:.::
NP_001 RRARPDSAPGGRTALHEACAAGHTACVHVLLVAGADPNIADQDGKRPLHLCRGPGTLECA
140 150 160 170 180 190
200 210 220 230 240 250
pF1KE4 KLLLEAGATVNLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTAC-
.:::. :: :. . : .:::::::: : . . : :..:: :...: : : .::
NP_001 ELLLRFGARVDGRSEEEEETPLHVAARLGHVELADLLLRRGACPDARNAEGWTPLLAACD
200 210 220 230 240 250
260 270 280 290 300
pF1KE4 ----AGAEGPGSCRRHQAAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYG
. ... .. : :: ::::: :: . .. ::: :: : ....:::: :
NP_001 VRCQSITDAEATTARCLQLCSLLLSAGADADAADQDKQRPLHLACRRGHAAVVELLLSCG
260 270 280 290 300 310
310 320 330 340 350 360
pF1KE4 ARAEVPNGAGHTPMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFP
. :.. . .::::. ::::. . :: . :::..:: : : ..:.. .. :
NP_001 VSANTMDYGGHTPLHCALQGPAAALAQSPEHVVRALLNHGAVRVWPGALPKVLERWSTCP
320 330 340 350 360 370
370 380 390 400 410 420
pF1KE4 RALEVLLNAYPCVPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARL
:..:::.:.: : : : : :: ..:. :::: . .: :::.::::.: :.:..:
NP_001 RTIEVLMNTYSVVQLPEEAVGLVTPETLQKHQRFYSSLFALVRQPRSLQHLSRCALRSHL
380 390 400 410 420 430
430 440 450
pF1KE4 GSRCRQGATRLPLPPLLRDYLLLRVEGCIQ
. :. :::::: : :: : :: .
NP_001 EGSLPQALPRLPLPPRLLRYLQLDFEGVLY
440 450 460
>>NP_057200 (OMIM: 605761) ankyrin repeat and SOCS box p (426 aa)
initn: 599 init1: 221 opt: 562 Z-score: 445.0 bits: 91.5 E(85289): 4.8e-18
Smith-Waterman score: 687; 33.5% identity (62.5% similar) in 403 aa overlap (64-452:24-425)
40 50 60 70 80 90
pF1KE4 QQCRSRRCPSSPRARLTRPHRSCRDPAVHHALFSGNLQQVQA-LFQDEEAANMIVETVS-
:: :... ...: :.: . .. . :. .
NP_057 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDE
10 20 30 40 50
100 110 120 130 140
pF1KE4 NQLAWSAEQGFWVLTPKTKQT--APLAIATARGYTDCARHLIRQGAELDARVGGRAALHE
:.. : .::.:. . : :.. . : ... :...: :. ..: .. : .:.. ::
NP_057 NMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHV
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE4 ACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG-E
:: :. :::..: ::: : . : : ::.:: : :. ::: :. ::.::. .. .
NP_057 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE4 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGA---EGPGSCRRHQA
..:::::.:: :: . ::.:.:::: : ... :: : : : . .:.
NP_057 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHL
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE4 AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCAL
. : ::. :.. : ..:::.: : : ...:. ::.:.. . : . .. .:
NP_057 VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE4 QAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFPRALEVLLNAYPCVPSCET
.... : .::. . ::..:: . : .... : . :.:.::..::: .
NP_057 KVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNTK
300 310 320 330 340 350
390 400 410 420 430
pF1KE4 WVEAVLPELWKEHEAFYSS--ALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPL
: .:. . ... :: : ..: :.:: :.::.: :.: : .::... : ::
NP_057 WRRAIPDDDLEKYWDFYHSLFTVC-CNSPRTLMHLSRCAIRRTLHNRCHRAIPLLSLPLS
360 370 380 390 400 410
440 450
pF1KE4 LRDYLLLRVEGCIQ
:. ::::. :: :
NP_057 LKKYLLLEPEGIIY
420
>>XP_016867792 (OMIM: 605761) PREDICTED: ankyrin repeat (368 aa)
initn: 482 init1: 221 opt: 552 Z-score: 438.2 bits: 90.0 E(85289): 1.1e-17
Smith-Waterman score: 552; 32.7% identity (62.5% similar) in 336 aa overlap (64-386:24-358)
40 50 60 70 80 90
pF1KE4 QQCRSRRCPSSPRARLTRPHRSCRDPAVHHALFSGNLQQVQA-LFQDEEAANMIVETVS-
:: :... ...: :.: . .. . :. .
XP_016 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDE
10 20 30 40 50
100 110 120 130 140
pF1KE4 NQLAWSAEQGFWVLTPKTKQT--APLAIATARGYTDCARHLIRQGAELDARVGGRAALHE
:.. : .::.:. . : :.. . : ... :...: :. ..: .. : .:.. ::
XP_016 NMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHV
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE4 ACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG-E
:: :. :::..: ::: : . : : ::.:: : :. ::: :. ::.::. .. .
