Result of FASTA (omim) for
pFN21AE3555
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3555, 5207 aa
1>>>pF1KE3555 5207 - 5207 aa - 5207 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.2406+/-0.000668; mu= 10.2016+/- 0.041
mean_var=225.7712+/-48.415, 0's: 0 Z-trim(110.3): 77 B-trim: 380 in 1/52
Lambda= 0.085357
statistics sampled from 18532 (18580) to 18532 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.544), E-opt: 0.2 (0.218), width: 16
Scan time: 34.070
The best scores are: opt bits E(85289)
NP_001243000 (OMIM: 607151,613768) E3 ubiquitin-pr (5207) 34762 4297.5 0
XP_006722058 (OMIM: 607151,613768) PREDICTED: E3 u (5256) 34142 4221.1 0
XP_005257603 (OMIM: 607151,613768) PREDICTED: E3 u (5256) 34142 4221.1 0
XP_005257602 (OMIM: 607151,613768) PREDICTED: E3 u (5256) 34142 4221.1 0
XP_016880394 (OMIM: 607151,613768) PREDICTED: E3 u (4921) 32647 4037.0 0
XP_011523386 (OMIM: 607151,613768) PREDICTED: E3 u (4825) 31340 3876.1 0
XP_011523388 (OMIM: 607151,613768) PREDICTED: E3 u (4192) 27061 3349.1 0
XP_011523389 (OMIM: 607151,613768) PREDICTED: E3 u (3824) 24290 3007.8 0
NP_066005 (OMIM: 607151,613768) E3 ubiquitin-prote (1063) 6841 858.7 0
>>NP_001243000 (OMIM: 607151,613768) E3 ubiquitin-protei (5207 aa)
initn: 34762 init1: 34762 opt: 34762 Z-score: 23137.5 bits: 4297.5 E(85289): 0
Smith-Waterman score: 34762; 99.9% identity (99.9% similar) in 5207 aa overlap (1-5207:1-5207)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LLLPESKGGSSEPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPP
::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
NP_001 LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 ATTPPFKTHCQEAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_001 ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYS
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 DLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 LIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::::
NP_001 LIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEAL
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 DWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::.:::::
NP_001 DWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLS
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 TSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEP
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 EEESERHILELQEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSE
:::::::::::.::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSE
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 LKIMCTVDHQGQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLN
:::::::::: :::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLN
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 FTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FTDNFDDFRRETLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINE
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 LKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKVFVDLASISAGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALD
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 KDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPD
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 TVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVLHLILPESPGSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLS
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE3 QAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQM
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE3 EHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRD
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE3 VLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLE
1750 1760 1770 1780 1790 1800
1810 1820 1830 1840 1850 1860
pF1KE3 TLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYD
1810 1820 1830 1840 1850 1860
1870 1880 1890 1900 1910 1920
pF1KE3 EVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQH
1870 1880 1890 1900 1910 1920
1930 1940 1950 1960 1970 1980
pF1KE3 REDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 REDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVF
1930 1940 1950 1960 1970 1980
1990 2000 2010 2020 2030 2040
pF1KE3 NDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALL
1990 2000 2010 2020 2030 2040
2050 2060 2070 2080 2090 2100
pF1KE3 PFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEIL
2050 2060 2070 2080 2090 2100
2110 2120 2130 2140 2150 2160
pF1KE3 ERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFC
2110 2120 2130 2140 2150 2160
2170 2180 2190 2200 2210 2220
pF1KE3 SETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFAR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFAR
2170 2180 2190 2200 2210 2220
2230 2240 2250 2260 2270 2280
pF1KE3 FLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVT
2230 2240 2250 2260 2270 2280
2290 2300 2310 2320 2330 2340
pF1KE3 MDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKV
:::::::::::::::::::::::::::::::::::::::::::::::::::::.::::::
NP_001 MDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKV
2290 2300 2310 2320 2330 2340
2350 2360 2370 2380 2390 2400
pF1KE3 IKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNM
2350 2360 2370 2380 2390 2400
2410 2420 2430 2440 2450 2460
pF1KE3 LKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMI
2410 2420 2430 2440 2450 2460
2470 2480 2490 2500 2510 2520
pF1KE3 YSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSRVREAENVAFANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHI
2470 2480 2490 2500 2510 2520
2530 2540 2550 2560 2570 2580
pF1KE3 IAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAACNPYRKHSEEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVW
2530 2540 2550 2560 2570 2580
2590 2600 2610 2620 2630 2640
pF1KE3 DFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRD
2590 2600 2610 2620 2630 2640
2650 2660 2670 2680 2690 2700
pF1KE3 VERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKK
2650 2660 2670 2680 2690 2700
2710 2720 2730 2740 2750 2760
pF1KE3 DSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIE
2710 2720 2730 2740 2750 2760
2770 2780 2790 2800 2810 2820
pF1KE3 LKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIIS
2770 2780 2790 2800 2810 2820
2830 2840 2850 2860 2870 2880
pF1KE3 TFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVG
2830 2840 2850 2860 2870 2880
2890 2900 2910 2920 2930 2940
pF1KE3 FVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVGISNWALDPAKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYE
2890 2900 2910 2920 2930 2940
2950 2960 2970 2980 2990 3000
pF1KE3 TVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFL
2950 2960 2970 2980 2990 3000
3010 3020 3030 3040 3050 3060
pF1KE3 ANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFF
3010 3020 3030 3040 3050 3060
3070 3080 3090 3100 3110 3120
pF1KE3 EGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYY
3070 3080 3090 3100 3110 3120
3130 3140 3150 3160 3170 3180
pF1KE3 VHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVL
3130 3140 3150 3160 3170 3180
3190 3200 3210 3220 3230 3240
pF1KE3 EKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPR
3190 3200 3210 3220 3230 3240
3250 3260 3270 3280 3290 3300
pF1KE3 ALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFL
3250 3260 3270 3280 3290 3300
3310 3320 3330 3340 3350 3360
pF1KE3 QAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QAHLHTADLERHAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLK
3310 3320 3330 3340 3350 3360
3370 3380 3390 3400 3410 3420
pF1KE3 EVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKL
3370 3380 3390 3400 3410 3420
3430 3440 3450 3460 3470 3480
pF1KE3 SRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHR
3430 3440 3450 3460 3470 3480
3490 3500 3510 3520 3530 3540
pF1KE3 AEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCV
3490 3500 3510 3520 3530 3540
3550 3560 3570 3580 3590 3600
pF1KE3 QSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHP
3550 3560 3570 3580 3590 3600
3610 3620 3630 3640 3650 3660
pF1KE3 LEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPW
3610 3620 3630 3640 3650 3660
3670 3680 3690 3700 3710 3720
pF1KE3 ARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLE
3670 3680 3690 3700 3710 3720
3730 3740 3750 3760 3770 3780
pF1KE3 ELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVST
3730 3740 3750 3760 3770 3780
3790 3800 3810 3820 3830 3840
pF1KE3 EEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLH
3790 3800 3810 3820 3830 3840
3850 3860 3870 3880 3890 3900
pF1KE3 SLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDE
3850 3860 3870 3880 3890 3900
3910 3920 3930 3940 3950 3960
pF1KE3 HMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLR
3910 3920 3930 3940 3950 3960
3970 3980 3990 4000 4010 4020
pF1KE3 ENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRC
3970 3980 3990 4000 4010 4020
4030 4040 4050 4060 4070 4080
pF1KE3 LRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKD
4030 4040 4050 4060 4070 4080
4090 4100 4110 4120 4130 4140
pF1KE3 NAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLK
4090 4100 4110 4120 4130 4140
4150 4160 4170 4180 4190 4200
pF1KE3 YSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEE
4150 4160 4170 4180 4190 4200
4210 4220 4230 4240 4250 4260
pF1KE3 EGRFLKAYSPASRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EGRFLKAYSPASRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYL
4210 4220 4230 4240 4250 4260
