Result of FASTA (omim) for
pFN21AE4002
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE4002, 203 aa
1>>>pF1KE4002 203 - 203 aa - 203 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.0378+/-0.000438; mu= 14.9310+/- 0.027
mean_var=82.9355+/-18.096, 0's: 0 Z-trim(112.6): 166 B-trim: 1321 in 2/47
Lambda= 0.140833
statistics sampled from 21326 (21577) to 21326 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.63), E-opt: 0.2 (0.253), width: 16
Scan time: 4.690
The best scores are: opt bits E(85289)
NP_201572 (OMIM: 612128) ras-like protein family m ( 203) 1392 292.5 3.1e-79
XP_016880790 (OMIM: 612128) PREDICTED: ras-like pr ( 203) 1392 292.5 3.1e-79
XP_016880789 (OMIM: 612128) PREDICTED: ras-like pr ( 211) 988 210.4 1.6e-54
NP_006468 (OMIM: 602220) ras-like protein family m ( 203) 680 147.8 1.1e-35
XP_011528125 (OMIM: 602220) PREDICTED: ras-like pr ( 155) 501 111.4 8.1e-25
XP_011528123 (OMIM: 602220) PREDICTED: ras-like pr ( 223) 501 111.5 1e-24
XP_011528124 (OMIM: 602220) PREDICTED: ras-like pr ( 223) 501 111.5 1e-24
NP_996563 (OMIM: 612403) ras-like protein family m ( 242) 227 55.9 6.4e-08
XP_016883322 (OMIM: 610388) PREDICTED: GTP-binding ( 306) 212 52.9 6.2e-07
XP_005260461 (OMIM: 610388) PREDICTED: GTP-binding ( 306) 212 52.9 6.2e-07
NP_076429 (OMIM: 612404) ras-like protein family m ( 248) 209 52.2 8.2e-07
XP_011527097 (OMIM: 610388) PREDICTED: GTP-binding ( 304) 203 51.1 2.2e-06
NP_001238847 (OMIM: 179530) ras-related protein Ra ( 142) 186 47.3 1.4e-05
NP_001238846 (OMIM: 179530) ras-related protein Ra ( 142) 186 47.3 1.4e-05
NP_001238850 (OMIM: 179530) ras-related protein Ra ( 165) 186 47.4 1.6e-05
XP_011514759 (OMIM: 601293) PREDICTED: GTP-binding ( 173) 186 47.4 1.6e-05
NP_001010942 (OMIM: 179530) ras-related protein Ra ( 184) 186 47.4 1.7e-05
NP_056461 (OMIM: 179530) ras-related protein Rap-1 ( 184) 186 47.4 1.7e-05
NP_001010935 (OMIM: 179520) ras-related protein Ra ( 184) 184 47.0 2.2e-05
XP_016857453 (OMIM: 179520) PREDICTED: ras-related ( 184) 184 47.0 2.2e-05
XP_016857451 (OMIM: 179520) PREDICTED: ras-related ( 184) 184 47.0 2.2e-05
XP_016857452 (OMIM: 179520) PREDICTED: ras-related ( 184) 184 47.0 2.2e-05
NP_001278825 (OMIM: 179520) ras-related protein Ra ( 184) 184 47.0 2.2e-05
NP_002875 (OMIM: 179520) ras-related protein Rap-1 ( 184) 184 47.0 2.2e-05
XP_011528342 (OMIM: 612842) PREDICTED: GTP-binding ( 266) 183 47.0 3.3e-05
XP_005261499 (OMIM: 612842) PREDICTED: GTP-binding ( 266) 183 47.0 3.3e-05
XP_016884191 (OMIM: 612842) PREDICTED: GTP-binding ( 266) 183 47.0 3.3e-05
NP_055125 (OMIM: 612842) GTP-binding protein Rhes ( 266) 183 47.0 3.3e-05
XP_016884190 (OMIM: 612842) PREDICTED: GTP-binding ( 278) 183 47.0 3.4e-05
NP_001318055 (OMIM: 612403) ras-like protein famil ( 200) 173 44.8 0.00011
NP_001122322 (OMIM: 179503) GTP-binding protein RA ( 308) 173 45.0 0.00015
NP_004156 (OMIM: 179503) GTP-binding protein RAD [ ( 308) 173 45.0 0.00015
NP_057168 (OMIM: 605550) dexamethasone-induced Ras ( 281) 172 44.8 0.00016
XP_016857450 (OMIM: 179520) PREDICTED: ras-related ( 195) 168 43.8 0.00022
XP_016857449 (OMIM: 179520) PREDICTED: ras-related ( 195) 168 43.8 0.00022
NP_001096139 (OMIM: 600098) ras-related protein R- ( 127) 164 42.8 0.00029
NP_001170786 (OMIM: 600098) ras-related protein R- ( 127) 164 42.8 0.00029
NP_001243749 (OMIM: 609591,615355) GTP-binding pro ( 183) 165 43.2 0.00032
XP_011509876 (OMIM: 179551) PREDICTED: ras-related ( 195) 165 43.2 0.00034
NP_001170785 (OMIM: 600098) ras-related protein R- ( 169) 164 42.9 0.00035
XP_016872852 (OMIM: 600098) PREDICTED: ras-related ( 182) 164 42.9 0.00037
