Result of FASTA (omim) for
pFN21AE4034
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4034, 244 aa
1>>>pF1KE4034 244 - 244 aa - 244 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0929+/-0.000303; mu= 16.6718+/- 0.019
mean_var=91.6462+/-18.398, 0's: 0 Z-trim(119.8): 96 B-trim: 873 in 1/51
Lambda= 0.133973
statistics sampled from 34197 (34310) to 34197 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.761), E-opt: 0.2 (0.402), width: 16
Scan time: 7.700
The best scores are: opt bits E(85289)
XP_005265776 (OMIM: 612405) PREDICTED: ADP-ribosyl ( 265) 442 94.8 1.6e-19
XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosyl ( 182) 320 71.1 1.5e-12
NP_004302 (OMIM: 604695) ADP-ribosylation factor-l ( 182) 320 71.1 1.5e-12
NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 ( 175) 313 69.7 3.7e-12
NP_001168 (OMIM: 603425) ADP-ribosylation factor-l ( 181) 313 69.7 3.8e-12
NP_060654 (OMIM: 616596) ADP-ribosylation factor-l ( 186) 307 68.6 8.7e-12
NP_996802 (OMIM: 612405) ADP-ribosylation factor-l ( 123) 304 67.8 9.8e-12
XP_006714099 (OMIM: 612405) PREDICTED: ADP-ribosyl ( 123) 304 67.8 9.8e-12
XP_005265777 (OMIM: 612405) PREDICTED: ADP-ribosyl ( 123) 304 67.8 9.8e-12
NP_620150 (OMIM: 616597) ADP-ribosylation factor-l ( 186) 302 67.6 1.7e-11
NP_001658 (OMIM: 601175) ADP-ribosylation factor-l ( 184) 298 66.8 2.9e-11
NP_001651 (OMIM: 601177) ADP-ribosylation factor 4 ( 180) 297 66.6 3.3e-11
NP_001019398 (OMIM: 103180) ADP-ribosylation facto ( 181) 295 66.3 4.3e-11
NP_001649 (OMIM: 103180) ADP-ribosylation factor 1 ( 181) 295 66.3 4.3e-11
NP_001650 (OMIM: 103190) ADP-ribosylation factor 3 ( 181) 295 66.3 4.3e-11
XP_005268913 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 181) 295 66.3 4.3e-11
NP_001019397 (OMIM: 103180) ADP-ribosylation facto ( 181) 295 66.3 4.3e-11
NP_001019399 (OMIM: 103180) ADP-ribosylation facto ( 181) 295 66.3 4.3e-11
NP_001653 (OMIM: 103188) ADP-ribosylation factor 5 ( 180) 291 65.5 7.3e-11
NP_997625 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 289 65.1 1e-10
NP_001032241 (OMIM: 604786) ADP-ribosylation facto ( 200) 289 65.1 1e-10
NP_001182325 (OMIM: 604786) ADP-ribosylation facto ( 200) 289 65.1 1e-10
NP_005729 (OMIM: 604786) ADP-ribosylation factor-l ( 200) 289 65.1 1e-10
XP_011523084 (OMIM: 600732) PREDICTED: ADP-ribosyl ( 201) 287 64.8 1.3e-10
NP_001652 (OMIM: 600732) ADP-ribosylation factor-l ( 201) 287 64.8 1.3e-10
XP_005266310 (OMIM: 609351) PREDICTED: ADP-ribosyl ( 196) 284 64.2 2e-10
NP_612459 (OMIM: 609351) ADP-ribosylation factor-l ( 196) 284 64.2 2e-10
NP_150231 (OMIM: 601747) E3 ubiquitin-protein liga ( 546) 276 63.1 1.2e-09
NP_005728 (OMIM: 604787) ADP-ribosylation factor-l ( 192) 270 61.5 1.3e-09
NP_001269360 (OMIM: 604787) ADP-ribosylation facto ( 201) 270 61.5 1.3e-09
XP_005248554 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 398) 272 62.2 1.6e-09
NP_079323 (OMIM: 614439) ADP-ribosylation factor-l ( 192) 267 60.9 1.9e-09
