Result of FASTA (omim) for
pFN21AE3524
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3524, 570 aa
1>>>pF1KE3524 570 - 570 aa - 570 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.4860+/-0.000358; mu= 9.9720+/- 0.022
mean_var=154.3624+/-31.746, 0's: 0 Z-trim(118.7): 173 B-trim: 0 in 0/58
Lambda= 0.103229
statistics sampled from 31662 (31837) to 31662 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.719), E-opt: 0.2 (0.373), width: 16
Scan time: 8.950
The best scores are: opt bits E(85289)
NP_033664 (OMIM: 600892) single-minded homolog 2 s ( 570) 3834 583.0 8.8e-166
NP_005060 (OMIM: 600892) single-minded homolog 2 l ( 667) 3524 536.9 7.8e-152
XP_011527996 (OMIM: 600892) PREDICTED: single-mind ( 566) 2878 440.6 6.3e-123
XP_005267157 (OMIM: 601665,603128) PREDICTED: sing ( 766) 2245 346.4 1.9e-94
NP_005059 (OMIM: 601665,603128) single-minded homo ( 766) 2245 346.4 1.9e-94
XP_016866686 (OMIM: 601665,603128) PREDICTED: sing ( 766) 2245 346.4 1.9e-94
XP_011534374 (OMIM: 601665,603128) PREDICTED: sing ( 481) 2198 339.3 1.7e-92
XP_016883931 (OMIM: 600892) PREDICTED: single-mind ( 327) 2153 332.5 1.3e-90
NP_851397 (OMIM: 603348) hypoxia-inducible factor ( 735) 939 151.9 6.6e-36
NP_001521 (OMIM: 603348) hypoxia-inducible factor ( 826) 939 152.0 7.2e-36
NP_001230013 (OMIM: 603348) hypoxia-inducible fact ( 850) 939 152.0 7.3e-36
NP_001421 (OMIM: 603349,611783) endothelial PAS do ( 870) 818 134.0 2e-30
XP_011531000 (OMIM: 603349,611783) PREDICTED: endo ( 883) 818 134.0 2e-30
XP_005259212 (OMIM: 609976) PREDICTED: hypoxia-ind ( 587) 777 127.7 1e-28
XP_005259213 (OMIM: 609976) PREDICTED: hypoxia-ind ( 587) 777 127.7 1e-28
XP_016882627 (OMIM: 609976) PREDICTED: hypoxia-ind ( 663) 777 127.8 1.1e-28
NP_690007 (OMIM: 609976) hypoxia-inducible factor ( 667) 777 127.8 1.1e-28
NP_690008 (OMIM: 609976) hypoxia-inducible factor ( 669) 777 127.8 1.1e-28
XP_016882626 (OMIM: 609976) PREDICTED: hypoxia-ind ( 703) 777 127.8 1.2e-28
XP_016882625 (OMIM: 609976) PREDICTED: hypoxia-ind ( 707) 777 127.8 1.2e-28
XP_016882624 (OMIM: 609976) PREDICTED: hypoxia-ind ( 709) 777 127.8 1.2e-28
XP_016882623 (OMIM: 609976) PREDICTED: hypoxia-ind ( 711) 777 127.8 1.2e-28
XP_005259209 (OMIM: 609976) PREDICTED: hypoxia-ind ( 713) 777 127.8 1.2e-28
XP_016882622 (OMIM: 609976) PREDICTED: hypoxia-ind ( 749) 777 127.8 1.2e-28
XP_016882621 (OMIM: 609976) PREDICTED: hypoxia-ind ( 755) 777 127.8 1.2e-28
XP_011535374 (OMIM: 609430) PREDICTED: neuronal PA ( 900) 569 96.9 3e-19
XP_011535373 (OMIM: 609430) PREDICTED: neuronal PA ( 936) 569 96.9 3.1e-19
XP_011535371 (OMIM: 609430) PREDICTED: neuronal PA ( 966) 569 96.9 3.1e-19
XP_016877072 (OMIM: 609430) PREDICTED: neuronal PA ( 983) 569 96.9 3.2e-19
XP_016877075 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 543 93.0 4.1e-18
XP_016877077 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 543 93.0 4.1e-18
XP_016877076 (OMIM: 609430) PREDICTED: neuronal PA ( 831) 543 93.0 4.1e-18
NP_071406 (OMIM: 609430) neuronal PAS domain-conta ( 901) 543 93.0 4.4e-18
NP_001159365 (OMIM: 609430) neuronal PAS domain-co ( 903) 543 93.0 4.4e-18
XP_011535372 (OMIM: 609430) PREDICTED: neuronal PA ( 918) 543 93.0 4.4e-18
NP_775182 (OMIM: 609430) neuronal PAS domain-conta ( 920) 543 93.0 4.4e-18
NP_001158221 (OMIM: 609430) neuronal PAS domain-co ( 933) 543 93.0 4.5e-18
XP_016877074 (OMIM: 609430) PREDICTED: neuronal PA ( 939) 543 93.0 4.5e-18
XP_011535369 (OMIM: 609430) PREDICTED: neuronal PA ( 950) 543 93.0 4.5e-18
XP_016877073 (OMIM: 609430) PREDICTED: neuronal PA ( 956) 543 93.0 4.6e-18
XP_005268049 (OMIM: 609430) PREDICTED: neuronal PA ( 967) 543 93.0 4.6e-18
XP_005268048 (OMIM: 609430) PREDICTED: neuronal PA ( 969) 543 93.0 4.6e-18
XP_016877071 (OMIM: 609430) PREDICTED: neuronal PA ( 986) 543 93.1 4.7e-18
NP_690009 (OMIM: 609976) hypoxia-inducible factor ( 450) 494 85.5 4e-16
XP_016882631 (OMIM: 609976) PREDICTED: hypoxia-ind ( 474) 494 85.5 4.2e-16
