Result of FASTA (omim) for
pFN21AE3644
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3644, 534 aa
1>>>pF1KE3644 534 - 534 aa - 534 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.9493+/-0.000435; mu= 20.7971+/- 0.027
mean_var=70.3665+/-13.753, 0's: 0 Z-trim(110.2): 41 B-trim: 51 in 3/51
Lambda= 0.152894
statistics sampled from 18451 (18483) to 18451 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.577), E-opt: 0.2 (0.217), width: 16
Scan time: 7.440
The best scores are: opt bits E(85289)
NP_003896 (OMIM: 603385) NEDD8-activating enzyme E ( 534) 3511 784.2 0
NP_001273429 (OMIM: 603385) NEDD8-activating enzym ( 537) 3495 780.6 0
NP_001018169 (OMIM: 603385) NEDD8-activating enzym ( 528) 3407 761.2 0
XP_011521724 (OMIM: 603385) PREDICTED: NEDD8-activ ( 445) 2934 656.8 3.8e-188
XP_005256272 (OMIM: 603385) PREDICTED: NEDD8-activ ( 445) 2934 656.8 3.8e-188
NP_001018170 (OMIM: 603385) NEDD8-activating enzym ( 445) 2934 656.8 3.8e-188
NP_005491 (OMIM: 613294) SUMO-activating enzyme su ( 346) 334 83.2 1.4e-15
XP_006723026 (OMIM: 613294) PREDICTED: SUMO-activa ( 378) 334 83.3 1.5e-15
NP_001139186 (OMIM: 613294) SUMO-activating enzyme ( 266) 332 82.7 1.5e-15
XP_006723028 (OMIM: 613294) PREDICTED: SUMO-activa ( 281) 332 82.7 1.6e-15
NP_001139185 (OMIM: 613294) SUMO-activating enzyme ( 299) 332 82.7 1.7e-15
XP_016881624 (OMIM: 613294) PREDICTED: SUMO-activa ( 349) 332 82.8 1.9e-15
XP_016885270 (OMIM: 301830,314370) PREDICTED: ubiq (1058) 250 65.1 1.2e-09
XP_016885269 (OMIM: 301830,314370) PREDICTED: ubiq (1058) 250 65.1 1.2e-09
NP_695012 (OMIM: 301830,314370) ubiquitin-like mod (1058) 250 65.1 1.2e-09
NP_003325 (OMIM: 301830,314370) ubiquitin-like mod (1058) 250 65.1 1.2e-09
XP_005272706 (OMIM: 301830,314370) PREDICTED: ubiq (1064) 250 65.1 1.2e-09
XP_016885268 (OMIM: 301830,314370) PREDICTED: ubiq (1064) 250 65.1 1.2e-09
XP_011542256 (OMIM: 301830,314370) PREDICTED: ubiq (1072) 250 65.1 1.2e-09
XP_016885267 (OMIM: 301830,314370) PREDICTED: ubiq (1086) 250 65.1 1.2e-09
XP_016885266 (OMIM: 301830,314370) PREDICTED: ubiq (1109) 250 65.1 1.3e-09
XP_011532373 (OMIM: 191325) PREDICTED: ubiquitin-l ( 910) 223 59.1 6.7e-08
XP_011532372 (OMIM: 191325) PREDICTED: ubiquitin-l ( 960) 223 59.1 7e-08
XP_005265487 (OMIM: 191325) PREDICTED: ubiquitin-l ( 987) 223 59.1 7.2e-08
XP_006713384 (OMIM: 191325) PREDICTED: ubiquitin-l (1005) 223 59.1 7.3e-08
NP_003326 (OMIM: 191325) ubiquitin-like modifier-a (1012) 223 59.1 7.3e-08
XP_016863848 (OMIM: 611361) PREDICTED: ubiquitin-l (1009) 219 58.2 1.3e-07
NP_060697 (OMIM: 611361) ubiquitin-like modifier-a (1052) 219 58.3 1.4e-07
XP_016881625 (OMIM: 613294) PREDICTED: SUMO-activa ( 282) 189 51.2 5e-06
NP_005490 (OMIM: 613295) SUMO-activating enzyme su ( 640) 173 47.9 0.00011
NP_937838 (OMIM: 603172) NEDD8-activating enzyme E ( 449) 157 44.3 0.00095
NP_003959 (OMIM: 603172) NEDD8-activating enzyme E ( 463) 157 44.3 0.00098
>>NP_003896 (OMIM: 603385) NEDD8-activating enzyme E1 re (534 aa)
initn: 3511 init1: 3511 opt: 3511 Z-score: 4185.6 bits: 784.2 E(85289): 0
Smith-Waterman score: 3511; 100.0% identity (100.0% similar) in 534 aa overlap (1-534:1-534)
10 20 30 40 50 60
pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
430 440 450 460 470 480
490 500 510 520 530
pF1KE3 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_003 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
490 500 510 520 530
>>NP_001273429 (OMIM: 603385) NEDD8-activating enzyme E1 (537 aa)
initn: 3171 init1: 3171 opt: 3495 Z-score: 4166.5 bits: 780.6 E(85289): 0
Smith-Waterman score: 3495; 99.4% identity (99.4% similar) in 537 aa overlap (1-534:1-537)
10 20 30 40 50
pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPG---IGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::: ::::
NP_001 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGNVGIGSF
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 TIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDP
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPD
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 NALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTY
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 KEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINI
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 TKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAV
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 GNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 NPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPDNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 YVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YVHEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
490 500 510 520 530
>>NP_001018169 (OMIM: 603385) NEDD8-activating enzyme E1 (528 aa)
initn: 3403 init1: 3403 opt: 3407 Z-score: 4061.7 bits: 761.2 E(85289): 0
Smith-Waterman score: 3407; 98.7% identity (99.0% similar) in 525 aa overlap (10-534:4-528)
10 20 30 40 50 60
pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
.: . :::::::::::::::::::::::::::::::::::::::::::
NP_001 MDAQQTKTNEARLWGDHGQEALESAHVCLINATATGTEILKNLVLPGIGSFTII
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSFF
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNAL
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE3 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKEK
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITKQ
240 250 260 270 280 290
310 320 330 340 350 360
pF1KE3 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGNH
300 310 320 330 340 350
370 380 390 400 410 420
pF1KE3 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNPD
360 370 380 390 400 410
430 440 450 460 470 480
pF1KE3 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYVH
420 430 440 450 460 470
490 500 510 520 530
pF1KE3 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
480 490 500 510 520
>>XP_011521724 (OMIM: 603385) PREDICTED: NEDD8-activatin (445 aa)
initn: 2934 init1: 2934 opt: 2934 Z-score: 3498.8 bits: 656.8 E(85289): 3.8e-188
Smith-Waterman score: 2934; 100.0% identity (100.0% similar) in 445 aa overlap (90-534:1-445)
60 70 80 90 100 110
pF1KE3 IDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSF
::::::::::::::::::::::::::::::
XP_011 MEFLQELNSDVSGSFVEESPENLLDNDPSF
10 20 30
120 130 140 150 160 170
pF1KE3 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE3 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE3 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE3 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE3 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE3 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE3 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
400 410 420 430 440
>>XP_005256272 (OMIM: 603385) PREDICTED: NEDD8-activatin (445 aa)
initn: 2934 init1: 2934 opt: 2934 Z-score: 3498.8 bits: 656.8 E(85289): 3.8e-188
Smith-Waterman score: 2934; 100.0% identity (100.0% similar) in 445 aa overlap (90-534:1-445)
60 70 80 90 100 110
pF1KE3 IDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSF
::::::::::::::::::::::::::::::
XP_005 MEFLQELNSDVSGSFVEESPENLLDNDPSF
10 20 30
120 130 140 150 160 170
pF1KE3 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE3 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE3 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE3 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE3 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE3 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE3 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
400 410 420 430 440
>>NP_001018170 (OMIM: 603385) NEDD8-activating enzyme E1 (445 aa)
initn: 2934 init1: 2934 opt: 2934 Z-score: 3498.8 bits: 656.8 E(85289): 3.8e-188