XP_016864933 (OMIM: 601747) PREDICTED: E3 ubiquiti ( 569) 272 62.3 2e-09
NP_150230 (OMIM: 601747) E3 ubiquitin-protein liga ( 569) 272 62.3 2e-09
NP_001647 (OMIM: 601747) E3 ubiquitin-protein liga ( 574) 272 62.3 2e-09
NP_878899 (OMIM: 608922,612291) ADP-ribosylation f ( 428) 264 60.7 4.9e-09
NP_001167621 (OMIM: 608922,612291) ADP-ribosylatio ( 428) 264 60.7 4.9e-09
NP_036229 (OMIM: 608960) ADP-ribosylation factor-l ( 179) 257 58.9 6.9e-09
NP_816931 (OMIM: 209900,268000,600151,608845,61357 ( 186) 255 58.5 9.3e-09
XP_016862800 (OMIM: 209900,268000,600151,608845,61 ( 186) 255 58.5 9.3e-09
NP_115522 (OMIM: 209900,268000,600151,608845,61357 ( 186) 255 58.5 9.3e-09
NP_001265222 (OMIM: 209900,268000,600151,608845,61 ( 186) 255 58.5 9.3e-09
NP_001186674 (OMIM: 601175) ADP-ribosylation facto ( 157) 254 58.3 9.4e-09
NP_001310442 (OMIM: 209900,268000,600151,608845,61 ( 193) 255 58.6 9.5e-09
NP_848930 (OMIM: 608909) ADP-ribosylation factor-l ( 179) 254 58.3 1e-08
XP_016862801 (OMIM: 209900,268000,600151,608845,61 ( 159) 252 57.9 1.2e-08
NP_001310443 (OMIM: 209900,268000,600151,608845,61 ( 159) 252 57.9 1.2e-08
XP_016856722 (OMIM: 103180) PREDICTED: ADP-ribosyl ( 212) 252 58.0 1.5e-08
XP_011510837 (OMIM: 608922,612291) PREDICTED: ADP- ( 403) 254 58.7 1.8e-08
XP_006719454 (OMIM: 103190) PREDICTED: ADP-ribosyl ( 137) 238 55.1 7.3e-08
>>XP_005265776 (OMIM: 612405) PREDICTED: ADP-ribosylatio (265 aa)
initn: 441 init1: 403 opt: 442 Z-score: 471.7 bits: 94.8 E(85289): 1.6e-19
Smith-Waterman score: 442; 37.3% identity (69.6% similar) in 217 aa overlap (34-244:49-261)
10 20 30 40 50 60
pF1KE4 RPLGPLVLALGGAAAVLGSVLFILWKTYFGRGRERRWDRGEAWWGAEAARLPEWDEWDPE
.:.:.. : . : :. . : . . :
XP_005 KIGEKGREEKVKRKEVEQKIKQKQEKQERRKGKEKEEKRTK--QGKETNKEKEQFKGQEE
20 30 40 50 60 70
70 80 90 100 110
pF1KE4 DEEDEEPAL-----EELEQ-REVLVLGLDGAGKSTFLRVLSGKPPLEGHIPTWGFNSVRL
:... .: : ::. ...::::::::::.. :. :... .. :: ::..: .
XP_005 KGENKDSTLTRTPLEPLEKNKQILVLGLDGAGKTSVLHSLASNRVQHSVAPTQGFHAVCI
80 90 100 110 120 130
120 130 140 150 160 170
pF1KE4 PTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADRLRLPWARQELHKLLDKDPD
:.: ....::::::. .: ::. ..:. .:.:::::::. ::: :.. ::.:. .:
XP_005 NTEDSQMEFLEIGGSKPFRSYWEMYLSKGLLLIFVVDSADHSRLPEAKKYLHQLIAANPV
140 150 160 170 180 190
180 190 200 210 220 230
pF1KE4 LPVVVVANKQDLSEAMSMGELQRELGLQAIDNQREVFLLAASIAPAGPTFEEPGTVHIWK
::.:: :::::: :. . .... :.:. . :.:..::... .. : : :.:.. :
XP_005 LPLVVFANKQDLEAAYHITDIHEALALSEVGNDRKMFLFGTYLTKNGS--EIPSTMQDAK
200 210 220 230 240 250
240
pF1KE4 LLLELLS
:. :.
XP_005 DLIAQLAADVQ
260
>>XP_016871749 (OMIM: 604695) PREDICTED: ADP-ribosylatio (182 aa)
initn: 314 init1: 201 opt: 320 Z-score: 346.3 bits: 71.1 E(85289): 1.5e-12
Smith-Waterman score: 320; 38.4% identity (74.6% similar) in 138 aa overlap (76-210:16-151)
50 60 70 80 90 100
pF1KE4 WWGAEAARLPEWDEWDPEDEEDEEPALEELEQREVLVLGLDGAGKSTFLRVLSGKPPLEG
.. ..:.::::.:::.:.:. :... .
