Result of FASTA (omim) for
pFN21AE3926
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3926, 551 aa
1>>>pF1KE3926 551 - 551 aa - 551 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.5501+/-0.000379; mu= 0.8930+/- 0.024
mean_var=271.8275+/-57.040, 0's: 0 Z-trim(122.3): 101 B-trim: 1945 in 1/55
Lambda= 0.077791
statistics sampled from 40214 (40339) to 40214 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.788), E-opt: 0.2 (0.473), width: 16
Scan time: 12.090
The best scores are: opt bits E(85289)
NP_112174 (OMIM: 606125) probable E3 ubiquitin-pro ( 551) 3866 447.1 6.5e-125
NP_001332879 (OMIM: 606125) probable E3 ubiquitin- ( 519) 2246 265.3 3.3e-70
NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase ( 630) 318 49.0 5.3e-05
NP_060677 (OMIM: 616755) E3 ubiquitin-protein liga ( 475) 281 44.7 0.00076
XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 555) 280 44.7 0.00092
NP_741983 (OMIM: 617007) tripartite motif-containi ( 493) 277 44.3 0.0011
NP_006461 (OMIM: 609505) tripartite motif-containi ( 564) 272 43.8 0.0017
NP_001269307 (OMIM: 600986) tripartite motif-conta ( 633) 270 43.6 0.0022
XP_005273509 (OMIM: 617007) PREDICTED: tripartite ( 298) 260 42.2 0.0028
XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquiti ( 291) 253 41.4 0.0047
NP_477514 (OMIM: 607564) tripartite motif-containi ( 488) 253 41.6 0.0068
NP_001003818 (OMIM: 607564) tripartite motif-conta ( 516) 253 41.6 0.0071
NP_001287681 (OMIM: 609317) E3 ubiquitin-protein l ( 573) 254 41.8 0.0071
XP_016857901 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 467) 252 41.5 0.0072
NP_006501 (OMIM: 602165) zinc finger protein RFP [ ( 513) 251 41.4 0.0083
XP_011542587 (OMIM: 607868) PREDICTED: E3 ubiquiti ( 391) 247 40.9 0.0093
>>NP_112174 (OMIM: 606125) probable E3 ubiquitin-protein (551 aa)
initn: 3866 init1: 3866 opt: 3866 Z-score: 2363.6 bits: 447.1 E(85289): 6.5e-125
Smith-Waterman score: 3866; 100.0% identity (100.0% similar) in 551 aa overlap (1-551:1-551)
10 20 30 40 50 60
pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 DVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 DVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLH
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY
490 500 510 520 530 540
550
pF1KE3 GQPSTKHYVTS
:::::::::::
NP_112 GQPSTKHYVTS
550
>>NP_001332879 (OMIM: 606125) probable E3 ubiquitin-prot (519 aa)
initn: 2245 init1: 2245 opt: 2246 Z-score: 1381.4 bits: 265.3 E(85289): 3.3e-70
Smith-Waterman score: 3589; 94.2% identity (94.2% similar) in 551 aa overlap (1-551:1-519)
10 20 30 40 50 60
pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAYN
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 THLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVC
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 DVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLH
:::::::::: ::::::::::::::::::
NP_001 DVEIRRNEIR--------------------------------EKVNQLKEEVRLQYEKLH
190 200
250 260 270 280 290 300
pF1KE3 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMK
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE3 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQ
270 280 290 300 310 320
370 380 390 400 410 420
pF1KE3 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSGQPLGPCS
330 340 350 360 370 380
430 440 450 460 470 480
pF1KE3 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 STQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNCYCSSVAN
390 400 410 420 430 440
490 500 510 520 530 540
pF1KE3 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HGGHQPYPRSGHFPWTVPSQEYSHPLPPTPSVPQSLPSLAVRDWLDASQQPGHQDFYRVY
450 460 470 480 490 500
550
pF1KE3 GQPSTKHYVTS
:::::::::::
NP_001 GQPSTKHYVTS
510
>>NP_005073 (OMIM: 600453) E3 ubiquitin/ISG15 ligase TRI (630 aa)
initn: 382 init1: 268 opt: 318 Z-score: 210.8 bits: 49.0 E(85289): 5.3e-05
Smith-Waterman score: 445; 27.4% identity (55.7% similar) in 318 aa overlap (8-306:5-315)
10 20 30 40 50
pF1KE3 MAENWKNC-FEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPECNQAY
: . ::: : :::. : ::: :: :::: .:..:.:: ... ::.: .:
NP_005 MAELCPLAEELSCSICLEPFKEPVTTPCGHNFCGSCLNETWAVQGSPYLCPQCRAVY
10 20 30 40 50
60 70 80 90 100
pF1KE3 NQKPGLEKNLKLTNIVEKF-NALHVEKPPAALHCVFCRRGPPLP-AQ------------K
. .: :.:: : :.::.: .: ...::: . : . : : :: :
NP_005 QARPQLHKNTVLCNVVEQFLQADLAREPPADVWTPPARASAPSPNAQVACDHCLKEAAVK
60 70 80 90 100 110
110 120 130 140 150 160
pF1KE3 VCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQ
.:: : : :: :.: :...:. : . :. .: ::: : . : .. .:.