4270 4280 4290 4300 4310 4320
pF1KE3 QQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDH
4270 4280 4290 4300 4310 4320
4330 4340 4350 4360 4370 4380
pF1KE3 PGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVA
4330 4340 4350 4360 4370 4380
4390 4400 4410 4420 4430 4440
pF1KE3 ILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLD
4390 4400 4410 4420 4430 4440
4450 4460 4470 4480 4490 4500
pF1KE3 GTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERV
4450 4460 4470 4480 4490 4500
4510 4520 4530 4540 4550 4560
pF1KE3 HWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 HWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLG
4510 4520 4530 4540 4550 4560
4570 4580 4590 4600 4610 4620
pF1KE3 NPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHI
4570 4580 4590 4600 4610 4620
4630 4640 4650 4660 4670 4680
pF1KE3 LKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKE
4630 4640 4650 4660 4670 4680
4690 4700 4710 4720 4730 4740
pF1KE3 IAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKI
4690 4700 4710 4720 4730 4740
4750 4760 4770 4780 4790 4800
pF1KE3 WSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 WSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQN
4750 4760 4770 4780 4790 4800
4810 4820 4830 4840 4850 4860
pF1KE3 VQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDL
4810 4820 4830 4840 4850 4860
4870 4880 4890 4900 4910 4920
pF1KE3 DLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHV
4870 4880 4890 4900 4910 4920
4930 4940 4950 4960 4970 4980
pF1KE3 ISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLV
4930 4940 4950 4960 4970 4980
4990 5000 5010 5020 5030 5040
pF1KE3 YRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGG
4990 5000 5010 5020 5030 5040
5050 5060 5070 5080 5090 5100
pF1KE3 DPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGE
5050 5060 5070 5080 5090 5100
5110 5120 5130 5140 5150 5160
pF1KE3 ISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRD
5110 5120 5130 5140 5150 5160
5170 5180 5190 5200
pF1KE3 TLVSYMQTKESEILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TLVSYMQTKESEILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
5170 5180 5190 5200
>>XP_006722058 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (5256 aa)
initn: 34130 init1: 34130 opt: 34142 Z-score: 22724.8 bits: 4221.1 E(85289): 0
Smith-Waterman score: 34526; 98.9% identity (99.0% similar) in 5239 aa overlap (18-5207:18-5256)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
:::::::::::::::::::::::::::::::::::::::::::
XP_006 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE---------------------------------
:::::::::::::::::::::::::::
XP_006 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD
70 80 90 100 110 120
90 100 110 120 130
pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
::::::::::::::::::::::::::::::::::::::::::::
XP_006 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_006 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_006 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_006 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740 1750
pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
1750 1760 1770 1780 1790 1800
1760 1770 1780 1790 1800 1810
pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
1810 1820 1830 1840 1850 1860
1820 1830 1840 1850 1860 1870
pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
1870 1880 1890 1900 1910 1920
1880 1890 1900 1910 1920 1930
pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160 2170
pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
2170 2180 2190 2200 2210 2220
2180 2190 2200 2210 2220 2230
pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
2230 2240 2250 2260 2270 2280
2240 2250 2260 2270 2280 2290
pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
2290 2300 2310 2320 2330 2340
2300 2310 2320 2330 2340 2350
pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_006 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY
2350 2360 2370 2380 2390 2400
2360 2370 2380 2390 2400 2410
pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
2410 2420 2430 2440 2450 2460
2420 2430 2440 2450 2460 2470
pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
2470 2480 2490 2500 2510 2520
2480 2490 2500 2510 2520 2530
pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
2530 2540 2550 2560 2570 2580
2540 2550 2560 2570 2580 2590
pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
2590 2600 2610 2620 2630 2640
2600 2610 2620 2630 2640 2650
pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
2650 2660 2670 2680 2690 2700
2660 2670 2680 2690 2700 2710
pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
2710 2720 2730 2740 2750 2760
2720 2730 2740 2750 2760 2770
pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
2770 2780 2790 2800 2810 2820
2780 2790 2800 2810 2820 2830
pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
2830 2840 2850 2860 2870 2880
2840 2850 2860 2870 2880 2890
pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
2890 2900 2910 2920 2930 2940
2900 2910 2920 2930 2940 2950
pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
2950 2960 2970 2980 2990 3000
2960 2970 2980 2990 3000 3010
pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
3010 3020 3030 3040 3050 3060
3020 3030 3040 3050 3060 3070
pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
3070 3080 3090 3100 3110 3120
3080 3090 3100 3110 3120 3130
pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
3130 3140 3150 3160 3170 3180
3140 3150 3160 3170 3180 3190
pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
3190 3200 3210 3220 3230 3240
3200 3210 3220 3230 3240 3250
pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
3250 3260 3270 3280 3290 3300
3260 3270 3280 3290 3300 3310
pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
3310 3320 3330 3340 3350 3360
3320 3330 3340 3350 3360 3370
pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
3370 3380 3390 3400 3410 3420
3380 3390 3400 3410 3420 3430
pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
3430 3440 3450 3460 3470 3480
3440 3450 3460 3470 3480 3490
pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
3490 3500 3510 3520 3530 3540
3500 3510 3520 3530 3540 3550
pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
3550 3560 3570 3580 3590 3600
3560 3570 3580 3590 3600 3610
pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
3610 3620 3630 3640 3650 3660
3620 3630 3640 3650 3660 3670
pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
3670 3680 3690 3700 3710 3720
3680 3690 3700 3710 3720 3730
pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
3730 3740 3750 3760 3770 3780
3740 3750 3760 3770 3780 3790
pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
3790 3800 3810 3820 3830 3840
3800 3810 3820 3830 3840 3850
pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
3850 3860 3870 3880 3890 3900
3860 3870 3880 3890 3900 3910
pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
3910 3920 3930 3940 3950 3960
3920 3930 3940 3950 3960 3970
pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
3970 3980 3990 4000 4010 4020
3980 3990 4000 4010 4020 4030
pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
4030 4040 4050 4060 4070 4080
4040 4050 4060 4070 4080 4090
pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
4090 4100 4110 4120 4130 4140
4100 4110 4120 4130 4140 4150
pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
4150 4160 4170 4180 4190 4200
4160 4170 4180 4190 4200 4210
pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
4210 4220 4230 4240 4250 4260
4220 4230 4240 4250 4260 4270
pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
4270 4280 4290 4300 4310 4320
4280 4290 4300 4310 4320 4330
pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
4330 4340 4350 4360 4370 4380
4340 4350 4360 4370 4380 4390
pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
4390 4400 4410 4420 4430 4440
4400 4410 4420 4430 4440 4450
pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
4450 4460 4470 4480 4490 4500
4460 4470 4480 4490 4500 4510
pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
4510 4520 4530 4540 4550 4560
4520 4530 4540 4550 4560 4570
pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
4570 4580 4590 4600 4610 4620
4580 4590 4600 4610 4620 4630
pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
4630 4640 4650 4660 4670 4680
4640 4650 4660 4670 4680 4690
pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
4690 4700 4710 4720 4730 4740
4700 4710 4720 4730 4740 4750
pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
4750 4760 4770 4780 4790 4800
4760 4770 4780 4790 4800 4810
pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG
4810 4820 4830 4840 4850 4860
4820 4830 4840 4850 4860 4870
pF1KE3 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP
4870 4880 4890 4900 4910 4920
4880 4890 4900 4910 4920 4930
pF1KE3 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP
4930 4940 4950 4960 4970 4980
4940 4950 4960 4970 4980 4990
pF1KE3 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF
4990 5000 5010 5020 5030 5040
5000 5010 5020 5030 5040 5050
pF1KE3 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ
5050 5060 5070 5080 5090 5100
5060 5070 5080 5090 5100 5110
pF1KE3 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP
5110 5120 5130 5140 5150 5160
5120 5130 5140 5150 5160 5170
pF1KE3 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES
5170 5180 5190 5200 5210 5220
