Result of FASTA (omim) for
pFN21AE3684
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3684, 489 aa
1>>>pF1KE3684 489 - 489 aa - 489 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 11.0270+/-0.000381; mu= -7.1384+/- 0.024
mean_var=330.8347+/-65.864, 0's: 0 Z-trim(123.7): 23 B-trim: 881 in 2/57
Lambda= 0.070513
statistics sampled from 43955 (43978) to 43955 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.797), E-opt: 0.2 (0.516), width: 16
Scan time: 12.320
The best scores are: opt bits E(85289)
NP_001276324 (OMIM: 600132,602280,613843) tubby-re ( 489) 3257 344.8 3.3e-94
NP_003313 (OMIM: 600132,602280,613843) tubby-relat ( 542) 2844 302.8 1.6e-81
NP_813977 (OMIM: 601197,616188) tubby protein homo ( 506) 1359 151.7 4.6e-36
XP_011518646 (OMIM: 601197,616188) PREDICTED: tubb ( 518) 1359 151.7 4.6e-36
XP_005253166 (OMIM: 601197,616188) PREDICTED: tubb ( 548) 1359 151.7 4.9e-36
NP_003311 (OMIM: 601197,616188) tubby protein homo ( 561) 1359 151.7 4.9e-36
NP_003315 (OMIM: 604730) tubby-related protein 3 i ( 442) 1228 138.3 4.2e-32
NP_001153880 (OMIM: 604730) tubby-related protein ( 501) 1193 134.8 5.5e-31
NP_003314 (OMIM: 602309) tubby-related protein 2 [ ( 520) 1035 118.7 3.9e-26
XP_011525557 (OMIM: 602309) PREDICTED: tubby-relat ( 487) 893 104.3 8.3e-22
XP_011525558 (OMIM: 602309) PREDICTED: tubby-relat ( 487) 893 104.3 8.3e-22
XP_011525555 (OMIM: 602309) PREDICTED: tubby-relat ( 528) 893 104.3 8.8e-22
XP_006723411 (OMIM: 602309) PREDICTED: tubby-relat ( 531) 893 104.3 8.8e-22
XP_006723410 (OMIM: 602309) PREDICTED: tubby-relat ( 531) 893 104.3 8.8e-22
XP_011525554 (OMIM: 602309) PREDICTED: tubby-relat ( 531) 893 104.3 8.8e-22
XP_011525556 (OMIM: 602309) PREDICTED: tubby-relat ( 498) 563 70.7 1.1e-11
>>NP_001276324 (OMIM: 600132,602280,613843) tubby-relate (489 aa)
initn: 3257 init1: 3257 opt: 3257 Z-score: 1812.2 bits: 344.8 E(85289): 3.3e-94
Smith-Waterman score: 3257; 99.8% identity (100.0% similar) in 489 aa overlap (1-489:1-489)
10 20 30 40 50 60
pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KPGEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KPGEEEEEEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPD
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDK
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KALKKKGTPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEERAPSPPVEVDEPRE
:::::::::::::::::::::::::::.::::::::::::::::::::::::::::::::
NP_001 KALKKKGTPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPRE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 FVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLIS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 GFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSG
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 SYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALS
430 440 450 460 470 480
pF1KE3 SFDGKLACE
:::::::::
NP_001 SFDGKLACE
>>NP_003313 (OMIM: 600132,602280,613843) tubby-related p (542 aa)
initn: 2812 init1: 2812 opt: 2844 Z-score: 1584.5 bits: 302.8 E(85289): 1.6e-81
Smith-Waterman score: 2996; 89.6% identity (89.8% similar) in 521 aa overlap (22-489:22-542)
10 20 30 40 50 60
pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR
:::::::::::::::::::::::::::::::::::::::
NP_003 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR
10 20 30 40 50 60
pF1KE3 KPG-----------------------------------------------------EEEE
::: ::::
NP_003 KPGAGRTGRPREEPSPDPAQARAPQTVYARFLRDPEAKKRDPRETFLVARAPDAEDEEEE
70 80 90 100 110 120
70 80 90 100 110 120
pF1KE3 EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EEEDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLR
130 140 150 160 170 180
130 140 150 160 170 180
pF1KE3 VRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKG
