Result of FASTA (omim) for
pFN21AE4086
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4086, 449 aa
1>>>pF1KE4086 449 - 449 aa - 449 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.4343+/-0.000411; mu= 14.3093+/- 0.026
mean_var=181.4950+/-38.862, 0's: 0 Z-trim(117.3): 231 B-trim: 1307 in 1/51
Lambda= 0.095201
statistics sampled from 28855 (29178) to 28855 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.711), E-opt: 0.2 (0.342), width: 16
Scan time: 8.640
The best scores are: opt bits E(85289)
NP_065091 (OMIM: 606124) tripartite motif-containi ( 452) 1348 197.8 5e-50
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 910 137.6 6.6e-32
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 906 137.1 9.6e-32
NP_003132 (OMIM: 109092) E3 ubiquitin-protein liga ( 475) 888 134.6 5.4e-31
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 781 119.9 1.4e-26
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 781 119.9 1.4e-26
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 781 119.9 1.4e-26
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 781 119.9 1.4e-26
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 781 119.9 1.4e-26
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 702 109.1 2.6e-23
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 694 108.0 5.7e-23
XP_016873516 (OMIM: 606124) PREDICTED: tripartite ( 375) 607 95.9 1.9e-19
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 565 90.3 1.2e-17
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 565 90.3 1.2e-17
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 502 81.4 4e-15
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 500 81.4 6e-15
XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 479 78.1 3e-14
XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 479 78.1 3e-14
NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 450 74.5 7e-13
NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 450 74.5 7e-13
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 450 74.5 7.1e-13
NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 445 73.8 1.1e-12
XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 445 73.8 1.1e-12
NP_001291425 (OMIM: 613184) E3 ubiquitin-protein l ( 262) 441 72.9 1.1e-12
NP_001008275 (OMIM: 613288) tripartite motif-conta ( 477) 439 73.0 2e-12
NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 434 72.3 3.2e-12
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 429 71.6 5.4e-12
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 429 71.6 5.4e-12
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 420 70.4 1.2e-11
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 420 70.4 1.3e-11
XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 412 69.3 2.6e-11
NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 412 69.3 2.6e-11
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 410 68.9 2.8e-11
XP_016873951 (OMIM: 608487) PREDICTED: tripartite ( 300) 408 68.5 2.8e-11
NP_149084 (OMIM: 608487) tripartite motif-containi ( 326) 408 68.5 3e-11
XP_005253241 (OMIM: 608487) PREDICTED: tripartite ( 326) 408 68.5 3e-11
NP_149083 (OMIM: 608487) tripartite motif-containi ( 347) 408 68.5 3.1e-11
NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 401 67.6 6.6e-11
NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 401 67.8 7.4e-11
XP_011512567 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 421) 397 67.1 1e-10
NP_008959 (OMIM: 609316) E3 ubiquitin-protein liga ( 425) 397 67.1 1e-10
XP_016873950 (OMIM: 608487) PREDICTED: tripartite ( 310) 393 66.4 1.2e-10
XP_011518728 (OMIM: 608487) PREDICTED: tripartite ( 310) 393 66.4 1.2e-10
XP_016873952 (OMIM: 608487) PREDICTED: tripartite ( 265) 391 66.0 1.3e-10
XP_006718421 (OMIM: 608487) PREDICTED: tripartite ( 265) 391 66.0 1.3e-10
XP_011518729 (OMIM: 608487) PREDICTED: tripartite ( 271) 381 64.7 3.5e-10
XP_011512566 (OMIM: 609316) PREDICTED: E3 ubiquiti ( 424) 381 64.9 4.6e-10
