Result of FASTA (omim) for
pFN21AE4049
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4049, 278 aa
1>>>pF1KE4049 278 - 278 aa - 278 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.5579+/-0.000531; mu= 8.0614+/- 0.032
mean_var=167.4026+/-36.741, 0's: 0 Z-trim(113.3): 676 B-trim: 1230 in 2/48
Lambda= 0.099127
statistics sampled from 21758 (22609) to 21758 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.265), width: 16
Scan time: 7.230
The best scores are: opt bits E(85289)
NP_078977 (OMIM: 615055) ankyrin repeat and SOCS b ( 278) 1871 280.1 3.1e-75
XP_011529918 (OMIM: 615050) PREDICTED: ankyrin rep ( 284) 713 114.5 2.2e-25
XP_011529919 (OMIM: 615050) PREDICTED: ankyrin rep ( 276) 700 112.7 8e-25
NP_543150 (OMIM: 615050) ankyrin repeat and SOCS b ( 329) 696 112.2 1.3e-24
XP_005262816 (OMIM: 615050) PREDICTED: ankyrin rep ( 329) 696 112.2 1.3e-24
XP_005274503 (OMIM: 300890) PREDICTED: ankyrin rep ( 294) 694 111.8 1.5e-24
NP_001026909 (OMIM: 300890) ankyrin repeat and SOC ( 294) 694 111.8 1.5e-24
XP_016884772 (OMIM: 300890) PREDICTED: ankyrin rep ( 377) 688 111.1 3.2e-24
NP_001012428 (OMIM: 300626) ankyrin repeat and SOC ( 302) 674 109.0 1.1e-23
NP_543149 (OMIM: 300626) ankyrin repeat and SOCS b ( 323) 674 109.0 1.2e-23
NP_076992 (OMIM: 300890) ankyrin repeat and SOCS b ( 262) 605 99.0 9.5e-21
NP_001162003 (OMIM: 300890) ankyrin repeat and SOC ( 262) 605 99.0 9.5e-21
XP_016884775 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 599 98.3 2.1e-20
XP_016884774 (OMIM: 300890) PREDICTED: ankyrin rep ( 345) 599 98.3 2.1e-20
NP_001188512 (OMIM: 300626) ankyrin repeat and SOC ( 306) 530 88.4 1.8e-17
XP_011543760 (OMIM: 300890) PREDICTED: ankyrin rep ( 265) 520 86.9 4.4e-17
XP_016884773 (OMIM: 300890) PREDICTED: ankyrin rep ( 348) 520 87.0 5.2e-17
XP_011543762 (OMIM: 300890) PREDICTED: ankyrin rep ( 233) 431 74.1 2.7e-13
NP_001162002 (OMIM: 300890) ankyrin repeat and SOC ( 252) 352 62.8 7.2e-10
XP_016863600 (OMIM: 106410,600919) PREDICTED: anky (1755) 354 64.1 2.1e-09
XP_016863599 (OMIM: 106410,600919) PREDICTED: anky (1763) 354 64.1 2.1e-09
XP_016863598 (OMIM: 106410,600919) PREDICTED: anky (1770) 354 64.1 2.1e-09
XP_016863596 (OMIM: 106410,600919) PREDICTED: anky (1797) 354 64.1 2.1e-09
XP_016863595 (OMIM: 106410,600919) PREDICTED: anky (1806) 354 64.1 2.1e-09
XP_016863594 (OMIM: 106410,600919) PREDICTED: anky (1810) 354 64.1 2.1e-09
XP_016863592 (OMIM: 106410,600919) PREDICTED: anky (1816) 354 64.1 2.1e-09
XP_016863593 (OMIM: 106410,600919) PREDICTED: anky (1818) 354 64.1 2.1e-09
XP_016863591 (OMIM: 106410,600919) PREDICTED: anky (1838) 354 64.1 2.2e-09
XP_016863590 (OMIM: 106410,600919) PREDICTED: anky (1839) 354 64.1 2.2e-09
XP_016863589 (OMIM: 106410,600919) PREDICTED: anky (1846) 354 64.1 2.2e-09
XP_016863588 (OMIM: 106410,600919) PREDICTED: anky (1850) 354 64.1 2.2e-09
XP_016863587 (OMIM: 106410,600919) PREDICTED: anky (1851) 354 64.1 2.2e-09
XP_016863586 (OMIM: 106410,600919) PREDICTED: anky (1858) 354 64.1 2.2e-09
