Result of FASTA (omim) for
pFN21AE3586
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3586, 205 aa
1>>>pF1KE3586 205 - 205 aa - 205 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.2608+/-0.000313; mu= 13.9040+/- 0.019
mean_var=64.5085+/-13.390, 0's: 0 Z-trim(116.2): 20 B-trim: 76 in 1/50
Lambda= 0.159686
statistics sampled from 27239 (27259) to 27239 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.715), E-opt: 0.2 (0.32), width: 16
Scan time: 6.040
The best scores are: opt bits E(85289)
NP_004419 (OMIM: 191164) ephrin-A1 isoform a precu ( 205) 1420 335.3 4.1e-92
NP_872626 (OMIM: 191164) ephrin-A1 isoform b precu ( 183) 941 224.9 6.2e-59
XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 201) 509 125.4 6.1e-29
NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo ( 228) 503 124.1 1.8e-28
NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo ( 238) 502 123.9 2.1e-28
NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo ( 213) 457 113.5 2.6e-25
NP_005218 (OMIM: 601380) ephrin-A4 isoform a precu ( 201) 435 108.4 8.2e-24
NP_872632 (OMIM: 601380) ephrin-A4 isoform c precu ( 193) 434 108.2 9.4e-24
NP_872631 (OMIM: 601380) ephrin-A4 isoform b precu ( 207) 421 105.2 7.9e-23
XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 210) 413 103.3 2.9e-22
XP_016881939 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 202) 394 98.9 5.8e-21
XP_016881938 (OMIM: 602756) PREDICTED: ephrin-A2 i ( 298) 394 99.0 8e-21
XP_016864694 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 268 69.8 2.4e-12
XP_011541553 (OMIM: 601535) PREDICTED: ephrin-A5 i ( 148) 268 69.8 2.4e-12
NP_004420 (OMIM: 300035,304110) ephrin-B1 precurso ( 346) 244 64.5 2.3e-10
NP_004084 (OMIM: 600527) ephrin-B2 precursor [Homo ( 333) 233 62.0 1.3e-09
NP_001397 (OMIM: 602297) ephrin-B3 precursor [Homo ( 340) 232 61.7 1.5e-09
XP_016875895 (OMIM: 600527) PREDICTED: ephrin-B2 i ( 335) 178 49.3 8.4e-06
>>NP_004419 (OMIM: 191164) ephrin-A1 isoform a precursor (205 aa)
initn: 1420 init1: 1420 opt: 1420 Z-score: 1774.7 bits: 335.3 E(85289): 4.1e-92
Smith-Waterman score: 1420; 99.0% identity (99.5% similar) in 205 aa overlap (1-205:1-205)
10 20 30 40 50 60
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPEVRVLHSIA
:::::::::::::::::::::::::::::::::::::: ::::::::::::::::::::.
NP_004 KEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHDNPQEKRLAADDPEVRVLHSIG
130 140 150 160 170 180
190 200
pF1KE3 HSAAPRLFPLAWTVLLLPLLLLQTP
:::::::::::::::::::::::::
NP_004 HSAAPRLFPLAWTVLLLPLLLLQTP
190 200
>>NP_872626 (OMIM: 191164) ephrin-A1 isoform b precursor (183 aa)
initn: 939 init1: 939 opt: 941 Z-score: 1179.1 bits: 224.9 E(85289): 6.2e-59
Smith-Waterman score: 1217; 88.3% identity (88.8% similar) in 205 aa overlap (1-205:1-183)
10 20 30 40 50 60
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVA
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_872 DAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEF
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 KEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPEVRVLHSIA
:::::::::: :::::: ::::::::::::::::::::.
NP_872 KEGHSYYYIS----------------------HSPQAHDNPQEKRLAADDPEVRVLHSIG
130 140 150
190 200
pF1KE3 HSAAPRLFPLAWTVLLLPLLLLQTP
:::::::::::::::::::::::::
NP_872 HSAAPRLFPLAWTVLLLPLLLLQTP
160 170 180
>>XP_006714628 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (201 aa)
initn: 311 init1: 277 opt: 509 Z-score: 640.6 bits: 125.4 E(85289): 6.1e-29
Smith-Waterman score: 509; 47.8% identity (73.3% similar) in 161 aa overlap (14-173:25-183)
10 20 30 40
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDI
: :.:::..:.::::::.:. :: : : .:::.:.
XP_006 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 ICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQ
.:::::: :: . :.:.::.:. . :. :. :: ::.:::: . .:: :.:::::
XP_006 FCPHYED-SVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQ
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 RFTPFTLGKEFKEGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAHVNPQEKRLAA
::::.:: ::. :. :.:::. : .. : ::.::: : . . . ..:.. . ::
XP_006 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFVR-PTNDTVHESAEPSRGENAA
120 130 140 150 160 170
170 180 190 200
pF1KE3 DDPEVRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP
. :..
