Result of FASTA (omim) for
pFN21AE3931
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3931, 545 aa
1>>>pF1KE3931 545 - 545 aa - 545 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.7216+/-0.000319; mu= 9.6359+/- 0.020
mean_var=182.9767+/-37.271, 0's: 0 Z-trim(123.1): 227 B-trim: 1746 in 1/57
Lambda= 0.094815
statistics sampled from 41932 (42213) to 41932 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.792), E-opt: 0.2 (0.495), width: 16
Scan time: 12.760
The best scores are: opt bits E(85289)
NP_291027 (OMIM: 610530) E3 ubiquitin-protein liga ( 630) 3738 523.4 7.9e-148
XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 543) 2791 393.8 7e-109
XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 520) 2788 393.4 9.1e-109
NP_963921 (OMIM: 610530) E3 ubiquitin-protein liga ( 518) 2772 391.2 4.1e-108
XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 541) 2772 391.2 4.2e-108
XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquiti ( 525) 2767 390.5 6.7e-108
NP_742013 (OMIM: 605700) E3 ubiquitin-protein liga ( 488) 869 130.9 9e-30
NP_976038 (OMIM: 609315) tripartite motif-containi ( 511) 780 118.7 4.3e-26
NP_067076 (OMIM: 605700) E3 ubiquitin-protein liga ( 518) 666 103.1 2.2e-21
XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 450) 656 101.7 5e-21
XP_006711842 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 656 101.7 5.2e-21
XP_011542512 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 656 101.7 5.2e-21
NP_001020111 (OMIM: 606123) E3 ubiquitin-protein l ( 477) 656 101.7 5.2e-21
NP_057186 (OMIM: 606123) E3 ubiquitin-protein liga ( 477) 656 101.7 5.2e-21
XP_011542511 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 477) 656 101.7 5.2e-21
NP_060543 (OMIM: 613184) E3 ubiquitin-protein liga ( 485) 653 101.3 7.1e-21
NP_006769 (OMIM: 605701) tripartite motif-containi ( 481) 619 96.7 1.8e-19
XP_011512523 (OMIM: 605701) PREDICTED: tripartite ( 499) 619 96.7 1.8e-19
XP_011512525 (OMIM: 605701) PREDICTED: tripartite ( 499) 619 96.7 1.8e-19
XP_011512524 (OMIM: 605701) PREDICTED: tripartite ( 499) 619 96.7 1.8e-19
NP_439893 (OMIM: 605701) tripartite motif-containi ( 395) 613 95.8 2.7e-19
XP_011512527 (OMIM: 605701) PREDICTED: tripartite ( 413) 613 95.8 2.8e-19
NP_006065 (OMIM: 606559) E3 ubiquitin-protein liga ( 498) 582 91.6 6e-18
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 571 90.1 1.7e-17
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 571 90.1 1.8e-17
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 544 86.4 2.3e-16
NP_660215 (OMIM: 607868) E3 ubiquitin-protein liga ( 468) 531 84.6 7.3e-16
XP_005249434 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16
NP_003440 (OMIM: 600830) tripartite motif-containi ( 539) 532 84.8 7.3e-16
XP_006715243 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16
XP_005249431 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16
XP_005249435 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16
XP_005249433 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16
XP_005249432 (OMIM: 600830) PREDICTED: tripartite ( 539) 532 84.8 7.3e-16
NP_001229712 (OMIM: 600830) tripartite motif-conta ( 539) 532 84.8 7.3e-16
NP_001128327 (OMIM: 606123) E3 ubiquitin-protein l ( 343) 521 83.1 1.5e-15
NP_067629 (OMIM: 605684) tripartite motif-containi ( 488) 502 80.7 1.2e-14
NP_001003827 (OMIM: 605684) tripartite motif-conta ( 488) 502 80.7 1.2e-14
XP_005253240 (OMIM: 608487) PREDICTED: tripartite ( 493) 493 79.5 2.8e-14
NP_149023 (OMIM: 608487) tripartite motif-containi ( 493) 493 79.5 2.8e-14
XP_016856908 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 485 78.1 3.7e-14
XP_016856907 (OMIM: 606123) PREDICTED: E3 ubiquiti ( 262) 485 78.1 3.7e-14
NP_001186502 (OMIM: 606559) E3 ubiquitin-protein l ( 494) 488 78.8 4.5e-14
NP_001268380 (OMIM: 612548) E3 ubiquitin-protein l ( 487) 481 77.8 8.6e-14
NP_835226 (OMIM: 612548) E3 ubiquitin-protein liga ( 487) 481 77.8 8.6e-14
NP_976042 (OMIM: 609315) tripartite motif-containi ( 329) 475 76.8 1.1e-13
NP_001268379 (OMIM: 612548) E3 ubiquitin-protein l ( 486) 473 76.7 1.8e-13
XP_011514091 (OMIM: 612548) PREDICTED: E3 ubiquiti ( 486) 473 76.7 1.8e-13
NP_976039 (OMIM: 609315) tripartite motif-containi ( 303) 466 75.6 2.5e-13