XP_016857447 (OMIM: 179510) PREDICTED: ras-related ( 219) 162 42.6 0.00056
NP_002858 (OMIM: 179510) ras-related protein Rab-3 ( 219) 162 42.6 0.00056
NP_006261 (OMIM: 165090) ras-related protein R-Ras ( 218) 159 42.0 0.00085
NP_005252 (OMIM: 600164) GTP-binding protein GEM [ ( 296) 158 41.9 0.0012
NP_859053 (OMIM: 600164) GTP-binding protein GEM [ ( 296) 158 41.9 0.0012
NP_055814 (OMIM: 612398) ras-related protein Rab-2 ( 225) 156 41.4 0.0013
NP_112586 (OMIM: 605950,615222) ras-related protei ( 229) 155 41.2 0.0016
XP_011530601 (OMIM: 605950,615222) PREDICTED: ras- ( 277) 155 41.3 0.0018
NP_001138399 (OMIM: 604497) NF-kappa-B inhibitor-i ( 191) 150 40.1 0.0028
>>NP_201572 (OMIM: 612128) ras-like protein family membe (203 aa)
initn: 1392 init1: 1392 opt: 1392 Z-score: 1543.4 bits: 292.5 E(85289): 3.1e-79
Smith-Waterman score: 1392; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203)
10 20 30 40 50 60
pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_201 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_201 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_201 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA
130 140 150 160 170 180
190 200
pF1KE4 RCKHVHAALRFQGALRRNRCAIM
:::::::::::::::::::::::
NP_201 RCKHVHAALRFQGALRRNRCAIM
190 200
>>XP_016880790 (OMIM: 612128) PREDICTED: ras-like protei (203 aa)
initn: 1392 init1: 1392 opt: 1392 Z-score: 1543.4 bits: 292.5 E(85289): 3.1e-79
Smith-Waterman score: 1392; 100.0% identity (100.0% similar) in 203 aa overlap (1-203:1-203)
10 20 30 40 50 60
pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE4 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIGTSE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE4 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSVGCA
130 140 150 160 170 180
190 200
pF1KE4 RCKHVHAALRFQGALRRNRCAIM
:::::::::::::::::::::::
XP_016 RCKHVHAALRFQGALRRNRCAIM
190 200
>>XP_016880789 (OMIM: 612128) PREDICTED: ras-like protei (211 aa)
initn: 1007 init1: 988 opt: 988 Z-score: 1099.6 bits: 210.4 E(85289): 1.6e-54
Smith-Waterman score: 988; 99.3% identity (100.0% similar) in 147 aa overlap (1-147:60-206)
10 20 30
pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFS
::::::::::::::::::::::::::::::
XP_016 TVAEPPAPGICSPGEPQTAARTRWRSGAGGMVSTYRVAVLGARGVGKSAIVRQFLYNEFS
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE4 EVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYIL
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE4 VYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_016 VYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLILAA
150 160 170 180 190 200
160 170 180 190 200
pF1KE4 WKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM
XP_016 SL
210
>>NP_006468 (OMIM: 602220) ras-like protein family membe (203 aa)
initn: 619 init1: 426 opt: 680 Z-score: 761.6 bits: 147.8 E(85289): 1.1e-35
Smith-Waterman score: 680; 52.9% identity (74.5% similar) in 208 aa overlap (1-203:1-203)
10 20 30 40 50 60
pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTTARRLYLPAVVMNGHVHDLQILDF
: .. ::::::: ::::.::.::::.... : :: . ::: :::...: :.::.: :
NP_006 MGGSLRVAVLGAPGVGKTAIIRQFLFGDYPERHRPTDGPRLYRPAVLLDGAVYDLSIRDG
10 20 30 40 50 60
70 80 90 100 110
pF1KE4 P---PISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFEYVKTIRQQILETRVIG
: :. : . .:: :. .:... :..:::::: :::.:::..::.: ::: :
NP_006 DVAGPGSS-PGGP-EEWPDAKDWSLQDTDAFVLVYDICSPDSFDYVKALRQRIAETRPAG
70 80 90 100 110
120 130 140 150 160 170
pF1KE4 TSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAKYNWHILLLFSELLKSV
. :.::..:::::: :: : :: .. :::. :.:::.:::::::::.: :: :::.