NP_005 TCLVCMASFCQEHLQPHFDSPAFQDHPLQPPVRDLLRRKCSQHNRLREFFCPEHSECICH
120 130 140 150 160 170
170 180 190 200 210 220
pF1KE3 YCCYY----SGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLV
: : : ... :.: .:. : . .... . ..: . .. . .
NP_005 ICLVEHKTCSPASLSQASADLEAT---LRHKLTVMYSQINGASRALDDVRNRQQDVRMTA
180 190 200 210 220 230
230 240 250 260 270 280
pF1KE3 EEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKK
..::.::..: : ... ::: . ... . . . . :. . : .. .: .
NP_005 NRKVEQLQQE----YTEMKALLDASETTSTRKIKEEEKRVNSKFDTIYQILLKKKSEIQT
240 250 260 270 280 290
290 300 310 320 330 340
pF1KE3 LLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKE
: .. . : .. :........
NP_005 LKEEIEQSLTKRDEFEFLEKASKLRGISTKPVYIPEVELNHKLIKGIHQSTIDLKNELKQ
300 310 320 330 340 350
>>NP_060677 (OMIM: 616755) E3 ubiquitin-protein ligase T (475 aa)
initn: 261 init1: 161 opt: 281 Z-score: 190.0 bits: 44.7 E(85289): 0.00076
Smith-Waterman score: 316; 24.4% identity (53.1% similar) in 303 aa overlap (8-305:3-251)
10 20 30 40 50
pF1KE3 MAENWKNC-FEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKD--SGLVRCPECNQ
: ...::.: ::: .. .::.: :.: ::: :: : :... .: :::: .
NP_060 MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRR
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 AYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQS
.. . :.: .:::.::::..... :: : : :: :.
NP_060 TFAE-PALAPSLKLANIVERYSSF------------------PLDAILNARRAARPC-QA
60 70 80 90
120 130 140 150 160 170
pF1KE3 HVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGH
: : :. . : .... .: . : . :. :
NP_060 H-------------------DKVKLF------------CLTDRALLC-FFCDEPALHEQH
100 110 120
180 190 200 210 220 230
pF1KE3 SVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEK--VNQLKEEVRLQ
.: .. .:... : : . :.. :.. . : :. ..:.: : ...:. .
NP_060 QVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLK--RQLAETKSSTKSLRTTIGEA
130 140 150 160 170 180
240 250 260 270 280 290
pF1KE3 YEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTED
.:.::.:: : . .: :. :. .. .. . ......... :: . .:.
NP_060 FERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQQLRKVQEGAQILQERLAETDR
190 200 210 220 230 240
300 310 320 330 340 350
pF1KE3 VSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTP
.:. .. :.
NP_060 HTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQYTIWKSLFQDIHPVPAALTLDP
250 260 270 280 290 300
>>XP_016857118 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (555 aa)
initn: 261 init1: 161 opt: 280 Z-score: 188.5 bits: 44.7 E(85289): 0.00092
Smith-Waterman score: 315; 24.3% identity (53.2% similar) in 301 aa overlap (9-305:85-331)
10 20 30
pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGC
...::.: ::: .. .::.: :.: ::: :
XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 IGEAWAKD--SGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCR
: : :... .: :::: ... . :.: .:::.::::.....