XP_016 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE4 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGA----EGPGSCRRHQ
..:::::.:: :: . ::.:.:::: : ... :: : : : : : . :.
XP_016 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTE-HH
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE4 AAARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCA
. : ::. :.. : ..:::.: : : ...:. ::.:.. . : . .. .
XP_016 LVCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYV
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE4 LQAVQDSPNWEPEVLFAALLDYGAQPVRP----EMLKHCANFPRALEVLLNAYPCVPSCE
:.... : .::. . ::..:: . : .... : . :.:.::..::: .
XP_016 LKVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVIQACHSCPKAIEVVVNAYEHIRWNT
300 310 320 330 340 350
390 400 410 420 430 440
pF1KE4 TWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLL
: .:.
XP_016 KWRRAIPDDDLEGIRK
360
>>NP_665879 (OMIM: 605761) ankyrin repeat and SOCS box p (349 aa)
initn: 431 init1: 221 opt: 496 Z-score: 396.1 bits: 82.1 E(85289): 2.5e-15
Smith-Waterman score: 496; 31.6% identity (61.6% similar) in 320 aa overlap (64-372:24-343)
40 50 60 70 80 90
pF1KE4 QQCRSRRCPSSPRARLTRPHRSCRDPAVHHALFSGNLQQVQA-LFQDEEAANMIVETVS-
:: :... ...: :.: . .. . :. .
NP_665 MDGTTAPVTKSGAAKLVKRNFLEALKSNDFGKLKAILIQRQIDVDTVFEVEDE
10 20 30 40 50
100 110 120 130 140
pF1KE4 NQLAWSAEQGFWVLTPKTKQT--APLAIATARGYTDCARHLIRQGAELDARVGGRAALHE
:.. : .::.:. . : :.. . : ... :...: :. ..: .. : .:.. ::
NP_665 NMVLASYKQGYWLPSYKLKSSWATGLHLSVLFGHVECLLVLLDHNATINCRPNGKTPLHV
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE4 ACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATVNLAAG-E
:: :. :::..: ::: : . : : ::.:: : :. ::: :. ::.::. .. .
NP_665 ACEMANVDCVKILCDRGAKLNCYSLSGHTALHFCTTPSSILCAKQLVWRGANVNMKTNNQ
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE4 SQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGA---EGPGSCRRHQA
..:::::.:: :: . ::.:.:::: : ... :: : : : . .:.
NP_665 DEETPLHTAAHFGLSELVAFYVEHGAIVDSVNAHMETPLAIAAYWALRFKEQEYSTEHHL
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE4 AARRLLEAGADARAAGRKRHTPLHNACANGCGGLAELLLRYGARAEVPNGAGHTPMDCAL
. : ::. :.. : ..:::.: : : ...:. ::.:.. . : . .. .:
NP_665 VCRMLLDYKAEVNARDDDFKSPLHKAAWNCDHVLMHMMLEAGAEANLMDINGCAAIQYVL
240 250 260 270 280 290
330 340 350 360 370 380
pF1KE4 QAVQDSPNWEPEVLFAALLDYGAQPVRPEMLKH---CANFPRALEVLLNAYPCVPSCETW
.... : .::. . ::..:: . : .... : : .. . :
NP_665 KVTSVRPAAQPEICYQLLLNHGAARIYPPQFHKVRLCPVVSRLRKIQMAALSEISK
300 310 320 330 340
390 400 410 420 430 440
pF1KE4 VEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLPLPPLLRD
>>NP_001183959 (OMIM: 610500) ankyrin repeat and KH doma (581 aa)
initn: 368 init1: 198 opt: 320 Z-score: 260.5 bits: 57.8 E(85289): 9e-08
Smith-Waterman score: 335; 31.1% identity (59.2% similar) in 267 aa overlap (114-372:275-527)
90 100 110 120 130 140
pF1KE4 NMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-
:: :.. :: : .. :. . :..... .
NP_001 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT
250 260 270 280 290 300
150 160 170 180 190 200
pF1KE4 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV
: .:: ::: . : :..::. ::. . .:.: ::: . .. :..::. :: .
NP_001 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE4 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR
: ..: .:. : .: .: . : . :: ::: .:.. .::: :: .:
NP_001 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEAC--MDG------
370 380 390 400 410
270 280 290 300 310
pF1KE4 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGG---LAELLLRYGARAEVPNGAGHT
: .:: ::..::.. . . ..:: : .::: :: ::.. :: : : :.:
NP_001 HVEVARLLLDSGAQVNMPADSFESPLTLA---ACGGHVELAALLIERGANLEEVNDEGYT
420 430 440 450 460 470
320 330 340 350 360 370
pF1KE4 PMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPE----MLKHCANFPRALEVLLNAYPC
:. ..:.... . .:.: . .:: . . : :..: .. . :..:
NP_001 PL---MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD
480 490 500 510 520 530
380 390 400 410 420 430
pF1KE4 VPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLP
NP_001 IELGCSTPLMEASQEGHLELVKYLLASGQAGGHEDYFGGHRSGQASGEGGL
540 550 560 570 580
>>NP_060448 (OMIM: 610500) ankyrin repeat and KH domain- (616 aa)
initn: 368 init1: 198 opt: 320 Z-score: 260.2 bits: 57.8 E(85289): 9.4e-08
Smith-Waterman score: 335; 31.1% identity (59.2% similar) in 267 aa overlap (114-372:264-516)
90 100 110 120 130 140
pF1KE4 NMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-
:: :.. :: : .. :. . :..... .