NP_569074 (OMIM: 605684) tripartite motif-containi ( 270) 378 64.3 4.6e-10
XP_011512527 (OMIM: 605701) PREDICTED: tripartite ( 413) 376 64.2 7.3e-10
XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 373 63.6 7.9e-10
>>NP_065091 (OMIM: 606124) tripartite motif-containing p (452 aa)
initn: 1314 init1: 794 opt: 1348 Z-score: 1019.1 bits: 197.8 E(85289): 5e-50
Smith-Waterman score: 1348; 46.9% identity (71.4% similar) in 448 aa overlap (1-445:1-448)
10 20 30 40 50 60
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKTSE
:.: :::::.:::: .:.:::::::::::::::::::. : .. ..: : :..:
NP_065 MNSGILQVFQGELICPLCMNYFIDPVTIDCGHSFCRPCFYLNWQDIPFLVQCSECTKSTE
10 20 30 40 50 60
70 80 90 100 110
pF1KE4 KPNFNTNLVLKKLSSLARQTRPQN-INSSDNICVLHEETKELFCEADKRLLCGPCSESPE
. :..::. :::..::::.. ..: ...: :.:::..:::.:. ::: :: : :
NP_065 QINLKTNIHLKKMASLARKVSLWLFLSSEEQMCGTHRETKKIFCEVDRSLLCLLCSSSQE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 HMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYVSVRKRIIT
: : : :: ::::: ::::...:. ::: :.. ::: ::. . ::::..: . :
NP_065 HRYHRHRPIEWAAEEHREKLLQKMQSLWEKACENHRNLNVETTRTRCWKDYVNLRLEAIR
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 IQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRELWETCHMP
.::::: : :::...:. :.....:.:..:. :...:....: .. ::.:: : :: :
NP_065 AEYQKMPAFHHEEEKHNLEMLKKKGKEIFHRLHLSKAKMAHRMEILRGMYEELNEMCHKP
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE4 DVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWCITGVLDMLNNFRVDSALSTEMIPCYI
:: ::: .. :.. . .. :::.::::.. :::. : ::.::: .: : :
NP_065 DVELLQAFGDILHRSESVLLHMPQPLNPELSAGPITGLRDRLNQFRVHITLHHEEANNDI
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE4 SLSEDVRYVIFGDDHLSAPTDPQGVDSFAVWGAQAFTSGKHYWEVDVTLSSNWILGVCRD
: : .: . .: :: ..: :: .::.:.:::::.:::: : : :: .:::
NP_065 FLYEILRSMCIGCDHQDVPYFTATPRSFLAWGVQTFTSGKYYWEVHVGDSWNWAFGVCNM
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE4 SRTA-DANFVIDSDERFFLISSKRSN-HYSLSTNSPPLIQYVQRPLGRVGVFLDYDNGSV
: . : ::. .::.. ... . :: :.:: ..::. .: .:::.::: . .:
NP_065 YRKEKNQNEKIDGKAGLFLLGCVKNDIQCSLFTTSPLMLQYIPKPTSRVGLFLDCEAKTV
370 380 390 400 410 420
420 430 440
pF1KE4 SFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
:: ::...:::: .: ::: ::::.::
NP_065 SFVDVNQSSLIYTIPNCSFSPPLRPIFCCIHF
430 440 450
>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa)
initn: 815 init1: 301 opt: 910 Z-score: 693.9 bits: 137.6 E(85289): 6.6e-32
Smith-Waterman score: 910; 34.0% identity (61.3% similar) in 447 aa overlap (1-444:1-442)
10 20 30 40 50
pF1KE4 MDSDDLQV-FQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKTS
: . ::.. .:.: : ::..:: ::: ::::.::: :. : . ..:. :: ::. :
NP_660 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 EKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLCGPCSESPE
. :. : : :.. .::. .: . ...: :.: :: . ::::. : .: :
NP_660 PQRNLRPNRPLAKMAEMARRLHPPS-PVPQGVCPAHREPLAAFCGDELRLLCAACERSGE
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 HMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYVSVRKRIIT
: :: :. :::. . :: : ...: . :.. : : . .: ... .
NP_660 HWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETCVLWQKMVESQRQNVL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 IQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRELWETCHMP
..... .: ::::. :: ::.: :.. .:... ... :. .. .. :: :..:
NP_660 GEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 DVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLNNFRVDSALSTEMIPCY
. ::::.... :.. ...: :. : :: . : . :... : :: : .:. .
NP_660 ALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPE
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 ISLSEDVRYVIFGDDHLSAPTDPQGVD-SFAVWGAQAFTSGKHYWEVDVTLSSNWILGVC
. :::: : : :: . . : .:. : . : : . ::::.:::::.: ..: ::::
NP_660 LILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVC
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 RDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQRPLGRVGVFLDYDNGSV
:.. . . ... . :... : . : :: . : :::.::::. : .
