Result of FASTA (omim) for
pFN21AE3649
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3649, 437 aa
1>>>pF1KE3649 437 - 437 aa - 437 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.8260+/-0.000319; mu= 20.2928+/- 0.020
mean_var=67.0840+/-13.323, 0's: 0 Z-trim(116.7): 12 B-trim: 0 in 0/54
Lambda= 0.156590
statistics sampled from 28081 (28090) to 28081 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.697), E-opt: 0.2 (0.329), width: 16
Scan time: 8.800
The best scores are: opt bits E(85289)
NP_002019 (OMIM: 134636) protein farnesyltransfera ( 437) 3048 697.3 2e-200
NP_004573 (OMIM: 179080) geranylgeranyl transferas ( 331) 421 103.8 7.1e-22
NP_005014 (OMIM: 602031) geranylgeranyl transferas ( 377) 337 84.8 4e-16
XP_005272077 (OMIM: 602031) PREDICTED: geranylgera ( 381) 337 84.8 4.1e-16
XP_011541792 (OMIM: 602031) PREDICTED: geranylgera ( 408) 337 84.9 4.3e-16
XP_011541794 (OMIM: 602031) PREDICTED: geranylgera ( 285) 310 78.6 2.2e-14
>>NP_002019 (OMIM: 134636) protein farnesyltransferase s (437 aa)
initn: 3048 init1: 3048 opt: 3048 Z-score: 3719.5 bits: 697.3 E(85289): 2e-200
Smith-Waterman score: 3048; 100.0% identity (100.0% similar) in 437 aa overlap (1-437:1-437)
10 20 30 40 50 60
pF1KE3 MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 MASPSSFTYYCPPSSSPVWSEPLYSLRPEHARERLQDDSVETVTSIEQAKVEEKIQEVFS
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQ
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 IVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 LYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 GVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 SFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_002 YHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPV
370 380 390 400 410 420
430
pF1KE3 PGFEELKDETSAEPATD
:::::::::::::::::
NP_002 PGFEELKDETSAEPATD
430
>>NP_004573 (OMIM: 179080) geranylgeranyl transferase ty (331 aa)
initn: 490 init1: 209 opt: 421 Z-score: 513.7 bits: 103.8 E(85289): 7.1e-22
Smith-Waterman score: 521; 29.9% identity (59.5% similar) in 338 aa overlap (76-410:21-321)
50 60 70 80 90 100
pF1KE3 IEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYL-KRGLRQLTDAYE-CLDAS-RPW
::: :. . : .. : :: :.. :
NP_004 MGTPQKDVIIKSDAPDTLLLEKHADYIASYGSKK--DDYEYCMSEYLRMS
10 20 30 40
110 120 130 140 150 160
pF1KE3 LCYWILHSLELLDEPIPQIVATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCI
:: : ..:. . . .. .. :.. :: ::.... :. ::: : .::. : .
NP_004 GIYWGLTVMDLMGQ-LHRMNREEILAFIKSCQHECGGISASIGHDPHLLYTLSAVQILTL
50 60 70 80 90 100
170 180 190 200 210 220
pF1KE3 IGTEEAYDIINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLF
.. ..:. .:...:. .:.. :::: . ::.:.: ..::... .: . .
NP_004 Y---DSINVIDVNKVVEYVKGLQKEDGSFAGDIWGEIDTRFSFCAVATLALLGKLDAINV
110 120 130 140 150 160
230 240 250 260 270 280
pF1KE3 EGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKRERSLNLKSLLQWVTSRQM
: . :.. :.:..::.: :: :.:.: .: . :.: .. ...: : :. ::.
NP_004 EKAIEFVLSCMNFDGGFGCRPGSESHAGQIYCCTGFLAITSQLHQVNSDLLGWWLCERQL
170 180 190 200 210 220
290 300 310 320 330 340
pF1KE3 RFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMC
::..:: .:: : :::.: . : .. : ::. .. :...:: :
NP_004 P-SGGLNGRPEKLPDVCYSWWVLASLKIIGRL------------HWI-DREKLRNFILAC
230 240 250 260 270
350 360 370 380 390 400
pF1KE3 CQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYN
. .::. :.:: : .:: . ..:::. :: :. ..:..::.
NP_004 QDEETGGFADRPGDMVDPFHTLFGIAGLSL--------------LG--EEQIKPVNPVFC
280 290 300 310
410 420 430
pF1KE3 IGPDKVIQATTYFLQKPVPGFEELKDETSAEPATD
. :..:.:
NP_004 M-PEEVLQRVNVQPELVS
320 330
>>NP_005014 (OMIM: 602031) geranylgeranyl transferase ty (377 aa)
initn: 324 init1: 132 opt: 337 Z-score: 410.4 bits: 84.8 E(85289): 4e-16
Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (70-377:17-336)
40 50 60 70 80 90
pF1KE3 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS
:: . :..: ....: :. : . : :..:
NP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS
10 20 30 40
100 110 120 130 140
pF1KE3 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGGG--------
: . .. : .:..:: . : : . .: . . . :: :.
NP_005 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN
50 60 70 80 90 100
150 160 170 180 190
pF1KE3 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M
:.. : :.: ::.... : :.: . . .:.: : : .:. :::: .