XP_016 ITEHWVRQEAQGARDCPECRRTFAE-PALAPSLKLANIVERYSSF---------------
120 130 140 150
100 110 120 130 140 150
pF1KE3 RGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHC
:: : : :: :.: : :. . :
XP_016 ---PLDAILNARRAARPC-QAH-------------------DKVKLF------------C
160 170 180
160 170 180 190 200 210
pF1KE3 EAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLES
.... .: . : . :. :.: .. .:... : : . :.. :.. . : :.
XP_016 LTDRALLC-FFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLK-
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 DKRLVEEK--VNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGE
..:.: : ...:. . .:.::.:: : . .: :. :. .. .. . ..
XP_016 -RQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTDIEQKVQRYSQ
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 RMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFL
....... :: . .:. .:. .. :.
XP_016 QLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQY
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 NEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSG
XP_016 TIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSV
370 380 390 400 410 420
>>NP_741983 (OMIM: 617007) tripartite motif-containing p (493 aa)
initn: 270 init1: 159 opt: 277 Z-score: 187.4 bits: 44.3 E(85289): 0.0011
Smith-Waterman score: 277; 26.2% identity (51.1% similar) in 393 aa overlap (9-380:15-387)
10 20 30 40 50
pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPE
:.:::.: .: : . : : : :::::::... : . . ::
NP_741 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVS-PTCPV
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 CNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRC----
: . . :. : :.:.:::. :. : : : : .. : :
NP_741 C-KDRASPADLRTNHTLNNLVEKL--LREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDK
60 70 80 90 100 110
120 130 140 150 160
pF1KE3 EAPCCQSHV----QTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQY
: ::. .. : : :: .: : :: ...: : : .. .
NP_741 ELLCCSCQADPRHQGHRVQPVKDTAH------DFRAKCRNMEHALR----EKAKAFWAMR
120 130 140 150 160
170 180 190 200 210 220
pF1KE3 CCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLV-EEKV
: . :. :. .. ...::. . : .. :. .:: : : . . .:.:. .::.
NP_741 RSYEAIAK--HNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKM
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE3 NQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAK----FCSENAAQALHLGERMQEAKK
.:: ::... .....: : .. : : : ... ::. . . .. : . .. :
NP_741 KQLTEETEVLAHEIERLQMEMKEDDVSFLMKHKSRKRRLFCTMEP-EPVQPGM-LIDVCK
230 240 250 260 270 280
290 300 310 320 330
pF1KE3 LLGSLQL-----LFDKTEDVSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKLFLNE
::::: .. ..:.: : . ... .. .. :: . .. : . : .
NP_741 YLGSLQYRVWKKMLASVESVPFSFDPNTAAGWLSVSDDLTSVTNHGYRVQVENPERFSS-
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE3 VAKKEKQLRKMLEGPFSTPVPF--LQSVPLYPCGV-SSSGAEKRKHSTAFPEASFLETSS
: : . .: . : . ::: . : ..:::: ..::
NP_741 -APCLLGSRVFSQGSHAWEVALGGLQSWRVGVVRVRQDSGAEGHSHSCYHDTRSGFWYVC
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE3 GPVGGQYGAAGTASGEGQSGQPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQ
NP_741 RTQGVEGDHCVTSDPATSPLVLAIPRRLRVELECEEGELSFYDAERHCHLYTFHARFGEV
410 420 430 440 450 460
>>NP_006461 (OMIM: 609505) tripartite motif-containing p (564 aa)
initn: 159 init1: 131 opt: 272 Z-score: 183.6 bits: 43.8 E(85289): 0.0017
Smith-Waterman score: 279; 25.1% identity (53.4% similar) in 307 aa overlap (92-390:77-366)
70 80 90 100 110
pF1KE3 KPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFC----RRGPPLPAQKVCLRCEAPCCQS
: :: :: . : : :: : . :.
NP_006 SSEKLGRETEEQDSDSAEQGDPAGEGKEVLCDFCLDDTRR---VKAVKSCLTCMVNYCEE
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE3 HVQTHLQQPSTARGHLLVEADDVRAWS-CPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQG
:.: : : ..:::.: . : :: :.. : .: .:: :: :.:
NP_006 HLQPH-QVNIKLQSHLLTEPVKDHNWRYCPAHHSPLSAFCCPDQQCICQDCCQ---EHSG
110 120 130 140 150
180 190 200 210 220 230
pF1KE3 HSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQY
:.. ... : . . :. : ::.. . :. . .:..... : .:...: ...:.