XP_016863585 (OMIM: 106410,600919) PREDICTED: anky (1862) 354 64.1 2.2e-09
NP_001120965 (OMIM: 106410,600919) ankyrin-2 isofo (1863) 354 64.1 2.2e-09
XP_016863583 (OMIM: 106410,600919) PREDICTED: anky (1871) 354 64.1 2.2e-09
XP_016863584 (OMIM: 106410,600919) PREDICTED: anky (1871) 354 64.1 2.2e-09
NP_066187 (OMIM: 106410,600919) ankyrin-2 isoform (1872) 354 64.1 2.2e-09
XP_016863580 (OMIM: 106410,600919) PREDICTED: anky (1879) 354 64.1 2.2e-09
XP_016863582 (OMIM: 106410,600919) PREDICTED: anky (1881) 354 64.1 2.2e-09
XP_016863581 (OMIM: 106410,600919) PREDICTED: anky (1882) 354 64.1 2.2e-09
XP_016863579 (OMIM: 106410,600919) PREDICTED: anky (1886) 354 64.1 2.2e-09
XP_016863578 (OMIM: 106410,600919) PREDICTED: anky (1887) 354 64.1 2.2e-09
XP_016863577 (OMIM: 106410,600919) PREDICTED: anky (1893) 354 64.1 2.2e-09
XP_016863576 (OMIM: 106410,600919) PREDICTED: anky (1898) 354 64.2 2.2e-09
XP_016863575 (OMIM: 106410,600919) PREDICTED: anky (1899) 354 64.2 2.2e-09
XP_016863574 (OMIM: 106410,600919) PREDICTED: anky (1902) 354 64.2 2.2e-09
XP_016863573 (OMIM: 106410,600919) PREDICTED: anky (1915) 354 64.2 2.2e-09
XP_016863572 (OMIM: 106410,600919) PREDICTED: anky (1917) 354 64.2 2.2e-09
XP_016863571 (OMIM: 106410,600919) PREDICTED: anky (1926) 354 64.2 2.2e-09
>>NP_078977 (OMIM: 615055) ankyrin repeat and SOCS box p (278 aa)
initn: 1871 init1: 1871 opt: 1871 Z-score: 1471.7 bits: 280.1 E(85289): 3.1e-75
Smith-Waterman score: 1871; 100.0% identity (100.0% similar) in 278 aa overlap (1-278:1-278)
10 20 30 40 50 60
pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE4 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_078 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL
190 200 210 220 230 240
250 260 270
pF1KE4 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
::::::::::::::::::::::::::::::::::::::
NP_078 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
250 260 270
>>XP_011529918 (OMIM: 615050) PREDICTED: ankyrin repeat (284 aa)
initn: 1006 init1: 680 opt: 713 Z-score: 576.6 bits: 114.5 E(85289): 2.2e-25
Smith-Waterman score: 713; 42.1% identity (71.1% similar) in 266 aa overlap (12-277:18-283)
10 20 30 40 50
pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSIT
::.: :..:.:.::::..:. : :. :. .: :: ::.: .:
XP_011 MSRIYLDSGWCEVPWGDGDLGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVT
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE4 PLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPP
::: : : .. :.. :: :::.:.: .::: ::: .::..:: :..::: ::::..
XP_011 PLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE4 LYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGA
:: ::: .: ::. .::. : ... . :.::::.::: ... :. :: :::
XP_011 SCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGA
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE4 NVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEY
.:. .: .: :: ::. ........:.:::..: :.... .: : . ::: . .