NP_976040 (OMIM: 609315) tripartite motif-containi ( 303) 466 75.6 2.5e-13
>>NP_291027 (OMIM: 610530) E3 ubiquitin-protein ligase T (630 aa)
initn: 3738 init1: 3738 opt: 3738 Z-score: 2775.0 bits: 523.4 E(85289): 7.9e-148
Smith-Waterman score: 3738; 100.0% identity (100.0% similar) in 545 aa overlap (1-545:86-630)
10 20 30
pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
::::::::::::::::::::::::::::::
NP_291 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR
480 490 500 510 520 530
460 470 480 490 500 510
pF1KE3 RLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_291 RLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNA
540 550 560 570 580 590
520 530 540
pF1KE3 ETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
:::::::::::::::::::::::::::::::::::
NP_291 ETLAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
600 610 620 630
>>XP_006714992 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (543 aa)
initn: 2788 init1: 2788 opt: 2791 Z-score: 2075.7 bits: 393.8 E(85289): 7e-109
Smith-Waterman score: 2791; 93.7% identity (95.0% similar) in 443 aa overlap (1-443:86-527)
10 20 30
pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
::::::::::::::::::::::::::::::
XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR
:::::::::::::::: . .: : :.. .: :: . : ::
XP_006 LGAQGFRSGRHYWEVEEPKEPSWP-PAQPSLTYYVCPTGLHGSLIMRTAAWSSLPVCLAQ
480 490 500 510 520 530
460 470 480 490 500 510
pF1KE3 RLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNA
XP_006 PWDWNLSRG
540
>>XP_006714995 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (520 aa)
initn: 2783 init1: 2783 opt: 2788 Z-score: 2073.7 bits: 393.4 E(85289): 9.1e-109
Smith-Waterman score: 2788; 98.5% identity (99.0% similar) in 413 aa overlap (1-413:86-498)
10 20 30
pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
::::::::::::::::::::::::::::::
XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR
:::::::::::::::: . .:
XP_006 LGAQGFRSGRHYWEVEEPKEPSWPPAQPSLTYYVCPTDRPEFSFT
480 490 500 510 520
>>NP_963921 (OMIM: 610530) E3 ubiquitin-protein ligase T (518 aa)
initn: 2772 init1: 2772 opt: 2772 Z-score: 2061.9 bits: 391.2 E(85289): 4.1e-108
Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:86-489)
10 20 30
pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
::::::::::::::::::::::::::::::
NP_963 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_963 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR
::::::::::::::
NP_963 LGAQGFRSGRHYWEEPKEPSWPPAQPSLTYYVCPTDRPEFSFT
480 490 500 510
>>XP_006714993 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (541 aa)
initn: 2772 init1: 2772 opt: 2772 Z-score: 2061.7 bits: 391.2 E(85289): 4.2e-108
Smith-Waterman score: 2772; 100.0% identity (100.0% similar) in 404 aa overlap (1-404:86-489)
10 20 30
pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
::::::::::::::::::::::::::::::
XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR
::::::::::::::
XP_006 LGAQGFRSGRHYWEEPKEPSWPPAQPSLTYYVCPTGLHGSLIMRTAAWSSLPVCLAQPWD
480 490 500 510 520 530
>>XP_006714994 (OMIM: 610530) PREDICTED: E3 ubiquitin-pr (525 aa)
initn: 2869 init1: 2767 opt: 2767 Z-score: 2058.2 bits: 390.5 E(85289): 6.7e-108
Smith-Waterman score: 2767; 99.3% identity (99.8% similar) in 406 aa overlap (1-406:86-491)
10 20 30
pF1KE3 MRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
::::::::::::::::::::::::::::::
XP_006 RDELDREEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRS
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SWDNMDYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPP
120 130 140 150 160 170
100 110 120 130 140 150
pF1KE3 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 APRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALK
180 190 200 210 220 230
160 170 180 190 200 210
pF1KE3 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKE
240 250 260 270 280 290
220 230 240 250 260 270
pF1KE3 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAE
300 310 320 330 340 350
280 290 300 310 320 330
pF1KE3 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTD
360 370 380 390 400 410
340 350 360 370 380 390
pF1KE3 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCV
420 430 440 450 460 470
400 410 420 430 440 450
pF1KE3 LGAQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRR
::::::::::::: ..
