Result of FASTA (omim) for
pFN21AE3965
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3965, 332 aa
1>>>pF1KE3965 332 - 332 aa - 332 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6011+/-0.000426; mu= 15.9445+/- 0.026
mean_var=103.9290+/-22.115, 0's: 0 Z-trim(113.7): 128 B-trim: 1089 in 1/49
Lambda= 0.125807
statistics sampled from 23050 (23193) to 23050 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.64), E-opt: 0.2 (0.272), width: 16
Scan time: 7.260
The best scores are: opt bits E(85289)
NP_006559 (OMIM: 606138) cell growth regulator wit ( 332) 2246 418.3 1.1e-116
XP_016876420 (OMIM: 606138) PREDICTED: cell growth ( 272) 1849 346.2 4.8e-95
XP_011534664 (OMIM: 606138) PREDICTED: cell growth ( 272) 1849 346.2 4.8e-95
XP_016876421 (OMIM: 606138) PREDICTED: cell growth ( 272) 1849 346.2 4.8e-95
NP_114404 (OMIM: 606130) RING finger protein 26 [H ( 433) 179 43.3 0.0012
XP_011520744 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 339) 166 40.8 0.005
XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 514) 168 41.3 0.0052
NP_001243787 (OMIM: 608299) E3 ubiquitin-protein l ( 180) 162 39.8 0.0053
XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 530) 168 41.4 0.0053
NP_001135763 (OMIM: 607559) E3 ubiquitin-protein l ( 530) 168 41.4 0.0053
XP_016878581 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 531) 168 41.4 0.0053
XP_011520743 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 539) 168 41.4 0.0054
NP_001135762 (OMIM: 607559) E3 ubiquitin-protein l ( 552) 168 41.4 0.0055
XP_005255277 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 552) 168 41.4 0.0055
XP_016878580 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 168 41.4 0.0055
XP_005255276 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 553) 168 41.4 0.0055
NP_001135761 (OMIM: 607559) E3 ubiquitin-protein l ( 554) 168 41.4 0.0055
XP_005255275 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 555) 168 41.4 0.0055
NP_056061 (OMIM: 607559) E3 ubiquitin-protein liga ( 576) 168 41.4 0.0056
XP_005255274 (OMIM: 607559) PREDICTED: E3 ubiquiti ( 577) 168 41.4 0.0057
NP_079402 (OMIM: 608299) E3 ubiquitin-protein liga ( 372) 162 40.1 0.0088
NP_919247 (OMIM: 608299) E3 ubiquitin-protein liga ( 373) 162 40.1 0.0088
>>NP_006559 (OMIM: 606138) cell growth regulator with RI (332 aa)
initn: 2246 init1: 2246 opt: 2246 Z-score: 2215.8 bits: 418.3 E(85289): 1.1e-116
Smith-Waterman score: 2246; 99.7% identity (100.0% similar) in 332 aa overlap (1-332:1-332)
10 20 30 40 50 60
pF1KE3 MAAVFLVTLYEYSPLFYIAVVFTCFIVTTGLVLGWFGWDVPVILRNSEETQFSTRVFKKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MAAVFLVTLYEYSPLFYIAVVFTCFIVTTGLVLGWFGWDVPVILRNSEETQFSTRVFKKQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 MRQVKNPFGLEITNPSSASITTGITLTTDCLEDSLLTCYWGCNVQKLYEALQKHVYCFRI
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
NP_006 MRQVKNPFGLEITNPSSASITTGITLTTDCLEDSLLTCYWGCSVQKLYEALQKHVYCFRI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 STPQALEDALYSEYLYQEQYFIKKDSKEEIYCQLPRDTKIEDFGTVPRSRYPLVALLTLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 STPQALEDALYSEYLYQEQYFIKKDSKEEIYCQLPRDTKIEDFGTVPRSRYPLVALLTLA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 DEDDREIYDIISMVSVIHIPDRTYKLSCRILYQYLLLAQGQFHDLKQLFMSANNNFTPSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 DEDDREIYDIISMVSVIHIPDRTYKLSCRILYQYLLLAQGQFHDLKQLFMSANNNFTPSN