Smith-Waterman score: 2934; 100.0% identity (100.0% similar) in 445 aa overlap (90-534:1-445)
60 70 80 90 100 110
pF1KE3 IDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLDNDPSF
::::::::::::::::::::::::::::::
NP_001 MEFLQELNSDVSGSFVEESPENLLDNDPSF
10 20 30
120 130 140 150 160 170
pF1KE3 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIESHPDNA
40 50 60 70 80 90
180 190 200 210 220 230
pF1KE3 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIPKTYKE
100 110 120 130 140 150
240 250 260 270 280 290
pF1KE3 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRCINITK
160 170 180 190 200 210
300 310 320 330 340 350
pF1KE3 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREKAKKDAAAVGN
220 230 240 250 260 270
360 370 380 390 400 410
pF1KE3 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCRSLAEEYGLDTINKDEIISSMDNP
280 290 300 310 320 330
420 430 440 450 460 470
pF1KE3 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DNEIVLYLMLRAVDRFHKQQGRYPGVSNYQVEEDIGKLKSCLTGFLQEYGLSVMVKDDYV
340 350 360 370 380 390
480 490 500 510 520 530
pF1KE3 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HEFCRYGAAEPHTIAAFLGGAAAQEVIKIITKQFVIFNNTYIYSGMSQTSATFQL
400 410 420 430 440
>>NP_005491 (OMIM: 613294) SUMO-activating enzyme subuni (346 aa)
initn: 415 init1: 272 opt: 334 Z-score: 400.8 bits: 83.2 E(85289): 1.4e-15
Smith-Waterman score: 334; 25.7% identity (58.8% similar) in 311 aa overlap (12-317:18-316)
10 20 30 40 50
pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGI
.::::.:::: ..:. :....: :.. . :.:: :::.: :.
NP_005 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 GSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLD
..:..: .::. :: : .:... .:.:.:::::..: :.:: :. :. . :..
NP_005 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEK
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 NDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIES
. ::: .: .: : ... ... .. ...: .. ..: :: . :: .:
NP_005 KPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 HPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSE-TNGRI
. : . .. : ...: . : :: : . ..: :: ... .
NP_005 KTKVAKVSQGVEDGPDTKRAKLDSSETT-MVKKKVVFCP---VKEALEVDWSSEKAKAAL
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 PKTYKEKEDFRDLIRQGILKNENGAPED-EENFEEAIKNVNTALNTTQIPSSIEDIFNDD
.: .. .. :.. :... . . ::. : .. : .:.. : :.. .:
NP_005 KRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSLGISP---DLLPED
240 250 260 270 280 290
300 310 320 330 340
pF1KE3 ---RCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADSGKYIKLQNVYREK
:. ....: ... : . ..:
NP_005 FVRYCF--SEMAPVCAVVGGILAQEIVKALSQRDPPHNNFFFFDGMKGNGIVECLGPK
300 310 320 330 340
>>XP_006723026 (OMIM: 613294) PREDICTED: SUMO-activating (378 aa)
initn: 383 init1: 272 opt: 334 Z-score: 400.3 bits: 83.3 E(85289): 1.5e-15
Smith-Waterman score: 334; 25.7% identity (58.8% similar) in 311 aa overlap (12-317:54-352)
10 20 30 40
pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATAT
.::::.:::: ..:. :....: :.. .
XP_006 LSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGL
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE3 GTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVS
:.:: :::.: :. ..:..: .::. :: : .:... .:.:.:::::..: :.:: :.
XP_006 GAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE3 GSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGY
:. . :.. . ::: .: .: : ... ... .. ...: .. ..: ::
XP_006 ---VKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGY
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE3 MRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKY
. :: .: . : . .. : ...: . : :: : .
XP_006 TFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETT-MVKKKVVFCP---VKEAL
210 220 230 240 250
230 240 250 260 270
pF1KE3 LAQWYSE-TNGRIPKTYKEKEDFRDLIRQGILKNENGAPED-EENFEEAIKNVNTALNTT
..: :: ... . .: .. .. :.. :... . . ::. : .. : .:..