XP_006 LGAQGFRSGRHYWSLKNPPGLQLSLLSPTMSVQQTGQNLASLERDLEWSP
480 490 500 510 520
>>NP_742013 (OMIM: 605700) E3 ubiquitin-protein ligase T (488 aa)
initn: 1011 init1: 472 opt: 869 Z-score: 655.4 bits: 130.9 E(85289): 9e-30
Smith-Waterman score: 999; 37.1% identity (65.6% similar) in 453 aa overlap (94-545:62-478)
70 80 90 100 110 120
pF1KE3 DEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVI
: : :: :::. ::.::: ::..::..
NP_742 CLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 RQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQ
.:.. . .. :...::.:.:::.::: :.::.:..: :..:. :.::::....:
NP_742 KQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQ
100 110 120 130 140
190 200 210 220 230 240
pF1KE3 EYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQ
::: ::: .:::...:. . . :..::.. ::: ..:. . :: .: : : :::
NP_742 EYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQ
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE3 AGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNR
: ::.: .. : : :..:... .:..: ::.. . :.:...:.:.: :...
NP_742 QVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEK
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE3 CEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSP
::.:. . : . . :. .::. ... .:.::::.:::: :.::
NP_742 CEKVKTMEVTSVSIELEKNFSNFPRQYFALRKILKQLI----ADVTLDPETAHPNLVLSE
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE3 DRRGVRLAERR-QEVADHPKRFSADCCVLGAQGFRSGRHYWEVEVGGRRGWAVGAAREST
::..:...: : ... : :.::. :::...:: ::::::::::: . ::::. :.:.
NP_742 DRKSVKFVETRLRDLPDTPRRFTFYPCVLATEGFTSGRHYWEVEVGDKTHWAVGVCRDSV
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE3 HHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVGTNGKRYQAQSSTEQ
.: .. : ::. . ..: :: .: : ..:
NP_742 SRKGELTP-----------------------LPETGYWRVRLW----NGDKY-AATTTPF
390 400 410
490 500 510 520 530 540
pF1KE3 TLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRIK
: : . ::.: :..:::::: :.:::. .:..::. .: :...:.: .. : .
NP_742 TPLHIKVKPKRVGIFLDYEAGTLSFYNVTDRSHIYTFTDTFT-EKLWPLFYPGIRAGRKN
420 430 440 450 460 470
pF1KE3 LCP
:
NP_742 AAPLTIRPPTDWE
480
>>NP_976038 (OMIM: 609315) tripartite motif-containing p (511 aa)
initn: 954 init1: 399 opt: 780 Z-score: 589.4 bits: 118.7 E(85289): 4.3e-26
Smith-Waterman score: 907; 36.6% identity (61.7% similar) in 475 aa overlap (87-545:72-511)
60 70 80 90 100 110
pF1KE3 EEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQL
:: : : :::::. ..::: ::
NP_976 VECGHSFCRACIGRCWERPGAGSVGAATRAPPFPLP-----CPQCREPARPSQLRPNRQL
50 60 70 80 90
120 130 140 150 160
pF1KE3 ANMVQVIRQMH-PT--PGR-GSRVTDQGI----CPKHQEALKLFCEVDEEAICVVCRESR
: .. ..:.. :. ::. ::... : .: : .::.:. : .:::::: ..:
NP_976 AAVATLLRRFSLPAAAPGEHGSQAAAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAR
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE3 SHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAV
:..:.:.::.:.::: : :..... :.:.:: . ... :... :: .:: .: :
NP_976 EHREHAVLPLDEAVQEAKELLESRLRVLKKELEDCEVFRSTEKKESKELLKQMAAEQEKV
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE3 ASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQ
..:: : ::.:... : ::.:. . . . ..:. . .:::.: .. :: .:.