NP_005 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE3 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF
:.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: ::
NP_005 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF
170 180 190 200 210 220
260 270 280 290 300
pF1KE3 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP
::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. :
NP_005 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG
::. ... :... ..::: . .::. : . : :. . . :
NP_005 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG
290 300 310 320
370 380 390 400 410 420
pF1KE3 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE
::. .. :
NP_005 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVHIST
330 340 350 360 370
>>XP_005272077 (OMIM: 602031) PREDICTED: geranylgeranyl (381 aa)
initn: 324 init1: 132 opt: 337 Z-score: 410.3 bits: 84.8 E(85289): 4.1e-16
Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (70-377:17-336)
40 50 60 70 80 90
pF1KE3 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS
:: . :..: ....: :. : . : :..:
XP_005 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS
10 20 30 40
100 110 120 130 140
pF1KE3 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGGG--------
: . .. : .:..:: . : : . .: . . . :: :.
XP_005 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN
50 60 70 80 90 100
150 160 170 180 190
pF1KE3 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M
:.. : :.: ::.... : :.: . . .:.: : : .:. :::: .
XP_005 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE3 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF
:.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: ::
XP_005 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF
170 180 190 200 210 220
260 270 280 290 300
pF1KE3 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP
::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. :
XP_005 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG
::. ... :... ..::: . .::. : . : :. . . :
XP_005 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG
290 300 310 320
370 380 390 400 410 420
pF1KE3 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE
::. .. :
XP_005 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENVESYNQISC
330 340 350 360 370 380
>>XP_011541792 (OMIM: 602031) PREDICTED: geranylgeranyl (408 aa)
initn: 320 init1: 132 opt: 337 Z-score: 409.9 bits: 84.9 E(85289): 4.3e-16
Smith-Waterman score: 392; 28.4% identity (55.6% similar) in 338 aa overlap (70-377:17-336)
40 50 60 70 80 90
pF1KE3 VETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLVLQREKHFHYLKRGLRQLTDAYECLDAS
:: . :..: ....: :. : . : :..:
XP_011 MAATEDERLAGSGEGERLDFLRDRHVRFFQRCLQVLPERYSSLETS
10 20 30 40
100 110 120 130 140
pF1KE3 RPWLCYWILHSLELLD--------EPIPQIVATDVCQFLELCQSPEGGFGGG--------
: . .. : .:..:: . : : . .: . . . :: :.
XP_011 RLTIAFFALSGLDMLDSLDVVNKDDIIEWIYSLQVLPTEDRSNLNRCGFRGSSYLGIPFN
50 60 70 80 90 100
150 160 170 180 190
pF1KE3 PGQYP---------HLAPTYAAVNALCIIGTEEAYDIINREKLLQYLYSLKQPDGSFL-M
:.. : :.: ::.... : :.: . . .:.: : : .:. :::: .
XP_011 PSKAPGTAHPYDSGHIAMTYTGLSCLVILGDDLSR--VNKEACLAGLRALQLEDGSFCAV
110 120 130 140 150 160
200 210 220 230 240 250
pF1KE3 HVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTF
:.: :.: .:::. . . : . .. . .: : .....:.. :.:.::: ::
XP_011 PEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQGAGLESHGGSTF
170 180 190 200 210 220
260 270 280 290 300
pF1KE3 CGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLP
::.:.: .. : :. .. : : .: :: ..:..:: :: :: ::::: .. :
XP_011 CGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVDTCYSFWVGATLK
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 LLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSG
::. ... :... ..::: . .::. : . : :. . . :
XP_011 LLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSHPDALHAYFGICG
290 300 310 320
370 380 390 400 410 420
pF1KE3 LSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQKPVPGFEELKDE
::. .. :
XP_011 LSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENKEFPGLKDLCFKNIGS
330 340 350 360 370 380
>>XP_011541794 (OMIM: 602031) PREDICTED: geranylgeranyl (285 aa)
initn: 324 init1: 132 opt: 310 Z-score: 379.1 bits: 78.6 E(85289): 2.2e-14
Smith-Waterman score: 328; 30.9% identity (59.1% similar) in 230 aa overlap (153-377:2-213)
130 140 150 160 170 180
pF1KE3 ATDVCQFLELCQSPEGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYDIINREKLLQYLY
::.... : :.: . . .:.: : :
XP_011 MTYTGLSCLVILGDDLSR--VNKEACLAGLR
10 20
190 200 210 220 230 240
pF1KE3 SLKQPDGSFL-MHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGG
.:. :::: . :.: :.: .:::. . . : . .. . .: : .....:..
XP_011 ALQLEDGSFCAVPEGSENDMRFVYCASCICYMLNNWSGMDMKKAITYIRRSMSYDNGLAQ
30 40 50 60 70 80
250 260 270 280 290
pF1KE3 VPGMEAHGGYTFCGLAALVIL-KRERSLNLKSL---LQWVTSRQMRFEGGFQGRCNKLVD
:.:.::: ::::.:.: .. : :. .. : : .: :: ..:..:: :: ::
XP_011 GAGLESHGGSTFCGIASLCLMGKLEEVFSEKELNRIKRWCIMRQ---QNGYHGRPNKPVD
90 100 110 120 130 140
300 310 320 330 340 350
pF1KE3 GCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKS
::::: .. : ::. ... :... ..::: . .::. : .
XP_011 TCYSFWVGATLKLLK-----------IFQYTNFEKN--RNYILSTQDRLVGGFAKWPDSH
150 160 170 180 190
360 370 380 390 400 410
pF1KE3 RDFYHTCYCLSGLSIAQHFGSGAMLHDVVLGVPENALQPTHPVYNIGPDKVIQATTYFLQ
: :. . . :::. .. :
XP_011 PDALHAYFGICGLSLMEESGICKVHPALNVSTRTSERLLDLHQSWKTKDSKQCSENKEFP
200 210 220 230 240 250
437 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 00:46:11 2016 done: Mon Nov 7 00:46:13 2016
Total Scan time: 8.800 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]