Result of FASTA (omim) for
pFN21AE3583
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3583, 418 aa
1>>>pF1KE3583 418 - 418 aa - 418 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.2914+/-0.000395; mu= 13.5665+/- 0.025
mean_var=107.2646+/-21.958, 0's: 0 Z-trim(114.1): 181 B-trim: 683 in 1/53
Lambda= 0.123836
statistics sampled from 23508 (23700) to 23508 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.645), E-opt: 0.2 (0.278), width: 16
Scan time: 9.090
The best scores are: opt bits E(85289)
NP_006494 (OMIM: 602707) 26S protease regulatory s ( 418) 2693 492.0 1.2e-138
NP_694546 (OMIM: 602707) 26S protease regulatory s ( 387) 2227 408.7 1.3e-113
NP_002793 (OMIM: 602706) 26S protease regulatory s ( 440) 1311 245.1 2.5e-64
XP_016876959 (OMIM: 602706) PREDICTED: 26S proteas ( 367) 1296 242.4 1.4e-63
NP_001317141 (OMIM: 602706) 26S protease regulator ( 367) 1296 242.4 1.4e-63
NP_001186092 (OMIM: 601681) 26S protease regulator ( 398) 1052 198.8 2e-50
NP_002796 (OMIM: 601681) 26S protease regulatory s ( 406) 1052 198.8 2e-50
NP_002797 (OMIM: 602708) 26S protease regulatory s ( 403) 1029 194.7 3.5e-49
NP_002795 (OMIM: 186852) 26S protease regulatory s ( 439) 1018 192.8 1.5e-48
XP_016873515 (OMIM: 186852) PREDICTED: 26S proteas ( 461) 977 185.5 2.4e-46
NP_002794 (OMIM: 154365) 26S protease regulatory s ( 433) 960 182.4 1.9e-45
XP_016876961 (OMIM: 602708) PREDICTED: 26S proteas ( 288) 886 169.1 1.3e-41
NP_009057 (OMIM: 167320,601023,613954,616687) tran ( 806) 654 127.9 8.8e-29
XP_011523903 (OMIM: 604581,610246,614487) PREDICTE ( 730) 630 123.6 1.6e-27
NP_006787 (OMIM: 604581,610246,614487) AFG3-like p ( 797) 630 123.6 1.7e-27
NP_001230075 (OMIM: 602426) nuclear valosin-contai ( 667) 605 119.1 3.3e-26
XP_011542502 (OMIM: 602426) PREDICTED: nuclear val ( 765) 605 119.2 3.7e-26
XP_011542501 (OMIM: 602426) PREDICTED: nuclear val ( 765) 605 119.2 3.7e-26
XP_011542500 (OMIM: 602426) PREDICTED: nuclear val ( 777) 605 119.2 3.7e-26
XP_016856871 (OMIM: 602426) PREDICTED: nuclear val ( 839) 605 119.2 3.9e-26
XP_016856870 (OMIM: 602426) PREDICTED: nuclear val ( 839) 605 119.2 3.9e-26
XP_011542498 (OMIM: 602426) PREDICTED: nuclear val ( 883) 605 119.2 4.1e-26
XP_016856869 (OMIM: 602426) PREDICTED: nuclear val ( 889) 605 119.2 4.1e-26
XP_016856867 (OMIM: 602426) PREDICTED: nuclear val ( 917) 605 119.2 4.2e-26
XP_016879087 (OMIM: 602783,607259) PREDICTED: para ( 561) 584 115.3 3.9e-25
XP_016879086 (OMIM: 602783,607259) PREDICTED: para ( 618) 584 115.3 4.2e-25
NP_003110 (OMIM: 602783,607259) paraplegin isoform ( 795) 584 115.4 5.1e-25
XP_006721327 (OMIM: 602783,607259) PREDICTED: para ( 809) 584 115.4 5.1e-25
XP_016856875 (OMIM: 602426) PREDICTED: nuclear val ( 738) 572 113.3 2.1e-24
NP_996671 (OMIM: 602426) nuclear valosin-containin ( 750) 572 113.3 2.1e-24
NP_001230076 (OMIM: 602426) nuclear valosin-contai ( 765) 572 113.3 2.2e-24
XP_016856872 (OMIM: 602426) PREDICTED: nuclear val ( 812) 572 113.3 2.3e-24
NP_002524 (OMIM: 602426) nuclear valosin-containin ( 856) 572 113.3 2.4e-24
XP_016856868 (OMIM: 602426) PREDICTED: nuclear val ( 890) 572 113.3 2.4e-24
NP_001304728 (OMIM: 613940,616577) spermatogenesis ( 695) 558 110.7 1.1e-23
XP_011529981 (OMIM: 613940,616577) PREDICTED: sper ( 790) 558 110.8 1.3e-23
XP_016863317 (OMIM: 613940,616577) PREDICTED: sper ( 819) 558 110.8 1.3e-23