5180 5190 5200
pF1KE3 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
::::::::::::::::::::::::::::::::::::
XP_006 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
5230 5240 5250
>>XP_005257603 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (5256 aa)
initn: 34130 init1: 34130 opt: 34142 Z-score: 22724.8 bits: 4221.1 E(85289): 0
Smith-Waterman score: 34526; 98.9% identity (99.0% similar) in 5239 aa overlap (18-5207:18-5256)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
:::::::::::::::::::::::::::::::::::::::::::
XP_005 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE---------------------------------
:::::::::::::::::::::::::::
XP_005 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD
70 80 90 100 110 120
90 100 110 120 130
pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_005 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_005 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_005 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740 1750
pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
1750 1760 1770 1780 1790 1800
1760 1770 1780 1790 1800 1810
pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
1810 1820 1830 1840 1850 1860
1820 1830 1840 1850 1860 1870
pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
1870 1880 1890 1900 1910 1920
1880 1890 1900 1910 1920 1930
pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160 2170
pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
2170 2180 2190 2200 2210 2220
2180 2190 2200 2210 2220 2230
pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
2230 2240 2250 2260 2270 2280
2240 2250 2260 2270 2280 2290
pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
2290 2300 2310 2320 2330 2340
2300 2310 2320 2330 2340 2350
pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_005 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY
2350 2360 2370 2380 2390 2400
2360 2370 2380 2390 2400 2410
pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
2410 2420 2430 2440 2450 2460
2420 2430 2440 2450 2460 2470
pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
2470 2480 2490 2500 2510 2520
2480 2490 2500 2510 2520 2530
pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
2530 2540 2550 2560 2570 2580
2540 2550 2560 2570 2580 2590
pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
2590 2600 2610 2620 2630 2640
2600 2610 2620 2630 2640 2650
pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
2650 2660 2670 2680 2690 2700
2660 2670 2680 2690 2700 2710
pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
2710 2720 2730 2740 2750 2760
2720 2730 2740 2750 2760 2770
pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
2770 2780 2790 2800 2810 2820
2780 2790 2800 2810 2820 2830
pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
2830 2840 2850 2860 2870 2880
2840 2850 2860 2870 2880 2890
pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
2890 2900 2910 2920 2930 2940
2900 2910 2920 2930 2940 2950
pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
2950 2960 2970 2980 2990 3000
2960 2970 2980 2990 3000 3010
pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
3010 3020 3030 3040 3050 3060
3020 3030 3040 3050 3060 3070
pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
3070 3080 3090 3100 3110 3120
3080 3090 3100 3110 3120 3130
pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
3130 3140 3150 3160 3170 3180
3140 3150 3160 3170 3180 3190
pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
3190 3200 3210 3220 3230 3240
3200 3210 3220 3230 3240 3250
pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
3250 3260 3270 3280 3290 3300
3260 3270 3280 3290 3300 3310
pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
3310 3320 3330 3340 3350 3360
3320 3330 3340 3350 3360 3370
pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
3370 3380 3390 3400 3410 3420
3380 3390 3400 3410 3420 3430
pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
3430 3440 3450 3460 3470 3480
3440 3450 3460 3470 3480 3490
pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
3490 3500 3510 3520 3530 3540
3500 3510 3520 3530 3540 3550
pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
3550 3560 3570 3580 3590 3600
3560 3570 3580 3590 3600 3610
pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
3610 3620 3630 3640 3650 3660
3620 3630 3640 3650 3660 3670
pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
3670 3680 3690 3700 3710 3720
3680 3690 3700 3710 3720 3730
pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
3730 3740 3750 3760 3770 3780
3740 3750 3760 3770 3780 3790
pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
3790 3800 3810 3820 3830 3840
3800 3810 3820 3830 3840 3850
pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
3850 3860 3870 3880 3890 3900
3860 3870 3880 3890 3900 3910
pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
3910 3920 3930 3940 3950 3960
3920 3930 3940 3950 3960 3970
pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
3970 3980 3990 4000 4010 4020
3980 3990 4000 4010 4020 4030
pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
4030 4040 4050 4060 4070 4080
4040 4050 4060 4070 4080 4090
pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
4090 4100 4110 4120 4130 4140
4100 4110 4120 4130 4140 4150
pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
4150 4160 4170 4180 4190 4200
4160 4170 4180 4190 4200 4210
pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
4210 4220 4230 4240 4250 4260
4220 4230 4240 4250 4260 4270
pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
4270 4280 4290 4300 4310 4320
4280 4290 4300 4310 4320 4330
pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
4330 4340 4350 4360 4370 4380
4340 4350 4360 4370 4380 4390
pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
4390 4400 4410 4420 4430 4440
4400 4410 4420 4430 4440 4450
pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
4450 4460 4470 4480 4490 4500
4460 4470 4480 4490 4500 4510
pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
4510 4520 4530 4540 4550 4560
4520 4530 4540 4550 4560 4570
pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
4570 4580 4590 4600 4610 4620
4580 4590 4600 4610 4620 4630
pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
4630 4640 4650 4660 4670 4680
4640 4650 4660 4670 4680 4690
pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
4690 4700 4710 4720 4730 4740
4700 4710 4720 4730 4740 4750
pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
4750 4760 4770 4780 4790 4800
4760 4770 4780 4790 4800 4810
pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG
4810 4820 4830 4840 4850 4860
4820 4830 4840 4850 4860 4870
pF1KE3 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP
4870 4880 4890 4900 4910 4920
4880 4890 4900 4910 4920 4930
pF1KE3 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP
4930 4940 4950 4960 4970 4980
4940 4950 4960 4970 4980 4990
pF1KE3 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF
4990 5000 5010 5020 5030 5040
5000 5010 5020 5030 5040 5050
pF1KE3 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ
5050 5060 5070 5080 5090 5100
5060 5070 5080 5090 5100 5110
pF1KE3 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP
5110 5120 5130 5140 5150 5160
5120 5130 5140 5150 5160 5170
pF1KE3 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES
5170 5180 5190 5200 5210 5220
5180 5190 5200
pF1KE3 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
::::::::::::::::::::::::::::::::::::
XP_005 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
5230 5240 5250
>>XP_005257602 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (5256 aa)
initn: 34130 init1: 34130 opt: 34142 Z-score: 22724.8 bits: 4221.1 E(85289): 0
Smith-Waterman score: 34526; 98.9% identity (99.0% similar) in 5239 aa overlap (18-5207:18-5256)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
:::::::::::::::::::::::::::::::::::::::::::
XP_005 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE---------------------------------
:::::::::::::::::::::::::::
XP_005 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD
70 80 90 100 110 120
90 100 110 120 130
pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
::::::::::::::::::::::::::::::::::::::::::::
XP_005 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_005 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_005 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_005 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740 1750
pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
1750 1760 1770 1780 1790 1800
1760 1770 1780 1790 1800 1810
pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
1810 1820 1830 1840 1850 1860
1820 1830 1840 1850 1860 1870
pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
1870 1880 1890 1900 1910 1920
1880 1890 1900 1910 1920 1930
pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160 2170
pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
2170 2180 2190 2200 2210 2220
2180 2190 2200 2210 2220 2230
pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
2230 2240 2250 2260 2270 2280
2240 2250 2260 2270 2280 2290
pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
2290 2300 2310 2320 2330 2340
2300 2310 2320 2330 2340 2350
pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_005 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY
2350 2360 2370 2380 2390 2400
2360 2370 2380 2390 2400 2410
pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