XP_006 QTPRIPSRLLAILLFLLAMLLTL
180 190 200
>>NP_001953 (OMIM: 601535) ephrin-A5 precursor [Homo sap (228 aa)
initn: 504 init1: 275 opt: 503 Z-score: 632.3 bits: 124.1 E(85289): 1.8e-28
Smith-Waterman score: 503; 48.1% identity (74.1% similar) in 158 aa overlap (14-170:25-179)
10 20 30 40
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDI
: :.:::..:.::::::.:. :: : : .:::.:.
NP_001 MLHVEMLTLVFLVLWMCVFSQDPGSKAVADRYAVYWNSSNPRFQRGDYHIDVCINDYLDV
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 ICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQ
.:::::: :: . :.:.::.:. . :. :. :: ::.:::: . .:: :.:::::
NP_001 FCPHYED-SVPEDKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQ
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 RFTPFTLGKEFKEGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAHVNPQEKRLAA
::::.:: ::. :. :.:::. : .. : ::.::: : . :.: . .. ... . .
NP_001 LFTPFSLGFEFRPGREYFYISSAIPDNGRRSCLKLKVFV--RPTNSCMKTIGVHDRVFDV
120 130 140 150 160 170
170 180 190 200
pF1KE3 DDPEVRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP
.:
NP_001 NDKVENSLEPADDTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
180 190 200 210 220
>>NP_004943 (OMIM: 601381) ephrin-A3 precursor [Homo sap (238 aa)
initn: 503 init1: 271 opt: 502 Z-score: 630.8 bits: 123.9 E(85289): 2.1e-28
Smith-Waterman score: 510; 39.4% identity (66.5% similar) in 221 aa overlap (7-204:19-238)
10 20 30 40
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVD
:::. . : ..::.:.::::: ..: : ::..:..:::.:
NP_004 MAAAPLLLLLLLVPVPLLPLLAQGPGGALGNRHAVYWNSSNQHLRREGYTVQVNVNDYLD
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 IICPHYEDHSVADAA-------MEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGP
: ::::.. .:. .: :::.::.: .. :. :. :. ::.:::: : :.:
NP_004 IYCPHYNSSGVGPGAGPGPGGGAEQYVLYMVSRNGYRTCNA-SQGFKRWECNRPHAPHSP
70 80 90 100 110
110 120 130 140 150
pF1KE3 EKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVS-GKITHS------
:.::::::.. :.:: ::. :: ::::: : :. . .:::.:: : .. .::
NP_004 IKFSEKFQRYSAFSLGYEFHAGHEYYYISTPTHNLHWKCLRMKVFVCCASTSHSGEKPVP
120 130 140 150 160 170
160 170 180 190 200
pF1KE3 --PQAHVNPQEK-----RLAADDPEVRVLHSIAHSAAPRL--FPLAWTVLLLPLLLLQTP
:: ..:. : . ...:.: :.. ...:. .::: . .. . .: .
NP_004 TLPQFTMGPNVKINVLEDFEGENPQVPKLEKSISGTSPKREHLPLAVGIAFFLMTFLAS
180 190 200 210 220 230
>>NP_001396 (OMIM: 602756) ephrin-A2 precursor [Homo sap (213 aa)
initn: 470 init1: 362 opt: 457 Z-score: 575.5 bits: 113.5 E(85289): 2.6e-25
Smith-Waterman score: 467; 42.7% identity (62.5% similar) in 192 aa overlap (16-195:32-211)
10 20 30
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFR---NED---YTI
: .::..:.:: :::.:. ..: ::.
NP_001 APAQRPLLPLLLLLLPLPPPPFARAEDAARANSDRYAVYWNRSNPRFHAGAGDDGGGYTV
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 HVQLNDYVDIICPHYEDHSVADAAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKH
.:..:::.:: :::: ::.:.::.:. : . :. ... ::.::::.:
NP_001 EVSINDYLDIYCPHYGAPLPPAERMEHYVLYMVNGEGHASCDHRQRGFKRWECNRPAAPG
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 GPEKLSEKFQRFTPFTLGKEFKEGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAH
:: :.::::: ::::.:: ::. :: ::::: . :: :::::: .