NP_001332785 (OMIM: 613940,616577) spermatogenesis ( 892) 558 110.8 1.4e-23
NP_660208 (OMIM: 613940,616577) spermatogenesis-as ( 893) 558 110.8 1.4e-23
XP_016863319 (OMIM: 613940,616577) PREDICTED: sper ( 593) 544 108.2 5.7e-23
NP_001303242 (OMIM: 601498,614862,614863,616617) p ( 892) 542 108.0 1e-22
XP_016863318 (OMIM: 613940,616577) PREDICTED: sper ( 765) 541 107.7 1e-22
XP_011512963 (OMIM: 601498,614862,614863,616617) P ( 952) 542 108.0 1.1e-22
XP_016863316 (OMIM: 613940,616577) PREDICTED: sper ( 823) 541 107.8 1.1e-22
NP_000278 (OMIM: 601498,614862,614863,616617) pero ( 980) 542 108.0 1.1e-22
XP_016863315 (OMIM: 613940,616577) PREDICTED: sper ( 859) 541 107.8 1.1e-22
XP_011529980 (OMIM: 613940,616577) PREDICTED: sper ( 916) 541 107.8 1.2e-22
XP_016863314 (OMIM: 613940,616577) PREDICTED: sper ( 917) 541 107.8 1.2e-22
XP_016867808 (OMIM: 214100,234580,601539,602136) P ( 700) 537 107.0 1.5e-22
NP_001269607 (OMIM: 214100,234580,601539,602136) p (1075) 537 107.1 2.2e-22
>>NP_006494 (OMIM: 602707) 26S protease regulatory subun (418 aa)
initn: 2693 init1: 2693 opt: 2693 Z-score: 2610.4 bits: 492.0 E(85289): 1.2e-138
Smith-Waterman score: 2693; 100.0% identity (100.0% similar) in 418 aa overlap (1-418:1-418)
10 20 30 40 50 60
pF1KE3 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
310 320 330 340 350 360
370 380 390 400 410
pF1KE3 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_006 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
370 380 390 400 410
>>NP_694546 (OMIM: 602707) 26S protease regulatory subun (387 aa)
initn: 2208 init1: 2208 opt: 2227 Z-score: 2161.0 bits: 408.7 E(85289): 1.3e-113
Smith-Waterman score: 2425; 92.6% identity (92.6% similar) in 418 aa overlap (1-418:1-387)
10 20 30 40 50 60
pF1KE3 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
:::::::::::::::::::::::::::::::::::::::::::::
NP_694 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYK---------------
10 20 30 40
70 80 90 100 110 120
pF1KE3 IKDEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
::::::::::::::::::::::::::::::::::::::::::::
NP_694 ----------------EEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTID
50 60 70 80
130 140 150 160 170 180
pF1KE3 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 RELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREA
90 100 110 120 130 140
190 200 210 220 230 240
pF1KE3 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 VELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYL
150 160 170 180 190 200
250 260 270 280 290 300
pF1KE3 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 GEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFD
210 220 230 240 250 260
310 320 330 340 350 360
pF1KE3 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 QNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDL
270 280 290 300 310 320
370 380 390 400 410
pF1KE3 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_694 EDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
330 340 350 360 370 380
>>NP_002793 (OMIM: 602706) 26S protease regulatory subun (440 aa)
initn: 1255 init1: 1226 opt: 1311 Z-score: 1275.7 bits: 245.1 E(85289): 2.5e-64
Smith-Waterman score: 1311; 50.7% identity (83.2% similar) in 369 aa overlap (46-412:64-432)
20 30 40 50 60 70
pF1KE3 PALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQ--KNLKKEFL
::.. ..: ..::.:.... : :...