2410 2420 2430 2440 2450 2460
2420 2430 2440 2450 2460 2470
pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
2470 2480 2490 2500 2510 2520
2480 2490 2500 2510 2520 2530
pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
2530 2540 2550 2560 2570 2580
2540 2550 2560 2570 2580 2590
pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
2590 2600 2610 2620 2630 2640
2600 2610 2620 2630 2640 2650
pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
2650 2660 2670 2680 2690 2700
2660 2670 2680 2690 2700 2710
pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
2710 2720 2730 2740 2750 2760
2720 2730 2740 2750 2760 2770
pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
2770 2780 2790 2800 2810 2820
2780 2790 2800 2810 2820 2830
pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
2830 2840 2850 2860 2870 2880
2840 2850 2860 2870 2880 2890
pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
2890 2900 2910 2920 2930 2940
2900 2910 2920 2930 2940 2950
pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
2950 2960 2970 2980 2990 3000
2960 2970 2980 2990 3000 3010
pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
3010 3020 3030 3040 3050 3060
3020 3030 3040 3050 3060 3070
pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
3070 3080 3090 3100 3110 3120
3080 3090 3100 3110 3120 3130
pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
3130 3140 3150 3160 3170 3180
3140 3150 3160 3170 3180 3190
pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
3190 3200 3210 3220 3230 3240
3200 3210 3220 3230 3240 3250
pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
3250 3260 3270 3280 3290 3300
3260 3270 3280 3290 3300 3310
pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
3310 3320 3330 3340 3350 3360
3320 3330 3340 3350 3360 3370
pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
3370 3380 3390 3400 3410 3420
3380 3390 3400 3410 3420 3430
pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
3430 3440 3450 3460 3470 3480
3440 3450 3460 3470 3480 3490
pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
3490 3500 3510 3520 3530 3540
3500 3510 3520 3530 3540 3550
pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
3550 3560 3570 3580 3590 3600
3560 3570 3580 3590 3600 3610
pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
3610 3620 3630 3640 3650 3660
3620 3630 3640 3650 3660 3670
pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
3670 3680 3690 3700 3710 3720
3680 3690 3700 3710 3720 3730
pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
3730 3740 3750 3760 3770 3780
3740 3750 3760 3770 3780 3790
pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
3790 3800 3810 3820 3830 3840
3800 3810 3820 3830 3840 3850
pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
3850 3860 3870 3880 3890 3900
3860 3870 3880 3890 3900 3910
pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
3910 3920 3930 3940 3950 3960
3920 3930 3940 3950 3960 3970
pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
3970 3980 3990 4000 4010 4020
3980 3990 4000 4010 4020 4030
pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
4030 4040 4050 4060 4070 4080
4040 4050 4060 4070 4080 4090
pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
4090 4100 4110 4120 4130 4140
4100 4110 4120 4130 4140 4150
pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
4150 4160 4170 4180 4190 4200
4160 4170 4180 4190 4200 4210
pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
4210 4220 4230 4240 4250 4260
4220 4230 4240 4250 4260 4270
pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
4270 4280 4290 4300 4310 4320
4280 4290 4300 4310 4320 4330
pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
4330 4340 4350 4360 4370 4380
4340 4350 4360 4370 4380 4390
pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
4390 4400 4410 4420 4430 4440
4400 4410 4420 4430 4440 4450
pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
4450 4460 4470 4480 4490 4500
4460 4470 4480 4490 4500 4510
pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
4510 4520 4530 4540 4550 4560
4520 4530 4540 4550 4560 4570
pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
4570 4580 4590 4600 4610 4620
4580 4590 4600 4610 4620 4630
pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
4630 4640 4650 4660 4670 4680
4640 4650 4660 4670 4680 4690
pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
4690 4700 4710 4720 4730 4740
4700 4710 4720 4730 4740 4750
pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
4750 4760 4770 4780 4790 4800
4760 4770 4780 4790 4800 4810
pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG
4810 4820 4830 4840 4850 4860
4820 4830 4840 4850 4860 4870
pF1KE3 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 FLSKHSSDGLRQLLHNRITVFLSTWNKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLP
4870 4880 4890 4900 4910 4920
4880 4890 4900 4910 4920 4930
pF1KE3 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RRRGLGLCATALVSYLIRLHNEIVYAVEKLSKENNSYSVDAAEVTELHVISYEVERDLTP
4930 4940 4950 4960 4970 4980
4940 4950 4960 4970 4980 4990
pF1KE3 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LILSNCQYQVEEGRETVQEFDLEKIQRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLF
4990 5000 5010 5020 5030 5040
5000 5010 5020 5030 5040 5050
pF1KE3 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MDIKNKMAQDSLPSSVISAISGQLQSYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQ
5050 5060 5070 5080 5090 5100
5060 5070 5080 5090 5100 5110
pF1KE3 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DILQMGDQTIHVLKALNRCQLKHTIALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSP
5110 5120 5130 5140 5150 5160
5120 5130 5140 5150 5160 5170
pF1KE3 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENAKLLSTFLNQTGLDAFLLELHEMIILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKES
5170 5180 5190 5200 5210 5220
5180 5190 5200
pF1KE3 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
::::::::::::::::::::::::::::::::::::
XP_005 EILPEMASQFPEEILLASCVSVWKTAAVLKWNREMR
5230 5240 5250
>>XP_016880394 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (4921 aa)
initn: 32646 init1: 32646 opt: 32647 Z-score: 21730.3 bits: 4037.0 E(85289): 0
Smith-Waterman score: 32647; 99.8% identity (99.9% similar) in 4901 aa overlap (307-5207:21-4921)
280 290 300 310 320 330
pF1KE3 EPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQEAETKTKDETAAAEEKVGKNEQGEP
: ::::::::: :::::::::::::::
XP_016 MIQTKLWPSGCSHSSGERVRKPTSAEAETKTKDEMAAAEEKVGKNEQGEP
10 20 30 40 50
340 350 360 370 380 390
pF1KE3 EDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPD
60 70 80 90 100 110
400 410 420 430 440 450
pF1KE3 LHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYN
120 130 140 150 160 170
460 470 480 490 500 510
pF1KE3 GESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITD
180 190 200 210 220 230
520 530 540 550 560 570
pF1KE3 GPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLW
240 250 260 270 280 290
580 590 600 610 620 630
pF1KE3 TDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELL
300 310 320 330 340 350
640 650 660 670 680 690
pF1KE3 LEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALP
360 370 380 390 400 410
700 710 720 730 740 750
pF1KE3 VLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEP
420 430 440 450 460 470
760 770 780 790 800 810
pF1KE3 LFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQN
480 490 500 510 520 530
820 830 840 850 860 870
pF1KE3 VQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVC
540 550 560 570 580 590
880 890 900 910 920 930
pF1KE3 RMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEI
600 610 620 630 640 650
940 950 960 970 980 990
pF1KE3 EVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFE
660 670 680 690 700 710
1000 1010 1020 1030 1040 1050
pF1KE3 KCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLAD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLAD
720 730 740 750 760 770
1060 1070 1080 1090 1100 1110
pF1KE3 VKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTKVVGDLLSGTILVGQLELIIKHKNQF
780 790 800 810 820 830
1120 1130 1140 1150 1160 1170
pF1KE3 LDIWQLREKSLSPQDEKCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFG
::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::::
XP_016 LDIWQLREKSLSPQDEQCAVEEALDWRREELLLLKKEKRCVDSLLKMCGNVKHLIQVDFG
840 850 860 870 880 890
1180 1190 1200 1210 1220 1230
pF1KE3 VLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLF
::::::::::::::::::.:::::::::::::::::::::::::::::::::::::::::
XP_016 VLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHYHLSSQVQEMAGKIDLLRDSHIFQLF
900 910 920 930 940 950
1240 1250 1260 1270 1280 1290
pF1KE3 WREAAEPLSEPKEDQEAAELLSEPEEESERHILELQEVYDYLYQPSYRKFIKLHQDLKSG
:::::::::::::::::::::::::::::::::::.::::::::::::::::::::::::
XP_016 WREAAEPLSEPKEDQEAAELLSEPEEESERHILELEEVYDYLYQPSYRKFIKLHQDLKSG
960 970 980 990 1000 1010
1300 1310 1320 1330 1340 1350
pF1KE3 EVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQGQRDWIKDRVEQIKEYHHLHQAVHAA
:::::::::::::::::::::::::::::::::: :::::::::::::::::::::::::
XP_016 EVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQDQRDWIKDRVEQIKEYHHLHQAVHAA
1020 1030 1040 1050 1060 1070
1360 1370 1380 1390 1400 1410
pF1KE3 KVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRETLDQINQELIQAKKLLQDISEARCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRETLDQINQELIQAKKLLQDISEARCK
1080 1090 1100 1110 1120 1130
1420 1430 1440 1450 1460 1470