NP_976 GAEFQALRAFLVEQEGRLLGRLEELSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQK
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE3 GGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAAR---
: .::..: :..:: .: : . : . . . : ... : . : . :
NP_976 PDLDFLQEFKSTLSRCSNVPGPKPTTVSSEMKNKVWNVSLKTFVLKGMLKKFKEDLRGEL
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE3 -----VDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQGFRSGR
:.::::::::.: :.:: : .::::.:: :.. .:: ::... ::.. :: :::
NP_976 EKEEKVELTLDPDTANPRLILSLDLKGVRLGERAQDLPNHPCRFDTNTRVLASCGFSSGR
340 350 360 370 380 390
410 420 430 440 450 460
pF1KE3 HYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLL
:.::::::.. ::: :.::::. ::. : :
NP_976 HHWEVEVGSKDGWAFGVARESV--------------------------RRKGLTPFTP--
400 410 420
470 480 490 500 510 520
pF1KE3 QREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFS
.. :: . :: .: : .: :.. :: .. : : :: :.: ..:: .: . :..::
NP_976 EEGVWALQLNGGQYWAVTSPERSPLSCGHLSR-VRVALDLEVGAVSFYAVEDMRHLYTFR
430 440 450 460 470 480
530 540
pF1KE3 AAFLGERVFPFFRVLSKGTRIKLCP
. : :::::.: : : :: ... :
NP_976 VNFQ-ERVFPLFSVCSTGTYLRIWP
490 500 510
>>NP_067076 (OMIM: 605700) E3 ubiquitin-protein ligase T (518 aa)
initn: 984 init1: 445 opt: 666 Z-score: 505.0 bits: 103.1 E(85289): 2.2e-21
Smith-Waterman score: 940; 35.2% identity (61.5% similar) in 483 aa overlap (94-545:62-508)
70 80 90 100 110 120
pF1KE3 DEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVI
: : :: :::. ::.::: ::..::..
NP_067 CLEYLKEPVIIECGHNFCKACITRWWEDLERDFPCPVCRKTSRYRSLRPNRQLGSMVEIA
40 50 60 70 80 90
130 140 150 160 170 180
pF1KE3 RQMHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQ
.:.. . .. :...::.:.:::.::: :.::.:..: :..:. :.::::....:
NP_067 KQLQAVK---RKIRDESLCPQHHEALSLFCYEDQEAVCLICAISHTHRAHTVVPLDDATQ
100 110 120 130 140
190 200 210 220 230 240
pF1KE3 EYKAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQ
::: ::: .:::...:. . . :..::.. ::: ..:. . :: .: : : :::
NP_067 EYKEKLQKCLEPLEQKLQEITRCKSSEEKKPGELKRLVESRRQQILREFEELHRRLDEEQ
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE3 AGLERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETF--
: ::.: .. : : :..:... .:..: ::.. . :.:...:.:.: :.
NP_067 QVLLSRLEEEEQDILQRLRENAAHLGDKRRDLAHLAAEVEGKCLQSGFEMLKDVKSTLEK
210 220 230 240 250 260
310 320 330
pF1KE3 ----------------------------NRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIV
::::.:. . : . . :. .
NP_067 NIPRKFGGSLSTICPRDHKALLGLVKEINRCEKVKTMEVTSVSIELEKNFSNFPRQYFAL
270 280 290 300 310 320
340 350 360 370 380 390
pF1KE3 RKMSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERR-QEVADHPKRFSADCCVLG
::. ... .:.::::.:::: :.:: ::..:...: : ... : :.::. :::.
NP_067 RKILKQLI----ADVTLDPETAHPNLVLSEDRKSVKFVETRLRDLPDTPRRFTFYPCVLA
330 340 350 360 370 380
400 410 420 430 440 450
pF1KE3 AQGFRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRL
..:: ::::::::::: . ::::. :.:. .: .. :
NP_067 TEGFTSGRHYWEVEVGDKTHWAVGVCRDSVSRKGELTP----------------------
390 400 410 420
460 470 480 490 500 510
pF1KE3 HLPQQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAET
::. . ..: :: .: : ..: : : . ::.: :..:::::: :.:::.