NP_002 GKKKKKTKGPDAASKLPLVTPHTQCRLKLLKLERIKDYLLMEEEFIRNQEQMKPLEEKQE
40 50 60 70 80 90
80 90 100 110 120 130
pF1KE3 HAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALH
. . .: ... :. .: . : .:.: :::....::..:: ::: .:..::.:. :: :.
NP_002 EERSKVDDLRGTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLN
100 110 120 130 140 150
140 150 160 170 180 190
pF1KE3 KHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQ
.. .:.. :: ..: . .. .. :. ::::::.: : ::..:.::::::: : :..
NP_002 HKVHAVIGVLMDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEE
160 170 180 190 200 210
200 210 220 230 240 250
pF1KE3 IGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRL
.:: ::.::..::::: :::.::::::..:.:.:.::::::..:::::.::..::..::.
NP_002 MGIKPPKGVILYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRV
220 230 240 250 260 270
260 270 280 290 300 310
pF1KE3 AKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNR
:.:.::.:.::::::::.:::.:...:..::.:: .::::::.::::. .:::::::::
NP_002 AEEHAPSIVFIDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNR
280 290 300 310 320 330
320 330 340 350 360 370
pF1KE3 ADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGA
.::::::.::::.::::::::::.. :. ::. ::.:.:...: :.: . : .:::
NP_002 IETLDPALIRPGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGA
340 350 360 370 380 390
380 390 400 410
pF1KE3 DINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
::..:: :.:..:.:: :. : .::.:. ..:. : ..
NP_002 DIKAICTEAGLMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
400 410 420 430 440
>>XP_016876959 (OMIM: 602706) PREDICTED: 26S protease re (367 aa)
initn: 1255 init1: 1226 opt: 1296 Z-score: 1262.4 bits: 242.4 E(85289): 1.4e-63
Smith-Waterman score: 1296; 51.3% identity (83.6% similar) in 359 aa overlap (56-412:1-359)
30 40 50 60 70 80
pF1KE3 GLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQ--KNLKKEFLHAQEEVKRIQ
..::.:.... : :... . . .: ..
XP_016 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR
10 20 30
90 100 110 120 130 140
pF1KE3 SIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVL
. :. .: . : .:.: :::....::..:: ::: .:..::.:. :: :... .:.. ::
XP_016 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE3 PPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVL
..: . .. .. :. ::::::.: : ::..:.::::::: : :...:: ::.::.
XP_016 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 MYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIF
.::::: :::.::::::..:.:.:.::::::..:::::.::..::..::.:.:.::.:.:
XP_016 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE3 IDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLR
:::::::.:::.:...:..::.:: .::::::.::::. .::::::::: .::::::.:
XP_016 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE3 PGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESG
:::.::::::::::.. :. ::. ::.:.:...: :.: . : .:::::..:: :.:
XP_016 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG
280 290 300 310 320 330
390 400 410
pF1KE3 MLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
..:.:: :. : .::.:. ..:. : ..
