Result of FASTA (omim) for
pFN21AE4030
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4030, 237 aa
1>>>pF1KE4030 237 - 237 aa - 237 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3559+/-0.000354; mu= 12.3632+/- 0.022
mean_var=207.0492+/-45.537, 0's: 0 Z-trim(121.1): 113 B-trim: 1682 in 1/50
Lambda= 0.089133
statistics sampled from 37091 (37244) to 37091 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.783), E-opt: 0.2 (0.437), width: 16
Scan time: 7.100
The best scores are: opt bits E(85289)
NP_061153 (OMIM: 612451) E3 ubiquitin-protein liga ( 228) 752 108.4 1.1e-23
NP_937761 (OMIM: 616319) E3 ubiquitin-protein liga ( 151) 298 49.8 3.1e-06
XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 151) 298 49.8 3.1e-06
XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquiti ( 199) 297 49.8 4e-06
NP_001178253 (OMIM: 616319) E3 ubiquitin-protein l ( 245) 297 50.0 4.5e-06
NP_057355 (OMIM: 616319) E3 ubiquitin-protein liga ( 245) 297 50.0 4.5e-06
XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 u ( 191) 244 43.0 0.00044
XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 u ( 196) 244 43.0 0.00045
NP_060301 (OMIM: 610432,616260) E3 ubiquitin-prote ( 232) 245 43.2 0.00045
NP_004286 (OMIM: 602464) TNF receptor-associated f ( 470) 237 42.7 0.0014
XP_011508259 (OMIM: 602356) PREDICTED: TNF recepto ( 631) 222 40.9 0.0062
XP_011524347 (OMIM: 610432,616260) PREDICTED: E3 u ( 227) 212 39.0 0.0085
>>NP_061153 (OMIM: 612451) E3 ubiquitin-protein ligase R (228 aa)
initn: 616 init1: 410 opt: 752 Z-score: 546.5 bits: 108.4 E(85289): 1.1e-23
Smith-Waterman score: 752; 45.2% identity (71.7% similar) in 230 aa overlap (10-234:2-225)
10 20 30 40 50
pF1KE4 MAMFRSLVASAQQRQ-----PPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCG
.::::. ::::. . : ...:::.:::::..:: . :::.::.
NP_061 MAAQQRDCGGAAQLAGPAAEADPL-GRFTCPVCLEVYEKPVQV-PCGHVFCS
10 20 30 40 50
60 70 80 90 100 110
pF1KE4 ECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHIS
::: ::. .:.: .:: . : .:...:.:. : .. :.:: :. :.:.: :..
NP_061 ACLQECLKPKKPVCGVCRSALAPGV--RAVELERQIESTETSCHGCRKNFFLSKIRSHVA
60 70 80 90 100
120 130 140 150 160 170
pF1KE4 SCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRS
.: : :. . . : .. .. : :.::: :: :::: .:.::. ::.:: : .
NP_061 TCSKYQNYIMEGVK--ATIKDASLQPRNVPNRYTFPCPYCPEKNFDQEGLVEHCKLFHST
110 120 130 140 150 160
180 190 200 210 220 230
pF1KE4 DPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLS
: . ::::::..::::::.:.:::: .:. .::.:::::::::..::: .. .: :.
NP_061 DTKSVVCPICASMPWGDPNYRSANFREHIQRRHRFSYDTFVDYDVDEEDMMNQVLQRSII
170 180 190 200 210 220
pF1KE4 EN
NP_061 DQ
>>NP_937761 (OMIM: 616319) E3 ubiquitin-protein ligase R (151 aa)
initn: 435 init1: 297 opt: 298 Z-score: 232.8 bits: 49.8 E(85289): 3.1e-06
Smith-Waterman score: 298; 34.3% identity (62.9% similar) in 140 aa overlap (98-237:18-150)
70 80 90 100 110 120
pF1KE4 LCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANC
: :.. . : :. ..: .:... ..
NP_937 MAEDLSAATSYTEDDFYCPVCQE---VLKTPVRTTACQHVNRSETST
10 20 30 40
130 140 150 160 170 180
pF1KE4 PKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSA
. : : :. .. :: :: : :. .:.:. :: .: . :.:::: .