NP_060 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT
240 250 260 270 280 290
150 160 170 180 190 200
pF1KE4 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV
: .:: ::: . : :..::. ::. . .:.: ::: . .. :..::. :: .
NP_060 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI
300 310 320 330 340 350
210 220 230 240 250 260
pF1KE4 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR
: ..: .:. : .: .: . : . :: ::: .:.. .::: :: .:
NP_060 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEAC--MDG------
360 370 380 390 400
270 280 290 300 310
pF1KE4 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGG---LAELLLRYGARAEVPNGAGHT
: .:: ::..::.. . . ..:: : .::: :: ::.. :: : : :.:
NP_060 HVEVARLLLDSGAQVNMPADSFESPLTLA---ACGGHVELAALLIERGANLEEVNDEGYT
410 420 430 440 450 460
320 330 340 350 360 370
pF1KE4 PMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPE----MLKHCANFPRALEVLLNAYPC
:. ..:.... . .:.: . .:: . . : :..: .. . :..:
NP_060 PL---MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD
470 480 490 500 510
380 390 400 410 420 430
pF1KE4 VPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLP
NP_060 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA
520 530 540 550 560 570
>>NP_078944 (OMIM: 610500) ankyrin repeat and KH domain- (627 aa)
initn: 368 init1: 198 opt: 320 Z-score: 260.1 bits: 57.8 E(85289): 9.5e-08
Smith-Waterman score: 335; 31.1% identity (59.2% similar) in 267 aa overlap (114-372:275-527)
90 100 110 120 130 140
pF1KE4 NMIVETVSNQLAWSAEQGFWVLTPKTKQTAPLAIATARGYTDCARHLIRQGAELDARVG-
:: :.. :: : .. :. . :..... .
NP_078 ACSAGYYELAQVLLAMHANVEDRGNKGDITPLMAASSGGYLDIVKLLLLHDADVNSQSAT
250 260 270 280 290 300
150 160 170 180 190 200
pF1KE4 GRAALHEACARAQFDCVRLLLTFGAKANVLTEEGTTPLHLCTIPESLQCAKLLLEAGATV
: .:: ::: . : :..::. ::. . .:.: ::: . .. :..::. :: .
NP_078 GNTALTYACAGGFVDIVKVLLNEGANIEDHNENGHTPLMEAASAGHVEVARVLLDHGAGI
310 320 330 340 350 360
210 220 230 240 250 260
pF1KE4 NLAAGESQETPLHVAAARGLEQHVALYLEHGADVGLRTSQGETALNTACAGAEGPGSCRR
: ..: .:. : .: .: . : . :: ::: .:.. .::: :: .:
NP_078 NTHSNEFKESALTLACYKGHLDMVRFLLEAGADQEHKTDEMHTALMEAC--MDG------
370 380 390 400 410
270 280 290 300 310
pF1KE4 HQAAARRLLEAGADARAAGRKRHTPLHNACANGCGG---LAELLLRYGARAEVPNGAGHT
: .:: ::..::.. . . ..:: : .::: :: ::.. :: : : :.:
NP_078 HVEVARLLLDSGAQVNMPADSFESPLTLA---ACGGHVELAALLIERGANLEEVNDEGYT
420 430 440 450 460 470
320 330 340 350 360 370
pF1KE4 PMDCALQAVQDSPNWEPEVLFAALLDYGAQPVRPE----MLKHCANFPRALEVLLNAYPC
:. ..:.... . .:.: . .:: . . : :..: .. . :..:
NP_078 PL---MEAAREGHEEMVALLLAQGANINAQTEETQETALTLACCGGFSEVADFLIKAGAD
480 490 500 510 520 530
380 390 400 410 420 430
pF1KE4 VPSCETWVEAVLPELWKEHEAFYSSALCMVNQPRQLQHLARLAVRARLGSRCRQGATRLP
NP_078 IELGCSTPLMEASQEGHLELVKYLLASGANVHATTATGDTALTYACENGHTDVADVLLQA
540 550 560 570 580 590
453 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:16:10 2016 done: Mon Nov 7 15:16:12 2016
Total Scan time: 8.290 Total Display time: 0.070
Function used was FASTA [36.3.4 Apr, 2011]