XP_016 MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDI--S
10 20 30 40
110 120 130 140 150 160
pF1KE4 HI-PTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADRLRLPWA
:: :: ::: . .. :.... .:::....: :::.. ..:.:..:.::::: :. .
XP_016 HITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEET
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE4 RQELHKLLDKDPD--LPVVVVANKQDLSEAMSMGELQRELGLQAIDNQREVFLLAASIAP
::: .::... .::.. :::::: : .:. . :.:..: ..
XP_016 GQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTG
110 120 130 140 150 160
230 240
pF1KE4 AGPTFEEPGTVHIWKLLLELLS
XP_016 EGVQDGMNWVCKNVNAKKK
170 180
>>NP_004302 (OMIM: 604695) ADP-ribosylation factor-like (182 aa)
initn: 314 init1: 201 opt: 320 Z-score: 346.3 bits: 71.1 E(85289): 1.5e-12
Smith-Waterman score: 320; 38.4% identity (74.6% similar) in 138 aa overlap (76-210:16-151)
50 60 70 80 90 100
pF1KE4 WWGAEAARLPEWDEWDPEDEEDEEPALEELEQREVLVLGLDGAGKSTFLRVLSGKPPLEG
.. ..:.::::.:::.:.:. :... .
NP_004 MGLLSILRKLKSAPDQEVRILLLGLDNAGKTTLLKQLASEDI--S
10 20 30 40
110 120 130 140 150 160
pF1KE4 HI-PTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADRLRLPWA
:: :: ::: . .. :.... .:::....: :::.. ..:.:..:.::::: :. .
NP_004 HITPTQGFNIKSVQSQGFKLNVWDIGGQRKIRPYWKNYFENTDILIYVIDSADRKRFEET
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE4 RQELHKLLDKDPD--LPVVVVANKQDLSEAMSMGELQRELGLQAIDNQREVFLLAASIAP
::: .::... .::.. :::::: : .:. . :.:..: ..
NP_004 GQELAELLEEEKLSCVPVLIFANKQDLLTAAPASEIAEGLNLHTIRDRVWQIQSCSALTG
110 120 130 140 150 160
230 240
pF1KE4 AGPTFEEPGTVHIWKLLLELLS
NP_004 EGVQDGMNWVCKNVNAKKK
170 180
>>NP_001654 (OMIM: 600464) ADP-ribosylation factor 6 [Ho (175 aa)
initn: 310 init1: 186 opt: 313 Z-score: 339.2 bits: 69.7 E(85289): 3.7e-12
Smith-Waterman score: 313; 37.8% identity (67.3% similar) in 156 aa overlap (76-229:13-164)
50 60 70 80 90 100
pF1KE4 WWGAEAARLPEWDEWDPEDEEDEEPALEELEQREVLVLGLDGAGKSTFLRVLSGKPPLEG
:.: .:.::::.:::.:.: :. .
NP_001 MGKVLSKIFGNKEMR-ILMLGLDAAGKTTILYKLKLGQSVTT
10 20 30 40
110 120 130 140 150 160
pF1KE4 HIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADRLRLPWAR
::: ::: . :. . .. ..::....: :... . .. :.:::: ::: :. ::
NP_001 -IPTVGFNVETVTYKNVKFNVWDVGGQDKIRPLWRHYYTGTQGLIFVVDCADRDRIDEAR
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE4 QELHKLL-DKDP-DLPVVVVANKQDLSEAMSMGELQRELGLQAIDNQREVFLLAASIAPA
::::... :.. : ... :::::: .::. :.:..::: : .. . . : : .
NP_001 QELHRIINDREMRDAIILIFANKQDLPDAMKPHEIQEKLGLTRIRDRN--WYVQPSCATS
110 120 130 140 150
230 240
pF1KE4 GPTFEEPGTVHIWKLLLELLS
: . :
NP_001 GDGLYEGLTWLTSNYKS
160 170
>>NP_001168 (OMIM: 603425) ADP-ribosylation factor-like (181 aa)
initn: 310 init1: 165 opt: 313 Z-score: 339.0 bits: 69.7 E(85289): 3.8e-12
Smith-Waterman score: 313; 37.8% identity (69.6% similar) in 148 aa overlap (76-219:17-161)
50 60 70 80 90 100
pF1KE4 WWGAEAARLPEWDEWDPEDEEDEEPALEELEQREVLVLGLDGAGKSTFL-RVLSGKPPLE
:.: .:.::::::::.:.: :. :. .