XP_011 DVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQ
190 200 210 220 230 240
240 250 260 270
pF1KE4 YEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
.: :: .: ::::. .:. : :. : .:..: : ..:.:
XP_011 HEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
250 260 270 280
>>XP_011529919 (OMIM: 615050) PREDICTED: ankyrin repeat (276 aa)
initn: 1006 init1: 621 opt: 700 Z-score: 566.7 bits: 112.7 E(85289): 8e-25
Smith-Waterman score: 700; 41.3% identity (70.5% similar) in 271 aa overlap (7-277:5-275)
10 20 30 40 50 60
pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGACVNQVTVDSITPLHAAS
.: :. .: :..:.:.::::..:. : :. :. .: :: ::.: .:::: :
XP_011 MPLCNGGNLAVTGSWADRSPLHEAASQGRLLALRTLLSQGYNVNAVTLDHVTPLHEAC
10 20 30 40 50
70 80 90 100 110 120
pF1KE4 LQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLLLSYGAKVNPPLYTASP
: .. :.. :: :::.:.: .::: ::: .::..:: :..::: ::::.. ::
XP_011 LGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELLLEYGAKAQLESCLPSP
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE4 LHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLDCVKVLLNAGANVNAAK
::: .: ::. .::. : ... . :.::::.::: ... :. :: :::.:. .:
XP_011 THEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFHCIWKLLYAGADVQKGK
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE4 LHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPL
.: :: ::. ........:.:::..: :.... .: : . ::: . . .: ::
XP_011 YWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATSSSMVERILLQHEATPS
180 190 200 210 220 230
250 260 270
pF1KE4 TLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
.: ::::. .:. : :. : .:..: : ..:.:
XP_011 SLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
240 250 260 270
>>NP_543150 (OMIM: 615050) ankyrin repeat and SOCS box p (329 aa)
initn: 947 init1: 621 opt: 696 Z-score: 562.7 bits: 112.2 E(85289): 1.3e-24
Smith-Waterman score: 696; 41.8% identity (70.7% similar) in 263 aa overlap (15-277:66-328)
10 20 30 40
pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGAC
: :..:.:.::::..:. : :. :. .:
NP_543 AILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYN
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE4 VNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLL
:: ::.: .:::: : : .. :.. :: :::.:.: .::: ::: .::..:: :..::
NP_543 VNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE4 LSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLD
: ::::.. :: ::: .: ::. .::. : ... . :.::::.::: ...
NP_543 LEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFH
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE4 CVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWS
:. :: :::.:. .: .: :: ::. ........:.:::..: :.... .: : . :
NP_543 CIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATS
220 230 240 250 260 270
230 240 250 260 270
pF1KE4 SSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
:: . . .: :: .: ::::. .:. : :. : .:..: : ..:.:
NP_543 SSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
280 290 300 310 320
>>XP_005262816 (OMIM: 615050) PREDICTED: ankyrin repeat (329 aa)
initn: 947 init1: 621 opt: 696 Z-score: 562.7 bits: 112.2 E(85289): 1.3e-24
Smith-Waterman score: 696; 41.8% identity (70.7% similar) in 263 aa overlap (15-277:66-328)
10 20 30 40
pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLIESGAC
: :..:.:.::::..:. : :. :. .:
XP_005 AILSHFYIVKGNRKEAARIAAEFYGVTQGQGSWADRSPLHEAASQGRLLALRTLLSQGYN
40 50 60 70 80 90
50 60 70 80 90 100
pF1KE4 VNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIECVKLL
:: ::.: .:::: : : .. :.. :: :::.:.: .::: ::: .::..:: :..::
XP_005 VNAVTLDHVTPLHEACLGDHVACARTLLEAGANVNAITIDGVTPLFNACSQGSPSCAELL
100 110 120 130 140 150
110 120 130 140 150 160
pF1KE4 LSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAREHLD
: ::::.. :: ::: .: ::. .::. : ... . :.::::.::: ...
XP_005 LEYGAKAQLESCLPSPTHEAASKGHHECLDILISWGIDVDQEIPHLGTPLYVACMSQQFH
160 170 180 190 200 210
170 180 190 200 210 220
pF1KE4 CVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSDYTWS
:. :: :::.:. .: .: :: ::. ........:.:::..: :.... .: : . :
XP_005 CIWKLLYAGADVQKGKYWDTPLHAAAQQSSTEIVNLLLEFGADINAKNTELLRPIDVATS
220 230 240 250 260 270
230 240 250 260 270
pF1KE4 SSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
:: . . .: :: .: ::::. .:. : :. : .:..: : ..:.:
XP_005 SSMVERILLQHEATPSSLYQLCRLCIRSYIGKPRLHLIPQLQLPTLLKNFLQYR
280 290 300 310 320
>>XP_005274503 (OMIM: 300890) PREDICTED: ankyrin repeat (294 aa)
initn: 971 init1: 577 opt: 694 Z-score: 561.7 bits: 111.8 E(85289): 1.5e-24
Smith-Waterman score: 694; 42.3% identity (70.0% similar) in 267 aa overlap (10-275:29-291)
10 20 30 40
pF1KE4 MEPRAADGCFLGD-VGFWVERTPVHEAAQRGESLQLQQLIE
..:: :. : .:.:::: .:..:.:..::
XP_005 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDW---SPMHEAAIHGHQLSLRNLIS
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 SGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIEC
.: :: .:.: ..::: : : :. ::..:: ::::.. . : ::: .::.::: .:
XP_005 QGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDC
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAR
:.:::..::.:.: :::.::: : ::: :: :.:.. . :.::::..::
XP_005 VNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACEN
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 EHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSD
.. ::: ::..::.:: .: ... :: .:.. . .: .:..::.. :.. .::.: .
