Result of FASTA (omim) for
pFN21AE4064
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4064, 344 aa
1>>>pF1KE4064 344 - 344 aa - 344 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8678+/-0.000326; mu= 19.3556+/- 0.020
mean_var=70.1350+/-13.944, 0's: 0 Z-trim(115.6): 235 B-trim: 0 in 0/53
Lambda= 0.153146
statistics sampled from 25881 (26118) to 25881 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.678), E-opt: 0.2 (0.306), width: 16
Scan time: 8.090
The best scores are: opt bits E(85289)
NP_001254501 (OMIM: 609871) TBC1 domain family mem ( 468) 537 127.6 5.3e-29
XP_011517145 (OMIM: 609871) PREDICTED: TBC1 domain ( 468) 537 127.6 5.3e-29
XP_016870388 (OMIM: 609871) PREDICTED: TBC1 domain ( 483) 537 127.6 5.5e-29
NP_001254500 (OMIM: 609871) TBC1 domain family mem ( 928) 537 127.8 8.9e-29
NP_056342 (OMIM: 613620) TBC1 domain family member ( 808) 504 120.5 1.3e-26
XP_006718602 (OMIM: 610831) PREDICTED: carabin iso ( 446) 497 118.7 2.4e-26
XP_006718603 (OMIM: 610831) PREDICTED: carabin iso ( 446) 497 118.7 2.4e-26
XP_006718601 (OMIM: 610831) PREDICTED: carabin iso ( 446) 497 118.7 2.4e-26
NP_940919 (OMIM: 610831) carabin isoform 1 [Homo s ( 446) 497 118.7 2.4e-26
NP_114143 (OMIM: 610020) TBC1 domain family member ( 508) 494 118.1 4.1e-26
NP_001191169 (OMIM: 610020) TBC1 domain family mem ( 515) 485 116.1 1.7e-25
NP_060891 (OMIM: 609871) TBC1 domain family member ( 917) 485 116.4 2.5e-25
NP_001288778 (OMIM: 610440) small G protein signal ( 660) 460 110.7 9.1e-24
XP_016884266 (OMIM: 610440) PREDICTED: small G pro ( 672) 460 110.7 9.3e-24
XP_016884265 (OMIM: 610440) PREDICTED: small G pro ( 682) 460 110.7 9.4e-24
XP_011528464 (OMIM: 610440) PREDICTED: small G pro ( 686) 460 110.7 9.4e-24
XP_016884264 (OMIM: 610440) PREDICTED: small G pro ( 686) 460 110.7 9.4e-24
XP_005261632 (OMIM: 610440) PREDICTED: small G pro ( 699) 460 110.7 9.5e-24
XP_011528461 (OMIM: 610440) PREDICTED: small G pro ( 703) 460 110.7 9.6e-24
XP_011528462 (OMIM: 610440) PREDICTED: small G pro ( 703) 460 110.7 9.6e-24
XP_005261631 (OMIM: 610440) PREDICTED: small G pro ( 739) 460 110.7 9.9e-24
NP_056520 (OMIM: 610440) small G protein signaling ( 749) 460 110.8 1e-23
XP_005261630 (OMIM: 610440) PREDICTED: small G pro ( 756) 460 110.8 1e-23
XP_005261629 (OMIM: 610440) PREDICTED: small G pro ( 766) 460 110.8 1e-23
XP_011543304 (OMIM: 610831) PREDICTED: carabin iso ( 313) 445 107.1 5.2e-23
XP_011511972 (OMIM: 609850) PREDICTED: TBC1 domain ( 494) 393 95.8 2.1e-19
XP_006714064 (OMIM: 609850) PREDICTED: TBC1 domain ( 546) 393 95.8 2.3e-19
XP_016863410 (OMIM: 609850) PREDICTED: TBC1 domain (1039) 393 96.1 3.7e-19
XP_016857774 (OMIM: 602942) PREDICTED: ecotropic v ( 741) 391 95.5 3.9e-19
XP_005262706 (OMIM: 609850) PREDICTED: TBC1 domain (1146) 393 96.1 3.9e-19
NP_055988 (OMIM: 609850) TBC1 domain family member (1168) 393 96.1 4e-19
XP_016857773 (OMIM: 602942) PREDICTED: ecotropic v ( 777) 391 95.5 4e-19
XP_016863409 (OMIM: 609850) PREDICTED: TBC1 domain (1181) 393 96.1 4e-19
XP_016857772 (OMIM: 602942) PREDICTED: ecotropic v ( 785) 391 95.5 4e-19
XP_011511968 (OMIM: 609850) PREDICTED: TBC1 domain (1188) 393 96.1 4e-19
XP_011511967 (OMIM: 609850) PREDICTED: TBC1 domain (1201) 393 96.1 4.1e-19
NP_005656 (OMIM: 602942) ecotropic viral integrati ( 810) 391 95.5 4.1e-19
XP_016863408 (OMIM: 609850) PREDICTED: TBC1 domain (1222) 393 96.1 4.1e-19