XP_005259210 (OMIM: 609976) PREDICTED: hypoxia-ind ( 594) 494 85.6 5e-16
NP_071907 (OMIM: 609976) hypoxia-inducible factor ( 600) 494 85.6 5e-16
XP_016882630 (OMIM: 609976) PREDICTED: hypoxia-ind ( 642) 494 85.6 5.3e-16
XP_016882628 (OMIM: 609976) PREDICTED: hypoxia-ind ( 642) 494 85.6 5.3e-16
XP_016882629 (OMIM: 609976) PREDICTED: hypoxia-ind ( 642) 494 85.6 5.3e-16
>>NP_033664 (OMIM: 600892) single-minded homolog 2 short (570 aa)
initn: 3834 init1: 3834 opt: 3834 Z-score: 3097.3 bits: 583.0 E(85289): 8.8e-166
Smith-Waterman score: 3834; 100.0% identity (100.0% similar) in 570 aa overlap (1-570:1-570)
10 20 30 40 50 60
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_033 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT
490 500 510 520 530 540
550 560 570
pF1KE3 AGSRSSHGGGWQMETEPSRFGQTCPLSASK
::::::::::::::::::::::::::::::
NP_033 AGSRSSHGGGWQMETEPSRFGQTCPLSASK
550 560 570
>>NP_005060 (OMIM: 600892) single-minded homolog 2 long (667 aa)
initn: 3524 init1: 3524 opt: 3524 Z-score: 2846.9 bits: 536.9 E(85289): 7.8e-152
Smith-Waterman score: 3524; 100.0% identity (100.0% similar) in 525 aa overlap (1-525:1-525)
10 20 30 40 50 60
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 STSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_005 LQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFL
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRT
:::::::::::::::::::::::::::::::::::::::::::::
NP_005 STLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAP
490 500 510 520 530 540
550 560 570
pF1KE3 AGSRSSHGGGWQMETEPSRFGQTCPLSASK
NP_005 PSFPSCGHYREEPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLL
550 560 570 580 590 600
>>XP_011527996 (OMIM: 600892) PREDICTED: single-minded h (566 aa)
initn: 2878 init1: 2878 opt: 2878 Z-score: 2327.9 bits: 440.6 E(85289): 6.3e-123
Smith-Waterman score: 2878; 100.0% identity (100.0% similar) in 424 aa overlap (102-525:1-424)
80 90 100 110 120 130
pF1KE3 PLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELTGNSIYEYIHPS
::::::::::::::::::::::::::::::
XP_011 MYISETASVHLGLSQVELTGNSIYEYIHPS
10 20 30
140 150 160 170 180 190
pF1KE3 DHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGYKVIHCSGYLKI
40 50 60 70 80 90
200 210 220 230 240 250
pF1KE3 RQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDLKLIFLDSRVTE
100 110 120 130 140 150
260 270 280 290 300 310
pF1KE3 VTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYA
160 170 180 190 200 210
320 330 340 350 360 370
pF1KE3 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTALSTSQETRKLVK
220 230 240 250 260 270
380 390 400 410 420 430
pF1KE3 PKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAPPELQPHSESSDLL
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE3 YTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEVARFFLSTLPASGECQW
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE3 HYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKVGGLRTAGSRSSHGGGW
::::::::::::::::::::::::::::::::::
XP_011 HYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEAPAAAVRRFGEDTAPPSFPSCGHYRE
400 410 420 430 440 450
560 570
pF1KE3 QMETEPSRFGQTCPLSASK
XP_011 EPALGPAKAARQAARDGARLALARAAPECCAPPTPEAPGAPAQLPFVLLNYHRVLARRGP
460 470 480 490 500 510
>>XP_005267157 (OMIM: 601665,603128) PREDICTED: single-m (766 aa)
initn: 2166 init1: 2070 opt: 2245 Z-score: 1816.6 bits: 346.4 E(85289): 1.9e-94
Smith-Waterman score: 2245; 69.2% identity (84.7% similar) in 510 aa overlap (1-504:1-503)
10 20 30 40 50 60
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
:::::::::.:::::::.:::::::::::::::::::::::::::::::::::.::::::
XP_005 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
:.:::. ::..:::.:..:::::::::::::.:::: :::::::::::::::::::::::
XP_005 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.::
XP_005 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
:::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::.