NP_660 RENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPL----RDPPRRVGIFLDYEAGHL
360 370 380 390 400 410
420 430 440
pF1KE4 SFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
::.... :::.. :: ::. :::.:
NP_660 SFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
420 430 440 450 460
>>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa)
initn: 557 init1: 259 opt: 906 Z-score: 690.9 bits: 137.1 E(85289): 9.6e-32
Smith-Waterman score: 906; 34.2% identity (61.5% similar) in 447 aa overlap (1-444:1-441)
10 20 30 40 50
pF1KE4 MDSDDLQV-FQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKTS
: . ::.. .:.: : ::..:: ::: ::::.::: :. : . ..:. :: ::. :
XP_016 MAAPDLSTNLQEEATCAICLDYFTDPVMTDCGHNFCRECIRRCWGQPEGPYACPECRELS
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 EKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLCGPCSESPE
. :. : : :.. .::. .: . ...: :.: :: . ::::. : .: :
XP_016 PQRNLRPNRPLAKMAEMARRLHPPS-PVPQGVCPAHREPLAAFCGDELRLLCAACERSGE
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 HMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYVSVRKRIIT
: :: :. :::. . :: : ...: . :.. : : : ..: ... .
XP_016 HWAHRVRPLQDAAEDLKAKLEKSLEHLRKQMQDALLFQAQADETC-VLWQMVESQRQNVL
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 IQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRELWETCHMP
..... .: ::::. :: ::.: :.. .:... ... :. .. .. :: :..:
XP_016 GEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSAHLAELIAELEGRCQLP
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 DVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLNNFRVDSALSTEMIPCY
. ::::.... :.. ...: :. : :: . : . :... : :: : .:. .
XP_016 ALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLRRFRGDVTLDPDTANPE
240 250 260 270 280 290
300 310 320 330 340 350
pF1KE4 ISLSEDVRYVIFGDDHLSAPTDPQGVD-SFAVWGAQAFTSGKHYWEVDVTLSSNWILGVC
. :::: : : :: . . : .:. : . : : . ::::.:::::.: ..: ::::
XP_016 LILSEDRRSVQRGDLRQALPDSPERFDPGPCVLGQERFTSGRHYWEVEVGDRTSWALGVC
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE4 RDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQRPLGRVGVFLDYDNGSV
:.. . . ... . :... : . : :: . : :::.::::. : .
XP_016 RENVNRKEKGELSAGNGFWILVFLGSYYNSSERALAPL----RDPPRRVGIFLDYEAGHL
360 370 380 390 400 410
420 430 440
pF1KE4 SFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
::.... :::.. :: ::. :::.:
XP_016 SFYSATDGSLLFIFPEIPFSGTLRPLFSPLSSSPTPMTICRPKGGSGDTLAPQ
420 430 440 450 460
>>NP_003132 (OMIM: 109092) E3 ubiquitin-protein ligase T (475 aa)
initn: 656 init1: 276 opt: 888 Z-score: 677.4 bits: 134.6 E(85289): 5.4e-31
Smith-Waterman score: 888; 36.0% identity (63.1% similar) in 453 aa overlap (6-447:7-449)
10 20 30 40 50
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAPMRCPSCRKT-
: .. .:. : ::.. :..::.:.::::::. :. .. : . :: ::.
NP_003 MASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKGGGSV--CPVCRQRF
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 ---SEKPNFN-TNLV--LKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLCG
. .:: . .:.: ::..:. ::. ... . :..: : .:::: : . ::
NP_003 LLKNLRPNRQLANMVNNLKEISQEARE------GTQGERCAVHGERLHLFCEKDGKALCW
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE4 PCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHS-LKDYV
:..: .: :. :. ::.: .::: . : . .:: ..:. : . .. : :
NP_003 VCAQSRKHRDHAMVPLEEAAQEYQEKLQVALGELRR-KQELAEKLEVEIAIKRADWKKTV
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 SVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRE
..: : .. .. :: :::::.:: ::.. .: .. : .......:. . .... :
NP_003 ETQKSRIHAEFVQQKNFLVEEEQRQLQELEKDEREQLRILGEKEAKLAQQSQALQELISE
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE4 LWETCHMPDVVLLQDVRNVSARTDLAQMQKPQPVNPELTSWC-ITGVLDMLNNFRVDSAL
: . :: . :::.: : :.. ... . ..::: : : . :. :: . : .:
NP_003 LDRRCHSSALELLQEVIIVLERSESWNLKDLDITSPELRSVCHVPGLKKMLRTCAVHITL
240 250 260 270 280 290
300 310 320 330 340
pF1KE4 STEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGVDSFA-VWGAQAFTSGKHYWEVDVTLS
. . .. :::: : : .:: . : : . . ::. : ::: : ::::::::::: .