190 200 210 220 230 240
190 200 210 220 230 240
pF1KE3 TPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAP
::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::
NP_003 TPKGARKEEEEEEEAATVIKKSNQKGKAKGKGKKKAKEERAPSPPVEVDEPREFVLRPAP
250 260 270 280 290 300
250 260 270 280 290 300
pF1KE3 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKVFLLAGRKRKRSKTANYLISIDPTNLS
310 320 330 340 350 360
310 320 330 340 350 360
pF1KE3 RGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 RGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVASLRQELAAVIYETNVLGFRGPRR
370 380 390 400 410 420
370 380 390 400 410 420
pF1KE3 MTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQ
430 440 450 460 470 480
430 440 450 460 470 480
pF1KE3 GRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 GRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLA
490 500 510 520 530 540
pF1KE3 CE
::
NP_003 CE
>>NP_813977 (OMIM: 601197,616188) tubby protein homolog (506 aa)
initn: 1473 init1: 780 opt: 1359 Z-score: 768.5 bits: 151.7 E(85289): 4.6e-36
Smith-Waterman score: 1437; 48.6% identity (70.5% similar) in 502 aa overlap (12-489:9-506)
10 20 30 40 50 60
pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPR
: : ..:. . . . .:: :. .::: : . ..::
NP_813 MTSKPHSDWIPYSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMVQANADGRPR
10 20 30 40 50
70 80 90 100 110
pF1KE3 KPGEEEEEEEDEEDEE------EEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRG
. .. ::. : . . .: : . . .: . .:.:: . :
NP_813 SRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAKRTKAAATAG
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE3 DLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARKSPAAMFLVG
:. : . .. .::. . . :....: .. :. :. . . :
NP_813 GQGGAARKEKKGKHKGTSGPAA----LAEDKSEAQGPVQILTVGQSDHAQDAGETAAGGG
120 130 140 150 160 170
180 190 200 210 220
pF1KE3 E---GSPDKKALKKKGTPKGA---RKEEEEEEEAATVIK-NSNQKGKAKGKGKKKAKEER
: :. . ....:: .. . ::.:::.... . ::: . .. . :. .
NP_813 ERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATSRKSVREAAS
180 190 200 210 220 230
230 240 250 260 270
pF1KE3 APSP-----PV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTE--
:::: :: ::.. .::.::::::: :..::.:::::::::::::.:::::: :
NP_813 APSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTYFLHLDREDG
240 250 260 270 280 290
280 290 300 310 320 330
pF1KE3 KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRG
::::::::::::.:::.:::::.:::.:::::...::::::::.:..:::.::: :::..
NP_813 KKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKA
300 310 320 330 340 350
340 350 360 370 380 390
pF1KE3 YSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVR
:... : :::::::: ::::::::.:::.:.::.:::. .::: ::::: . ::.:
NP_813 SSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPRNEHETLLAR
360 370 380 390 400 410
400 410 420 430 440 450
pF1KE3 WQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRV
::::. ::.:::.:: ::::::. ::.:::.:::::::::::::.:..::::::.:::::
NP_813 WQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRV
420 430 440 450 460 470
460 470 480
pF1KE3 AEDAFTLDYRYPLCALQAFAIALSSFDGKLACE
:::.::.:: :::::::::::::::::.:::::
NP_813 AEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
480 490 500
>>XP_011518646 (OMIM: 601197,616188) PREDICTED: tubby pr (518 aa)
initn: 1473 init1: 780 opt: 1359 Z-score: 768.4 bits: 151.7 E(85289): 4.6e-36
Smith-Waterman score: 1431; 48.8% identity (70.8% similar) in 500 aa overlap (17-489:23-518)
10 20 30 40 50
pF1KE3 MPLRDETLREVWASDSGH---EEESLSPEAPRRPKQRPAPAQRLRKKRTEAPES
:: ..:. . . . .:: :. .::: :
XP_011 MEPGTGAVLTEKSCCARQTSRLGHSVLDDEGRNLRQQKLDRQRALLEQKQKKKRQEPLMV
10 20 30 40 50 60
60 70 80 90 100
pF1KE3 PCPTGSKPRKPGEEEEEEEDEEDEE------EEAEEKKEKILLPPKKPLREKSSADLKER
. ..::. .. ::. : . . .: : . . .: . .