NP_937 SD---NTETYQENTSS-SGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVS
50 60 70 80 90 100
190 200 210 220 230
pF1KE4 MPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN
.:::::: . ::..:: .::.:.: ::. ..:::. .:.:. :.. :
NP_937 LPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
110 120 130 140 150
>>XP_005258343 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (151 aa)
initn: 435 init1: 297 opt: 298 Z-score: 232.8 bits: 49.8 E(85289): 3.1e-06
Smith-Waterman score: 298; 34.3% identity (62.9% similar) in 140 aa overlap (98-237:18-150)
70 80 90 100 110 120
pF1KE4 LCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSCLKVQEQMANC
: :.. . : :. ..: .:... ..
XP_005 MAEDLSAATSYTEDDFYCPVCQE---VLKTPVRTTACQHVNRSETST
10 20 30 40
130 140 150 160 170 180
pF1KE4 PKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSA
. : : :. .. :: :: : :. .:.:. :: .: . :.:::: .
XP_005 SD---NTETYQENTSS-SGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVS
50 60 70 80 90 100
190 200 210 220 230
pF1KE4 MPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN
.:::::: . ::..:: .::.:.: ::. ..:::. .:.:. :.. :
XP_005 LPWGDPSQITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
110 120 130 140 150
>>XP_005258342 (OMIM: 616319) PREDICTED: E3 ubiquitin-pr (199 aa)
initn: 468 init1: 297 opt: 297 Z-score: 230.9 bits: 49.8 E(85289): 4e-06
Smith-Waterman score: 388; 33.2% identity (58.0% similar) in 193 aa overlap (69-237:8-198)
40 50 60 70 80 90
pF1KE4 VYHRPVAIGSCGHTFCGECLQPCLQVPSPLCPLCRLPFDPKKV---DKATHVEKQLSSYK
::::: .. ..: .:. . ...
XP_005 MRESGAHCPLCRGNVTRRERACPERALDLENIMRKFS
10 20 30
100 110 120 130 140
pF1KE4 APCRGCNKKVTLAKMRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRS-------
. :: : :.. . .:: : .:: : :.... ...: :: .: :::
XP_005 GSCRCCAKQIKFYRMRHHYKSCKKYQDEYG-VSSIIPNFQISQDSVGN-SNRSETSTSDN
40 50 60 70 80 90
150 160 170 180 190
pF1KE4 --------------TFACPYCGARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPS
:: :: : :. .:.:. :: .: . :.:::: ..::::::
XP_005 TETYQENTSSSGHPTFKCPLCQESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPS
100 110 120 130 140 150
200 210 220 230
pF1KE4 YKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSLSEN
. ::..:: .::.:.: ::. ..:::. .:.:. :.. :
XP_005 QITRNFVSHLNQRHQFDYGEFVNLQLDEETQYQTAVEESFQVNI
160 170 180 190
>>NP_001178253 (OMIM: 616319) E3 ubiquitin-protein ligas (245 aa)
initn: 578 init1: 297 opt: 297 Z-score: 230.0 bits: 50.0 E(85289): 4.5e-06
Smith-Waterman score: 499; 32.9% identity (57.8% similar) in 237 aa overlap (25-237:10-244)
10 20 30 40 50 60
pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQP
: : .. ::.: :: . :: .: :.:: .:.
NP_001 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLT
10 20 30 40
70 80 90 100 110
pF1KE4 CLQVPSPLCPLCRLPFDPKKV---DKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSC
.. . ::::: .. ..: .:. . .... :: : :.. . .:: : .::
NP_001 AMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSC
50 60 70 80 90 100
120 130 140 150
pF1KE4 LKVQEQMANCPKFVPVVPTSQPIPSNIPNRS---------------------TFACPYCG
: :.... ...: :: .: ::: :: :: :
NP_001 KKYQDEYG-VSSIIPNFQISQDSVGN-SNRSETSTSDNTETYQENTSSSGHPTFKCPLCQ
110 120 130 140 150 160
160 170 180 190 200 210
pF1KE4 ARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFV
:. .:.:. :: .: . :.:::: ..:::::: . ::..:: .::.:.: ::
NP_001 ESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFV
170 180 190 200 210 220
220 230
pF1KE4 DYSIDEEAAFQAALALSLSEN
. ..:::. .:.:. :.. :
NP_001 NLQLDEETQYQTAVEESFQVNI
230 240
>>NP_057355 (OMIM: 616319) E3 ubiquitin-protein ligase R (245 aa)
initn: 578 init1: 297 opt: 297 Z-score: 230.0 bits: 50.0 E(85289): 4.5e-06
Smith-Waterman score: 499; 32.9% identity (57.8% similar) in 237 aa overlap (25-237:10-244)
10 20 30 40 50 60
pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQP
: : .. ::.: :: . :: .: :.:: .:.