XP_016 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
340 350 360
>>NP_001317141 (OMIM: 602706) 26S protease regulatory su (367 aa)
initn: 1255 init1: 1226 opt: 1296 Z-score: 1262.4 bits: 242.4 E(85289): 1.4e-63
Smith-Waterman score: 1296; 51.3% identity (83.6% similar) in 359 aa overlap (56-412:1-359)
30 40 50 60 70 80
pF1KE3 GLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQ--KNLKKEFLHAQEEVKRIQ
..::.:.... : :... . . .: ..
NP_001 MEEEFIRNQEQMKPLEEKQEEERSKVDDLR
10 20 30
90 100 110 120 130 140
pF1KE3 SIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLKPNASVALHKHSNALVDVL
. :. .: . : .:.: :::....::..:: ::: .:..::.:. :: :... .:.. ::
NP_001 GTPMSVGTLEEIIDDNHAIVSTSVGSEHYVSILSFVDKDLLEPGCSVLLNHKVHAVIGVL
40 50 60 70 80 90
150 160 170 180 190 200
pF1KE3 PPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVL
..: . .. .. :. ::::::.: : ::..:.::::::: : :...:: ::.::.
NP_001 MDDTDPLVTVMKVEKAPQETYADIGGLDNQIQEIKESVELPLTHPEYYEEMGIKPPKGVI
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 MYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIF
.::::: :::.::::::..:.:.:.::::::..:::::.::..::..::.:.:.::.:.:
NP_001 LYGPPGTGKTLLAKAVANQTSATFLRVVGSELIQKYLGDGPKLVRELFRVAEEHAPSIVF
160 170 180 190 200 210
270 280 290 300 310 320
pF1KE3 IDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLR
:::::::.:::.:...:..::.:: .::::::.::::. .::::::::: .::::::.:
NP_001 IDEIDAIGTKRYDSNSGGEREIQRTMLELLNQLDGFDSRGDVKVIMATNRIETLDPALIR
220 230 240 250 260 270
330 340 350 360 370 380
pF1KE3 PGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVARPDKISGADINSICQESG
:::.::::::::::.. :. ::. ::.:.:...: :.: . : .:::::..:: :.:
NP_001 PGRIDRKIEFPLPDEKTKKRIFQIHTSRMTLADDVTLDDLIMAKDDLSGADIKAICTEAG
280 290 300 310 320 330
390 400 410
pF1KE3 MLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
..:.:: :. : .::.:. ..:. : ..
NP_001 LMALRERRMKVTNEDFKKSKENVLYKKQEGTPEGLYL
340 350 360
>>NP_001186092 (OMIM: 601681) 26S protease regulatory su (398 aa)
initn: 1003 init1: 1003 opt: 1052 Z-score: 1026.3 bits: 198.8 E(85289): 2e-50
Smith-Waterman score: 1054; 43.5% identity (71.8% similar) in 379 aa overlap (48-414:14-390)
20 30 40 50 60 70
pF1KE3 LSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKNLKKEFLHAQ-
: : .: . ..:...::.. :.::
NP_001 MELEEGKAGSGLRQYYLSKIEELQLIVNDKSQNLRR--LQAQR
10 20 30 40
80 90 100 110 120
pF1KE3 -----------EEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRELLK
::.. .: .:. ..:.:.. ..: ... : . ..:: . .
NP_001 NELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPEGKFVVDVDKNIDINDVT
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE3 PNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVELPL
:: :::.. : .: .:: ..: . .. .. :: : :::.: : .:..:..:::.
NP_001 PNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIGGLDKQIKEIKEVIELPV
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE3 THFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGEGPR
: ::.. .:: :.:::.::::: :::.::.:::::: .:::: :::.:::..::: :
NP_001 KHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFIRVSGSELVQKFIGEGAR
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE3 MVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQNVNV
:::..: .:.:.::.:::.::::.:...:... .:.: :::: .::::::.:::. . :.