NP_003 DPDTANPWLILSEDRRQVRLGDTQQSIPGNEERFDSYPMVLGAQHFHSGKHYWEVDVTGK
300 310 320 330 340 350
350 360 370 380 390 400
pF1KE4 SNWILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQYVQRPLGRVGVF
: ::::::: ..:...: :. : ...: .: : ..: : .::.:
NP_003 EAWDLGVCRDSVRRKGHFLLSSKSGFWTIWLWNKQKYEAGTY-PQTPLHLQVPPCQVGIF
360 370 380 390 400 410
410 420 430 440
pF1KE4 LDYDNGSVSFFDVS-KGSLIYGFPPSSFSSPLRPFFCFGCT
:::. : :::.... .:::::.: .:..:::::: :
NP_003 LDYEAGMVSFYNITDHGSLIYSFSECAFTGPLRPFFSPGFNDGGKNTAPLTLCPLNIGSQ
420 430 440 450 460 470
NP_003 GSTDY
>>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26
Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459)
10 20 30 40 50
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M
.:.: : ::..:: ::: :::.::: :. : :..:. .
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL
:: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. .
XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY
: : :: :: : : :.. . :: ..:.:: : .: : .: ... .
XP_011 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR
:. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. .
XP_011 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL
180 190 200 210 220 230
240 250 260 270 280
pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV
.: : . . .:::... .: . ...: :. :. :. . : . : ...: .:
XP_011 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330
pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK
: . .. :. : :. . .: :.: . .: : :... : ::.::.
XP_011 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ
::::: ...... : ::::::. . .. :.... .....: ::: :
XP_011 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV
360 370 380 390 400
400 410 420 430 440
pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.:
XP_011 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS
410 420 430 440 450 460
XP_011 TVTMWVKG
470
>>XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26
Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459)
10 20 30 40 50
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M
.:.: : ::..:: ::: :::.::: :. : :..:. .
XP_006 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL
:: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. .
XP_006 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY
: : :: :: : : :.. . :: ..:.:: : .: : .: ... .
XP_006 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR
:. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. .
XP_006 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL
180 190 200 210 220 230
240 250 260 270 280
pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV
.: : . . .:::... .: . ...: :. :. :. . : . : ...: .:
XP_006 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330
pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK
: . .. :. : :. . .: :.: . .: : :... : ::.::.
XP_006 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ
::::: ...... : ::::::. . .. :.... .....: ::: :
XP_006 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV
360 370 380 390 400
400 410 420 430 440
pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.:
XP_006 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS
410 420 430 440 450 460
XP_006 TVTMWVKG
470
>>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa)
initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26
Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459)
10 20 30 40 50
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M
.:.: : ::..:: ::: :::.::: :. : :..:. .
NP_057 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL
:: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. .
NP_057 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY
: : :: :: : : :.. . :: ..:.:: : .: : .: ... .
NP_057 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR
:. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. .
NP_057 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL
180 190 200 210 220 230
240 250 260 270 280
pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV
.: : . . .:::... .: . ...: :. :. :. . : . : ...: .:
NP_057 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330
pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK
: . .. :. : :. . .: :.: . .: : :... : ::.::.
NP_057 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ
::::: ...... : ::::::. . .. :.... .....: ::: :
NP_057 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV
360 370 380 390 400
400 410 420 430 440
pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.:
NP_057 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS
410 420 430 440 450 460
NP_057 TVTMWVKG
470
>>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa)
initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26
Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459)
10 20 30 40 50
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M
.:.: : ::..:: ::: :::.::: :. : :..:. .
NP_001 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL
:: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. .
NP_001 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY
: : :: :: : : :.. . :: ..:.:: : .: : .: ... .
NP_001 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR
:. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. .
NP_001 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL
180 190 200 210 220 230
240 250 260 270 280
pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV
.: : . . .:::... .: . ...: :. :. :. . : . : ...: .:
NP_001 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330
pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK
: . .. :. : :. . .: :.: . .: : :... : ::.::.
NP_001 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ
::::: ...... : ::::::. . .. :.... .....: ::: :
NP_001 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV
360 370 380 390 400
400 410 420 430 440
pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.:
NP_001 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS
410 420 430 440 450 460
NP_001 TVTMWVKG
470
>>XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 713 init1: 288 opt: 781 Z-score: 598.0 bits: 119.9 E(85289): 1.4e-26
Smith-Waterman score: 781; 31.9% identity (62.0% similar) in 461 aa overlap (9-447:10-459)
10 20 30 40 50
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------M
.:.: : ::..:: ::: :::.::: :. : :..:. .
XP_011 MEAVELARKLQEEATCSICLDYFTDPVMTTCGHNFCRACIQLSWEKARGKKGRRKRKGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 RCPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLL
:: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. .