XP_005 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
:::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.:
XP_005 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
.:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. ..
XP_005 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS
310 320 330 340 350 360
370 380 390 400 410
pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP-
. : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.:
XP_005 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ
370 380 390 400 410
420 430 440 450 460 470
pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV
: .: :. . ..: : :: : :: . .. . .:. ::.
XP_005 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE3 ARFFLSTLPASGECQWHYANPLVP-SSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGK
.:.::.: : .:. : . .: ...::
XP_005 GRYFLGT-PQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSV
480 490 500 510 520 530
>>NP_005059 (OMIM: 601665,603128) single-minded homolog (766 aa)
initn: 2166 init1: 2070 opt: 2245 Z-score: 1816.6 bits: 346.4 E(85289): 1.9e-94
Smith-Waterman score: 2245; 69.2% identity (84.7% similar) in 510 aa overlap (1-504:1-503)
10 20 30 40 50 60
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
:::::::::.:::::::.:::::::::::::::::::::::::::::::::::.::::::
NP_005 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
:.:::. ::..:::.:..:::::::::::::.:::: :::::::::::::::::::::::
NP_005 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.::
NP_005 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
:::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::.
NP_005 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
:::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.:
NP_005 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
.:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. ..
NP_005 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS
310 320 330 340 350 360
370 380 390 400 410
pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP-
. : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.:
NP_005 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ
370 380 390 400 410
420 430 440 450 460 470
pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV
: .: :. . ..: : :: : :: . .. . .:. ::.
NP_005 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE3 ARFFLSTLPASGECQWHYANPLVP-SSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGK
.:.::.: : .:. : . .: ...::
NP_005 GRYFLGT-PQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSV
480 490 500 510 520 530
>>XP_016866686 (OMIM: 601665,603128) PREDICTED: single-m (766 aa)
initn: 2166 init1: 2070 opt: 2245 Z-score: 1816.6 bits: 346.4 E(85289): 1.9e-94
Smith-Waterman score: 2245; 69.2% identity (84.7% similar) in 510 aa overlap (1-504:1-503)
10 20 30 40 50 60
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
:::::::::.:::::::.:::::::::::::::::::::::::::::::::::.::::::
XP_016 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
:.:::. ::..:::.:..:::::::::::::.:::: :::::::::::::::::::::::
XP_016 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.::
XP_016 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
:::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::.
XP_016 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
:::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.:
XP_016 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
.:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. ..
XP_016 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS
310 320 330 340 350 360
370 380 390 400 410
pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP-
. : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.:
XP_016 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ
370 380 390 400 410
420 430 440 450 460 470
pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV
: .: :. . ..: : :: : :: . .. . .:. ::.