XP_016863407 (OMIM: 609850) PREDICTED: TBC1 domain (1228) 393 96.1 4.1e-19
XP_016857770 (OMIM: 602942) PREDICTED: ecotropic v ( 818) 391 95.5 4.2e-19
NP_001295177 (OMIM: 602942) ecotropic viral integr ( 821) 391 95.5 4.2e-19
XP_011511966 (OMIM: 609850) PREDICTED: TBC1 domain (1241) 393 96.1 4.2e-19
XP_011511965 (OMIM: 609850) PREDICTED: TBC1 domain (1242) 393 96.1 4.2e-19
XP_016857769 (OMIM: 602942) PREDICTED: ecotropic v ( 826) 391 95.5 4.2e-19
XP_011511964 (OMIM: 609850) PREDICTED: TBC1 domain (1255) 393 96.1 4.2e-19
XP_005262704 (OMIM: 609850) PREDICTED: TBC1 domain (1262) 393 96.1 4.2e-19
XP_005262703 (OMIM: 609850) PREDICTED: TBC1 domain (1275) 393 96.1 4.3e-19
XP_011511962 (OMIM: 609850) PREDICTED: TBC1 domain (1282) 393 96.1 4.3e-19
XP_016857766 (OMIM: 602942) PREDICTED: ecotropic v ( 854) 391 95.6 4.3e-19
XP_011511961 (OMIM: 609850) PREDICTED: TBC1 domain (1295) 393 96.2 4.3e-19
>>NP_001254501 (OMIM: 609871) TBC1 domain family member (468 aa)
initn: 347 init1: 242 opt: 537 Z-score: 641.6 bits: 127.6 E(85289): 5.3e-29
Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:93-394)
10 20
pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY
: : . . : ::: :.. : :
NP_001 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI
70 80 90 100 110 120
30 40 50 60 70 80
pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS
. . : : .:. .:. : : :: : .:. .: ::: ::: ::: :
NP_001 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV
130 140 150 160 170
90 100 110 120 130
pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN
..: ..:: :..:: :....: .. :. :::::::.: .: :. . :
NP_001 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR
180 190 200 210 220 230
140 150 160 170 180 190
pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK
::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . .
NP_001 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ
240 250 260 270 280 290
200 210 220 230 240 250
pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG
.::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. ::
NP_001 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG
300 310 320 330 340 350
260 270 280 290 300 310
pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS
.:..:: ::...: ... ::. . .: . .. .::
NP_001 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ
360 370 380 390 400 410
320 330 340
pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA
NP_001 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA
420 430 440 450 460
>>XP_011517145 (OMIM: 609871) PREDICTED: TBC1 domain fam (468 aa)
initn: 347 init1: 242 opt: 537 Z-score: 641.6 bits: 127.6 E(85289): 5.3e-29
Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:93-394)
10 20
pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY
: : . . : ::: :.. : :
XP_011 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI
70 80 90 100 110 120
30 40 50 60 70 80
pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS
. . : : .:. .:. : : :: : .:. .: ::: ::: ::: :
XP_011 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV
130 140 150 160 170
90 100 110 120 130
pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN
..: ..:: :..:: :....: .. :. :::::::.: .: :. . :
XP_011 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR
180 190 200 210 220 230
140 150 160 170 180 190
pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK
::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . .
XP_011 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ
240 250 260 270 280 290
200 210 220 230 240 250
pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG
.::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. ::
XP_011 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG
300 310 320 330 340 350
260 270 280 290 300 310
pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS
.:..:: ::...: ... ::. . .: . .. .::
XP_011 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ
360 370 380 390 400 410
320 330 340
pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA
XP_011 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA
420 430 440 450 460
>>XP_016870388 (OMIM: 609871) PREDICTED: TBC1 domain fam (483 aa)
initn: 347 init1: 242 opt: 537 Z-score: 641.4 bits: 127.6 E(85289): 5.5e-29
Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:108-409)
10 20
pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY
: : . . : ::: :.. : :
XP_016 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI
80 90 100 110 120 130
30 40 50 60 70 80
pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS
. . : : .:. .:. : : :: : .:. .: ::: ::: ::: :
XP_016 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV
140 150 160 170 180 190
90 100 110 120 130
pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN
..: ..:: :..:: :....: .. :. :::::::.: .: :. . :
XP_016 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR
200 210 220 230 240 250
140 150 160 170 180 190
pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK
::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . .
XP_016 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ
260 270 280 290 300 310
200 210 220 230 240 250
pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG
.::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. ::
XP_016 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG
320 330 340 350 360 370
260 270 280 290 300 310
pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS
.:..:: ::...: ... ::. . .: . .. .::
XP_016 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ
380 390 400 410 420 430
320 330 340
pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA
XP_016 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA
440 450 460 470 480
>>NP_001254500 (OMIM: 609871) TBC1 domain family member (928 aa)
initn: 347 init1: 242 opt: 537 Z-score: 637.6 bits: 127.8 E(85289): 8.9e-29
Smith-Waterman score: 543; 35.2% identity (61.9% similar) in 307 aa overlap (5-295:553-854)
10 20
pF1KE4 MQPAERSRVPRIDPYGFERPEDFD--D----AAY
: : . . : ::: :.. : :
NP_001 DEASECSELLRQLVQEALQWEAGEASSDSIELSPISKYDEYGFLTVPDYEVEDLKLLAKI
530 540 550 560 570 580
30 40 50 60 70 80
pF1KE4 EKFFSSYLVTLTRRAI------KWSRLLQGGGVPRSRTVKRYVRKGVPLEHRARVWMVLS
. . : : .:. .:. : : :: : .:. .: ::: ::: ::: :
NP_001 QALESRSHHLLGLEAVDRPLRERWAAL--GDLVP-SAELKQLLRAGVPREHRPRVWRWLV
590 600 610 620 630
90 100 110 120 130
pF1KE4 GAQAQMDQNPGYYHQLL---QGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYN
..: ..:: :..:: :....: .. :. :::::::.: .: :. . :
NP_001 HLRVQHLHTPGCYQELLSRGQAREHPAARQ-IELDLNRTFPNNKHFTCPTSS-FPDKLRR
640 650 660 670 680 690
140 150 160 170 180 190
pF1KE4 VLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRILP-DYYSPAMLGLK
::::.. .: .:::::.: .:. .:. ..:: .:: : :.: :.: ::: .. . .
NP_001 VLLAFSWQNPTIGYCQGLNRLAAIALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQ
700 710 720 730 740 750
200 210 220 230 240 250
pF1KE4 TDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEG
.::.:: .:. ::: . : . . : .:.. ::. .:.: : . .::.:: .. ::
NP_001 VDQRVLQDLLSEKLPRLMAHLGQHHVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEG
760 770 780 790 800 810
260 270 280 290 300 310
pF1KE4 SKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPS
.:..:: ::...: ... ::. . .: . .. .::
NP_001 TKVVFRYALAIFKYNEKEILRLQNGLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQ
820 830 840 850 860 870
320 330 340
pF1KE4 QGAPPHLQPGGCSDHPEGAQDGHQWA
NP_001 LRQLRMVHRERLEAELRELEQLKAEYLERRASRRRAVSEGCASEDEVEGEA
880 890 900 910 920
>>NP_056342 (OMIM: 613620) TBC1 domain family member 10B (808 aa)
initn: 544 init1: 264 opt: 504 Z-score: 599.0 bits: 120.5 E(85289): 1.3e-26
Smith-Waterman score: 504; 32.1% identity (59.6% similar) in 287 aa overlap (11-293:303-583)
10 20 30 40
pF1KE4 MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLT
. : ::: ... . . :: : ..