NP_006 HTIVSLDAARRDKEAELQCTQLDLERKLKLNENAISRLQANQKSVLVSVSEVKAVAEMQF
160 170 180 190 200 210
240 250 260 270 280 290
pF1KE3 EKLHQLLDEDLRQTVEVLD-KAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTED
.: . . ... :. : :: . . :. .: :: : : .: :. . ..
NP_006 GELLAAVRKAQANVMLFLEEKEQAALSQANGIKA-HLEYRSAEMEKSKQELERMAAISNT
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE3 VSFMKNTKSVKILMDRTQTCTSSSLSPTKIGHLNSKL--FLNEVAKKEKQLRKMLEGPFS
:.:... . : : : :. :..:: . . .... .: ..::. ..
NP_006 VQFLEEYCKFKNTEDIT--------FPSVYVGLKDKLSGIRKVITESTVHLIQLLEN-YK
280 290 300 310 320
360 370 380 390 400 410
pF1KE3 TPVPFLQSVPLYPCGVSSSGAEKRKHSTAFPEASFLETSSGPVGGQYGAAGTASGEGQSG
. ... : .. :.. .::. :. :: : :
NP_006 KKLQEFSKEEEYDIRTQVSAVVQRKYWTSKPEPSTREQFLQYAYDITFDPDTAHKYLRLQ
330 340 350 360 370 380
420 430 440 450 460 470
pF1KE3 QPLGPCSSTQHLVALPGGAQPVHSSPVFPPSQYPNGSAAQQPMLPQYGGRKILVCSVDNC
NP_006 EENRKVTNTTPWEHPYPDLPSRFLHWRQVLSQQSLYLHRYYFEVEIFGAGTYVGLTCKGI
390 400 410 420 430 440
>>NP_001269307 (OMIM: 600986) tripartite motif-containin (633 aa)
initn: 80 init1: 80 opt: 270 Z-score: 181.7 bits: 43.6 E(85289): 0.0022
Smith-Waterman score: 270; 23.9% identity (55.2% similar) in 268 aa overlap (52-311:4-265)
30 40 50 60 70
pF1KE3 FVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPEC--NQAYNQK--PGLEKNLKLTNIVEK
:: : . ... :: .:: : .::.
NP_001 MFPCPACQGDVELGERGLAGLFRNLTLERVVER
10 20 30
80 90 100 110 120 130
pF1KE3 F-NALHVEKPPAALHCVFCRRGPPLPAQKVCLRCEAPCCQSHVQT-HLQQPSTARGHLLV
. ... : .:. : .:. ::: : : : .:.: :. . : . :. . .
NP_001 YRQSVSV---GGAILCQLCK-PPPLEATKGCTECRATFCNECFKLFHPWGTQKAQHEPTL
40 50 60 70 80
140 150 160 170 180 190
pF1KE3 EADDVRAWS--CPQHNAYRLYHCEAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKML
. . : . ::.:. ..:.. : ::: : .:.::.. : . .. :
NP_001 PTLSFRPKGLMCPDHKEEVTHYCKTCQRLVCQLC-RVRRTHSGHKITPVLSAYQALKDKL
90 100 110 120 130 140
200 210 220 230 240 250
pF1KE3 MKQQDRLEEREQDIEDQLYKLESDKRLVEEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEV
:. . .. .. :. .:: : .: . .: :::: . : .:.: . ...