XP_016 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE3 ARFFLSTLPASGECQWHYANPLVP-SSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGK
.:.::.: : .:. : . .: ...::
XP_016 GRYFLGT-PQAGREPWWGSRAALPLTKASPESREAYENSMPHIASVHRIHGRGHWDEDSV
480 490 500 510 520 530
>>XP_011534374 (OMIM: 601665,603128) PREDICTED: single-m (481 aa)
initn: 2070 init1: 2070 opt: 2198 Z-score: 1781.6 bits: 339.3 E(85289): 1.7e-92
Smith-Waterman score: 2198; 71.4% identity (85.9% similar) in 482 aa overlap (1-477:1-476)
10 20 30 40 50 60
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
:::::::::.:::::::.:::::::::::::::::::::::::::::::::::.::::::
XP_011 MKEKSKNAARTRREKENSEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRVVFPEGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
:.:::. ::..:::.:..:::::::::::::.:::: :::::::::::::::::::::::
XP_011 GEAWGHSSRTSPLDNVGRELGSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
::::::::::.:::::::::::::: : :..::::::::::::::::::::::::::.::
XP_011 GNSIYEYIHPADHDEMTAVLTAHQPYHSHFVQEYEIERSFFLRMKCVLAKRNAGLTCGGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
:::::::::::::: :::: .:.::: :::::::.::::::.:::::.:::::::::::.
XP_011 KVIHCSGYLKIRQYSLDMSPFDGCYQNVGLVAVGHSLPPSAVTEIKLHSNMFMFRASLDM
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
:::::::::.:.:::::::::::::::::::::.:::: :::::::::::::::::.:.:
XP_011 KLIFLDSRVAELTGYEPQDLIEKTLYHHVHGCDTFHLRCAHHLLLVKGQVTTKYYRFLAK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
.:::::::::::.::::::::::::::::::::. ::: :::::.:.:..: :. ..
XP_011 HGGWVWVQSYATIVHNSRSSRPHCIVSVNYVLTDTEYKGLQLSLDQISASKPAFSYTSSS
310 320 330 340 350 360
370 380 390 400 410
pF1KE3 S-TSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQMDKLECGQLGNWRASPPASAAAP-
. : ..:: .: . .. :.: ::.::: :::.:. .. : . ..: .:: ...:.:
XP_011 TPTMTDNRKGAKSRLSSSKSKSRTSPYP--QYSGFHTERSESDHDSQWGGSPLTDTASPQ
370 380 390 400 410
420 430 440 450 460 470
pF1KE3 ---PELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSSKKPMLPAKFGQPQGSPCEV
: .: :. . ..: : :: : :: . .. . .:. ::.
XP_011 LLDPADRPGSQHDASCAYRQFSDRSSLCYG-FALDHSRLVEERHFHTQAC---EGGRCEA
420 430 440 450 460 470
480 490 500 510 520 530
pF1KE3 ARFFLSTLPASGECQWHYANPLVPSSSSPAKNPPEPPANTARHSLVPSYEGGSGLLVGKV
.:
XP_011 GRARSLG
480
>>XP_016883931 (OMIM: 600892) PREDICTED: single-minded h (327 aa)
initn: 2153 init1: 2153 opt: 2153 Z-score: 1747.7 bits: 332.5 E(85289): 1.3e-90
Smith-Waterman score: 2153; 100.0% identity (100.0% similar) in 325 aa overlap (1-325:1-325)
10 20 30 40 50 60
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASIIRLTTSYLKMRAVFPEGL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMYISETASVHLGLSQVELT
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLRMKCVLAKRNAGLTCSGY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVIHCSGYLKIRQYMLDMSLYDSCYQIVGLVAVGQSLPPSAITEIKLYSNMFMFRASLDL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHLRYAHHLLLVKGQVTTKYYRLLSK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 RGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEYKELQLSLEQVSTAKSQDSWRTAL
:::::::::::::::::::::::::
XP_016 RGGWVWVQSYATVVHNSRSSRPHCIGD
310 320
>>NP_851397 (OMIM: 603348) hypoxia-inducible factor 1-al (735 aa)
initn: 972 init1: 436 opt: 939 Z-score: 765.7 bits: 151.9 E(85289): 6.6e-36
Smith-Waterman score: 939; 39.9% identity (71.6% similar) in 391 aa overlap (2-385:19-394)
10 20 30 40
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASII
::::..::..:: ::. :::::. :::: ..:.:::::..