NP_001 GPLKFSEKFQLFTPFSLGFEFRPGHEYYYISATPPNAVDRPCLRLKV------------Y
130 140 150 160
160 170 180 190 200
pF1KE3 VNPQEKRL-AADDPEVRVLHSIAHSAAPRLF----PLAWTVLLLPLLLLQTP
: : .. : : .: .: . .. ::: :. ::.:
NP_001 VRPTNETLYEAPEPIFTSNNSCSSPGGCRLFLSTIPVLWTLLGS
170 180 190 200 210
>>NP_005218 (OMIM: 601380) ephrin-A4 isoform a precursor (201 aa)
initn: 427 init1: 196 opt: 435 Z-score: 548.4 bits: 108.4 E(85289): 8.2e-24
Smith-Waterman score: 435; 43.6% identity (67.3% similar) in 156 aa overlap (4-158:11-162)
10 20 30 40 50
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH
::: .:: ... ::.:.::::::.. : .... ::::.::.:::
NP_005 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT
:: . .. : . ::.:. :. :: .. . :: :. : : ..:::.::::
NP_005 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPE
::.:: :: :..::::: : . .::::.:.: : .: .::
NP_005 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERKSESAHPVGSPGESGTSGWR
120 130 140 150 160 170
180 190 200
pF1KE3 VRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP
NP_005 GGDTPSPLCLLLLLLLLILRLLRIL
180 190 200
>>NP_872632 (OMIM: 601380) ephrin-A4 isoform c precursor (193 aa)
initn: 389 init1: 196 opt: 434 Z-score: 547.5 bits: 108.2 E(85289): 9.4e-24
Smith-Waterman score: 434; 42.0% identity (66.9% similar) in 169 aa overlap (4-171:11-171)
10 20 30 40 50
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH
::: .:: ... ::.:.::::::.. : .... ::::.::.:::
NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT
:: . .. : . ::.:. :. :: .. . :: :. : : ..:::.::::
NP_872 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPE
::.:: :: :..::::: : . .::::.:.: : . : .: :.: . ...::
NP_872 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERNLP-SH--PKEPE-SSQDPL
120 130 140 150 160 170
180 190 200
pF1KE3 VRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP
NP_872 EEEGSLLPALGVPIQTDKMEH
180 190
>>NP_872631 (OMIM: 601380) ephrin-A4 isoform b precursor (207 aa)
initn: 389 init1: 196 opt: 421 Z-score: 530.8 bits: 105.2 E(85289): 7.9e-23
Smith-Waterman score: 421; 43.9% identity (67.6% similar) in 148 aa overlap (4-150:11-154)
10 20 30 40 50
pF1KE3 MEFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPH
::: .:: ... ::.:.::::::.. : .... ::::.::.:::
NP_872 MRLLPLLRTVLWAAFLGSPLRGGSSLRHVVYWNSSNPRLLRGDAVVELGLNDYLDIVCPH
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 YEDHSVADAAMEQYILYLVEHEEYQLCQPQS-KDQVRWQCNRPSAKHGPEKLSEKFQRFT
:: . .. : . ::.:. :. :: .. . :: :. : : ..:::.::::
NP_872 YEGPGPPEGP-ETFALYMVDWPGYESCQAEGPRAYKRWVCSLP---FGHVQFSEKIQRFT
70 80 90 100 110
120 130 140 150 160 170
pF1KE3 PFTLGKEFKEGHSYYYISKPIHQHEDRCLRLKVTVSGKITHSPQAHVNPQEKRLAADDPE
::.:: :: :..::::: : . .::::.:.: :
NP_872 PFSLGFEFLPGETYYYISVPTPESSGQCLRLQVSVCCKERRARVLPRSPGGGGIPAACTG
120 130 140 150 160 170
180 190 200
pF1KE3 VRVLHSIAHSAAPRLFPLAWTVLLLPLLLLQTP
NP_872 GANSDRQDGALMGEIRGSEVTLAGACPLITG
180 190 200
>>XP_011541552 (OMIM: 601535) PREDICTED: ephrin-A5 isofo (210 aa)
initn: 414 init1: 275 opt: 413 Z-score: 520.8 bits: 103.3 E(85289): 2.9e-22
Smith-Waterman score: 413; 45.7% identity (71.4% similar) in 140 aa overlap (32-170:25-161)
10 20 30 40 50 60
pF1KE3 EFLWAPLLGLCCSLAAADRHTVFWNSSNPKFRNEDYTIHVQLNDYVDIICPHYEDHSVAD
:. :: : : .:::.:..:::::: :: .
XP_011 MQTLEPACFRFSLHTNTNKQCTLGFQRGDYHIDVCINDYLDVFCPHYED-SVPE
10 20 30 40 50
70 80 90 100 110 120
pF1KE3 AAMEQYILYLVEHEEYQLCQPQSKDQVRWQCNRPSAKHGPEKLSEKFQRFTPFTLGKEFK
:.:.::.:. . :. :. :: ::.:::: . .:: :.::::: ::::.:: ::.
XP_011 DKTERYVLYMVNFDGYSACDHTSKGFKRWECNRPHSPNGPLKFSEKFQLFTPFSLGFEFR
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE3 EGHSYYYISKPIHQHEDR-CLRLKVTVSGKITHSPQAHVNPQEKRLAADDPEVRVLHSIA
:. :.:::. : .. : ::.::: : . :.: . .. ... . ..:
XP_011 PGREYFYISSAIPDNGRRSCLKLKVFV--RPTNSCMKTIGVHDRVFDVNDKVENSLEPAD
120 130 140 150 160 170
190 200
pF1KE3 HSAAPRLFPLAWTVLLLPLLLLQTP
XP_011 DTVHESAEPSRGENAAQTPRIPSRLLAILLFLLAMLLTL
180 190 200 210
205 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:57:03 2016 done: Sun Nov 6 01:57:04 2016
Total Scan time: 6.040 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]