NP_006 APEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAKYNWHVLRLFRELLR--
120 130 140 150 160 170
180 190 200
pF1KE4 GCA--RCKHVHAALRFQGALRRNRCAIM
:: : . .: :::.::::. ::..:
NP_006 -CALVRARPAHPALRLQGALHPARCSLM
180 190 200
>>XP_011528125 (OMIM: 602220) PREDICTED: ras-like protei (155 aa)
initn: 495 init1: 426 opt: 501 Z-score: 566.6 bits: 111.4 E(85289): 8.1e-25
Smith-Waterman score: 501; 55.2% identity (76.9% similar) in 134 aa overlap (72-203:25-155)
50 60 70 80 90 100
pF1KE4 YLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFE
.:: :. .:... :..:::::: :::.
XP_011 MRMSKDPLHPKHVSCGGSLHSWVQEEWPDAKDWSLQDTDAFVLVYDICSPDSFD
10 20 30 40 50
110 120 130 140 150 160
pF1KE4 YVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAK
:::..::.: ::: :. :.::..:::::: :: : :: .. :::. :.:::.:::::
XP_011 YVKALRQRIAETRPAGAPEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAK
60 70 80 90 100 110
170 180 190 200
pF1KE4 YNWHILLLFSELLKSVGCA--RCKHVHAALRFQGALRRNRCAIM
::::.: :: :::. :: : . .: :::.::::. ::..:
XP_011 YNWHVLRLFRELLR---CALVRARPAHPALRLQGALHPARCSLM
120 130 140 150
>>XP_011528123 (OMIM: 602220) PREDICTED: ras-like protei (223 aa)
initn: 496 init1: 426 opt: 501 Z-score: 564.5 bits: 111.5 E(85289): 1e-24
Smith-Waterman score: 501; 55.2% identity (76.9% similar) in 134 aa overlap (72-203:93-223)
50 60 70 80 90 100
pF1KE4 YLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFE
.:: :. .:... :..:::::: :::.
XP_011 GASSVWKSGRGSGWEGASILERVRGAGHAEEEWPDAKDWSLQDTDAFVLVYDICSPDSFD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 YVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAK
:::..::.: ::: :. :.::..:::::: :: : :: .. :::. :.:::.:::::
XP_011 YVKALRQRIAETRPAGAPEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAK
130 140 150 160 170 180
170 180 190 200
pF1KE4 YNWHILLLFSELLKSVGCA--RCKHVHAALRFQGALRRNRCAIM
::::.: :: :::. :: : . .: :::.::::. ::..:
XP_011 YNWHVLRLFRELLR---CALVRARPAHPALRLQGALHPARCSLM
190 200 210 220
>>XP_011528124 (OMIM: 602220) PREDICTED: ras-like protei (223 aa)
initn: 496 init1: 426 opt: 501 Z-score: 564.5 bits: 111.5 E(85289): 1e-24
Smith-Waterman score: 501; 55.2% identity (76.9% similar) in 134 aa overlap (72-203:93-223)
50 60 70 80 90 100
pF1KE4 YLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCFDSFE
.:: :. .:... :..:::::: :::.
XP_011 GASSVWKSGRGSGWEGASILERVRGAGHAEEEWPDAKDWSLQDTDAFVLVYDICSPDSFD
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE4 YVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVECSAK
:::..::.: ::: :. :.::..:::::: :: : :: .. :::. :.:::.:::::
XP_011 YVKALRQRIAETRPAGAPEAPILVVGNKRDRQRLRFGPRRALAALVRRGWRCGYLECSAK
130 140 150 160 170 180
170 180 190 200
pF1KE4 YNWHILLLFSELLKSVGCA--RCKHVHAALRFQGALRRNRCAIM
::::.: :: :::. :: : . .: :::.::::. ::..:
XP_011 YNWHVLRLFRELLR---CALVRARPAHPALRLQGALHPARCSLM
190 200 210 220
>>NP_996563 (OMIM: 612403) ras-like protein family membe (242 aa)
initn: 201 init1: 74 opt: 227 Z-score: 263.2 bits: 55.9 E(85289): 6.4e-08
Smith-Waterman score: 227; 31.2% identity (63.6% similar) in 173 aa overlap (6-177:29-196)
10 20 30
pF1KE4 MVSTYRVAVLGARGVGKSAIVRQFLYNEFSEVCVPTT
..::::: :::::.. .:: ..: :.:
NP_996 MRPLSMSGHFLLAPIPESSSDYLLPKDIKLAVLGAGRVGKSAMIVRFLTKRFIGDYEPNT
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE4 ARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQEWADTCCRGLRSVHAYILVYDICCF
.. :: : ..: .::: : : . ..: . .:. . .. .....:::.: .