NP_057 MAEDLSAATSYTEDDFYCPVCQEVLKTPVRTTACQHVFCRKCFLT
10 20 30 40
70 80 90 100 110
pF1KE4 CLQVPSPLCPLCRLPFDPKKV---DKATHVEKQLSSYKAPCRGCNKKVTLAKMRVHISSC
.. . ::::: .. ..: .:. . .... :: : :.. . .:: : .::
NP_057 AMRESGAHCPLCRGNVTRRERACPERALDLENIMRKFSGSCRCCAKQIKFYRMRHHYKSC
50 60 70 80 90 100
120 130 140 150
pF1KE4 LKVQEQMANCPKFVPVVPTSQPIPSNIPNRS---------------------TFACPYCG
: :.... ...: :: .: ::: :: :: :
NP_057 KKYQDEYG-VSSIIPNFQISQDSVGN-SNRSETSTSDNTETYQENTSSSGHPTFKCPLCQ
110 120 130 140 150 160
160 170 180 190 200 210
pF1KE4 ARNLDQQELVKHCVESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFV
:. .:.:. :: .: . :.:::: ..:::::: . ::..:: .::.:.: ::
NP_057 ESNFTRQRLLDHCNSNHLFQIVPVTCPICVSLPWGDPSQITRNFVSHLNQRHQFDYGEFV
170 180 190 200 210 220
220 230
pF1KE4 DYSIDEEAAFQAALALSLSEN
. ..:::. .:.:. :.. :
NP_057 NLQLDEETQYQTAVEESFQVNI
230 240
>>XP_011524349 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (191 aa)
initn: 236 init1: 109 opt: 244 Z-score: 194.2 bits: 43.0 E(85289): 0.00044
Smith-Waterman score: 298; 30.9% identity (52.7% similar) in 165 aa overlap (12-176:23-164)
10 20 30 40
pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSC
..:. : :. ... : .:::: :.:: :
XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPV-------TSFDCAVCLEVLHQPVRT-RC
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 GHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAK
::.:: :. :. . :: :: . :.. :: : :...: : :. : :..
XP_011 GHVFCRSCIATSLKNNKWTCPYCR-AYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 MRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHC
::.:: .: : . :. :. . . ::.: :.: .. :. ::
XP_011 MRAHIRTCQKYID------KYGPLQELEETAARCV-------CPFC-QRELYEDSLLDHC
120 130 140 150
170 180 190 200 210 220
pF1KE4 VESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAA
. :::.
XP_011 ITHHRSERRPVDNNTKIHLSCCCPRPHFHPQVPQ
160 170 180 190
>>XP_011524348 (OMIM: 610432,616260) PREDICTED: E3 ubiqu (196 aa)
initn: 268 init1: 109 opt: 244 Z-score: 194.1 bits: 43.0 E(85289): 0.00045
Smith-Waterman score: 298; 30.9% identity (52.7% similar) in 165 aa overlap (12-176:23-164)
10 20 30 40
pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSC
..:. : :. ... : .:::: :.:: :
XP_011 MGSVLSTDSGKSAPASATARALERRRDPELPV-------TSFDCAVCLEVLHQPVRT-RC
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 GHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAK
::.:: :. :. . :: :: . :.. :: : :...: : :. : :..
XP_011 GHVFCRSCIATSLKNNKWTCPYCR-AYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 MRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHC
::.:: .: : . :. :. . . ::.: :.: .. :. ::
XP_011 MRAHIRTCQKYID------KYGPLQELEETAARCV-------CPFC-QRELYEDSLLDHC
120 130 140 150
170 180 190 200 210 220
pF1KE4 VESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAA
. :::.