NP_001 MVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRTMLELLNQLDGFEATKNI
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 KVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLEDYVA
:::::::: : :: :::::::.::::::: :... . :.. . ::::.. ..:. .
NP_001 KVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIHSRKMNLTRGINLRKIAE
290 300 310 320 330 340
370 380 390 400 410
pF1KE3 RPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEFYK
:::.....: :.:: :.:: : : .::: : :..:: ...
NP_001 LMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQKDSEKNMSIKKLWK
350 360 370 380 390
>>NP_002796 (OMIM: 601681) 26S protease regulatory subun (406 aa)
initn: 1045 init1: 1003 opt: 1052 Z-score: 1026.2 bits: 198.8 E(85289): 2e-50
Smith-Waterman score: 1073; 42.5% identity (70.8% similar) in 400 aa overlap (27-414:1-398)
10 20 30 40 50 60
pF1KE3 MEEIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEY
... ::: .::. . : : .: .
NP_002 MALDGPEQMELEEGKAGSGLRQYYLSKIEELQLI
10 20 30
70 80 90 100
pF1KE3 IKDEQKNLKKEFLHAQ------------EEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTG
..:...::.. :.:: ::.. .: .:. ..:.:.. ..:
NP_002 VNDKSQNLRR--LQAQRNELNAKVRLLREELQLLQEQGSYVGEVVRAMDKKKVLVKVHPE
40 50 60 70 80 90
110 120 130 140 150 160
pF1KE3 SNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIG
... : . ..:: . . :: :::.. : .: .:: ..: . .. .. :: : ::
NP_002 GKFVVDVDKNIDINDVTPNCRVALRNDSYTLHKILPNKVDPLVSLMMVEKVPDSTYEMIG
100 110 120 130 140 150
170 180 190 200 210 220
pF1KE3 GMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFI
:.: : .:..:..:::. : ::.. .:: :.:::.::::: :::.::.:::::: .::
NP_002 GLDKQIKEIKEVIELPVKHPELFEALGIAQPKGVLLYGPPGTGKTLLARAVAHHTDCTFI
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE3 RVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRI
:: :::.:::..::: ::::..: .:.:.::.:::.::::.:...:... .:.: ::::
NP_002 RVSGSELVQKFIGEGARMVRELFVMAREHAPSIIFMDEIDSIGSSRLEGGSGGDSEVQRT
220 230 240 250 260 270
290 300 310 320 330 340
pF1KE3 LLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTI
.::::::.:::. . :.:::::::: : :: :::::::.::::::: :... . :..
NP_002 MLELLNQLDGFEATKNIKVIMATNRIDILDSALLRPGRIDRKIEFPPPNEEARLDILKIH
280 290 300 310 320 330
350 360 370 380 390 400
pF1KE3 TSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIK
. ::::.. ..:. . :::.....: :.:: :.:: : : .::: : :..
NP_002 SRKMNLTRGINLRKIAELMPGASGAEVKGVCTEAGMYALRERRVHVTQEDFEMAVAKVMQ
340 350 360 370 380 390
410
pF1KE3 KDEQEHEFYK
:: ...
NP_002 KDSEKNMSIKKLWK
400
>>NP_002797 (OMIM: 602708) 26S protease regulatory subun (403 aa)
initn: 1025 init1: 975 opt: 1029 Z-score: 1004.0 bits: 194.7 E(85289): 3.5e-49
Smith-Waterman score: 1029; 41.6% identity (72.9% similar) in 387 aa overlap (33-418:17-401)
10 20 30 40 50 60
pF1KE3 EIGILVEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIK
.:.: . : . ::: .. : .. . . ..
NP_002 MAIPGIPYERRLLIMADPRD-KALQDYRKKLLEHKE-IDGRLKELR
10 20 30 40
70 80 90 100 110 120
pF1KE3 DEQKNLKKEFLHAQEEVKRIQSIPLVIGQFLEAVDQNTAIVGSTTGSNYYVRILSTIDRE
.. :.: :.. ......: .::. ..:. :. . .. :: .:.: : : .:.