XP_011 QANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGATRPTAPASAK
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 RAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKDPSGSPASARK
:.:: . : :. : . .. .::. . . :....: .. :. :.
XP_011 RTKAAATAGGQGGAARKEKKGKHKGTSGPAA----LAEDKSEAQGPVQILTVGQSDHAQD
130 140 150 160 170
170 180 190 200 210
pF1KE3 SPAAMFLVGE---GSPDKKALKKKGTPKGA---RKEEEEEEEAATVIK-NSNQKGKAKGK
. . :: :. . ....:: .. . ::.:::.... . ::: . .. .
XP_011 AGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLNSNTRPSSATS
180 190 200 210 220 230
220 230 240 250 260 270
pF1KE3 GKKKAKEERAPSP-----PV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMDRGMYPSY
:. . :::: :: ::.. .::.::::::: :..::.:::::::::::::.:
XP_011 RKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKKGMDRGMYPTY
240 250 260 270 280 290
280 290 300 310 320
pF1KE3 FLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLLGNRFTVF
::::: : ::::::::::::.:::.:::::.:::.:::::...::::::::.:..:::.
XP_011 FLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRSNLMGTKFTVY
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE3 DNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENERVPIRPR
::: :::.. :... : :::::::: ::::::::.:::.:.::.:::. .::: ::::
XP_011 DNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNMVHERVSIRPR
360 370 380 390 400 410
390 400 410 420 430 440
pF1KE3 NASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIVHADDPD
: . ::.:::::. ::.:::.:: ::::::. ::.:::.:::::::::::::.:..:::
XP_011 NEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKNFQIIHGNDPD
420 430 440 450 460 470
450 460 470 480
pF1KE3 YIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE
:::.::::::::.::.:: :::::::::::::::::.:::::
XP_011 YIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
480 490 500 510
>>XP_005253166 (OMIM: 601197,616188) PREDICTED: tubby pr (548 aa)
initn: 1483 init1: 780 opt: 1359 Z-score: 768.0 bits: 151.7 E(85289): 4.9e-36
Smith-Waterman score: 1449; 48.8% identity (70.9% similar) in 502 aa overlap (12-489:51-548)
10 20 30 40
pF1KE3 MPLRDETLREVWASDSGHEEESLSPEAPRRPKQRPAPAQRL
:. :: ..:. . . . .:: :.
XP_005 PAPPPPAEPRAEPEAAMEGVSSHRTLSYSRWSYDSVLDDEGRNLRQQKLDRQRALLEQKQ
30 40 50 60 70 80
50 60 70 80 90
pF1KE3 RKKRTEAPESPCPTGSKPRKPGEEEEEEEDEEDEE------EEAEEKKEKILLPPKKPLR
.::: : . ..::. .. ::. : . . .: : .
XP_005 KKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQVQEADSLASVQLGA
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE3 EKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKMRKTKKKGSGEADKD
. .: . .:.:: . : :. : . .. .::. . . :....: ..
XP_005 TRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAA----LAEDKSEAQGPVQIL
150 160 170 180 190
160 170 180 190 200
pF1KE3 PSGSPASARKSPAAMFLVGE---GSPDKKALKKKGTPKGA---RKEEEEEEEAATVIK-N
:. :. . . :: :. . ....:: .. . ::.:::.... . :
XP_005 TVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDEEDEEENSSSSSQLN
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE3 SNQKGKAKGKGKKKAKEERAPSP-----PV--EVDEPREFVLRPAPQGRTVRCRLTRDKK
:: . .. . :. . :::: :: ::.. .::.::::::: :..::.:::::
XP_005 SNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAPQGITIKCRITRDKK
260 270 280 290 300 310
270 280 290 300 310
pF1KE3 GMDRGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRS
::::::::.:::::: : ::::::::::::.:::.:::::.:::.:::::...::::::
XP_005 GMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTDLSRGGDSYIGKLRS
320 330 340 350 360 370
320 330 340 350 360 370
pF1KE3 NLLGNRFTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFRGPRRMTVIIPGMSA
::.:..:::.::: :::.. :... : :::::::: ::::::::.:::.:.::.:::.