pF1KE3 GLQALSLRKEFICWVREALGGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GLQALSLRKEFICWVREALGGINELKVFVDLASISAGENDIDVDRVACFHDAVQGYASLL
1140 1150 1160 1170 1180 1190
1480 1490 1500 1510 1520 1530
pF1KE3 FKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCDSARNLEWLKTVNESHGSVERSSLTL
1200 1210 1220 1230 1240 1250
1540 1550 1560 1570 1580 1590
pF1KE3 ATAINQRGIYVIQAPKGGQKISPDTVLHLILPESPGSHEESREYSLEEVKELLNKLMLMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ATAINQRGIYVIQAPKGGQKISPDTVLHLILPESPGSHEESREYSLEEVKELLNKLMLMS
1260 1270 1280 1290 1300 1310
1600 1610 1620 1630 1640 1650
pF1KE3 GKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGNMLFRTWIAMAYCSPKQGVSLQMDFG
1320 1330 1340 1350 1360 1370
1660 1670 1680 1690 1700 1710
pF1KE3 LDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFVTQKRMEHFYLNFYTAEQLVYLSTEL
1380 1390 1400 1410 1420 1430
1720 1730 1740 1750 1760 1770
pF1KE3 RKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSEAARYRMRRVMEELPLMLLSEFSLVD
1440 1450 1460 1470 1480 1490
1780 1790 1800 1810 1820 1830
pF1KE3 KLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAGMGGSPVERCLPRGLQVGQPNLVVCG
1500 1510 1520 1530 1540 1550
1840 1850 1860 1870 1880 1890
pF1KE3 HSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTFEEVALLLRRCLTLGSLGHKVYSLLF
1560 1570 1580 1590 1600 1610
1900 1910 1920 1930 1940 1950
pF1KE3 ADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCDGDWEHCYLPSAFSQHKVFVTPQAPL
1620 1630 1640 1650 1660 1670
1960 1970 1980 1990 2000 2010
pF1KE3 EAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVASERAGVGKSLYVKRLHDKMKMQLNVK
1680 1690 1700 1710 1720 1730
2020 2030 2040 2050 2060 2070
pF1KE3 NVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLIL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVPVLFHLDVTSSVQTGIWVFLFKLLIL
1740 1750 1760 1770 1780 1790
2080 2090 2100 2110 2120 2130
pF1KE3 QYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSSSALRTRVPQFSFLDIFPKVTCRPPK
1800 1810 1820 1830 1840 1850
2140 2150 2160 2170 2180 2190
pF1KE3 EVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYLRRFNQNQDLDTFQYQEGSVEGTPEE
1860 1870 1880 1890 1900 1910
2200 2210 2220 2230 2240 2250
pF1KE3 CLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEASLFCNPSFIGDTLRGFKKFVVTFMI
1920 1930 1940 1950 1960 1970
2260 2270 2280 2290 2300 2310
pF1KE3 FMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 FMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAPFSLRKRWESEPHPYVFFNDDHTTMT
1980 1990 2000 2010 2020 2030
2320 2330 2340 2350 2360 2370
pF1KE3 FIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLER
:::::::::::::::::.::::::::::::::::::::::::::::::::::::::::::
XP_016 FIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLYQGLLLQRVPFNVDFDKLPRHKKLER
2040 2050 2060 2070 2080 2090
2380 2390 2400 2410 2420 2430
pF1KE3 LCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFRCGIPVIIMGETGCGKTRLIKFLSDL
2100 2110 2120 2130 2140 2150
2440 2450 2460 2470 2480 2490
pF1KE3 RRGGTNADTIKLVKVHGGTTADMIYSRVREAENVAFANKDQHQLDTILFFDEANTTEAIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RRGGTNADTIKLVKVHGGTTADMIYSRVREAENVAFANKDQHQLDTILFFDEANTTEAIS
2160 2170 2180 2190 2200 2210
2500 2510 2520 2530 2540 2550
pF1KE3 CIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHSEEMICRLESAGLGYRVSMEETADRL
2220 2230 2240 2250 2260 2270
2560 2570 2580 2590 2600 2610
pF1KE3 GSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVIT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEKLYIQQIVQRLVESISLDENGTRVIT
2280 2290 2300 2310 2320 2330
2620 2630 2640 2650 2660 2670
pF1KE3 EVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWFHEHSAMLLAQLNAFLSKSSVSKNHT
2340 2350 2360 2370 2380 2390
2680 2690 2700 2710 2720 2730
pF1KE3 ERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFFPKPYDDSRLLLDEITRAQDLFLDGV
2400 2410 2420 2430 2440 2450
2740 2750 2760 2770 2780 2790
pF1KE3 PLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKPGSSKSLAKTIVADAMQGPAAYSDLF
2460 2470 2480 2490 2500 2510
2800 2810 2820 2830 2840 2850
pF1KE3 RSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQGKDLQQYVSVVVLDEVGLAEDSPKMP
2520 2530 2540 2550 2560 2570
2860 2870 2880 2890 2900 2910
pF1KE3 LKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDPAKMNRGIFVSRGSPNETELIESAKG
2580 2590 2600 2610 2620 2630
2920 2930 2940 2950 2960 2970
pF1KE3 ICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFFGLRDYYSLIKMVFAAAKASNRKPSP
2640 2650 2660 2670 2680 2690
2980 2990 3000 3010 3020 3030
pF1KE3 QDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQED
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEEVSPMQLIKQNIFGPSQKVPGGEQED
2700 2710 2720 2730 2740 2750
3040 3050 3060 3070 3080 3090
pF1KE3 AESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFGSGFPKDQEYTQLCRNINRVKICMET
2760 2770 2780 2790 2800 2810
3100 3110 3120 3130 3140 3150
pF1KE3 GKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDLGLGTHRVKCRVHPNFRLIVIEEKDV
2820 2830 2840 2850 2860 2870
3160 3170 3180 3190 3200 3210
pF1KE3 VYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEELCAWVEKFINVKAHHFQKRHKYSPSD
2880 2890 2900 2910 2920 2930
3220 3230 3240 3250 3260 3270
pF1KE3 VFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VFIGYHSDACASVVLQVIERQGPRALTEELHQKVSEEAKSILLNCATPDAVVRLSAYSLG
2940 2950 2960 2970 2980 2990
3280 3290 3300 3310 3320 3330
pF1KE3 GFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLERHAIFTEITTFSRLLTSHDCEILESE
3000 3010 3020 3030 3040 3050
3340 3350 3360 3370 3380 3390
pF1KE3 VTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAKCKILIFQTDFEDGIRSAQLIASAKY
3060 3070 3080 3090 3100 3110
3400 3410 3420 3430 3440 3450
pF1KE3 SVINEINKIRENEDRIFVYFITKLSRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVINEINKIRENEDRIFVYFITKLSRVGRGTAYVGFHGGLWQSVHIDDLRRSTLMVSDVT
3120 3130 3140 3150 3160 3170
3460 3470 3480 3490 3500 3510
pF1KE3 RLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMETEASTSGEVAEVAEEAMETESSEKVG
3180 3190 3200 3210 3220 3230
3520 3530 3540 3550 3560 3570
pF1KE3 KETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQNESCTRNMRRVVLLLGLLNEDDACHA
3240 3250 3260 3270 3280 3290
3580 3590 3600 3610 3620 3630
pF1KE3 SFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQDALQEAGTFRHTLWKRVQGAVTPLL
3300 3310 3320 3330 3340 3350
3640 3650 3660 3670 3680 3690
pF1KE3 ASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSDTMLLNIPLVMNNERHKGEMAYIVVQ
3360 3370 3380 3390 3400 3410
3700 3710 3720 3730 3740 3750
pF1KE3 NHMNLSENASNNVPFSWKIKDYLEELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NHMNLSENASNNVPFSWKIKDYLEELWVQAQYITDAEGLPKKFVDIFQQTPLGRFLAQLH
3420 3430 3440 3450 3460 3470
3760 3770 3780 3790 3800 3810
pF1KE3 GEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GEPQQELLQCYLKDFILLTMRVSTEEELKFLQMALWSCTRKLKAASEAPEEEVSLPWVHL
3480 3490 3500 3510 3520 3530
3820 3830 3840 3850 3860 3870
pF1KE3 AYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHELAGCEMTLDAFAAMACTEMLTRNTLK
3540 3550 3560 3570 3580 3590
3880 3890 3900 3910 3920 3930
pF1KE3 PSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQAVIREVRAQWSRIFSTALFVEHVLLG
3600 3610 3620 3630 3640 3650
3940 3950 3960 3970 3980 3990
pF1KE3 TESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPFEAVMRTLCECKETASKTLSRFGIQP
3660 3670 3680 3690 3700 3710
4000 4010 4020 4030 4040 4050
pF1KE3 CSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMICPYCLTALPDEFSPAVSQAHREAIE
3720 3730 3740 3750 3760 3770
4060 4070 4080 4090 4100 4110
pF1KE3 KHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIESLLSLLFVQKGRLRDAAQRHCEHTKS
3780 3790 3800 3810 3820 3830
4120 4130 4140 4150 4160 4170
pF1KE3 LSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQEYLTLLKKKAFITEDKTELYMLFIN
3840 3850 3860 3870 3880 3890
4180 4190 4200 4210 4220 4230
pF1KE3 CLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPASRGREPANEASVEYLQEVARIRLCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 CLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPASRGREPANEASVEYLQEVARIRLCL
3900 3910 3920 3930 3940 3950
4240 4250 4260 4270 4280 4290
pF1KE3 DRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVENDWHRVYLVRKLSSQRGMEFVQGLS
3960 3970 3980 3990 4000 4010
4300 4310 4320 4330 4340 4350
pF1KE3 KPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYGDEYKALRDAVAKAVLECKPLGIKTA
4020 4030 4040 4050 4060 4070
4360 4370 4380 4390 4400 4410
pF1KE3 LKACKTPQSQQSAYFLLTLFREVAILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LKACKTPQSQQSAYFLLTLFREVAILYRSHNASLHPTPEQCEAVSKFIGECKILSPPDIS
4080 4090 4100 4110 4120 4130
4420 4430 4440 4450 4460 4470
pF1KE3 RFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAAAVLLCGQNELLEPLKNLAFSPATMA
4140 4150 4160 4170 4180 4190
4480 4490 4500 4510 4520 4530
pF1KE3 HAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPCSVGECGRPMEQSICIDCHAPIGGID
4200 4210 4220 4230 4240 4250
4540 4550 4560 4570 4580 4590
pF1KE3 HKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 HKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCDRGLPPVVFLLIRLLTHLALLLGASQ
4260 4270 4280 4290 4300 4310
4600 4610 4620 4630 4640 4650
pF1KE3 SSQALINIIKPPVRDPKGFLQQHILKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSQALINIIKPPVRDPKGFLQQHILKDLEQLAKMLGHSADETIGVVHLVLRRLLQEQHQL
4320 4330 4340 4350 4360 4370
4660 4670 4680 4690 4700 4710
pF1KE3 SSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEHLDKTLPTMNNLISQDKRISSNPVAK
4380 4390 4400 4410 4420 4430
4720 4730 4740 4750 4760 4770
pF1KE3 IIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEYLQHIVEQKNGKERVPILWHFLQKEA
4440 4450 4460 4470 4480 4490
4780 4790 4800 4810 4820 4830