NP_056 VSLMSGTLESLADDVSSMGSDSEINGLALRKTDKYGFLGGSQYSGS----LESSIPVDVA
280 290 300 310 320
50 60 70 80 90
pF1KE4 R-RAIKWSRLLQGGGVPRSRT---VKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYH
: : .:: .... :: :: :::.: ::..:. ::... ..:::: ..
NP_056 RQRELKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQYLSNSKELLEQNPGKFE
330 340 350 360 370 380
100 110 120 130 140 150
pF1KE4 QLLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQG
.: .. .:. :.:. ::.: :: . : . :. :: .: :: . ::::.
NP_056 ELERAPGDPKWLDVIEKDLHRQFPFHEMF-AARGGHGQQDLYRILKAYTIYRPDEGYCQA
390 400 410 420 430 440
160 170 180 190 200 210
pF1KE4 MNFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVG
. .:. : :. :..:: : . . :: ::: .. ... : :.. :.: : .
NP_056 QAPVAAVL-LMHMPAEQAFWCLVQICDKYLPGYYSAGLEAIQLDGEIFFALLRRASPLAH
450 460 470 480 490 500
220 230 240 250 260 270
pF1KE4 ALMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQEL
..: . .: ...::.:.:. :: .:::.:: .: :: ::::::::.:...
NP_056 RHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRHTLGS
510 520 530 540 550 560
280 290 300 310 320 330
pF1KE4 ILEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPSQGAPPHLQPGGCSDHPEG
. . : . . ..:.
NP_056 VEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEVTNLPVTEALIERENAAQLKKWRETRG
570 580 590 600 610 620
>>XP_006718602 (OMIM: 610831) PREDICTED: carabin isoform (446 aa)
initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26
Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293)
10 20 30 40 50 60
pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV
. .: .:: .. . :: ::
XP_006 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF
:::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . :
XP_006 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI
. :. : .:: :: . ::::... .:. : :. ::.:: : .
XP_006 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY
150 160 170 180 190 200
190 200 210 220 230 240
pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE
:: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. ::
XP_006 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP
210 220 230 240 250 260
250 260 270 280 290 300
pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF
::::.:: ...::....:::.:::..
XP_006 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA
270 280 290 300 310 320
>>XP_006718603 (OMIM: 610831) PREDICTED: carabin isoform (446 aa)
initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26
Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293)
10 20 30 40 50 60
pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV
. .: .:: .. . :: ::
XP_006 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF
:::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . :
XP_006 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI
. :. : .:: :: . ::::... .:. : :. ::.:: : .
XP_006 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY
150 160 170 180 190 200
190 200 210 220 230 240
pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE
:: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. ::
XP_006 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP
210 220 230 240 250 260
250 260 270 280 290 300
pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF
::::.:: ...::....:::.:::..
XP_006 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA
270 280 290 300 310 320
>>XP_006718601 (OMIM: 610831) PREDICTED: carabin isoform (446 aa)
initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26
Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293)
10 20 30 40 50 60
pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV
. .: .:: .. . :: ::
XP_006 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF
:::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . :
XP_006 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI
. :. : .:: :: . ::::... .:. : :. ::.:: : .
XP_006 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY
150 160 170 180 190 200
190 200 210 220 230 240
pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE
:: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. ::
XP_006 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP
210 220 230 240 250 260
250 260 270 280 290 300
pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF
::::.:: ...::....:::.:::..