XP_005 NLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFKGPRKMSVIVPGMNM
380 390 400 410 420 430
380 390 400 410 420 430
pF1KE3 ENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKN
.::: ::::: . ::.:::::. ::.:::.:: ::::::. ::.:::.::::::::::
XP_005 VHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYVLNFHGRVTQASVKN
440 450 460 470 480 490
440 450 460 470 480
pF1KE3 FQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE
:::.:..::::::.::::::::.::.:: :::::::::::::::::.:::::
XP_005 FQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFDSKLACE
500 510 520 530 540
>>NP_003311 (OMIM: 601197,616188) tubby protein homolog (561 aa)
initn: 1473 init1: 780 opt: 1359 Z-score: 767.9 bits: 151.7 E(85289): 4.9e-36
Smith-Waterman score: 1431; 48.1% identity (69.6% similar) in 516 aa overlap (4-489:52-561)
10 20
pF1KE3 MPLRDETLREVWASDSGHE------EESLSPEA
: : :. : :.: .:. . .
NP_003 FPGGTPWPMGSQHSKQHRKPGPLKRGHRRDRRTTRRKYWKE--GREIARVLDDEGRNLRQ
30 40 50 60 70
30 40 50 60 70 80
pF1KE3 PRRPKQRPAPAQRLRKKRTEAPESPCPTGSKPRKPGEEEEEEEDEEDEE------EEAEE
. .:: :. .::: : . ..::. .. ::. : . .
NP_003 QKLDRQRALLEQKQKKKRQEPLMVQANADGRPRSRRARQSEEQAPLVESYLSSSGSTSYQ
80 90 100 110 120 130
90 100 110 120 130 140
pF1KE3 KKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPPKPLRVRNKEAPAGEGTKM
.: : . . .: . .:.:: . : :. : . .. .::. .
NP_003 VQEADSLASVQLGATRPTAPASAKRTKAAATAGGQGGAARKEKKGKHKGTSGPAA----L
140 150 160 170 180 190
150 160 170 180 190
pF1KE3 RKTKKKGSGEADKDPSGSPASARKSPAAMFLVGE---GSPDKKALKKKGTPKGA---RKE
. :....: .. :. :. . . :: :. . ....:: .. . :
NP_003 AEDKSEAQGPVQILTVGQSDHAQDAGETAAGGGERPSGQDLRATMQRKGISSSMSFDEDE
200 210 220 230 240 250
200 210 220 230 240
pF1KE3 EEEEEEAATVIK-NSNQKGKAKGKGKKKAKEERAPSP--P-----VEVDEPREFVLRPAP
:.:::.... . ::: . .. . :. . :::: : :::.. .::.:::::
NP_003 EDEEENSSSSSQLNSNTRPSSATSRKSVREAASAPSPTAPEQPVDVEVQDLEEFALRPAP
260 270 280 290 300 310
250 260 270 280 290 300
pF1KE3 QGRTVRCRLTRDKKGMDRGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTN
:: :..::.:::::::::::::.:::::: : ::::::::::::.:::.:::::.:::.
NP_003 QGITIKCRITRDKKGMDRGMYPTYFLHLDREDGKKVFLLAGRKRKKSKTSNYLISVDPTD
320 330 340 350 360 370
310 320 330 340 350 360
pF1KE3 LSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYSTNVAS--LRQELAAVIYETNVLGFR
:::::...::::::::.:..:::.::: :::.. :... : :::::::: ::::::::.
NP_003 LSRGGDSYIGKLRSNLMGTKFTVYDNGVNPQKASSSTLESGTLRQELAAVCYETNVLGFK
380 390 400 410 420 430
370 380 390 400 410 420
pF1KE3 GPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYT
:::.:.::.:::. .::: ::::: . ::.:::::. ::.:::.:: ::::::. ::.