pF1KE3 ELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRGFLSKHSSDGLRQLLHNRITVFLSTW
4500 4510 4520 4530 4540 4550
4840 4850 4860 4870 4880 4890
pF1KE3 NKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NKLRRSLETNGEINLPKDYCSTDLDLDTEFEILLPRRRGLGLCATALVSYLIRLHNEIVY
4560 4570 4580 4590 4600 4610
4900 4910 4920 4930 4940 4950
pF1KE3 AVEKLSKENNSYSVDAAEVTELHVISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AVEKLSKENNSYSVDAAEVTELHVISYEVERDLTPLILSNCQYQVEEGRETVQEFDLEKI
4620 4630 4640 4650 4660 4670
4960 4970 4980 4990 5000 5010
pF1KE3 QRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QRQIVSRFLQGKPRLSLKGIPTLVYRHDWNYEHLFMDIKNKMAQDSLPSSVISAISGQLQ
4680 4690 4700 4710 4720 4730
5020 5030 5040 5050 5060 5070
pF1KE3 SYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SYSDACEVLSVVEVTLGFLSTAGGDPNMQLNVYTQDILQMGDQTIHVLKALNRCQLKHTI
4740 4750 4760 4770 4780 4790
5080 5090 5100 5110 5120 5130
pF1KE3 ALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ALWQFLSAHKSEQLLRLHKEPFGEISSRYKADLSPENAKLLSTFLNQTGLDAFLLELHEM
4800 4810 4820 4830 4840 4850
5140 5150 5160 5170 5180 5190
pF1KE3 IILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKESEILPEMASQFPEEILLASCVSVWKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IILKLKNPQTQTEERFRPQWSLRDTLVSYMQTKESEILPEMASQFPEEILLASCVSVWKT
4860 4870 4880 4890 4900 4910
5200
pF1KE3 AAVLKWNREMR
:::::::::::
XP_016 AAVLKWNREMR
4920
>>XP_011523386 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (4825 aa)
initn: 31328 init1: 31328 opt: 31340 Z-score: 20860.6 bits: 3876.1 E(85289): 0
Smith-Waterman score: 31724; 98.8% identity (98.9% similar) in 4806 aa overlap (18-4774:18-4823)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
:::::::::::::::::::::::::::::::::::::::::::
XP_011 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE---------------------------------
:::::::::::::::::::::::::::
XP_011 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD
70 80 90 100 110 120
90 100 110 120 130
pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_011 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_011 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_011 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740 1750
pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
1750 1760 1770 1780 1790 1800
1760 1770 1780 1790 1800 1810
pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
1810 1820 1830 1840 1850 1860
1820 1830 1840 1850 1860 1870
pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
1870 1880 1890 1900 1910 1920
1880 1890 1900 1910 1920 1930
pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160 2170
pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
2170 2180 2190 2200 2210 2220
2180 2190 2200 2210 2220 2230
pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
2230 2240 2250 2260 2270 2280
2240 2250 2260 2270 2280 2290
pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
2290 2300 2310 2320 2330 2340
2300 2310 2320 2330 2340 2350
pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_011 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY
2350 2360 2370 2380 2390 2400
2360 2370 2380 2390 2400 2410
pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
2410 2420 2430 2440 2450 2460
2420 2430 2440 2450 2460 2470
pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
2470 2480 2490 2500 2510 2520
2480 2490 2500 2510 2520 2530
pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
2530 2540 2550 2560 2570 2580
2540 2550 2560 2570 2580 2590
pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
2590 2600 2610 2620 2630 2640
2600 2610 2620 2630 2640 2650
pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
2650 2660 2670 2680 2690 2700
2660 2670 2680 2690 2700 2710
pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
2710 2720 2730 2740 2750 2760
2720 2730 2740 2750 2760 2770
pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
2770 2780 2790 2800 2810 2820
2780 2790 2800 2810 2820 2830
pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
2830 2840 2850 2860 2870 2880
2840 2850 2860 2870 2880 2890
pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
2890 2900 2910 2920 2930 2940
2900 2910 2920 2930 2940 2950
pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
2950 2960 2970 2980 2990 3000
2960 2970 2980 2990 3000 3010
pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
3010 3020 3030 3040 3050 3060
3020 3030 3040 3050 3060 3070
pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
3070 3080 3090 3100 3110 3120
3080 3090 3100 3110 3120 3130
pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
3130 3140 3150 3160 3170 3180
3140 3150 3160 3170 3180 3190
pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
3190 3200 3210 3220 3230 3240
3200 3210 3220 3230 3240 3250
pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
3250 3260 3270 3280 3290 3300
3260 3270 3280 3290 3300 3310
pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
3310 3320 3330 3340 3350 3360
3320 3330 3340 3350 3360 3370
pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
3370 3380 3390 3400 3410 3420
3380 3390 3400 3410 3420 3430
pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
3430 3440 3450 3460 3470 3480
3440 3450 3460 3470 3480 3490
pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
3490 3500 3510 3520 3530 3540
3500 3510 3520 3530 3540 3550
pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
3550 3560 3570 3580 3590 3600
3560 3570 3580 3590 3600 3610
pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
3610 3620 3630 3640 3650 3660
3620 3630 3640 3650 3660 3670
pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
3670 3680 3690 3700 3710 3720
3680 3690 3700 3710 3720 3730
pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
3730 3740 3750 3760 3770 3780
3740 3750 3760 3770 3780 3790
pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
3790 3800 3810 3820 3830 3840
3800 3810 3820 3830 3840 3850
pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
3850 3860 3870 3880 3890 3900
3860 3870 3880 3890 3900 3910
pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
3910 3920 3930 3940 3950 3960
3920 3930 3940 3950 3960 3970
pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
3970 3980 3990 4000 4010 4020
3980 3990 4000 4010 4020 4030
pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
4030 4040 4050 4060 4070 4080
4040 4050 4060 4070 4080 4090
pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
4090 4100 4110 4120 4130 4140
4100 4110 4120 4130 4140 4150
pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
4150 4160 4170 4180 4190 4200
4160 4170 4180 4190 4200 4210
pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
4210 4220 4230 4240 4250 4260
4220 4230 4240 4250 4260 4270
pF1KE3 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SRGREPANEASVEYLQEVARIRLCLDRAADFLSEPEGGPEMAKEKQCYLQQVKQFCIRVE
4270 4280 4290 4300 4310 4320
4280 4290 4300 4310 4320 4330
pF1KE3 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NDWHRVYLVRKLSSQRGMEFVQGLSKPGRPHQWVFPKDVVKQQGLRQDHPGQMDRYLVYG
4330 4340 4350 4360 4370 4380
4340 4350 4360 4370 4380 4390
pF1KE3 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DEYKALRDAVAKAVLECKPLGIKTALKACKTPQSQQSAYFLLTLFREVAILYRSHNASLH
4390 4400 4410 4420 4430 4440
4400 4410 4420 4430 4440 4450
pF1KE3 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PTPEQCEAVSKFIGECKILSPPDISRFATSLVDNSVPLLRAGPSDSNLDGTVTEMAIHAA
4450 4460 4470 4480 4490 4500
4460 4470 4480 4490 4500 4510
pF1KE3 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AVLLCGQNELLEPLKNLAFSPATMAHAFLPTMPEDLLAQARRWKGLERVHWYTCPNGHPC
4510 4520 4530 4540 4550 4560
4520 4530 4540 4550 4560 4570
pF1KE3 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SVGECGRPMEQSICIDCHAPIGGIDHKPRDGFHLVKDKADRTQTGHVLGNPQRRDVVTCD
4570 4580 4590 4600 4610 4620
4580 4590 4600 4610 4620 4630
pF1KE3 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGLPPVVFLLIRLLTHLALLLGASQSSQALINIIKPPVRDPKGFLQQHILKDLEQLAKML
4630 4640 4650 4660 4670 4680
4640 4650 4660 4670 4680 4690
pF1KE3 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GHSADETIGVVHLVLRRLLQEQHQLSSRRLLNFDTELSTKEMRNNWEKEIAAVISPELEH
4690 4700 4710 4720 4730 4740
4700 4710 4720 4730 4740 4750
pF1KE3 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LDKTLPTMNNLISQDKRISSNPVAKIIYGDPVTFLPHLPRKSVVHCSKIWSCRKRITVEY
4750 4760 4770 4780 4790 4800
4760 4770 4780 4790 4800 4810
pF1KE3 LQHIVEQKNGKERVPILWHFLQKEAELRLVKFLPEILALQRDLVKQFQNVQQVEYSSIRG
:::::::::::::::::::::::
XP_011 LQHIVEQKNGKERVPILWHFLQKMG
4810 4820
>>XP_011523388 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (4192 aa)
initn: 27049 init1: 27049 opt: 27061 Z-score: 18013.6 bits: 3349.1 E(85289): 0
Smith-Waterman score: 27445; 98.7% identity (98.8% similar) in 4173 aa overlap (18-4141:18-4190)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
:::::::::::::::::::::::::::::::::::::::::::
XP_011 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE---------------------------------
:::::::::::::::::::::::::::
XP_011 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD
70 80 90 100 110 120
90 100 110 120 130
pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_011 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_011 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_011 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740 1750
pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
1750 1760 1770 1780 1790 1800
1760 1770 1780 1790 1800 1810
pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