NP_851 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 RLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMY
::: :::..: .. : : : . ... :..:::::.:...:: ..:
NP_851 RLTISYLRVRKLLDAGDLDIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 ISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLR
::.... ..::.: ::::.:.... :: ::.:: .:: .. : .. .: . .::::::
NP_851 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLR
120 130 140 150 160 170
170 180 190 200 210
pF1KE3 MKCVLAKRN--AGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLP
:::.:..:. .. . .::.::.:.... : . . . :. .. :: . . .:
NP_851 MKCTLTSRGRTMNIKSATWKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIP
180 190 200 210 220
220 230 240 250 260 270
pF1KE3 -PSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHL
:: : :: : :. :. : :::.:. . : :.::. ::::..:. ...:.. :. : ::
NP_851 HPSNI-EIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHL
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE3 RYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEY
.:: ...:::::: ::.:.::::.:::.. :::..:...:.:.::: ::::.. :
NP_851 TKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQ
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE3 KELQLSLEQVSTA-KSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQM
..: .::.:. . : .: . .. .: :. . .... ::. .:
NP_851 HDLIFSLQQTECVLKPVES--SDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE3 DKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSS
NP_851 DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSS
410 420 430 440 450 460
>>NP_001521 (OMIM: 603348) hypoxia-inducible factor 1-al (826 aa)
initn: 972 init1: 436 opt: 939 Z-score: 765.0 bits: 152.0 E(85289): 7.2e-36
Smith-Waterman score: 939; 39.9% identity (71.6% similar) in 391 aa overlap (2-385:19-394)
10 20 30 40
pF1KE3 MKEKSKNAAKTRREKENGEFYELAKLLPLPSAITSQLDKASII
::::..::..:: ::. :::::. :::: ..:.:::::..
NP_001 MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVM
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 RLTTSYLKMRAVFPEGLGDAWGQPSRAGPLDGVAKELGSHLLQTLDGFVFVVASDGKIMY
::: :::..: .. : : : . ... :..:::::.:...:: ..:
NP_001 RLTISYLRVRKLLDAGDLDIE---------DDMKAQMNCFYLKALDGFVMVLTDDGDMIY
70 80 90 100 110
110 120 130 140 150 160
pF1KE3 ISETASVHLGLSQVELTGNSIYEYIHPSDHDEMTAVLTAHQPLHHHLLQEYEIERSFFLR
::.... ..::.: ::::.:.... :: ::.:: .:: .. : .. .: . .::::::
NP_001 ISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKG-KEQNTQRSFFLR
120 130 140 150 160 170
170 180 190 200 210
pF1KE3 MKCVLAKRN--AGLTCSGYKVIHCSGYLKIRQYMLDMSLYDSCYQ---IVGLVAVGQSLP
:::.:..:. .. . .::.::.:.... : . . . :. .. :: . . .:
NP_001 MKCTLTSRGRTMNIKSATWKVLHCTGHIHV--YDTNSNQPQCGYKKPPMTCLVLICEPIP
180 190 200 210 220
220 230 240 250 260 270
pF1KE3 -PSAITEIKLYSNMFMFRASLDLKLIFLDSRVTEVTGYEPQDLIEKTLYHHVHGCDVFHL
:: : :: : :. :. : :::.:. . : :.::. ::::..:. ...:.. :. : ::
NP_001 HPSNI-EIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHL
230 240 250 260 270 280
280 290 300 310 320 330
pF1KE3 RYAHHLLLVKGQVTTKYYRLLSKRGGWVWVQSYATVVHNSRSSRPHCIVSVNYVLTEIEY
.:: ...:::::: ::.:.::::.:::.. :::..:...:.:.::: ::::.. :
NP_001 TKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQ
290 300 310 320 330 340
340 350 360 370 380 390
pF1KE3 KELQLSLEQVSTA-KSQDSWRTALSTSQETRKLVKPKNTKMKTKLRTNPYPPQQYSSFQM
..: .::.:. . : .: . .. .: :. . .... ::. .:
NP_001 HDLIFSLQQTECVLKPVES--SDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAG
350 360 370 380 390 400
400 410 420 430 440 450
pF1KE3 DKLECGQLGNWRASPPASAAAPPELQPHSESSDLLYTPSYSLPFSYHYGHFPLDSHVFSS
NP_001 DTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSS
410 420 430 440 450 460
570 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Fri Nov 4 13:54:49 2016 done: Fri Nov 4 13:54:51 2016
Total Scan time: 8.950 Total Display time: 0.140
Function used was FASTA [36.3.4 Apr, 2011]