NP_003 GPRKMSVIVPGMNMVHERVSIRPRNEHETLLARWQNKNTESIIELQNKTPVWNDDTQSYV
440 450 460 470 480 490
430 440 450 460 470 480
pF1KE3 LNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFD
:::.:::::::::::::.:..::::::.::::::::.::.:: :::::::::::::::::
NP_003 LNFHGRVTQASVKNFQIIHGNDPDYIVMQFGRVAEDVFTMDYNYPLCALQAFAIALSSFD
500 510 520 530 540 550
pF1KE3 GKLACE
.:::::
NP_003 SKLACE
560
>>NP_003315 (OMIM: 604730) tubby-related protein 3 isofo (442 aa)
initn: 1237 init1: 754 opt: 1228 Z-score: 697.3 bits: 138.3 E(85289): 4.2e-32
Smith-Waterman score: 1228; 56.6% identity (82.7% similar) in 318 aa overlap (180-489:125-442)
150 160 170 180 190 200
pF1KE3 GEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEE--EEAATVIK
.. :.:. ... .:: . ..: . .
NP_003 PDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLER
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 -NSNQKGKAKGKGKKKAKEERAPSPPV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMD
:: .. .. : . . :. . ..:. ..:: ::::: :::::. :::.:::
NP_003 PNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMD
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE3 RGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLL
::..:.:...:. : .:.::::.::::.::::::::::::..::: ::...:::::::.
NP_003 RGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLM
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE3 GNRFTVFDNGQNPQRGYS-TNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENER
:..:::.: : :..: . ...: ::::::. ::::::::.:::.:.::::::. ....
NP_003 GTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQ
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE3 VPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIV
.: .:.: :.:: ::::.:.:.:.::::: ::::.:. ::.:::.::::::::::::::
NP_003 IPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIV
340 350 360 370 380 390
450 460 470 480
pF1KE3 HADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE
: .::::::.::::::.:.::::: :::::.:::.:.:::::.:::::
NP_003 HKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDSKLACE
400 410 420 430 440
>>NP_001153880 (OMIM: 604730) tubby-related protein 3 is (501 aa)
initn: 1202 init1: 719 opt: 1193 Z-score: 677.3 bits: 134.8 E(85289): 5.5e-31
Smith-Waterman score: 1193; 56.1% identity (82.4% similar) in 312 aa overlap (180-483:125-436)
150 160 170 180 190 200
pF1KE3 GEADKDPSGSPASARKSPAAMFLVGEGSPDKKALKKKGTPKGARKEEEEE--EEAATVIK
.. :.:. ... .:: . ..: . .
NP_001 PDEVHAPSVSSSVVEEDAENTVDTASKPGLQERLQKHDISESVNFDEETDGISQSACLER
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 -NSNQKGKAKGKGKKKAKEERAPSPPV--EVDEPREFVLRPAPQGRTVRCRLTRDKKGMD
:: .. .. : . . :. . ..:. ..:: ::::: :::::. :::.:::
NP_001 PNSASSQNSTDTGTSGSATAAQPADNLLGDIDDLEDFVYSPAPQGVTVRCRIIRDKRGMD
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE3 RGMYPSYFLHLDTE--KKVFLLAGRKRKRSKTANYLISIDPTNLSRGGENFIGKLRSNLL
::..:.:...:. : .:.::::.::::.::::::::::::..::: ::...:::::::.
NP_001 RGLFPTYYMYLEKEENQKIFLLAARKRKKSKTANYLISIDPVDLSREGESYVGKLRSNLM
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE3 GNRFTVFDNGQNPQRGYS-TNVASLRQELAAVIYETNVLGFRGPRRMTVIIPGMSAENER
:..:::.: : :..: . ...: ::::::. ::::::::.:::.:.::::::. ....