NP_001 TKSLTYILGNQDTVQTQICELEEAVRHTEVSGQQAKEEVSQLVRGLGAVLEEKRASLLQA
150 160 170 180 190 200
260 270 280 290 300 310
pF1KE3 LDKAQAKFCSENAAQALHLGERMQEAKKLLGSLQLLFDKTEDVSFMKNTKSVKILMDRTQ
... : . .. .:: .. . . ... :.: : .. .:.. :.. .:... . :
NP_001 IEECQQERLARLSAQ-IQEHRSLLDGSGLVGYAQEVLKETDQPCFVQAAKQLHNRIARAT
210 220 230 240 250 260
320 330 340 350 360 370
pF1KE3 TCTSSSLSPTKIGHLNSKLFLNEVAKKEKQLRKMLEGPFSTPVPFLQSVPLYPCGVSSSG
NP_001 EALQTFRPAASSSFRHCQLDVGREMKLLTELNFLRVPEAPVIDTQRTFAYDQIFLCWRLP
270 280 290 300 310 320
>>XP_005273509 (OMIM: 617007) PREDICTED: tripartite moti (298 aa)
initn: 245 init1: 159 opt: 260 Z-score: 180.0 bits: 42.2 E(85289): 0.0028
Smith-Waterman score: 260; 28.8% identity (52.8% similar) in 250 aa overlap (9-246:15-248)
10 20 30 40 50
pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGCIGEAWAKDSGLVRCPE
:.:::.: .: : . : : : :::::::... : . . . ::
XP_005 MERSPDVSPGPSRSFKEELLCAVCYDPFRDAVTLRCGHNFCRGCVSRCWEVQVSPT-CPV
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 CNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCRRGPPLPAQKVCLRC----
:.. . :. : :.:.:::. :. : : : : .. : :
XP_005 CKD-RASPADLRTNHTLNNLVEKL--LREEAEGARWTSYRFSRVCRLHRGQLSLFCLEDK
60 70 80 90 100 110
120 130 140 150 160
pF1KE3 EAPCCQSHV----QTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHCEAEQVAVCQY
: ::. .. : : :: .: : :: ...: : : .. .
XP_005 ELLCCSCQADPRHQGHRVQPVKDTAH------DFRAKCRNMEHALR----EKAKAFWAMR
120 130 140 150 160
170 180 190 200 210 220
pF1KE3 CCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLESDKRLV-EEKV
: . :. :. .. ...::. . : .. :. .:: : : . . .:.:. .::.
XP_005 RSYEAIAK--HNQVEAAWLEGRIRQEFDKLREFLRVEEQAILDAMAEETRQKQLLADEKM
170 180 190 200 210 220
230 240 250 260 270 280
pF1KE3 NQLKEEVRL---QYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERMQEAKKL
.:: ::... . :.:.. . ::
XP_005 KQLTEETEVLAHEIERLQMEMKEDDVSFLMTLLHHGARASPARHAYRCLQVPGLPAVPRL
230 240 250 260 270 280
>>XP_016857120 (OMIM: 616755) PREDICTED: E3 ubiquitin-pr (291 aa)
initn: 230 init1: 161 opt: 253 Z-score: 175.9 bits: 41.4 E(85289): 0.0047
Smith-Waterman score: 258; 26.4% identity (51.5% similar) in 227 aa overlap (9-233:85-255)
10 20 30
pF1KE3 MAENWKNCFEEELICPICLHVFVEPVQLPCKHNFCRGC
...::.: ::: .. .::.: :.: ::: :
XP_016 AAAATGSSDSAGSGLRGCAGPKRWLLSSRGLKDELLCSICLSIYQDPVSLGCEHYFCRRC
60 70 80 90 100 110
40 50 60 70 80 90
pF1KE3 IGEAWAKD--SGLVRCPECNQAYNQKPGLEKNLKLTNIVEKFNALHVEKPPAALHCVFCR
: : :... .: :::: ... . :.: .:::.::::.....
XP_016 ITEHWVRQEAQGARDCPECRRTFAE-PALAPSLKLANIVERYSSF---------------
120 130 140 150
100 110 120 130 140 150
pF1KE3 RGPPLPAQKVCLRCEAPCCQSHVQTHLQQPSTARGHLLVEADDVRAWSCPQHNAYRLYHC
:: : : :: :.: : :. . :
XP_016 ---PLDAILNARRAARPC-QAH-------------------DKVKLF------------C
160 170 180
160 170 180 190 200 210
pF1KE3 EAEQVAVCQYCCYYSGAHQGHSVCDVEIRRNEIRKMLMKQQDRLEEREQDIEDQLYKLES
.... .: . : . :. :.: .. .:... : : . :.. :.. . : :.
XP_016 LTDRALLC-FFCDEPALHEQHQVTGIDDAFDELQRELKDQLQALQDSEREHTEALQLLK-
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 DKRLVEEKVNQLKEEVRLQYEKLHQLLDEDLRQTVEVLDKAQAKFCSENAAQALHLGERM
..:.: : .:.. .:
XP_016 -RQLAETK--ELRQSLRNALGLWRSSWGLKTPLETQIYAPAWPPTHCGVSGRS
250 260 270 280 290
551 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 08:52:50 2016 done: Sun Nov 6 08:52:51 2016
Total Scan time: 12.090 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]