NP_001 MGGFFSSIFSSLFGTREMR-ILILGLDGAGKTTILYRLQVGE--VV
10 20 30 40
110 120 130 140 150 160
pF1KE4 GHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADRLRLPWA
::: ::: . :... .. ..::. ..: ::. . :..:....:::: :: :. .
NP_001 TTIPTIGFNVETVTYKNLKFQVWDLGGQTSIRPYWRCYYSNTDAVIYVVDSCDRDRIGIS
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE4 RQELHKLLDKDP--DLPVVVVANKQDLSEAMSMGELQRELGLQAI-DNQREVFLLAASIA
..:: .:... .:: :::::. .::. .:. ::: :. : . ..: .:.
NP_001 KSELVAMLEEEELRKAILVVFANKQDMEQAMTSSEMANSLGLPALKDRKWQIFKTSATKG
110 120 130 140 150 160
230 240
pF1KE4 PAGPTFEEPGTVHIWKLLLELLS
NP_001 TGLDEAMEWLVETLKSRQ
170 180
>>NP_060654 (OMIM: 616596) ADP-ribosylation factor-like (186 aa)
initn: 302 init1: 238 opt: 307 Z-score: 332.6 bits: 68.6 E(85289): 8.7e-12
Smith-Waterman score: 307; 36.2% identity (73.0% similar) in 141 aa overlap (76-213:19-157)
50 60 70 80 90 100
pF1KE4 WWGAEAARLPEWDEWDPEDEEDEEPALEELEQREVLVLGLDGAGKSTFLRVLSGKPPLEG
:. :. ..::. .::.::. :... :
NP_060 MLALISRLLDWFRSLFWKEEMELTLVGLQYSGKTTFVNVIASGQFSED
10 20 30 40
110 120 130 140 150 160
pF1KE4 HIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSADRLRLPWAR
::: ::: .. . . . .:::. .: .:... :...:...:.::: .. .:
NP_060 MIPTVGFNMRKVTKGNVTIKIWDIGGQPRFRSMWERYCRGVNAIVYMIDAADREKIEASR
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE4 QELHKLLDKDPDL---PVVVVANKQDLSEAMSMGELQRELGLQAIDNQREVFLLAASIAP
.:::.:::: :.: ::.:..::.:: .:.. .: ....:.::.. ::.
NP_060 NELHNLLDK-PQLQGIPVLVLGNKRDLPNALDEKQLIEKMNLSAIQD-REICCYSISCKE
110 120 130 140 150 160
230 240
pF1KE4 AGPTFEEPGTVHIWKLLLELLS
NP_060 KDNIDITLQWLIQHSKSRRS
170 180
>>NP_996802 (OMIM: 612405) ADP-ribosylation factor-like (123 aa)
initn: 324 init1: 291 opt: 304 Z-score: 331.6 bits: 67.8 E(85289): 9.8e-12
Smith-Waterman score: 304; 41.3% identity (74.4% similar) in 121 aa overlap (124-244:1-119)
100 110 120 130 140 150
pF1KE4 LRVLSGKPPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVV
...::::::. .: ::. ..:. .:.:::
NP_996 MEFLEIGGSKPFRSYWEMYLSKGLLLIFVV
10 20 30
160 170 180 190 200 210
pF1KE4 DSADRLRLPWARQELHKLLDKDPDLPVVVVANKQDLSEAMSMGELQRELGLQAIDNQREV
::::. ::: :.. ::.:. .: ::.:: :::::: :. . .... :.:. . :.:..
NP_996 DSADHSRLPEAKKYLHQLIAANPVLPLVVFANKQDLEAAYHITDIHEALALSEVGNDRKM
40 50 60 70 80 90
220 230 240
pF1KE4 FLLAASIAPAGPTFEEPGTVHIWKLLLELLS
::... .. : : :.:.. : :. :.