XP_005 QQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVE
180 190 200 210 220 230
230 240 250 260 270
pF1KE4 YTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
. : :. : : : .: ::::. .:: :.. .::.:: .: : ..:
XP_005 LVPPESPLAQLFLEREGPP-SLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
240 250 260 270 280 290
>>NP_001026909 (OMIM: 300890) ankyrin repeat and SOCS bo (294 aa)
initn: 971 init1: 577 opt: 694 Z-score: 561.7 bits: 111.8 E(85289): 1.5e-24
Smith-Waterman score: 694; 42.3% identity (70.0% similar) in 267 aa overlap (10-275:29-291)
10 20 30 40
pF1KE4 MEPRAADGCFLGD-VGFWVERTPVHEAAQRGESLQLQQLIE
..:: :. : .:.:::: .:..:.:..::
NP_001 MDGKQGGMDGSKPAGPRDFPGIRLLSNPLMGDAVSDW---SPMHEAAIHGHQLSLRNLIS
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 SGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIEC
.: :: .:.: ..::: : : :. ::..:: ::::.. . : ::: .::.::: .:
NP_001 QGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWHTPLFNACVSGSWDC
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 VKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACAR
:.:::..::.:.: :::.::: : ::: :: :.:.. . :.::::..::
NP_001 VNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHKISHLGTPLYLACEN
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE4 EHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPSD
.. ::: ::..::.:: .: ... :: .:.. . .: .:..::.. :.. .::.: .
NP_001 QQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGADTQAKNAEGKRPVE
180 190 200 210 220 230
230 240 250 260 270
pF1KE4 YTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
. : :. : : : .: ::::. .:: :.. .::.:: .: : ..:
NP_001 LVPPESPLAQLFLEREGPP-SLMQLCRLRIRKCFGIQQHHKITKLVLPEDLKQFLLHL
240 250 260 270 280 290
>>XP_016884772 (OMIM: 300890) PREDICTED: ankyrin repeat (377 aa)
initn: 971 init1: 577 opt: 688 Z-score: 555.8 bits: 111.1 E(85289): 3.2e-24
Smith-Waterman score: 691; 40.9% identity (67.7% similar) in 279 aa overlap (6-275:97-374)
10 20
pF1KE4 MEPRAADGCFLGDVGFW---------VERTPVHEA
:: . :. :.: . .:.:::
XP_016 SYKLSFLPDKLQGFLTDWSQFGKGRDISNFADLGLEGSCGLWRASSQLDAVSDWSPMHEA
70 80 90 100 110 120
30 40 50 60 70 80
pF1KE4 AQRGESLQLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGS
: .:..:.:..:: .: :: .:.: ..::: : : :. ::..:: ::::.. . :
XP_016 AIHGHQLSLRNLISQGWAVNIITADHVSPLHEACLGGHLSCVKILLKHGAQVNGVTADWH
130 140 150 160 170 180
90 100 110 120 130 140
pF1KE4 TPLCDACASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAH
::: .::.::: .::.:::..::.:.: :::.::: : ::: :: :.:.. .
XP_016 TPLFNACVSGSWDCVNLLLQHGASVQPESDLASPIHEAARRGHVECVNSLIAYGGNIDHK
190 200 210 220 230 240
150 160 170 180 190 200
pF1KE4 DCHFGTPLHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGG
:.::::..:: .. ::: ::..::.:: .: ... :: .:.. . .: .:..::.
