FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448

Query: pF1KE4076, 402 aa
  1>>>pF1KE4076 402 - 402 aa - 402 aa
Library: /omim/omim.rfq.tfa
  60827320 residues in 85289 sequences

Statistics:  Expectation_n fit: rho(ln(x))= 13.8680+/-0.000454; mu= -19.8663+/- 0.028
 mean_var=628.9751+/-130.607, 0's: 0 Z-trim(125.6): 14  B-trim: 1703 in 1/61
 Lambda= 0.051140
 statistics sampled from 49785 (49805) to 49785 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
 ktup: 2, E-join: 1 (0.834), E-opt: 0.2 (0.584), width:  16
 Scan time: 10.920

The best scores are:                                      opt bits E(85289)
NP_001096032 (OMIM: 613338) E3 ubiquitin-protein l ( 402) 2869 225.9 1.4e-58
NP_612405 (OMIM: 613336) E3 ubiquitin-protein liga ( 346) 1034 90.5 6.9e-18
NP_065865 (OMIM: 608208) E3 ubiquitin-protein liga ( 410)  975 86.2 1.6e-16


>>NP_001096032 (OMIM: 613338) E3 ubiquitin-protein ligas  (402 aa)
 initn: 2869 init1: 2869 opt: 2869  Z-score: 1172.9  bits: 225.9 E(85289): 1.4e-58
Smith-Waterman score: 2869; 100.0% identity (100.0% similar) in 402 aa overlap (1-402:1-402)

               10        20        30        40        50        60
pF1KE4 MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVPAAPRYLPPLPASPETPE
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVPAAPRYLPPLPASPETPE
               10        20        30        40        50        60

               70        80        90       100       110       120
pF1KE4 RAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAAKGGPG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAAKGGPG
               70        80        90       100       110       120

              130       140       150       160       170       180
pF1KE4 ESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQGAEQG
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQGAEQG
              130       140       150       160       170       180

              190       200       210       220       230       240
pF1KE4 ELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSISITLV
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSISITLV
              190       200       210       220       230       240

              250       260       270       280       290       300
pF1KE4 EKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCIGLIVH
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCIGLIVH
              250       260       270       280       290       300

              310       320       330       340       350       360
pF1KE4 EGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLTALRNRNLVHPT
       ::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRGESSTSRTLWLPLTALRNRNLVHPT
              310       320       330       340       350       360

              370       380       390       400  
pF1KE4 QLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVTSV
       ::::::::::::::::::::::::::::::::::::::::::
NP_001 QLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVTSV
              370       380       390       400  

>>NP_612405 (OMIM: 613336) E3 ubiquitin-protein ligase M  (346 aa)
 initn: 1103 init1: 923 opt: 1034  Z-score: 442.1  bits: 90.5 E(85289): 6.9e-18
Smith-Waterman score: 1037; 48.0% identity (69.0% similar) in 329 aa overlap (102-402:19-346)

              80        90       100        110       120       130
pF1KE4 VAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEG-PRRLPEAAAAKGGPGESEAGAGGER
                                     .: : ::  :.  ...:: : . :  .:  
NP_612             MLKSRLRMFLNELKLLVLTGGGRPRAEPQPRGGRGG-GCGWAPFAGCS
                           10        20        30         40       

              140       150       160                              
pF1KE4 ERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPI---------------------
        : : ::. :  .      . .:  . :::       :.                     
NP_612 TRDGDGDEEEYYGSEPRARGLAGDKEPRAGPLPPPAPPLPPPGALDALSLSSSLDSGLRT
        50        60        70        80        90       100       

       170       180       190       200       210       220       
pF1KE4 --CKICFQGAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMK
         :.::::: ::::::.::::::::: ::: ::..::::::::.:::: ..:.:.::. :
NP_612 PQCRICFQGPEQGELLSPCRCDGSVRCTHQPCLIRWISERGSWSCELCYFKYQVLAISTK
       110       120       130       140       150       160       

       230       240       250       260       270       280       
pF1KE4 QPCQWQSISITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMY
       .: :::.::.:..::::. :..::::::.::..::.::..:: : :::.:.:::::::::
NP_612 NPLQWQAISLTVIEKVQIAAIVLGSLFLVASISWLIWSSLSPSAKWQRQDLLFQICYGMY
       170       180       190       200       210       220       

       290       300       310       320       330           340   
pF1KE4 GFMDLVCIGLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEES----SRGESSTSRT
       ::::.::::::.:::..:::.::::.::: .: ::::::. ::  .    . :.:.   .
NP_612 GFMDVVCIGLIIHEGSSVYRIFKRWQAVNQQWKVLNYDKTKDIGGDAGGGTAGKSGPRNS
       230       240       250       260       270       280       

