FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE4070, 373 aa 1>>>pF1KE4070 373 - 373 aa - 373 aa Library: /omim/omim.rfq.tfa 60827320 residues in 85289 sequences Statistics: Expectation_n fit: rho(ln(x))= 8.4486+/-0.000387; mu= 3.3424+/- 0.024 mean_var=218.2077+/-45.027, 0's: 0 Z-trim(119.8): 47 B-trim: 0 in 0/55 Lambda= 0.086824 statistics sampled from 34188 (34245) to 34188 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.741), E-opt: 0.2 (0.402), width: 16 Scan time: 8.650 The best scores are: opt bits E(85289) NP_919247 (OMIM: 608299) E3 ubiquitin-protein liga ( 373) 2562 333.5 4.9e-91 NP_079402 (OMIM: 608299) E3 ubiquitin-protein liga ( 372) 2548 331.7 1.7e-90 NP_001243787 (OMIM: 608299) E3 ubiquitin-protein l ( 180) 1215 164.5 1.8e-40 NP_001017368 (OMIM: 609735) E3 ubiquitin-protein l ( 363) 981 135.4 2e-31 >>NP_919247 (OMIM: 608299) E3 ubiquitin-protein ligase R (373 aa) initn: 2562 init1: 2562 opt: 2562 Z-score: 1755.4 bits: 333.5 E(85289): 4.9e-91 Smith-Waterman score: 2562; 100.0% identity (100.0% similar) in 373 aa overlap (1-373:1-373) 10 20 30 40 50 60 pF1KE4 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE4 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE4 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE4 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE4 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE4 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_919 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC 310 320 330 340 350 360 370 pF1KE4 RQYVVRAVHVFKS ::::::::::::: NP_919 RQYVVRAVHVFKS 370 >>NP_079402 (OMIM: 608299) E3 ubiquitin-protein ligase R (372 aa) initn: 2548 init1: 2548 opt: 2548 Z-score: 1745.9 bits: 331.7 E(85289): 1.7e-90 Smith-Waterman score: 2548; 100.0% identity (100.0% similar) in 371 aa overlap (3-373:2-372) 10 20 30 40 50 60 pF1KE4 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN :::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 MKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGPFRFTPNPEFSTYPPAATEGPN 10 20 30 40 50 70 80 90 100 110 120 pF1KE4 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 IVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRRCSTCHLLQETAFQRPQLMRLK 60 70 80 90 100 110 130 140 150 160 170 180 pF1KE4 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 VKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMDTSSLNSSRSQTSSFFTRSF 120 130 140 150 160 170 190 200 210 220 230 240 pF1KE4 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 FSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTEDDDDDDDEDDDDEEENA 180 190 200 210 220 230 250 260 270 280 290 300 pF1KE4 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 EDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEKWELVEKVNRL 240 250 260 270 280 290 310 320 330 340 350 360 pF1KE4 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_079 YKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPIC 300 310 320 330 340 350 370 pF1KE4 RQYVVRAVHVFKS ::::::::::::: NP_079 