XP_006 EVDWSSEKAKAALKRTTSDYFLLQVLLKFRTDKGRDPSSDTYEEDSELLLQIRNDVLDSL
260 270 280 290 300 310
280 290 300 310 320 330
pF1KE3 QIPSSIEDIFNDD---RCINITKQTPSFWILARALKEFVAKEGQGNLPVRGTIPDMIADS
: :.. .: :. ....: ... : . ..:
XP_006 GISP---DLLPEDFVRYCF--SEMAPVCAVVGGILAQEIVKVLGCLRGLRPCLSGTLLTT
320 330 340 350 360 370
340 350 360 370 380 390
pF1KE3 GKYIKLQNVYREKAKKDAAAVGNHVAKLLQSIGQAPESISEKELKLLCSNSAFLRVVRCR
XP_006 TSSSSMA
>>NP_001139186 (OMIM: 613294) SUMO-activating enzyme sub (266 aa)
initn: 328 init1: 272 opt: 332 Z-score: 400.0 bits: 82.7 E(85289): 1.5e-15
Smith-Waterman score: 332; 30.6% identity (64.3% similar) in 196 aa overlap (12-207:18-210)
10 20 30 40 50
pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATATGTEILKNLVLPGI
.::::.:::: ..:. :....: :.. . :.:: :::.: :.
NP_001 MVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGLGAEIAKNLILAGV
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 GSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVSGSFVEESPENLLD
..:..: .::. :: : .:... .:.:.:::::..: :.:: :. :. . :..
NP_001 KGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD---VKVDTEDIEK
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 NDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGYMRIIIKEHPVIES
. ::: .: .: : ... ... .. ...: .. ..: :: . :: .:
NP_001 KPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGYTFANLGEHEFVEE
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE3 HPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKYLAQWYSETNGRIP
. : . .. : ...: . ..::
NP_001 KTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDWSSEKAKAALKRTT
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 KTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQIPSSIEDIFNDDRC
NP_001 SDYFLLQGTASPRWPQCVRWLEGFWHRKL
240 250 260
>>XP_006723028 (OMIM: 613294) PREDICTED: SUMO-activating (281 aa)
initn: 328 init1: 272 opt: 332 Z-score: 399.6 bits: 82.7 E(85289): 1.6e-15
Smith-Waterman score: 332; 30.6% identity (64.3% similar) in 196 aa overlap (12-207:54-246)
10 20 30 40
pF1KE3 MAQLGKLLKEQKYDRQLRLWGDHGQEALESAHVCLINATAT
.::::.:::: ..:. :....: :.. .
XP_006 LSGTGAEAGRAGAMVEKEEAGGGISEEEAAQYDRQIRLWGLEAQKRLRASRVLLVGLKGL
30 40 50 60 70 80
50 60 70 80 90 100
pF1KE3 GTEILKNLVLPGIGSFTIIDGNQVSGEDAGNNFFLQRSSIGKNRAEAAMEFLQELNSDVS
:.:: :::.: :. ..:..: .::. :: : .:... .:.:.:::::..: :.:: :.
XP_006 GAEIAKNLILAGVKGLTMLDHEQVTPEDPGAQFLIRTGSVGRNRAEASLERAQNLNPMVD
90 100 110 120 130 140
110 120 130 140 150 160
pF1KE3 GSFVEESPENLLDNDPSFFCRFTVVVATQLPESTSLRLADVLWNSQIPLLICRTYGLVGY
:. . :.. . ::: .: .: : ... ... .. ...: .. ..: ::
XP_006 ---VKVDTEDIEKKPESFFTQFDAVCLTCCSRDVIVKVDQICHKNSIKFFTGDVFGYHGY
150 160 170 180 190 200
170 180 190 200 210 220
pF1KE3 MRIIIKEHPVIESHPDNALEDLRLDKPFPELREHFQSYDLDHMEKKDHSHTPWIVIIAKY
. :: .: . : . .. : ...: . ..::
XP_006 TFANLGEHEFVEEKTKVAKVSQGVEDGPDTKRAKLDSSETTMVKKKVVFCPVKEALEVDW
210 220 230 240 250 260
230 240 250 260 270 280
pF1KE3 LAQWYSETNGRIPKTYKEKEDFRDLIRQGILKNENGAPEDEENFEEAIKNVNTALNTTQI
XP_006 SSEKAKAALKRTTSDYFLLQA
270 280
534 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:05:45 2016 done: Mon Nov 7 03:05:46 2016
Total Scan time: 7.440 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]