NP_002 EQLKELTKQYEKSENDLKALQSVGQIVGEVLKQLTEEKFIVKATNGPRYVVGCRRQLDKS
50 60 70 80 90 100
130 140 150 160 170 180
pF1KE3 LLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADIGGMDIQKQEVREAVE
:::.. ::: . ... :: :.: .. .. .. .: :..:::.. : .:.::..:
NP_002 KLKPGTRVALDMTTLTIMRYLPREVDPLVYNMSHEDPGNVSYSEIGGLSEQIRELREVIE
110 120 130 140 150 160
190 200 210 220 230 240
pF1KE3 LPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAFIRVVGSEFVQKYLGE
::::. ::....:: ::.: :.::::: :::.::.::: . :..::.: .:.::.::
NP_002 LPLTNPELFQRVGIIPPKGCLLYGPPGTGKTLLARAVASQLDCNFLKVVSSSIVDKYIGE
170 180 190 200 210 220
250 260 270 280 290 300
pF1KE3 GPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQRILLELLNQMDGFDQN
. :..:..: :... : :::.::::::. .::. :.::::.:: :.::::::::::
NP_002 SARLIREMFNYARDHQPCIIFMDEIDAIGGRRFSEGTSADREIQRTLMELLNQMDGFDTL
230 240 250 260 270 280
310 320 330 340 350 360
pF1KE3 VNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFSTITSKMNLSEEVDLED
::.:::::: :::::::::::::::::.. ::... . :.. .. .. :.: :
NP_002 HRVKMIMATNRPDTLDPALLRPGRLDRKIHIDLPNEQARLDILKIHAGPITKHGEIDYEA
290 300 310 320 330 340
370 380 390 400 410
pF1KE3 YVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVIKKDEQEHEF-YK
: : ..:::. ..: :.::.:.: .. .:. .:: :: . : . . : .. ::
NP_002 IVKLSDGFNGADLRNVCTEAGMFAIRADHDFVVQEDFMKAVRKVADSKKLESKLDYKPV
350 360 370 380 390 400
>>NP_002795 (OMIM: 186852) 26S protease regulatory subun (439 aa)
initn: 959 init1: 959 opt: 1018 Z-score: 992.8 bits: 192.8 E(85289): 1.5e-48
Smith-Waterman score: 1049; 40.2% identity (72.5% similar) in 400 aa overlap (38-417:39-438)
10 20 30 40 50 60
pF1KE3 VEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKN
:.. .: . :..:..... . . : .
NP_002 SPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQA
10 20 30 40 50 60
70 80 90 100
pF1KE3 LKKEFLHAQEEVKRIQSIPLVIGQFLEA--VDQNT------------------AIVGSTT
.: .. . .:..: ...: .... .: :: : :.. ..:
NP_002 MKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTST
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 GSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADI
..:.. ... .: : :::. :...: : ....:: : :: . . :..: .:.::
NP_002 RQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE3 GGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAF
::.: : ::. ::. ::..: : ....::.::.::::::::: :::.::.: : .: :.:
NP_002 GGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATF
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE3 IRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQR
....: ..:: ..:.: ..:::.: ::::.::.::::::.:::.:::::.. ..::::::
NP_002 LKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQR
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE3 ILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFST
.::::::.:::. :..:::: ::::.: ::::::: ::::::::::.:... . :..