NP_996 FLFGTYLTKNGS--EIPSTMQDAKDLIAQLAADVQ
100 110 120
>>XP_006714099 (OMIM: 612405) PREDICTED: ADP-ribosylatio (123 aa)
initn: 324 init1: 291 opt: 304 Z-score: 331.6 bits: 67.8 E(85289): 9.8e-12
Smith-Waterman score: 304; 41.3% identity (74.4% similar) in 121 aa overlap (124-244:1-119)
100 110 120 130 140 150
pF1KE4 LRVLSGKPPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVV
...::::::. .: ::. ..:. .:.:::
XP_006 MEFLEIGGSKPFRSYWEMYLSKGLLLIFVV
10 20 30
160 170 180 190 200 210
pF1KE4 DSADRLRLPWARQELHKLLDKDPDLPVVVVANKQDLSEAMSMGELQRELGLQAIDNQREV
::::. ::: :.. ::.:. .: ::.:: :::::: :. . .... :.:. . :.:..
XP_006 DSADHSRLPEAKKYLHQLIAANPVLPLVVFANKQDLEAAYHITDIHEALALSEVGNDRKM
40 50 60 70 80 90
220 230 240
pF1KE4 FLLAASIAPAGPTFEEPGTVHIWKLLLELLS
::... .. : : :.:.. : :. :.
XP_006 FLFGTYLTKNGS--EIPSTMQDAKDLIAQLAADVQ
100 110 120
>>XP_005265777 (OMIM: 612405) PREDICTED: ADP-ribosylatio (123 aa)
initn: 324 init1: 291 opt: 304 Z-score: 331.6 bits: 67.8 E(85289): 9.8e-12
Smith-Waterman score: 304; 41.3% identity (74.4% similar) in 121 aa overlap (124-244:1-119)
100 110 120 130 140 150
pF1KE4 LRVLSGKPPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVV
...::::::. .: ::. ..:. .:.:::
XP_005 MEFLEIGGSKPFRSYWEMYLSKGLLLIFVV
10 20 30
160 170 180 190 200 210
pF1KE4 DSADRLRLPWARQELHKLLDKDPDLPVVVVANKQDLSEAMSMGELQRELGLQAIDNQREV
::::. ::: :.. ::.:. .: ::.:: :::::: :. . .... :.:. . :.:..
XP_005 DSADHSRLPEAKKYLHQLIAANPVLPLVVFANKQDLEAAYHITDIHEALALSEVGNDRKM
40 50 60 70 80 90
220 230 240
pF1KE4 FLLAASIAPAGPTFEEPGTVHIWKLLLELLS
::... .. : : :.:.. : :. :.
XP_005 FLFGTYLTKNGS--EIPSTMQDAKDLIAQLAADVQ
100 110 120
>>NP_620150 (OMIM: 616597) ADP-ribosylation factor-like (186 aa)
initn: 296 init1: 231 opt: 302 Z-score: 327.3 bits: 67.6 E(85289): 1.7e-11
Smith-Waterman score: 302; 36.7% identity (70.0% similar) in 150 aa overlap (67-213:10-157)
40 50 60 70 80 90
pF1KE4 ERRWDRGEAWWGAEAARLPEWDEWDPEDEEDEEPALEELEQREVLVLGLDGAGKSTFLRV
: :: :. :. ..::. .::.::. :
NP_620 MIALFNKLLDWFKALFWKEEMELTLVGLQYSGKTTFVNV
10 20 30
100 110 120 130 140 150
pF1KE4 LSGKPPLEGHIPTWGFNSVRLPTKDFEVDLLEIGGSQNLRFYWKEFVSEVDVLVFVVDSA
... : ::: ::: .. . . : .:::. .: .:... :...:..::.:
NP_620 IASGQFNEDMIPTVGFNMRKITKGNVTIKLWDIGGQPRFRSMWERYCRGVSAIVYMVDAA
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE4 DRLRLPWARQELHKLLDKDPDL---PVVVVANKQDLSEAMSMGELQRELGLQAIDNQREV
:. .. ...:::.:::: :.: ::.:..::.:: :.. :: ....:.::.. ::.
NP_620 DQEKIEASKNELHNLLDK-PQLQGIPVLVLGNKRDLPGALDEKELIEKMNLSAIQD-REI
100 110 120 130 140 150
220 230 240
pF1KE4 FLLAASIAPAGPTFEEPGTVHIWKLLLELLS
NP_620 CCYSISCKEKDNIDITLQWLIQHSKSRRS
160 170 180
244 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 15:14:47 2016 done: Mon Nov 7 15:14:48 2016
Total Scan time: 7.700 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]