RQYVVRAVHVFKS 360 370 >>NP_001243787 (OMIM: 608299) E3 ubiquitin-protein ligas (180 aa) initn: 1215 init1: 1215 opt: 1215 Z-score: 847.7 bits: 164.5 E(85289): 1.8e-40 Smith-Waterman score: 1215; 99.4% identity (100.0% similar) in 179 aa overlap (195-373:2-180) 170 180 190 200 210 220 pF1KE4 LNSSRSQTSSFFTRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQSEITSANTED .::::::::::::::::::::::::::::: NP_001 MKGELMDGDQTSRSGVPAQVQSEITSANTED 10 20 30 230 240 250 260 270 280 pF1KE4 DDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNY :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 DDDDDDEDDDDEEENAEDRNPGLSKERVRASLSDLSSLDDVEGMSVRQLKEILARNFVNY 40 50 60 70 80 90 290 300 310 320 330 340 pF1KE4 SGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHM :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: NP_001 SGCCEKWELVEKVNRLYKENEENQKSYGERLQLQDEEDDSLCRICMDAVIDCVLLECGHM 100 110 120 130 140 150 350 360 370 pF1KE4 VTCTKCGKRMSECPICRQYVVRAVHVFKS ::::::::::::::::::::::::::::: NP_001 VTCTKCGKRMSECPICRQYVVRAVHVFKS 160 170 180 >>NP_001017368 (OMIM: 609735) E3 ubiquitin-protein ligas (363 aa) initn: 939 init1: 432 opt: 981 Z-score: 685.2 bits: 135.4 E(85289): 2e-31 Smith-Waterman score: 981; 43.9% identity (70.0% similar) in 380 aa overlap (9-373:1-363) 10 20 30 40 50 pF1KE4 MRKAGATSMWASCCGLLNEVMGTGAVRGQQSAFAGATGP-FRFTPNPEFSTYP-PAATEG :::.::. . . :: : .. :: .:..: :.. : NP_001 MWATCCNWF-------CLDGQPEEVPPPQGARMQAYSNPGYSSFPSPTGLE- 10 20 30 40 60 70 80 90 100 110 pF1KE4 PNIVCKACGLSFSVFRKKHVCCDCKKDFCSVCSVLQENLRR-CSTCHLLQETAFQRPQLM :. ::.:: :. .:..: ::::.:: .:: : : : :. .. ::::: .:: NP_001 PS--CKSCGAHFANTARKQTCLDCKKNFCMTCSSQVGNGPRLCLLCQRFRATAFQREELM 50 60 70 80 90 100 120 130 140 150 160 170 pF1KE4 RLKVKDLRQYLILRNIPIDTCREKEDLVDLVLCHHGLGSEDDMD-TSSLNSSRSQTSSFF ..::::::.:: :..: . :::::.:: ::: .. . :..: .:.:. . . ..:. NP_001 KMKVKDLRDYLSLHDISTEMCREKEELVLLVLGQQPVISQEDRTRASTLSPDFPEQQAFL 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE4 TRSFFSNYTAPSATMSSFQGELMDGDQTSRSGVPAQVQ-SEITSANTEDDDDDDDEDDDD :. :... :.. .: ... . : ::::: .. ..... .:... .. NP_001 TQPH-SSMVPPTSP------NLPSSSAQATSVPPAQVQENQQANGHVSQDQEEPVYLESV 170 180 190 200 210 240 250 260 270 280 290 pF1KE4 EEENAEDRNPGLSKERV-----RASLSDLSSLDDVEGMSVRQLKEILARNFVNYSGCCEK . :::.. ....: :::::::..:.:.::..:::::::::::::::.::::: NP_001 ARVPAEDETQSIDSEDSFVPGRRASLSDLTDLEDIEGLTVRQLKEILARNFVNYKGCCEK 220 230 240 250 260 270 300 310 320 330 340 pF1KE4 WELVEKVNRLYKENEENQKSY-GERLQ----LQDEEDDSLCRICMDAVIDCVLLECGHMV :::.:.:.::::... :. : . : . . ...::.::::. :::::::::::: NP_001 WELMERVTRLYKDQKGLQHLVSGAEDQNGGAVPSGLEENLCKICMDSPIDCVLLECGHMV 280 290 300 310 320 330 350 360 370 pF1KE4 TCTKCGKRMSECPICRQYVVRAVHVFKS :::::::::.:::::::::.::::::.: NP_001 TCTKCGKRMNECPICRQYVIRAVHVFRS 340 350 360 373 residues in 1 query sequences 60827320 residues in 85289 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 16:54:55 2016 done: Mon Nov 7 16:54:56 2016 Total Scan time: 8.650 Total Display time: 0.000 Function used was FASTA [36.3.4 Apr, 2011]