1810 1820 1830 1840 1850 1860
1820 1830 1840 1850 1860 1870
pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
1870 1880 1890 1900 1910 1920
1880 1890 1900 1910 1920 1930
pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160 2170
pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
2170 2180 2190 2200 2210 2220
2180 2190 2200 2210 2220 2230
pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
2230 2240 2250 2260 2270 2280
2240 2250 2260 2270 2280 2290
pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
2290 2300 2310 2320 2330 2340
2300 2310 2320 2330 2340 2350
pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_011 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY
2350 2360 2370 2380 2390 2400
2360 2370 2380 2390 2400 2410
pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
2410 2420 2430 2440 2450 2460
2420 2430 2440 2450 2460 2470
pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
2470 2480 2490 2500 2510 2520
2480 2490 2500 2510 2520 2530
pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
2530 2540 2550 2560 2570 2580
2540 2550 2560 2570 2580 2590
pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
2590 2600 2610 2620 2630 2640
2600 2610 2620 2630 2640 2650
pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
2650 2660 2670 2680 2690 2700
2660 2670 2680 2690 2700 2710
pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
2710 2720 2730 2740 2750 2760
2720 2730 2740 2750 2760 2770
pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
2770 2780 2790 2800 2810 2820
2780 2790 2800 2810 2820 2830
pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
2830 2840 2850 2860 2870 2880
2840 2850 2860 2870 2880 2890
pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
2890 2900 2910 2920 2930 2940
2900 2910 2920 2930 2940 2950
pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
2950 2960 2970 2980 2990 3000
2960 2970 2980 2990 3000 3010
pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
3010 3020 3030 3040 3050 3060
3020 3030 3040 3050 3060 3070
pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
3070 3080 3090 3100 3110 3120
3080 3090 3100 3110 3120 3130
pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
3130 3140 3150 3160 3170 3180
3140 3150 3160 3170 3180 3190
pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
3190 3200 3210 3220 3230 3240
3200 3210 3220 3230 3240 3250
pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
3250 3260 3270 3280 3290 3300
3260 3270 3280 3290 3300 3310
pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
3310 3320 3330 3340 3350 3360
3320 3330 3340 3350 3360 3370
pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
3370 3380 3390 3400 3410 3420
3380 3390 3400 3410 3420 3430
pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
3430 3440 3450 3460 3470 3480
3440 3450 3460 3470 3480 3490
pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
3490 3500 3510 3520 3530 3540
3500 3510 3520 3530 3540 3550
pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
3550 3560 3570 3580 3590 3600
3560 3570 3580 3590 3600 3610
pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
3610 3620 3630 3640 3650 3660
3620 3630 3640 3650 3660 3670
pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
3670 3680 3690 3700 3710 3720
3680 3690 3700 3710 3720 3730
pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
3730 3740 3750 3760 3770 3780
3740 3750 3760 3770 3780 3790
pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
3790 3800 3810 3820 3830 3840
3800 3810 3820 3830 3840 3850
pF1KE3 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WSCTRKLKAASEAPEEEVSLPWVHLAYQRFRSRLQNFSRILTIYPQVLHSLMEARWNHEL
3850 3860 3870 3880 3890 3900
3860 3870 3880 3890 3900 3910
pF1KE3 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGCEMTLDAFAAMACTEMLTRNTLKPSPQAWLQLVKNLSMPLELICSDEHMQGSGSLAQA
3910 3920 3930 3940 3950 3960
3920 3930 3940 3950 3960 3970
pF1KE3 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VIREVRAQWSRIFSTALFVEHVLLGTESRVPELQGLVTEHVFLLDKCLRENSDVKTHGPF
3970 3980 3990 4000 4010 4020
3980 3990 4000 4010 4020 4030
pF1KE3 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAVMRTLCECKETASKTLSRFGIQPCSICLGDAKDPVCLPCDHVHCLRCLRAWFASEQMI
4030 4040 4050 4060 4070 4080
4040 4050 4060 4070 4080 4090
pF1KE3 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CPYCLTALPDEFSPAVSQAHREAIEKHARFRQMCNSFFVDLVSTICFKDNAPPEKEVIES
4090 4100 4110 4120 4130 4140
4100 4110 4120 4130 4140 4150
pF1KE3 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYSFHDVKDYIQ
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLSLLFVQKGRLRDAAQRHCEHTKSLSPFNDVVDKTPVIRSVILKLLLKYRW
4150 4160 4170 4180 4190
4160 4170 4180 4190 4200 4210
pF1KE3 EYLTLLKKKAFITEDKTELYMLFINCLEDSILEKTSAYSRNDELNHLEEEGRFLKAYSPA
>>XP_011523389 (OMIM: 607151,613768) PREDICTED: E3 ubiqu (3824 aa)
initn: 24278 init1: 24278 opt: 24290 Z-score: 16170.0 bits: 3007.8 E(85289): 0
Smith-Waterman score: 24674; 98.5% identity (98.6% similar) in 3765 aa overlap (18-3733:18-3782)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
:::::::::::::::::::::::::::::::::::::::::::
XP_011 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQE---------------------------------
:::::::::::::::::::::::::::
XP_011 PCLFPGSDSWQENPEEPCSKASWTVQEGATSEVLVDAAVDLISDEWEAANAIPSKRRKQD
70 80 90 100 110 120
90 100 110 120 130
pF1KE3 ----------------SKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
::::::::::::::::::::::::::::::::::::::::::::
XP_011 AAPLEAASVPSADCEQSKKKKRKKKKKGNKSASSELASLPLSPASPCHLTLLSNPWPQDT
130 140 150 160 170 180
140 150 160 170 180 190
pF1KE3 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALGEAGVATGSEAQ
190 200 210 220 230 240
200 210 220 230 240 250
pF1KE3 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQELLLPESKGGSS
250 260 270 280 290 300
260 270 280 290 300 310
pF1KE3 EPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
:::::::::::::::::: :::::::::::::::::::::::::::::::::::::::::
XP_011 EPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPPATTPPFKTHCQ
310 320 330 340 350 360
320 330 340 350 360 370
pF1KE3 EAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
::::::::: ::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKNQEADVQEVKAS
370 380 390 400 410 420
380 390 400 410 420 430
pF1KE3 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICELHYTRDLGHDRV
430 440 450 460 470 480
440 450 460 470 480 490
pF1KE3 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCLFIKSSLLGSGD
490 500 510 520 530 540
500 510 520 530 540 550
pF1KE3 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSILQTWDTINLNS
550 560 570 580 590 600
560 570 580 590 600 610
pF1KE3 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVPLPDGKSTDFLP
610 620 630 640 650 660
620 630 640 650 660 670
pF1KE3 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHRDLSHILGIPQS
670 680 690 700 710 720
680 690 700 710 720 730
pF1KE3 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWAALEGLSFSPFR
730 740 750 760 770 780
740 750 760 770 780 790
pF1KE3 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEHLGRFPAHILDC
790 800 810 820 830 840
800 810 820 830 840 850
pF1KE3 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEALSPSYLTVCLKL
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE3 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQTVFQGTLAATK
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE3 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGDMEWRLTKEEPL
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE3 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYSDLRKFGIVLSA
1030 1040 1050 1060 1070 1080
1040 1050 1060 1070 1080 1090
pF1KE3 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKRLIAVADSVLTK
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KE3 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEKCAVEEALDWRREELLLLK
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_011 VVGDLLSGTILVGQLELIIKHKNQFLDIWQLREKSLSPQDEQCAVEEALDWRREELLLLK
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KE3 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTMTVRLSTSSNSQRATHY
:::::::::::::::::::::::::::::::::::::::::::.::::::::::::::::
XP_011 KEKRCVDSLLKMCGNVKHLIQVDFGVLAVRHSQDLSSKRLNDTVTVRLSTSSNSQRATHY
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KE3 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HLSSQVQEMAGKIDLLRDSHIFQLFWREAAEPLSEPKEDQEAAELLSEPEEESERHILEL
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 QEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQG
.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVYDYLYQPSYRKFIKLHQDLKSGEVTLAEIDVIFKDFVNKYTDLDSELKIMCTVDHQD
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QRDWIKDRVEQIKEYHHLHQAVHAAKVILQVKESLGLNGDFSVLNTLLNFTDNFDDFRRE
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLDQINQELIQAKKLLQDISEARCKGLQALSLRKEFICWVREALGGINELKVFVDLASIS
1450 1460 1470 1480 1490 1500
1460 1470 1480 1490 1500 1510
pF1KE3 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AGENDIDVDRVACFHDAVQGYASLLFKLDPSVDFSAFMKHLKKLWKALDKDQYLPRKLCD
1510 1520 1530 1540 1550 1560
1520 1530 1540 1550 1560 1570
pF1KE3 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SARNLEWLKTVNESHGSVERSSLTLATAINQRGIYVIQAPKGGQKISPDTVLHLILPESP
1570 1580 1590 1600 1610 1620
1580 1590 1600 1610 1620 1630
pF1KE3 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSHEESREYSLEEVKELLNKLMLMSGKKDRNNTEVERFSEVFCSVQRLSQAFIDLHSAGN
1630 1640 1650 1660 1670 1680
1640 1650 1660 1670 1680 1690