NP_001 GTKFTVYDRGICPMKGRGLVGAAHTRQELAAISYETNVLGFKGPRKMSVIIPGMTLNHKQ
280 290 300 310 320 330
390 400 410 420 430 440
pF1KE3 VPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDSGSYTLNFQGRVTQASVKNFQIV
.: .:.: :.:: ::::.:.:.:.::::: ::::.:. ::.:::.::::::::::::::
NP_001 IPYQPQNNHDSLLSRWQNRTMENLVELHNKAPVWNSDTQSYVLNFRGRVTQASVKNFQIV
340 350 360 370 380 390
450 460 470 480
pF1KE3 HADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIALSSFDGKLACE
: .::::::.::::::.:.::::: :::::.:::.:.:::::
NP_001 HKNDPDYIVMQFGRVADDVFTLDYNYPLCAVQAFGIGLSSFDKCIQTLRMQELCELHRQH
400 410 420 430 440 450
NP_001 HSAASLVHRTVCQRWVGHPWRLLPQTSLLWTDLSPPPVVPAPHQISM
460 470 480 490 500
>>NP_003314 (OMIM: 602309) tubby-related protein 2 [Homo (520 aa)
initn: 977 init1: 524 opt: 1035 Z-score: 590.2 bits: 118.7 E(85289): 3.9e-26
Smith-Waterman score: 1035; 40.7% identity (68.3% similar) in 454 aa overlap (41-483:77-520)
20 30 40 50 60
pF1KE3 VWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAP-ESPCPTGSKPRKPGEEEEEE
:::: .:: : .. . : . . :
NP_003 QANPDASPWLWRSCLREERLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTVSCGGDGRGE
50 60 70 80 90 100
70 80 90 100 110 120
pF1KE3 EDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPP--KPLR
. . :: .. . : . : ..:.:.:.: .. :: .::: . :
NP_003 RGLPTPRTEAVFRNLGLQSPFLSWLPDNSDAELEEVSVEN-------GSVSPPPFKQSPR
110 120 130 140 150
130 140 150 160 170 180
pF1KE3 VRNK--EAPAGEGTKMR-KTKKKGSGEADKDPSGSPASARKSPAAMF-LVGEGSPDKKAL
.: : .: ::. . .. .. :.: :.:. .: . . .. :. . : .
NP_003 IRRKGWQAHQRPGTRAEGESDSQDMGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKK
160 170 180 190 200 210
190 200 210 220 230 240
pF1KE3 KKKGTPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEE-RAPSPPVEVDEPREFV
.. . :. . ..:: . ..:. . : . . ...:. :.: : .: : . .:
NP_003 REASESTGTNSSAAHNEELSKALKG--EGGTDSDHMRHEASLAIRSPCPGLEEDM-EAYV
220 230 240 250 260 270
250 260 270 280 290 300
pF1KE3 LRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKV--FLLAGRKRKRSKTANYLIS
:::: : ..: :::::.:.:.:..: :.:.:.: .. ::::::::.::::.:::::
NP_003 LRPALPGTMMQCYLTRDKHGVDKGLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLIS
280 290 300 310 320 330
310 320 330 340 350
pF1KE3 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYST-NVASLRQELAAVIYETNV
.:::.::: :.::.::.:::.....::.:::: ::.: . : :.: .::::.:: :: ::
NP_003 LDPTHLSRDGDNFVGKVRSNVFSTKFTIFDNGVNPDREHLTRNTARIRQELGAVCYEPNV
340 350 360 370 380 390
360 370 380 390 400 410
pF1KE3 LGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDS
::. :::.::::.:: ...:.:. ..: : ...:: :.: ..:. :::: : :. ..
NP_003 LGYLGPRKMTVILPGTNSQNQRINVQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKEN
400 410 420 430 440 450
420 430 440 450 460 470
pF1KE3 GSYTLNFQGRVTQASVKNFQIVHADDPDYIVLQFGRVAEDAFTLDYRYPLCALQAFAIAL
: :::::.::::.::::::::: ...:::::::. :.::.:. .:. ::::.: :
NP_003 GVYTLNFHGRVTRASVKNFQIVDPKHQEHLVLQFGRVGPDTFTMDFCFPFSPLQAFSICL
460 470 480 490 500 510
480
pF1KE3 SSFDGKLACE
:::.