XP_016 ISHLGTPLYLACENQQRACVKKLLESGADVNQGKGQDSPLHAVARTASEELACLLMDFGA
250 260 270 280 290 300
210 220 230 240 250 260
pF1KE4 NIYARDNRGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLN
. :.. .::.: . . : :. : : : .: ::::. .:: :.. .::.::
XP_016 DTQAKNAEGKRPVELVPPESPLAQLFLEREGPP-SLMQLCRLRIRKCFGIQQHHKITKLV
310 320 330 340 350 360
270
pF1KE4 IPPRLIDYLSYN
.: : ..:
XP_016 LPEDLKQFLLHL
370
>>NP_001012428 (OMIM: 300626) ankyrin repeat and SOCS bo (302 aa)
initn: 785 init1: 548 opt: 674 Z-score: 546.1 bits: 109.0 E(85289): 1.1e-23
Smith-Waterman score: 674; 40.3% identity (69.8% similar) in 268 aa overlap (10-277:37-301)
10 20 30
pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESLQLQQLI
: :: :..:.:.:::: .:. : :. ::
NP_001 ENEKNCEVSERIRRSGPWKEISFGDYICHTFQGDC--WADRSPLHEAAAQGRLLALKTLI
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE4 ESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDACASGSIE
.:. :: ::.. .. :: : : :.. :.. :: ::.:.. .. :.::: .:: :::
NP_001 AQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNACCSGSAA
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE4 CVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTPLHVACA
::..:: .:::.. .. :::.::: : ::...:. ..:.. . ..::::.:::.
NP_001 CVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTPLYVACT
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE4 REHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDNRGKKPS
...:::: ::. ::.:. .. .: :: ::. .::..:..: ..:.:. :. .::.
NP_001 YQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNAQGKSAL
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE4 DYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLIDYLSYN
: . .:. . . : : .::::::. .:: : . : ::..: : .: :
NP_001 DLAAPKSSVEQALLLREGPP-ALSQLCRLCVRKCLGRACHQAIHKLHLPEPLERFLLYQ
250 260 270 280 290 300
>>NP_543149 (OMIM: 300626) ankyrin repeat and SOCS box p (323 aa)
initn: 785 init1: 548 opt: 674 Z-score: 545.8 bits: 109.0 E(85289): 1.2e-23
Smith-Waterman score: 674; 39.4% identity (69.0% similar) in 274 aa overlap (4-277:50-322)
10 20 30
pF1KE4 MEPRAADGCFLGDVGFWVERTPVHEAAQRGESL
: :. . : :..:.:.:::: .:. :
NP_543 TFFFFKLLIKVFLALLTHFYIVKGNRKEAARIAEEIYGGISDCWADRSPLHEAAAQGRLL
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE4 QLQQLIESGACVNQVTVDSITPLHAASLQGQARCVQLLLAAGAQVDARNIDGSTPLCDAC
:. :: .:. :: ::.. .. :: : : :.. :.. :: ::.:.. .. :.::: .::
NP_543 ALKTLIAQGVNVNLVTINRVSSLHEACLGGHVACAKALLENGAHVNGVTVHGATPLFNAC
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE4 ASGSIECVKLLLSYGAKVNPPLYTASPLHEACMSGSSECVRLLIDVGANLEAHDCHFGTP
::: ::..:: .:::.. .. :::.::: : ::...:. ..:.. . ..:::
NP_543 CSGSAACVNVLLEFGAKAQLEVHLASPIHEAVKRGHRECMEILLANNVNIDHEVPQLGTP
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE4 LHVACAREHLDCVKVLLNAGANVNAAKLHETALHHAAKVKNVDLIEMLIEFGGNIYARDN
:.:::. ...:::: ::. ::.:. .. .: :: ::. .::..:..: ..:.:. :.
NP_543 LYVACTYQRVDCVKKLLELGASVDHGQWLDTPLHAAARQSNVEVIHLLTDYGANLKRRNA
200 210 220 230 240 250
220 230 240 250 260 270
pF1KE4 RGKKPSDYTWSSSAPAKCFEYYEKTPLTLSQLCRVNLRKATGVRGLEKIAKLNIPPRLID
.::. : . .:. . . : : .::::::. .:: : . : ::..: :
NP_543 QGKSALDLAAPKSSVEQALLLREGPP-ALSQLCRLCVRKCLGRACHQAIHKLHLPEPLER
260 270 280 290 300 310
pF1KE4 YLSYN
.: :
NP_543 FLLYQ
320
278 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:16:05 2016 done: Sun Nov 6 04:16:06 2016
Total Scan time: 7.230 Total Display time: 0.010
Function used was FASTA [36.3.4 Apr, 2011]