XP_011 ITHHRSERRPVDFNIIEEALIRRVLDRSLLEYVNHSNTT
160 170 180 190
>>NP_060301 (OMIM: 610432,616260) E3 ubiquitin-protein l (232 aa)
initn: 403 init1: 189 opt: 245 Z-score: 194.1 bits: 43.2 E(85289): 0.00045
Smith-Waterman score: 438; 32.9% identity (55.6% similar) in 225 aa overlap (12-236:23-224)
10 20 30 40
pF1KE4 MAMFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSC
..:. : :. ... : .:::: :.:: :
NP_060 MGSVLSTDSGKSAPASATARALERRRDPELPV-------TSFDCAVCLEVLHQPVRT-RC
10 20 30 40 50
50 60 70 80 90 100
pF1KE4 GHTFCGECLQPCLQVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPCRGCNKKVTLAK
::.:: :. :. . :: :: . :.. :: : :...: : :. : :..
NP_060 GHVFCRSCIATSLKNNKWTCPYCR-AYLPSEGVPATDVAKRMKSEYKNCAECDTLVCLSE
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE4 MRVHISSCLKVQEQMANCPKFVPVVPTSQPIPSNIPNRSTFACPYCGARNLDQQELVKHC
::.:: .: : . :. :. . . ::.: :.: .. :. ::
NP_060 MRAHIRTCQKYID------KYGPLQELEETAARCV-------CPFC-QRELYEDSLLDHC
120 130 140 150
170 180 190 200 210 220
pF1KE4 VESHRSDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAA
. :::. : ::.: .: .:: :.....:: : . :: :.:..: ::: .. .
NP_060 ITHHRSERRPVFCPLCRLIPDENPSSFSGSLIRHLQVSHTLFYDDFIDFNIIEEALIRRV
160 170 180 190 200 210
230
pF1KE4 LALSLSEN
: :: :
NP_060 LDRSLLEYVNHSNTT
220 230
>>NP_004286 (OMIM: 602464) TNF receptor-associated facto (470 aa)
initn: 213 init1: 161 opt: 237 Z-score: 185.4 bits: 42.7 E(85289): 0.0014
Smith-Waterman score: 239; 25.7% identity (54.0% similar) in 187 aa overlap (33-211:18-186)
10 20 30 40 50 60
pF1KE4 MFRSLVASAQQRQPPAGPAGGDSGLEAQYTCPICLEVYHRPVAIGSCGHTFCGECLQPCL
::.: . ...:: ...::: :: ::: :
NP_004 MPGFDYKFLEKPKRRLLCPLCGKPMREPVQVSTCGHRFCDTCLQEFL
10 20 30 40
70 80 90 100 110
pF1KE4 QVPSPLCPLCRLPFDPKKVDKATHVEKQLSSYKAPC----RGCNKKVTLAKMRVHISSCL
. :: .::.: :. ..: :. . : .:: . : ... :...:
NP_004 SEGVFKCPEDQLPLDYAKIYPDPELEVQVLGLPIRCIHSEEGCRWSGPLRHLQGHLNTC-
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE4 KVQEQMANCPKFVPVVPTSQPIPSNI----PNRSTFACPYCGARNLDQQELVKHCVESHR
. .. ::. :. . . .:... :.: . : .:: .. . :::.
NP_004 --SFNVIPCPNRCPMKLSRRDLPAHLQHDCPKRR-LKCEFCGC------DFSGEAYESHE
110 120 130 140 150
180 190 200 210 220 230
pF1KE4 SDPNRVVCPICSAMPWGDPSYKSANFLQHLLHRHKFSYDTFVDYSIDEEAAFQAALALSL
. .:: :.. . .: ....:: .: :
NP_004 G-----MCPQESVYC---ENKCGARMMRRLLAQHATSECPKRTQPCTYCTKEFVFDTIQS
160 170 180 190 200
pF1KE4 SEN
NP_004 HQYQCPRLPVACPNQCGVGTVAREDLPGHLKDSCNTALVLCPFKDSGCKHRCPKLAMARH
210 220 230 240 250 260
237 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:18:53 2016 done: Sun Nov 6 04:18:54 2016
Total Scan time: 7.100 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]