NP_003 SSFN
520
>>XP_011525557 (OMIM: 602309) PREDICTED: tubby-related p (487 aa)
initn: 976 init1: 393 opt: 893 Z-score: 512.5 bits: 104.3 E(85289): 8.3e-22
Smith-Waterman score: 1010; 40.2% identity (67.1% similar) in 465 aa overlap (41-483:33-487)
20 30 40 50 60
pF1KE3 VWASDSGHEEESLSPEAPRRPKQRPAPAQRLRKKRTEAP-ESPCPTGSKPRKPGEEEEEE
:::: .:: : .. . : . . :
XP_011 QANPDASPWLWRSCLREERLLGDRGLGNPFLRKKVSEAHLPSGIHSALGTVSCGGDGRGE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 EDEEDEEEEAEEKKEKILLPPKKPLREKSSADLKERRAKAQGPRGDLGSPDPPP--KPLR
. . :: .. . : . : ..:.:.:.: .. :: .::: . :
XP_011 RGLPTPRTEAVFRNLGLQSPFLSWLPDNSDAELEEVSVEN-------GSVSPPPFKQSPR
70 80 90 100 110
130 140 150 160 170 180
pF1KE3 VRNK--EAPAGEGTKMR-KTKKKGSGEADKDPSGSPASARKSPAAMF-LVGEGSPDKKAL
.: : .: ::. . .. .. :.: :.:. .: . . .. :. . : .
XP_011 IRRKGWQAHQRPGTRAEGESDSQDMGDAHKSPNMGPNPGMDGDCVYENLAFQKEEDLEKK
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 KKKGTPKGARKEEEEEEEAATVIKNSNQKGKAKGKGKKKAKEE-RAPSPPVEVDEPREFV
.. . :. . ..:: . ..:. . : . . ...:. :.: : .: : . .:
XP_011 REASESTGTNSSAAHNEELSKALKG--EGGTDSDHMRHEASLAIRSPCPGLEEDM-EAYV
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 LRPAPQGRTVRCRLTRDKKGMDRGMYPSYFLHLDTEKKV--FLLAGRKRKRSKTANYLIS
:::: : ..: :::::.:.:.:..: :.:.:.: .. ::::::::.::::.:::::
XP_011 LRPALPGTMMQCYLTRDKHGVDKGLFPLYYLYLETSDSLQRFLLAGRKRRRSKTSNYLIS
240 250 260 270 280 290
310 320 330 340 350
pF1KE3 IDPTNLSRGGENFIGKLRSNLLGNRFTVFDNGQNPQRGYST-NVASLRQELAAVIYETNV
.:::.::: :.::.::.:::.....::.:::: ::.: . : :.: .::::.:: :: ::
XP_011 LDPTHLSRDGDNFVGKVRSNVFSTKFTIFDNGVNPDREHLTRNTARIRQELGAVCYEPNV
300 310 320 330 340 350
360 370 380 390 400 410
pF1KE3 LGFRGPRRMTVIIPGMSAENERVPIRPRNASDGLLVRWQNKTLESLIELHNKPPVWNDDS
::. :::.::::.:: ...:.:. ..: : ...:: :.: ..:. :::: : :. ..
XP_011 LGYLGPRKMTVILPGTNSQNQRINVQPLNEQESLLSRYQRGDKQGLLLLHNKTPSWDKEN
360 370 380 390 400 410
420 430 440 450 460
pF1KE3 GSYTLNFQGRVTQASVKNFQIV---H--------ADDPDYIVLQFGRVAEDAFTLDYRYP
: :::::.::::.::::::::: : : ...:::::::. :.::.:. .:
XP_011 GVYTLNFHGRVTRASVKNFQIVDPKHRELLETSLAGPEEHLVLQFGRVGPDTFTMDFCFP
420 430 440 450 460 470
470 480
pF1KE3 LCALQAFAIALSSFDGKLACE
. ::::.: ::::.
XP_011 FSPLQAFSICLSSFN
480
489 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 06:17:16 2016 done: Sun Nov 6 06:17:18 2016
Total Scan time: 12.320 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]