NP_002 TMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQI
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE3 ITSKMNLSEEVDLEDYVARPDKISGADINSICQESGMLAVRENRYIVLAKDFEKAYKTVI
. :::.: .:. :. . : ..::. ...: :.::.:.:.. . .:. .. :
NP_002 HSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAGMIALRRGATELTHEDYMEGILEVQ
370 380 390 400 410 420
410
pF1KE3 KKDEQEHEFYK
: . . ..:
NP_002 AKKKANLQYYA
430
>>XP_016873515 (OMIM: 186852) PREDICTED: 26S protease re (461 aa)
initn: 929 init1: 929 opt: 977 Z-score: 953.0 bits: 185.5 E(85289): 2.4e-46
Smith-Waterman score: 1008; 42.2% identity (73.5% similar) in 370 aa overlap (38-385:39-408)
10 20 30 40 50 60
pF1KE3 VEKAQDEIPALSVSRPQTGLSFLGPEPEDLEDLYSRYKKLQQELEFLEVQEEYIKDEQKN
:.. .: . :..:..... . . : .
XP_016 SPVTRQEKMATVWDEAEQDGIGEEVLKMSTEEIIQRTRLLDSEIKIMKSEVLRVTHELQA
10 20 30 40 50 60
70 80 90 100
pF1KE3 LKKEFLHAQEEVKRIQSIPLVIGQFLEA--VDQNT------------------AIVGSTT
.: .. . .:..: ...: .... .: :: : :.. ..:
XP_016 MKDKIKENSEKIKVNKTLPYLVSNVIELLDVDPNDQEEDGANIDLDSQRKGKCAVIKTST
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE3 GSNYYVRILSTIDRELLKPNASVALHKHSNALVDVLPPEADSSIMMLTSDQKPDVMYADI
..:.. ... .: : :::. :...: : ....:: : :: . . :..: .:.::
XP_016 RQTYFLPVIGLVDAEKLKPGDLVGVNKDSYLILETLPTEYDSRVKAMEVDERPTEQYSDI
130 140 150 160 170 180
170 180 190 200 210 220
pF1KE3 GGMDIQKQEVREAVELPLTHFELYKQIGIDPPRGVLMYGPPGCGKTMLAKAVAHHTTAAF
::.: : ::. ::. ::..: : ....::.::.::::::::: :::.::.: : .: :.:
XP_016 GGLDKQIQELVEAIVLPMNHKEKFENLGIQPPKGVLMYGPPGTGKTLLARACAAQTKATF
190 200 210 220 230 240
230 240 250 260 270 280
pF1KE3 IRVVGSEFVQKYLGEGPRMVRDVFRLAKENAPAIIFIDEIDAIATKRFDAQTGADREVQR
....: ..:: ..:.: ..:::.: ::::.::.::::::.:::.:::::.. ..::::::
XP_016 LKLAGPQLVQMFIGDGAKLVRDAFALAKEKAPSIIFIDELDAIGTKRFDSEKAGDREVQR
250 260 270 280 290 300
290 300 310 320 330 340
pF1KE3 ILLELLNQMDGFDQNVNVKVIMATNRADTLDPALLRPGRLDRKIEFPLPDRRQKRLIFST
.::::::.:::. :..:::: ::::.: ::::::: ::::::::::.:... . :..
XP_016 TMLELLNQLDGFQPNTQVKVIAATNRVDILDPALLRSGRLDRKIEFPMPNEEARARIMQI
310 320 330 340 350 360
350 360 370 380 390 400
pF1KE3 ITSKMNLSEEVDLEDYVARPDKISGADINSICQE--SGMLAVRENRYIVLAKDFEKAYKT
. :::.: .:. :. . : ..::. ...: : ::.:
XP_016 HSRKMNVSPDVNYEELARCTDDFNGAQCKAVCVEAVSGQLGWVRCFVPSCPLPGQDGGIW
370 380 390 400 410 420
410
pF1KE3 VIKKDEQEHEFYK
XP_016 LVETAEGRGLSLREPGKAFRRSDLDSVCPGCRA
430 440 450 460
418 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:06:49 2016 done: Mon Nov 7 03:06:51 2016
Total Scan time: 9.090 Total Display time: 0.060
Function used was FASTA [36.3.4 Apr, 2011]