NP_996 GK-LYSRLVYVEGDQLSLQIQDTPGGVQIQ-DSLPQVVDSLSKCVQWAEGFLLVYSITDY
70 80 90 100 110
100 110 120 130 140 150
pF1KE4 DSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHLVRKTWKCGYVE
::. .. . :.: .: :..:.:::::: :: ..: . . .:. . . ..:
NP_996 DSYLSIRPLYQHI--RKVHPDSKAPVIIVGNKGDLLHARQVQTQDGIQLANELGSL-FLE
120 130 140 150 160 170
160 170 180 190 200
pF1KE4 CSAKYNWH-ILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM
:.. :.. . .:..: : :
NP_996 ISTSENYEDVCDVFQHLCKEVSKMHGLSGERRRASIIPRPRSPNMQDLKRRFKQALSPKV
180 190 200 210 220 230
>>XP_016883322 (OMIM: 610388) PREDICTED: GTP-binding pro (306 aa)
initn: 169 init1: 70 opt: 212 Z-score: 245.5 bits: 52.9 E(85289): 6.2e-07
Smith-Waterman score: 212; 26.9% identity (60.7% similar) in 201 aa overlap (5-197:81-268)
10 20
pF1KE4 MVSTYRVAVLGARGVGKSAIVRQF-------LYN
:::..:: ::::.... : :..
XP_016 SLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAGKQERDLHE
60 70 80 90 100 110
30 40 50 60 70 80
pF1KE4 EFSEVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQE-WADTCCRGLRSVH
.... .:..:. .: .....:. : ..: .. .. :.. :.. : :..
XP_016 QLGDPALPSVAEDVYERTLTVDGEDTTLVVVD-----TWEAEKLDKSWSQESC--LQGGS
120 130 140 150 160
90 100 110 120 130 140
pF1KE4 AYILVYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHL
::..::.: ::: .. .: :. :. ....:::.:::: :: : : . . ..
XP_016 AYVIVYSIADRGSFESASELRIQL--RRTHQADHVPIILVGNKADLARCREVSVEE-GRA
170 180 190 200 210 220
150 160 170 180 190 200
pF1KE4 VRKTWKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM
.. : ..: :: . .. :: ..... : .. .: . : ::
XP_016 CAVVFDCKFIETSATLQHNVAELFEGVVRQL---RLRRRDSAAKEPPAPRRPASLAQRAR
230 240 250 260 270
XP_016 RFLARLTARSARRRALKARSKSCHNLAVL
280 290 300
>>XP_005260461 (OMIM: 610388) PREDICTED: GTP-binding pro (306 aa)
initn: 169 init1: 70 opt: 212 Z-score: 245.5 bits: 52.9 E(85289): 6.2e-07
Smith-Waterman score: 212; 26.9% identity (60.7% similar) in 201 aa overlap (5-197:81-268)
10 20
pF1KE4 MVSTYRVAVLGARGVGKSAIVRQF-------LYN
:::..:: ::::.... : :..
XP_005 SLNPPTQKPSPAPDDWSSESSDSEGSWEALYRVVLLGDPGVGKTSLASLFAGKQERDLHE
60 70 80 90 100 110
30 40 50 60 70 80
pF1KE4 EFSEVCVPTTARRLYLPAVVMNGHVHDLQILDFPPISAFPVNTLQE-WADTCCRGLRSVH
.... .:..:. .: .....:. : ..: .. .. :.. :.. : :..
XP_005 QLGDPALPSVAEDVYERTLTVDGEDTTLVVVD-----TWEAEKLDKSWSQESC--LQGGS
120 130 140 150 160
90 100 110 120 130 140
pF1KE4 AYILVYDICCFDSFEYVKTIRQQILETRVIGTSETPIIIVGNKRDLQRGRVIPRWNVSHL
::..::.: ::: .. .: :. :. ....:::.:::: :: : : . . ..
XP_005 AYVIVYSIADRGSFESASELRIQL--RRTHQADHVPIILVGNKADLARCREVSVEE-GRA
170 180 190 200 210 220
150 160 170 180 190 200
pF1KE4 VRKTWKCGYVECSAKYNWHILLLFSELLKSVGCARCKHVHAALRFQGALRRNRCAIM
.. : ..: :: . .. :: ..... : .. .: . : ::
XP_005 CAVVFDCKFIETSATLQHNVAELFEGVVRQL---RLRRRDSAAKEPPAPRRPASLAQRAR
230 240 250 260 270
XP_005 RFLARLTARSARRRALKARSKSCHNLAVL
280 290 300
203 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:39:41 2016 done: Mon Nov 7 16:39:41 2016
Total Scan time: 4.690 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]