XP_011 PCPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPI
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 CGPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDY
: : :: :: : : :.. . :: ..:.:: : .: : .: ... .
XP_011 CVVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGK
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE4 VSVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYR
:. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. .
XP_011 VKERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLL
180 190 200 210 220 230
240 250 260 270 280
pF1KE4 ELWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRV
.: : . . .:::... .: . ...: :. :. :. . : . : ...: .:
XP_011 QLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPR--TVCRVPGQIEVLRGFLE
240 250 260 270 280 290
290 300 310 320 330
pF1KE4 DSALSTEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK
: . .. :. : :. . .: :.: . .: : :... : ::.::.
XP_011 DVVPDATSAYPYLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ
::::: ...... : ::::::. . .. :.... .....: ::: :
XP_011 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV
360 370 380 390 400
400 410 420 430 440
pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.:
XP_011 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS
410 420 430 440 450 460
XP_011 TVTMWVKG
470
>>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa)
initn: 657 init1: 288 opt: 702 Z-score: 539.6 bits: 109.1 E(85289): 2.6e-23
Smith-Waterman score: 702; 31.5% identity (61.9% similar) in 441 aa overlap (30-447:4-432)
10 20 30 40 50
pF1KE4 MDSDDLQVFQNELICCICVNYFIDPVTIDCGHSFCRPCLCLCSEEGRAP---------MR
:::.::: :. : :..:. .
XP_011 MTTCGHNFCRACIQLSWEKARGKKGRRKRKGSFP
10 20 30
60 70 80 90 100 110
pF1KE4 CPSCRKTSEKPNFNTNLVLKKLSSLARQTRPQNINSSDNICVLHEETKELFCEADKRLLC
:: ::. : . :. : .: :.. .:.: .: .....: .: :.: .:::. :. .:
XP_011 CPECREMSPQRNLLPNRLLTKVAEMAQQ-HP-GLQKQD-LCQEHHEPLKLFCQKDQSPIC
40 50 60 70 80 90
120 130 140 150 160 170
pF1KE4 GPCSESPEHMAHSHSPIGWAAEECREKLIKEMDYLWEINQETRNNLNQETSTFHSLKDYV
: :: :: : : :.. . :: ..:.:: : .: : .: ... . :
XP_011 VVCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKV
100 110 120 130 140 150
180 190 200 210 220 230
pF1KE4 SVRKRIITIQYQKMPIFLDEEEQRHLQALEREAEELFQQLQDSQVRMTQHLERMKDMYRE
. :.. :.....:: ..: ::::: ::::: : :: ..:..: . . .. . .. . .
XP_011 KERRERIVLEFEKMNLYLVEEEQRLLQALETEEEETASRLRESVACLDRQGHSLELLLLQ
160 170 180 190 200 210
240 250 260 270 280
pF1KE4 LWETCHMPDVVLLQDVRNVSARTDLAQMQKPQ---PVNPELTSWC-ITGVLDMLNNFRVD
: : . . .:::... .: . ...: :. :. :. . : . : ...: .: :
XP_011 LEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTV--CRVPGQIEVLRGFLED
220 230 240 250 260
290 300 310 320 330
pF1KE4 SAL-STEMIPCYISLSEDVRYVIFGDDHLSAPTDPQGV---DSFAVW----GAQAFTSGK
. .: : :. : :. . .: :.: . .: : :... : ::.::.
XP_011 VVPDATSAYP-YLLLYESRQRRYLG----SSP-EGSGFCSKDRFVAYPCAVGQTAFSSGR
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE4 HYWEVDVTLSSN--WILGVCRDSRTADANFVIDSDERFFLISSKRSNHYSLSTNSPPLIQ
::::: ...... : ::::::. . .. :.... .....: ::: :
XP_011 HYWEVGMNITGDALWALGVCRDNVSRKDRVPKCPENGFWVVQLSKGTKY-LSTFSALTPV
330 340 350 360 370 380
400 410 420 430 440
pF1KE4 YVQRPLGRVGVFLDYDNGSVSFFDVSKGSLIYGFPPSSFSSPLRPFFCFGCT
....: ...:.:::.. : :::..:: :: .. . ..: .::.::::.:
XP_011 MLMEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQMVIS
390 400 410 420 430 440
XP_011 TVTMWVKG
450
449 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:52:01 2016 done: Mon Nov 7 16:52:02 2016
Total Scan time: 8.640 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]