NP_067 -LPETGYWRVRLW----NGDKY-AATTTPFTPLHIKVKPKRVGIFLDYEAGTLSFYNVTD
430 440 450 460 470
520 530 540
pF1KE3 LAHVHTFSAAFLGERVFPFFRVLSKGTRIKLCP
.:..::. .: :...:.: .. : . :
NP_067 RSHIYTFTDTFT-EKLWPLFYPGIRAGRKNAAPLTIRPPTDWE
480 490 500 510
>>XP_011542513 (OMIM: 606123) PREDICTED: E3 ubiquitin-pr (450 aa)
initn: 679 init1: 405 opt: 656 Z-score: 498.4 bits: 101.7 E(85289): 5e-21
Smith-Waterman score: 735; 32.9% identity (60.8% similar) in 441 aa overlap (96-532:33-429)
70 80 90 100 110 120
pF1KE3 EDEEEVLEEVEEEDLDPVTPLPPPPAPRRCFTCPQCRKSFPRRSFRPNLQLANMVQVIRQ
: ::.::. :.:.. :: :...... .:
XP_011 TCGHNFCRACIQLSWEKARGKKGRRKRKGSFPCPECREMSPQRNLLPNRLLTKVAEMAQQ
10 20 30 40 50 60
130 140 150 160 170 180
pF1KE3 MHPTPGRGSRVTDQGICPKHQEALKLFCEVDEEAICVVCRESRSHKQHSVVPLEEVVQEY
:: : . : .: .:.: :::::. :. ::::::::: :. : :.: ::.:: :
XP_011 -HP--G----LQKQDLCQEHHEPLKLFCQKDQSPICVVCRESREHRLHRVLPAEEAVQGY
70 80 90 100 110
190 200 210 220 230 240
pF1KE3 KAKLQGHVEPLRKHLEAVQKMKAKEERRVTELKSQMKSELAAVASEFGRLTRFLAEEQAG
: ::. .: ::... . ...:.::. ..: ....: . .. :: ... .:.::.
XP_011 KLKLEEDMEYLREQITRTGNLQAREEQSLAEWQGKVKERRERIVLEFEKMNLYLVEEEQR
120 130 140 150 160 170
250 260 270 280 290 300
pF1KE3 LERRLREMHEAQLGRAGAAASRLAEQAAQLSRLLAEAQERSQQGGLRLLQDIKETFNRCE
: . :. .: .: ... : .:. .: :: . .::: :: :..:::.:: ..: .
XP_011 LLQALETEEEETASRLRESVACLDRQGHSLELLLLQLEERSTQGPLQMLQDMKEPLSRKN
180 190 200 210 220 230
310 320 330 340 350 360
pF1KE3 EVQLQPPEVWSPDPCQPHSHDFLTDAIVRKMSRMFCQAARVDLTLDPDTAHPALMLSPDR
.:..: ::: .: : .:.. . : .. : : . :.. : .:.: :.: .:
XP_011 NVSVQCPEV-AP-PTRPRTVCRVPGQI--EVLRGFLE----DVVPDATSAYPYLLLYESR
240 250 260 270 280
370 380 390 400 410 420
pF1KE3 RGVRLAERRQEVADHPK-RFSADCCVLGAQGFRSGRHYWEV--EVGGRRGWAVGAAREST
. :. . . : :: : :..: .: :::::::: .. : ::.:. :...
XP_011 QRRYLGSSPEGSGFCSKDRFVAYPCAVGQTAFSSGRHYWEVGMNITGDALWALGVCRDNV
290 300 310 320 330 340
430 440 450 460 470 480
pF1KE3 HHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLPQQPLLQREVWCVG-TNGKRYQAQSSTE
.:..: :. : . : : ..: .: . :.
XP_011 SRKDRV--------------------------PKCP--ENGFWVVQLSKGTKYLSTFSAL
350 360 370
490 500 510 520 530 540
pF1KE3 QTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAHVHTFSAAFLGERVFPFFRVLSKGTRI
.. : : ..:..::.:::...::.. .:.::.: : . . :::
XP_011 TPVML-MEPPSHMGIFLDFEAGEVSFYSVSDGSHLHTYSQATFPGPLQPFFCLGAPKSGQ
380 390 400 410 420 430
pF1KE3 KLCP
XP_011 MVISTVTMWVKG
440 450
545 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:46:25 2016 done: Sun Nov 6 01:46:27 2016
Total Scan time: 12.760 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]