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 NSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDGCVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 NSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDGCVK
250 260 270 280 290 300
310 320 330
pF1KE3 YFQQCPMCRQFVQESFALCSQKEQDKDKPKTL
::::::::::::::::::::::::::::::::
NP_006 YFQQCPMCRQFVQESFALCSQKEQDKDKPKTL
310 320 330
>>XP_016876420 (OMIM: 606138) PREDICTED: cell growth reg (272 aa)
initn: 1849 init1: 1849 opt: 1849 Z-score: 1827.4 bits: 346.2 E(85289): 4.8e-95
Smith-Waterman score: 1849; 99.6% identity (100.0% similar) in 272 aa overlap (61-332:1-272)
40 50 60 70 80 90
pF1KE3 LVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDC
::::::::::::::::::::::::::::::
XP_016 MRQVKNPFGLEITNPSSASITTGITLTTDC
10 20 30
100 110 120 130 140 150
pF1KE3 LEDSLLTCYWGCNVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE3 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE3 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE3 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK
220 230 240 250 260 270
pF1KE3 TL
::
XP_016 TL
>>XP_011534664 (OMIM: 606138) PREDICTED: cell growth reg (272 aa)
initn: 1849 init1: 1849 opt: 1849 Z-score: 1827.4 bits: 346.2 E(85289): 4.8e-95
Smith-Waterman score: 1849; 99.6% identity (100.0% similar) in 272 aa overlap (61-332:1-272)
40 50 60 70 80 90
pF1KE3 LVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDC
::::::::::::::::::::::::::::::
XP_011 MRQVKNPFGLEITNPSSASITTGITLTTDC
10 20 30
100 110 120 130 140 150
pF1KE3 LEDSLLTCYWGCNVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE3 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE3 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE3 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK
220 230 240 250 260 270
pF1KE3 TL
::
XP_011 TL
>>XP_016876421 (OMIM: 606138) PREDICTED: cell growth reg (272 aa)
initn: 1849 init1: 1849 opt: 1849 Z-score: 1827.4 bits: 346.2 E(85289): 4.8e-95
Smith-Waterman score: 1849; 99.6% identity (100.0% similar) in 272 aa overlap (61-332:1-272)
40 50 60 70 80 90
pF1KE3 LVLGWFGWDVPVILRNSEETQFSTRVFKKQMRQVKNPFGLEITNPSSASITTGITLTTDC
::::::::::::::::::::::::::::::
XP_016 MRQVKNPFGLEITNPSSASITTGITLTTDC
10 20 30
100 110 120 130 140 150
pF1KE3 LEDSLLTCYWGCNVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI
::::::::::::.:::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEDSLLTCYWGCSVQKLYEALQKHVYCFRISTPQALEDALYSEYLYQEQYFIKKDSKEEI
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE3 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YCQLPRDTKIEDFGTVPRSRYPLVALLTLADEDDREIYDIISMVSVIHIPDRTYKLSCRI
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE3 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEEN
160 170 180 190 200 210
280 290 300 310 320 330
pF1KE3 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKPK
220 230 240 250 260 270
pF1KE3 TL
::
XP_016 TL
>>NP_114404 (OMIM: 606130) RING finger protein 26 [Homo (433 aa)
initn: 178 init1: 142 opt: 179 Z-score: 186.7 bits: 43.3 E(85289): 0.0012
Smith-Waterman score: 179; 37.5% identity (71.4% similar) in 56 aa overlap (268-316:374-429)
240 250 260 270 280 290
pF1KE3 PSNNSSSEEKNTDRSLLEKVGLSESEVEPSEENSKDCVVCQNGTVNWVLLPCRHTCLCDG
.:. : ::.::. . . .:::::: :::..
NP_114 TIRVTPVRGRERLNEEEPPGGQDPWKLLKEQEERKKCVICQDQSKTVLLLPCRHLCLCQA
350 360 370 380 390 400
300 310 320 330
pF1KE3 CVK-------YFQQCPMCRQFVQESFALCSQKEQDKDKPKTL
:.. : ..::.::. . ...