           350       360       370       380       390       400  
pF1KE4 LWLPLTALRNRNLVHPTQLTSPRFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVTSV
          : ..  .:  .   . :    .:::..:::....:: .  : ..:. :::::::.:
NP_612 RTGPTSGATSRPPAAQRMRTLLPQRCGYTILHLLGQLRPPDARSSSHSGREVVMRVTTV
       290       300       310       320       330       340      

>>NP_065865 (OMIM: 608208) E3 ubiquitin-protein ligase M  (410 aa)
 initn: 1124 init1: 958 opt: 975  Z-score: 417.6  bits: 86.2 E(85289): 1.6e-16
Smith-Waterman score: 1122; 47.2% identity (66.8% similar) in 392 aa overlap (28-402:57-410)

                  10        20        30        40          50     
pF1KE4    MSFEGGHGGSRCRGAESGDAEPPPQPPPPPPPTPPPGEPAPVP--AAPRYLPPLPAS
                                     ::  : :  :.: : :  ::   :: : :.
NP_065 PAPQMLRHQGLLKCRCRMLFNDLKVFLLRRPPQAPLPMHGDPQP-PGLAANNTLPALGAG
         30        40        50        60        70         80     

          60        70        80        90       100       110     
pF1KE4 PETPERAAGPSEPLGEVAPRCRGADELPPPPLPLQPAGQEVAAAGDSGEGPRRLPEAAAA
         .  :  :: : .:.  :       .:::: :: :.. :     :.  ::   : :.  
NP_065 GWAGWR--GPREVVGREPP------PVPPPP-PLPPSSVE-----DDWGGPATEPPASLL
          90         100              110            120       130 

         120       130       140       150       160       170     
pF1KE4 KGGPGESEAGAGGERERRGAGDQPETRSVCSSRSSSSGGGDQRAGHQHQHHQPICKICFQ
       ... ...      : .: . :.           : .::            . :.:.::::
NP_065 SSASSDDFCKEKTE-DRYSLGS-----------SLDSG-----------MRTPLCRICFQ
             140        150                             160        

         180       190       200       210       220       230     
pF1KE4 GAEQGELLNPCRCDGSVRYTHQLCLLKWISERGSWTCELCCYRYHVIAIKMKQPCQWQSI
       : ::::::.::::::::. ::: ::.::::::: :.:::: :.::::::. :.: :::.:
NP_065 GPEQGELLSPCRCDGSVKCTHQPCLIKWISERGCWSCELCYYKYHVIAISTKNPLQWQAI
      170       180       190       200       210       220        

         240       250       260       270       280       290     
pF1KE4 SITLVEKVQMIAVILGSLFLIASVTWLLWSAFSPYAVWQRKDILFQICYGMYGFMDLVCI
       :.:..::::. :.::::::::::..::.::.::: : :::.:.:::::::::::::.:::
NP_065 SLTVIEKVQVAAAILGSLFLIASISWLIWSTFSPSARWQRQDLLFQICYGMYGFMDVVCI
      230       240       250       260       270       280        

         300       310       320       330            340       350
pF1KE4 GLIVHEGAAVYRVFKRWRAVNLHWDVLNYDKATDIEESSRG-----ESSTSRTLWLPLTA
       :::.::: .:::.::::.::: .: ::::::. :.:... :     ..:.:    .: . 
NP_065 GLIIHEGPSVYRIFKRWQAVNQQWKVLNYDKTKDLEDQKAGGRTNPRTSSSTQANIPSSE
      290       300       310       320       330       340        

              360                 370       380       390       400
pF1KE4 LRNRNLVHPTQL--------TSP--RFQCGYVLLHLFNRMRPHEDLSEDNSSGEVVMRVT
        .. .   : :         ..:  . .:.:..::.....::::. :  .:: :.:::::
NP_065 EETAGTPAPEQGPAQAAGHPSGPLSHHHCAYTILHILSHLRPHEQRSPPGSSRELVMRVT
      350       360       370       380       390       400        

         
pF1KE4 SV
       .:
NP_065 TV
      410




402 residues in 1 query   sequences
60827320 residues in 85289 library sequences
 Tcomplib [36.3.4 Apr, 2011] (8 proc)
 start: Sun Nov  6 04:13:06 2016 done: Sun Nov  6 04:13:07 2016
 Total Scan time: 10.920 Total Display time: -0.020

Function used was FASTA [36.3.4 Apr, 2011]