Result of FASTA (omim) for
pFN21AE4006
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4006, 126 aa
1>>>pF1KE4006 126 - 126 aa - 126 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.4679+/-0.000259; mu= 11.1675+/- 0.016
mean_var=80.3630+/-15.610, 0's: 0 Z-trim(121.8): 31 B-trim: 82 in 1/53
Lambda= 0.143069
statistics sampled from 38856 (38887) to 38856 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.819), E-opt: 0.2 (0.456), width: 16
Scan time: 4.690
The best scores are: opt bits E(85289)
NP_001010858 (OMIM: 613754) E3 ubiquitin-protein l ( 235) 842 182.1 3.7e-46
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 160 41.6 0.0015
XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 148 38.9 0.0054
XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 148 38.9 0.0054
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 150 39.5 0.0063
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 148 39.0 0.0066
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 148 39.1 0.0082
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 148 39.1 0.0086
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 148 39.1 0.0086
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 148 39.1 0.0086
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 148 39.1 0.0086
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 148 39.1 0.0086
>>NP_001010858 (OMIM: 613754) E3 ubiquitin-protein ligas (235 aa)
initn: 842 init1: 842 opt: 842 Z-score: 949.6 bits: 182.1 E(85289): 3.7e-46
Smith-Waterman score: 842; 100.0% identity (100.0% similar) in 126 aa overlap (1-126:110-235)
10 20 30
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIM
::::::::::::::::::::::::::::::
NP_001 AAPARDGPASEAALQLLCRADAGPLCAACRMAAGPEPPEWEPRWRKALRGKENKGSVEIM
80 90 100 110 120 130
40 50 60 70 80 90
pF1KE4 RKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RKDLNDARDLHGQAESAAAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGL
140 150 160 170 180 190
100 110 120
pF1KE4 PEDELADPTERFRSLLQAVSELEKKHRNLGLSMLLQ
::::::::::::::::::::::::::::::::::::
NP_001 PEDELADPTERFRSLLQAVSELEKKHRNLGLSMLLQ
200 210 220 230
>>NP_660215 (OMIM: 607868) E3 ubiquitin-protein ligase T (468 aa)
initn: 167 init1: 151 opt: 160 Z-score: 184.6 bits: 41.6 E(85289): 0.0015
Smith-Waterman score: 160; 30.6% identity (71.2% similar) in 111 aa overlap (18-124:135-244)
10 20 30 40
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESA
:..: .: :.: .::...:: ...::. .
NP_660 DELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEK-SLEHLRKQMQDALLFQAQADET
110 120 130 140 150 160
50 60 70 80 90 100
pF1KE4 AAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEG--LPE--DELADPTERFR
..:. : ..:...: ....:: ...:::...::. :.:: ::. . : ..
NP_660 CVLWQKMVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSA
170 180 190 200 210 220
110 120
pF1KE4 SLLQAVSELEKKHRNLGLSMLLQ
: . ..::: . . .:..:
NP_660 HLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLR
230 240 250 260 270 280
>>XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (262 aa)
initn: 132 init1: 132 opt: 148 Z-score: 174.8 bits: 38.9 E(85289): 0.0054
Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238)
10 20 30 40 50
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM
.: .:.... . .:... :.. : :.:.:
XP_016 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
60 70 80 90 100 110
pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH
.::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :...
XP_016 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG
180 190 200 210 220
120
pF1KE4 RNLGLSMLLQ
..: : .:::
XP_016 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRTT
230 240 250 260
>>XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (262 aa)
initn: 132 init1: 132 opt: 148 Z-score: 174.8 bits: 38.9 E(85289): 0.0054
Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238)
10 20 30 40 50
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM
.: .:.... . .:... :.. : :.:.:
XP_016 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
60 70 80 90 100 110
pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH
.::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :...
XP_016 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG
180 190 200 210 220
120
pF1KE4 RNLGLSMLLQ
..: : .:::
XP_016 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRTT
230 240 250 260
>>XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquitin-pr (467 aa)
initn: 156 init1: 89 opt: 150 Z-score: 173.5 bits: 39.5 E(85289): 0.0063
Smith-Waterman score: 150; 30.6% identity (71.2% similar) in 111 aa overlap (18-124:135-243)
10 20 30 40
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESA
:..: .: :.: .::...:: ...::. .