NP_114 CTEILMRHPVYHRNCPLCRRGILQTLNVYL
410 420 430
>>XP_011520744 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (339 aa)
initn: 167 init1: 136 opt: 166 Z-score: 175.3 bits: 40.8 E(85289): 0.005
Smith-Waterman score: 166; 41.5% identity (67.9% similar) in 53 aa overlap (265-309:28-80)
240 250 260 270 280 290
pF1KE3 NFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWVLLPCR
:::.. ::..:::: . . ..::::
XP_011 MASGPRTTGAAPRGGSGAPGRASPQPREPSDDENSDNSNECVVCLSDLRDTLILPCR
10 20 30 40 50
300 310 320 330
pF1KE3 HTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL
: ::: .:. .. .::.::
XP_011 HLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSLEHDEH
60 70 80 90 100 110
>>XP_016878582 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (514 aa)
initn: 167 init1: 136 opt: 168 Z-score: 175.0 bits: 41.3 E(85289): 0.0052
Smith-Waterman score: 168; 37.9% identity (70.7% similar) in 58 aa overlap (260-309:222-279)
230 240 250 260 270 280
pF1KE3 MSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWV
...:..::.. ::..:::: . . .
XP_016 GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTL
200 210 220 230 240 250
290 300 310 320 330
pF1KE3 LLPCRHTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL
.::::: ::: .:. .. .::.::
XP_016 ILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSL
260 270 280 290 300 310
>>NP_001243787 (OMIM: 608299) E3 ubiquitin-protein ligas (180 aa)
initn: 177 init1: 158 opt: 162 Z-score: 174.9 bits: 39.8 E(85289): 0.0053
Smith-Waterman score: 162; 31.5% identity (67.1% similar) in 73 aa overlap (240-312:105-171)
210 220 230 240 250 260
pF1KE3 ILYQYLLLAQGQFHDLKQLFMSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE
: .:......: :.. :.. ::
NP_001 MSVRQLKEILARNFVNYSGCCEKWELVEKVNRLYKENEENQKSYGERLQLQD------EE
80 90 100 110 120
270 280 290 300 310 320
pF1KE3 NSKDCVVCQNGTVNWVLLPCRHTCLCDGCVKYFQQCPMCRQFVQESFALCSQKEQDKDKP
... : .:...... ::: : : : : : ...::.:::.:
NP_001 DDSLCRICMDAVIDCVLLECGHMVTCTKCGKRMSECPICRQYVVRAVHVFKS
130 140 150 160 170 180
330
pF1KE3 KTL
>>XP_005255278 (OMIM: 607559) PREDICTED: E3 ubiquitin-pr (530 aa)
initn: 167 init1: 136 opt: 168 Z-score: 174.8 bits: 41.4 E(85289): 0.0053
Smith-Waterman score: 168; 37.9% identity (70.7% similar) in 58 aa overlap (260-309:260-317)
230 240 250 260 270 280
pF1KE3 MSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWV
...:..::.. ::..:::: . . .
XP_005 GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTL
230 240 250 260 270 280
290 300 310 320 330
pF1KE3 LLPCRHTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL
.::::: ::: .:. .. .::.::
XP_005 ILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSL
290 300 310 320 330 340
>>NP_001135763 (OMIM: 607559) E3 ubiquitin-protein ligas (530 aa)
initn: 167 init1: 136 opt: 168 Z-score: 174.8 bits: 41.4 E(85289): 0.0053
Smith-Waterman score: 168; 37.9% identity (70.7% similar) in 58 aa overlap (260-309:260-317)
230 240 250 260 270 280
pF1KE3 MSANNNFTPSNNSSSEEKNTDRSLLEKVGLSESEVEPSEE----NSKDCVVCQNGTVNWV
...:..::.. ::..:::: . . .
NP_001 GSFSVKPLKQKQIVDRVSYLLQEIYGIENKNNQETKPSDDENSDNSNECVVCLSDLRDTL
230 240 250 260 270 280
290 300 310 320 330
pF1KE3 LLPCRHTCLCDGCVKYFQ----QCPMCRQFVQESFALCSQKEQDKDKPKTL
.::::: ::: .:. .. .::.::
NP_001 ILPCRHLCLCTSCADTLRYQANNCPICRLPFRALLQIRAVRKKPGALSPVSFSPVLAQSL
290 300 310 320 330 340
332 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:30:09 2016 done: Sun Nov 6 08:30:10 2016
Total Scan time: 7.260 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]