XP_006 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA
270 280 290 300 310 320
>>NP_940919 (OMIM: 610831) carabin isoform 1 [Homo sapie (446 aa)
initn: 509 init1: 299 opt: 497 Z-score: 594.1 bits: 118.7 E(85289): 2.4e-26
Smith-Waterman score: 497; 36.4% identity (61.9% similar) in 236 aa overlap (39-271:60-293)
10 20 30 40 50 60
pF1KE4 VPRIDPYGFERPEDFDDAAYEKFFSSYLVTLTRRAIKWSRLLQGGGVPRSRT---VKRYV
. .: .:: .. . :: ::
NP_940 GPGPYRQADRYGFIGGSSAEPGPGHPPADLIRQREMKWVEMTSHWEKTMSRRYKKVKMQC
30 40 50 60 70 80
70 80 90 100 110 120
pF1KE4 RKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQLLQGERNPRLEDAIRTDLNRTFPDNVKF
:::.: ::: : .: ::.. . ..:: :..: .. .:. ..: ::.: :: . :
NP_940 RKGIPSALRARCWPLLCGAHVCQKNSPGTYQELAEAPGDPQWMETIGRDLHRQFPLHEMF
90 100 110 120 130 140
130 140 150 160 170 180
pF1KE4 RKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNEEESFWLLDALVGRI
. :. : .:: :: . ::::... .:. : :. ::.:: : .
NP_940 VSPQGHG-QQGLLQVLKAYTLYRPEQGYCQAQGPVAAVL-LMHLPPEEAFWCLVQICEVY
150 160 170 180 190 200
190 200 210 220 230 240
pF1KE4 LPDYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLVSRWFICLFVDILPVE
:: ::.: : ... : ::. :.: :: : ....:: : . .::.:::. ::
NP_940 LPGYYGPHMEAVRLDAEVFMALLRRLLPHVHKHLQQVGVGPLLYLPEWFLCLFARSLPFP
210 220 230 240 250 260
250 260 270 280 290 300
pF1KE4 TVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKFKQITKGSFVMECHTF
::::.:: ...::....:::.:::..
NP_940 TVLRVWDAFLSEGARVLFRVGLTLVRLALGTAEQRGACPGLLETLGALRAIPPAQLQEEA
270 280 290 300 310 320
>>NP_114143 (OMIM: 610020) TBC1 domain family member 10A (508 aa)
initn: 467 init1: 261 opt: 494 Z-score: 589.8 bits: 118.1 E(85289): 4.1e-26
Smith-Waterman score: 494; 33.6% identity (60.0% similar) in 265 aa overlap (11-272:54-313)
10 20 30 40
pF1KE4 MQPAERSRVPRIDPYGFERPEDFDDAAYEKFFSSYLVTLT
::: .:: . ..: :. : .:
NP_114 ESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEV---PLEVLR
30 40 50 60 70 80
50 60 70 80 90
pF1KE4 RRAIKWSRLLQGGG---VPRSRTVKRYVRKGVPLEHRARVWMVLSGAQAQMDQNPGYYHQ
.: :: .:.. . . . .. .::.: :.:.:. :::......:::: . .
NP_114 QRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDE
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE4 LLQGERNPRLEDAIRTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGM
: .. .:. :.:. ::.: :: . : . :. :. :: :: . ::::..
NP_114 LDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHG-QQDLFRVLKAYTLYRPEEGYCQAQ
150 160 170 180 190
160 170 180 190 200 210
pF1KE4 NFIAGYLILITNNEEESFWLLDALVGRILPDYYSPAMLGLKTDQEVLGELVRAKLPAVGA
::. : :. :..:: : . . :: ::: . ... : :.: :.. :..
NP_114 APIAAVL-LMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHK
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE4 LMERLGVLWTLLVSRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELI
. : . : ...::.: : :: .:::.:: .: :: ::::::.:.:.:.
NP_114 HLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSP
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE4 LEATSVPDICDKFKQITKGSFVMECHTFMQVCGAARGSVPSQGAPPHLQPGGCSDHPEGA
NP_114 EKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGE
320 330 340 350 360 370
344 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:44:41 2016 done: Sun Nov 6 01:44:42 2016
Total Scan time: 8.090 Total Display time: 0.020
Function used was FASTA [36.3.4 Apr, 2011]