XP_016 DELRLLCAACERSGEHWAHRVRPLQDAAEDLKAKLEK-SLEHLRKQMQDALLFQAQADET
110 120 130 140 150 160
50 60 70 80 90 100
pF1KE4 AAVWKGHVMDRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEG--LPE--DELADPTERFR
..:. : ..:...: ....:: ...:::...::. :.:: ::. . : ..
XP_016 CVLWQ-MVESQRQNVLGEFERLRRLLAEEEQQLLQRLEEEELEVLPRLREGAAHLGQQSA
170 180 190 200 210 220
110 120
pF1KE4 SLLQAVSELEKKHRNLGLSMLLQ
: . ..::: . . .:..:
XP_016 HLAELIAELEGRCQLPALGLLQDIKDALRRVQDVKLQPPEVVPMELRTVCRVPGLVETLR
230 240 250 260 270 280
>>NP_001128327 (OMIM: 606123) E3 ubiquitin-protein ligas (343 aa)
initn: 132 init1: 132 opt: 148 Z-score: 173.2 bits: 39.0 E(85289): 0.0066
Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238)
10 20 30 40 50
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM
.: .:.... . .:... :.. : :.:.:
NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
60 70 80 90 100 110
pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH
.::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :...
NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG
180 190 200 210 220
120
pF1KE4 RNLGLSMLLQ
..: : .:::
NP_001 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE
230 240 250 260 270 280
>>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa)
initn: 132 init1: 132 opt: 148 Z-score: 171.5 bits: 39.1 E(85289): 0.0082
Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:123-211)
10 20 30 40 50
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM
.: .:.... . .:... :.. : :.:.:
XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
100 110 120 130 140 150
60 70 80 90 100 110
pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH
.::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :...
XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG
160 170 180 190 200
120
pF1KE4 RNLGLSMLLQ
..: : .:::
XP_011 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE
210 220 230 240 250 260
>>NP_057186 (OMIM: 606123) E3 ubiquitin-protein ligase T (477 aa)
initn: 132 init1: 132 opt: 148 Z-score: 171.1 bits: 39.1 E(85289): 0.0086
Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238)
10 20 30 40 50
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM
.: .:.... . .:... :.. : :.:.:
NP_057 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
60 70 80 90 100 110
pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH
.::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :...
NP_057 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG
180 190 200 210 220
120
pF1KE4 RNLGLSMLLQ
..: : .:::
NP_057 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE
230 240 250 260 270 280
>>NP_001020111 (OMIM: 606123) E3 ubiquitin-protein ligas (477 aa)
initn: 132 init1: 132 opt: 148 Z-score: 171.1 bits: 39.1 E(85289): 0.0086
Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238)
10 20 30 40 50
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM
.: .:.... . .:... :.. : :.:.:
NP_001 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
60 70 80 90 100 110
pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH
.::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :...
NP_001 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG
180 190 200 210 220
120
pF1KE4 RNLGLSMLLQ
..: : .:::
NP_001 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE
230 240 250 260 270 280
>>XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (477 aa)
initn: 132 init1: 132 opt: 148 Z-score: 171.1 bits: 39.1 E(85289): 0.0086
Smith-Waterman score: 155; 31.0% identity (71.0% similar) in 100 aa overlap (27-126:150-238)
10 20 30 40 50
pF1KE4 MAAGPEPPEWEPRWRKALRGKENKGSVEIMRKDLNDARDLHGQAESAAAVWKGHVM
.: .:.... . .:... :.. : :.:.:
XP_011 VCRESREHRLHRVLPAEEAVQGYKLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVK
120 130 140 150 160 170
60 70 80 90 100 110
pF1KE4 DRRKKALTDYKKLRAFFVEEEEHFLQEAEKEEGLPEDELADPTERFRSLLQAVSELEKKH
.::.. . ...:. ..::::...:: : :: .: :. :.: ..:. :...
XP_011 ERRERIVLEFEKMNLYLVEEEQRLLQALETEE----EETAS---RLR---ESVACLDRQG
180 190 200 210 220
120
pF1KE4 RNLGLSMLLQ
..: : .:::
XP_011 HSLEL-LLLQLEERSTQGPLQMLQDMKEPLSRKNNVSVQCPEVAPPTRPRTVCRVPGQIE
230 240 250 260 270 280
126 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:03:10 2016 done: Sun Nov 6 04:03:11 2016
Total Scan time: 4.690 Total Display time: -0.030
Function used was FASTA [36.3.4 Apr, 2011]