pF1KE3 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MLFRTWIAMAYCSPKQGVSLQMDFGLDLVTELKEGGDVTELLAALCRQMEHFLDSWKRFV
1690 1700 1710 1720 1730 1740
1700 1710 1720 1730 1740 1750
pF1KE3 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TQKRMEHFYLNFYTAEQLVYLSTELRKQPPSDAALTMLSFIKSNCTLRDVLRASVGCGSE
1750 1760 1770 1780 1790 1800
1760 1770 1780 1790 1800 1810
pF1KE3 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AARYRMRRVMEELPLMLLSEFSLVDKLRIIMEQSMRCLPAFLPDCLDLETLGHCLAHLAG
1810 1820 1830 1840 1850 1860
1820 1830 1840 1850 1860 1870
pF1KE3 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MGGSPVERCLPRGLQVGQPNLVVCGHSEVLPAALAVYMQTPSQPLPTYDEVLLCTPATTF
1870 1880 1890 1900 1910 1920
1880 1890 1900 1910 1920 1930
pF1KE3 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEVALLLRRCLTLGSLGHKVYSLLFADQLSYEVARQAEELFHNLCTQQHREDYQLVMVCD
1930 1940 1950 1960 1970 1980
1940 1950 1960 1970 1980 1990
pF1KE3 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GDWEHCYLPSAFSQHKVFVTPQAPLEAIQAYLAGHYRVPKQTLSAAAVFNDRLCVGIVAS
1990 2000 2010 2020 2030 2040
2000 2010 2020 2030 2040 2050
pF1KE3 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ERAGVGKSLYVKRLHDKMKMQLNVKNVPLKTIRLIDPQVDESRVLGALLPFLDAQYQKVP
2050 2060 2070 2080 2090 2100
2060 2070 2080 2090 2100 2110
pF1KE3 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLFHLDVTSSVQTGIWVFLFKLLILQYLMDINGKMWLRNPCHLYIVEILERRTSVPSRSS
2110 2120 2130 2140 2150 2160
2120 2130 2140 2150 2160 2170
pF1KE3 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SALRTRVPQFSFLDIFPKVTCRPPKEVIDMELSALRSDTEPGMDLWEFCSETFQRPYQYL
2170 2180 2190 2200 2210 2220
2180 2190 2200 2210 2220 2230
pF1KE3 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RRFNQNQDLDTFQYQEGSVEGTPEECLQHFLFHCGVINPSWSELRNFARFLNYQLRDCEA
2230 2240 2250 2260 2270 2280
2240 2250 2260 2270 2280 2290
pF1KE3 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SLFCNPSFIGDTLRGFKKFVVTFMIFMARDFATPSLHTSDQSPGKHMVTMDGVREEDLAP
2290 2300 2310 2320 2330 2340
2300 2310 2320 2330 2340 2350
pF1KE3 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAINHLTGKVIKRDVMTRDLY
::::::::::::::::::::::::::::::::::::::::::.:::::::::::::::::
XP_011 FSLRKRWESEPHPYVFFNDDHTTMTFIGFHLQPNINGSVDAISHLTGKVIKRDVMTRDLY
2350 2360 2370 2380 2390 2400
2360 2370 2380 2390 2400 2410
pF1KE3 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGLLLQRVPFNVDFDKLPRHKKLERLCLTLGIPQATDPDKTYELTTDNMLKILAIEMRFR
2410 2420 2430 2440 2450 2460
2420 2430 2440 2450 2460 2470
pF1KE3 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CGIPVIIMGETGCGKTRLIKFLSDLRRGGTNADTIKLVKVHGGTTADMIYSRVREAENVA
2470 2480 2490 2500 2510 2520
2480 2490 2500 2510 2520 2530
pF1KE3 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FANKDQHQLDTILFFDEANTTEAISCIKEVLCDHMVDGQPLAEDSGLHIIAACNPYRKHS
2530 2540 2550 2560 2570 2580
2540 2550 2560 2570 2580 2590
pF1KE3 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEMICRLESAGLGYRVSMEETADRLGSIPLRQLVYRVHALPPSLIPLVWDFGQLSDVAEK
2590 2600 2610 2620 2630 2640
2600 2610 2620 2630 2640 2650
pF1KE3 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LYIQQIVQRLVESISLDENGTRVITEVLCASQGFMRKTEDECSFVSLRDVERCVKVFRWF
2650 2660 2670 2680 2690 2700
2660 2670 2680 2690 2700 2710
pF1KE3 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HEHSAMLLAQLNAFLSKSSVSKNHTERDPVLWSLMLAIGVCYHASLEKKDSYRKAIARFF
2710 2720 2730 2740 2750 2760
2720 2730 2740 2750 2760 2770
pF1KE3 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKPYDDSRLLLDEITRAQDLFLDGVPLRKTIAKNLALKENVFMMVVCIELKIPLFLVGKP
2770 2780 2790 2800 2810 2820
2780 2790 2800 2810 2820 2830
pF1KE3 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GSSKSLAKTIVADAMQGPAAYSDLFRSLKQVHLVSFQCSPHSTPQGIISTFRQCARFQQG
2830 2840 2850 2860 2870 2880
2840 2850 2860 2870 2880 2890
pF1KE3 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KDLQQYVSVVVLDEVGLAEDSPKMPLKTLHPLLEDGCIEDDPAPHKKVGFVGISNWALDP
2890 2900 2910 2920 2930 2940
2900 2910 2920 2930 2940 2950
pF1KE3 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AKMNRGIFVSRGSPNETELIESAKGICSSDILVQDRVQGYFASFAKAYETVCKRQDKEFF
2950 2960 2970 2980 2990 3000
2960 2970 2980 2990 3000 3010
pF1KE3 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLRDYYSLIKMVFAAAKASNRKPSPQDIAQAVLRNFSGKDDIQALDIFLANLPEAKCSEE
3010 3020 3030 3040 3050 3060
3020 3030 3040 3050 3060 3070
pF1KE3 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VSPMQLIKQNIFGPSQKVPGGEQEDAESRYLLVLTKNYVALQILQQTFFEGDQQPEIIFG
3070 3080 3090 3100 3110 3120
3080 3090 3100 3110 3120 3130
pF1KE3 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SGFPKDQEYTQLCRNINRVKICMETGKMVLLLNLQNLYESLYDALNQYYVHLGGQKYVDL
3130 3140 3150 3160 3170 3180
3140 3150 3160 3170 3180 3190
pF1KE3 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLGTHRVKCRVHPNFRLIVIEEKDVVYKHFPIPLINRLEKHYLDINTVLEKWQKSIVEEL
3190 3200 3210 3220 3230 3240
3200 3210 3220 3230 3240 3250
pF1KE3 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CAWVEKFINVKAHHFQKRHKYSPSDVFIGYHSDACASVVLQVIERQGPRALTEELHQKVS
3250 3260 3270 3280 3290 3300
3260 3270 3280 3290 3300 3310
pF1KE3 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEAKSILLNCATPDAVVRLSAYSLGGFAAEWLSQEYFHRQRHNSFADFLQAHLHTADLER
3310 3320 3330 3340 3350 3360
3320 3330 3340 3350 3360 3370
pF1KE3 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HAIFTEITTFSRLLTSHDCEILESEVTGRAPKPTLLWLQQFDTEYSFLKEVRNCLTNTAK
3370 3380 3390 3400 3410 3420
3380 3390 3400 3410 3420 3430
pF1KE3 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 CKILIFQTDFEDGIRSAQLIASAKYSVINEINKIRENEDRIFVYFITKLSRVGRGTAYVG
3430 3440 3450 3460 3470 3480
3440 3450 3460 3470 3480 3490
pF1KE3 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FHGGLWQSVHIDDLRRSTLMVSDVTRLQHVTISQLFAPGDLPELGLEHRAEDGHEEAMET
3490 3500 3510 3520 3530 3540
3500 3510 3520 3530 3540 3550
pF1KE3 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EASTSGEVAEVAEEAMETESSEKVGKETSELGGSDVSILDTTRLLRSCVQSAVGMLRDQN
3550 3560 3570 3580 3590 3600
3560 3570 3580 3590 3600 3610
pF1KE3 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ESCTRNMRRVVLLLGLLNEDDACHASFLRVSKMRLSVFLKKQEESQFHPLEWLAREACNQ
3610 3620 3630 3640 3650 3660
3620 3630 3640 3650 3660 3670
pF1KE3 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DALQEAGTFRHTLWKRVQGAVTPLLASMISFIDRDGNLELLTRPDTPPWARDLWMFIFSD
3670 3680 3690 3700 3710 3720
3680 3690 3700 3710 3720 3730
pF1KE3 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TMLLNIPLVMNNERHKGEMAYIVVQNHMNLSENASNNVPFSWKIKDYLEELWVQAQYITD
3730 3740 3750 3760 3770 3780
3740 3750 3760 3770 3780 3790
pF1KE3 AEGLPKKFVDIFQQTPLGRFLAQLHGEPQQELLQCYLKDFILLTMRVSTEEELKFLQMAL
::
XP_011 AEVSVQFTSPRHFKVSAEGVRGPGGTRNLSILWQQEPVRWFLVP
3790 3800 3810 3820
>>NP_066005 (OMIM: 607151,613768) E3 ubiquitin-protein l (1063 aa)
initn: 6841 init1: 6841 opt: 6841 Z-score: 4565.1 bits: 858.7 E(85289): 0
Smith-Waterman score: 6841; 99.8% identity (99.8% similar) in 1008 aa overlap (1-1008:1-1008)
10 20 30 40 50 60
pF1KE3 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MECPSCQHVSKEETPKFCSQCGERLPPAAPIADSENNNSTMASASEGEMECGQELKEEGG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 PCLFPGSDSWQENPEEPCSKASWTVQESKKKKRKKKKKGNKSASSELASLPLSPASPCHL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 TLLSNPWPQDTALPHSQAQQSGPTGQPSQPPGTATTPLEGDGLSAPTEVGDSPLQAQALG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 EAGVATGSEAQSSPQFQDHTEGEDQDASIPSGGRGLSQEGTGPPTSAGEGHSRTEDAAQE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LLLPESKGGSSEPGTELQTTEQQAGASASTAVDAVAEPANAVKGAGKEMKEKTQRMKQPP
::::::::::::::::::::::::::::: ::::::::::::::::::::::::::::::
NP_066 LLLPESKGGSSEPGTELQTTEQQAGASASMAVDAVAEPANAVKGAGKEMKEKTQRMKQPP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 ATTPPFKTHCQEAETKTKDETAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
:::::::::::::::::::: :::::::::::::::::::::::::::::::::::::::
NP_066 ATTPPFKTHCQEAETKTKDEMAAAEEKVGKNEQGEPEDLKKPEGKNRSAAAVKNEKEQKN
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 QEADVQEVKASTLSPGGGVTVFFHAIISLHFPFNPDLHKVFIRGGEEFGESKWDSNICEL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 HYTRDLGHDRVLVEGIVCISKKHLDKYIPYKYVIYNGESFEYEFIYKHQQKKGEYVNRCL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 FIKSSLLGSGDWHQYYDIVYMKPHGRLQKVMNHITDGPRKDLVKGKQIAAALMLDSTFSI
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LQTWDTINLNSFFTQFEQFCFVLQQPMIYEGQAQLWTDLQYREKEVKRYLWQHLKKHVVP
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LPDGKSTDFLPVDCPVRSKLKTGLIVLFVVEKIELLLEGSLDWLCHLLTSDASSPDEFHR
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 DLSHILGIPQSWRLYLVNLCQRCMDTRTYTWLGALPVLHCCMELAPRHKDAWRQPEDTWA
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 ALEGLSFSPFREQMLDTSSLLQFMREKQHLLSIDEPLFRSWFSLLPLSHLVMYMENFIEH
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 LGRFPAHILDCLSGIYYRLPGLEQVLNTQDVQDVQNVQNILEMLLRLLDTYRDKIPEEAL
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 SPSYLTVCLKLHEAICSSTKLLKFYELPALSAEIVCRMIRLLSLVDSAGQRDETGNNSVQ
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 TVFQGTLAATKRWLREVFTKNMLTSSGASFTYVKEIEVWRRLVEIQFPAEHGWKESLLGD
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQSQTSILQGFSYS
::::::::::::::::::::::::::::::::::::::::::::::::
NP_066 MEWRLTKEEPLSQITAYCNSCWDTKGLEDSVAKTFEKCIIEAVSSACQVNNLSSWETDSG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 DLRKFGIVLSAVITKSWPRTADNFDDILKHLLTLADVKHVFRLCGTDEKILANVTEDAKR
NP_066 SQLCSAMTQLRAMKHPLGLSSSANSEIGKWAPSSLAKGNGAEI
1030 1040 1050 1060
5207 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 20:24:02 2016 done: Mon Nov 7 20:24:08 2016
Total Scan time: 34.070 Total Display time: 7.500
Function used was FASTA [36.3.4 Apr, 2011]