Result of FASTA (omim) for
pFN21AE3488
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3488, 1826 aa
1>>>pF1KE3488 1826 - 1826 aa - 1826 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 7.5694+/-0.000353; mu= 15.0616+/- 0.022
mean_var=156.6137+/-31.390, 0's: 0 Z-trim(119.6): 300 B-trim: 57 in 1/57
Lambda= 0.102485
statistics sampled from 33507 (33846) to 33507 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.703), E-opt: 0.2 (0.397), width: 16
Scan time: 19.080
The best scores are: opt bits E(85289)
NP_722516 (OMIM: 607798) transcription initiation (1826) 12325 1835.5 0
XP_005262352 (OMIM: 300966,313650,314250) PREDICTE (1927) 11601 1728.5 0
XP_005262353 (OMIM: 300966,313650,314250) PREDICTE (1926) 11589 1726.7 0
NP_004597 (OMIM: 300966,313650,314250) transcripti (1893) 10977 1636.2 0
NP_001273003 (OMIM: 300966,313650,314250) transcri (1895) 10963 1634.1 0
XP_006724745 (OMIM: 300966,313650,314250) PREDICTE (1800) 10864 1619.5 0
XP_005262354 (OMIM: 300966,313650,314250) PREDICTE (1906) 10407 1551.9 0
NP_620278 (OMIM: 300966,313650,314250) transcripti (1872) 9783 1459.7 0
XP_005262357 (OMIM: 300966,313650,314250) PREDICTE ( 999) 6499 973.9 0
NP_001276975 (OMIM: 607576) cat eye syndrome criti (1300) 263 52.0 4.6e-05
XP_011544434 (OMIM: 607576) PREDICTED: cat eye syn (1409) 263 52.0 4.9e-05
XP_011544431 (OMIM: 607576) PREDICTED: cat eye syn (1436) 263 52.0 4.9e-05
XP_016884274 (OMIM: 607576) PREDICTED: cat eye syn (1463) 263 52.0 5e-05
NP_001276976 (OMIM: 607576) cat eye syndrome criti (1464) 263 52.0 5e-05
XP_011544430 (OMIM: 607576) PREDICTED: cat eye syn (1436) 249 49.9 0.00021
XP_016879937 (OMIM: 602301) PREDICTED: histone ace ( 476) 237 47.8 0.0003
XP_006721881 (OMIM: 602301) PREDICTED: histone ace ( 477) 237 47.8 0.0003
NP_066564 (OMIM: 602301) histone acetyltransferase ( 837) 237 48.0 0.00047
XP_006721880 (OMIM: 602301) PREDICTED: histone ace ( 838) 237 48.0 0.00047
XP_016870654 (OMIM: 601541) PREDICTED: bromodomain ( 725) 217 45.0 0.0032
NP_031397 (OMIM: 601541) bromodomain-containing pr ( 726) 217 45.0 0.0032
XP_006717354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 217 45.0 0.0032
XP_011517354 (OMIM: 601541) PREDICTED: bromodomain ( 726) 217 45.0 0.0032
XP_016883269 (OMIM: 615713) PREDICTED: protein kin ( 909) 216 44.9 0.0043
XP_016883268 (OMIM: 615713) PREDICTED: protein kin ( 917) 216 44.9 0.0043
XP_016862912 (OMIM: 602303) PREDICTED: histone ace ( 735) 210 44.0 0.0067
XP_016862913 (OMIM: 602303) PREDICTED: histone ace ( 735) 210 44.0 0.0067
NP_003875 (OMIM: 602303) histone acetyltransferase ( 832) 210 44.0 0.0074
>>NP_722516 (OMIM: 607798) transcription initiation fact (1826 aa)
initn: 12325 init1: 12325 opt: 12325 Z-score: 9848.3 bits: 1835.5 E(85289): 0
Smith-Waterman score: 12325; 100.0% identity (100.0% similar) in 1826 aa overlap (1-1826:1-1826)
10 20 30 40 50 60
pF1KE3 MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 MRPGCDLLLRAAATVTAAIMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDDE
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 CKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 CKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDES
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 QRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 QRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSES
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 GEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 GEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDAT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 KLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKKHRELIQEEQIQEVECS
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 VESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 VESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVAEW
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 RYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADEN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 RYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLADEN
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 FLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 FLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLDDD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 KPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEEAT
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 SNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 SNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQGLR
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 GTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPLLK
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 HIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 HIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATKIK
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 NYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 NYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPETD
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 FLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 FLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSKDR
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 PRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 PRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAKVS
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 PEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 PEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFIAA
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 MKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 MKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLSLK
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 NAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQER
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 NAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQER
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 YKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 YKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSREW
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 EEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 EEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEYVR
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 CETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 CETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQEKE
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQEE
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 ELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 ELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTT
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 VHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 VHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKII
1390 1400 1410 1420 1430 1440
1450 1460 1470 1480 1490 1500
pF1KE3 TRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 TRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKL
1450 1460 1470 1480 1490 1500
1510 1520 1530 1540 1550 1560
pF1KE3 KEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYY
1510 1520 1530 1540 1550 1560
1570 1580 1590 1600 1610 1620
pF1KE3 KMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 KMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICY
1570 1580 1590 1600 1610 1620
1630 1640 1650 1660 1670 1680
pF1KE3 QTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 QTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRD
1630 1640 1650 1660 1670 1680
1690 1700 1710 1720 1730 1740
pF1KE3 ASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 ASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG
1690 1700 1710 1720 1730 1740
1750 1760 1770 1780 1790 1800
pF1KE3 DGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_722 DGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDSDV
1750 1760 1770 1780 1790 1800
1810 1820
pF1KE3 GYGGIRPKQPFMLQHASGEHKDGHGK
::::::::::::::::::::::::::
NP_722 GYGGIRPKQPFMLQHASGEHKDGHGK
1810 1820
>>XP_005262352 (OMIM: 300966,313650,314250) PREDICTED: t (1927 aa)
initn: 11673 init1: 9223 opt: 11601 Z-score: 9269.4 bits: 1728.5 E(85289): 0
Smith-Waterman score: 11601; 94.5% identity (98.0% similar) in 1824 aa overlap (1-1817:1-1824)
10 20 30 40 50
pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: :::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.:: :::::::::: :::::::::: ::::::::::::::::::::::::::::::::::
XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY
: ::::::::.::::.::::::::::::: :::.:::.:::::.::::::::::::::::
XP_005 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::.::.:::::::.::::::::::::::::::::::::
XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ
:::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::
XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
:::::::::::::::::::::::::.::::::.. :::::::::::::::::::::::::
XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK
::::::::: :::::::::::::::::::::::::::::::::.::::::::::::::::
XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI
:::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS
::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: :
XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE3 RDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPP
:::::::::::.::::: .:::::: : ::.:::::::::::.::::::::::::: :
XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP
1690 1700 1710 1720 1730 1740
1740 1750 1760 1770 1780 1790
pF1KE3 APEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSE
:::: ::::::::::::::::.:::::::::.:::::::::::::::::::::::::::
XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE
1750 1760 1770 1780 1790 1800
1800 1810 1820
pF1KE3 SGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK
:::::::: :::::::: :::. .
XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE
1810 1820 1830 1840 1850 1860
>>XP_005262353 (OMIM: 300966,313650,314250) PREDICTED: t (1926 aa)
initn: 11242 init1: 5776 opt: 11589 Z-score: 9259.9 bits: 1726.7 E(85289): 0
Smith-Waterman score: 11589; 94.5% identity (97.9% similar) in 1824 aa overlap (1-1817:1-1823)
10 20 30 40 50
pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: :::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.:: :::::::::: :::::::::: ::::::::::::::::::::::::::::::::::
XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY
: ::::::::.:::: ::::::::::::: :::.:::.:::::.::::::::::::::::
XP_005 EREEQERKELQRMLL-AGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190
1200 1210 1220 1230 1240 1250
pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::.::.:::::::.::::::::::::::::::::::::
XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1200 1210 1220 1230 1240 1250
1260 1270 1280 1290 1300 1310
pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ
:::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::
XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1260 1270 1280 1290 1300 1310
1320 1330 1340 1350 1360 1370
pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
:::::::::::::::::::::::::.::::::.. :::::::::::::::::::::::::
XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1320 1330 1340 1350 1360 1370
1380 1390 1400 1410 1420 1430
pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK
::::::::: :::::::::::::::::::::::::::::::::.::::::::::::::::
XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1380 1390 1400 1410 1420 1430
1440 1450 1460 1470 1480 1490
pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1440 1450 1460 1470 1480 1490
1500 1510 1520 1530 1540 1550
pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1500 1510 1520 1530 1540 1550
1560 1570 1580 1590 1600 1610
pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI
:::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1560 1570 1580 1590 1600 1610
1620 1630 1640 1650 1660 1670
pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS
::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: :
XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1620 1630 1640 1650 1660 1670
1680 1690 1700 1710 1720 1730
pF1KE3 RDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPP
:::::::::::.::::: .:::::: : ::.:::::::::::.::::::::::::: :
XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP
1680 1690 1700 1710 1720 1730
1740 1750 1760 1770 1780 1790
pF1KE3 APEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSE
:::: ::::::::::::::::.:::::::::.:::::::::::::::::::::::::::
XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE
1740 1750 1760 1770 1780 1790
1800 1810 1820
pF1KE3 SGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK
:::::::: :::::::: :::. .
XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE
1800 1810 1820 1830 1840 1850
>>NP_004597 (OMIM: 300966,313650,314250) transcription i (1893 aa)
initn: 11725 init1: 9223 opt: 10977 Z-score: 8770.9 bits: 1636.2 E(85289): 0
Smith-Waterman score: 11351; 93.2% identity (96.6% similar) in 1819 aa overlap (1-1817:1-1790)
10 20 30 40 50
pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
NP_004 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
NP_004 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: :::
NP_004 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.:: :::::::::: :::::::::: ::::::::::::::::::::::::::::::::::
NP_004 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
NP_004 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
NP_004 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
NP_004 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
NP_004 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_004 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
NP_004 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
NP_004 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_004 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
NP_004 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
NP_004 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
NP_004 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_004 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_004 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_004 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY
: ::::::::.::::.::::::::::::: :::.:::.:::::.::::::::::::::::
NP_004 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::.::.:::::::.::::::::::::::::::::::::
NP_004 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ
:::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::
NP_004 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
:::::::::::::::::::::::::.::::::.. :::::::::::::::::::::::::
NP_004 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK
::::::::: :::::::::::::::::::::::::::::::::.::::::::::::::::
NP_004 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_004 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI
:::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_004 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS
::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: :
NP_004 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE3 RDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPE
:::::::::::.::::: .::::::. : :: :
NP_004 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED--------------
1690 1700 1710
1740 1750 1760 1770 1780 1790
pF1KE3 GGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS
::::::::::::::::.:::::::::.::::::::::::::::::::::::::::::::
NP_004 -GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS
1720 1730 1740 1750 1760 1770
1800 1810 1820
pF1KE3 DVGYGGIRPKQPFMLQHASGEHKDGHGK
::: :::::::: :::. .
NP_004 DVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKS
1780 1790 1800 1810 1820 1830
>>NP_001273003 (OMIM: 300966,313650,314250) transcriptio (1895 aa)
initn: 11659 init1: 8991 opt: 10963 Z-score: 8759.7 bits: 1634.1 E(85289): 0
Smith-Waterman score: 11337; 93.1% identity (96.5% similar) in 1821 aa overlap (1-1817:1-1792)
10 20 30 40 50
pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
NP_001 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
NP_001 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: :::
NP_001 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.:: :::::::::: :::::::::: ::::::::::::::::::::::::::::::::::
NP_001 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
NP_001 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
NP_001 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
NP_001 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
NP_001 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_001 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
NP_001 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
NP_001 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_001 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
NP_001 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
NP_001 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
NP_001 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_001 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
970 980 990 1000 1010 1020
1020 1030 1040 1050 1060 1070
pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_001 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1030 1040 1050 1060 1070 1080
1080 1090 1100 1110 1120 1130
pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_001 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1090 1100 1110 1120 1130 1140
1140 1150 1160 1170 1180 1190
pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY
: ::::::::.::::.::::::::::::: :::.:::.:::::.::::::::::::::::
NP_001 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1150 1160 1170 1180 1190 1200
1200 1210 1220 1230 1240 1250
pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::.::.:::::::.::::::::::::::::::::::::
NP_001 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1210 1220 1230 1240 1250 1260
1260 1270 1280 1290 1300 1310
pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ
:::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::
NP_001 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1270 1280 1290 1300 1310 1320
1320 1330 1340 1350 1360 1370
pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
:::::::::::::::::::::::::.::::::.. :::::::::::::::::::::::::
NP_001 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1330 1340 1350 1360 1370 1380
1380 1390 1400 1410 1420 1430
pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK
::::::::: :::::::::::::::::::::::::::::::::.::::::::::::::::
NP_001 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1390 1400 1410 1420 1430 1440
1440 1450 1460 1470 1480 1490
pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_001 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1450 1460 1470 1480 1490 1500
1500 1510 1520 1530 1540 1550
pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1510 1520 1530 1540 1550 1560
1560 1570 1580 1590 1600 1610
pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI
:::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_001 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1570 1580 1590 1600 1610 1620
1620 1630 1640 1650 1660 1670
pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQ--PPDMYDTNTSLS
::::.::::::::::::::::::::::::::::::::::::::: : :::.::::::::
NP_001 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQAKPPDLYDTNTSLS
1630 1640 1650 1660 1670 1680
1680 1690 1700 1710 1720 1730
pF1KE3 TSRDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPA
::::::::::::.::::: .::::::. : :: :
NP_001 MSRDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED------------
1690 1700 1710
1740 1750 1760 1770 1780 1790
pF1KE3 PEGGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGS
::::::::::::::::.:::::::::.::::::::::::::::::::::::::::::
NP_001 ---GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGS
1720 1730 1740 1750 1760 1770
1800 1810 1820
pF1KE3 DSDVGYGGIRPKQPFMLQHASGEHKDGHGK
::::: :::::::: :::. .
NP_001 DSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDP
1780 1790 1800 1810 1820 1830
>>XP_006724745 (OMIM: 300966,313650,314250) PREDICTED: t (1800 aa)
initn: 11050 init1: 9223 opt: 10864 Z-score: 8680.9 bits: 1619.5 E(85289): 0
Smith-Waterman score: 10864; 94.9% identity (98.0% similar) in 1697 aa overlap (127-1817:1-1697)
100 110 120 130 140 150
pF1KE3 EGWIRSTEDAVDYSDINEVAEDESQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMP
::::::: ::::::::::::::::::::::
XP_006 MGSLQPLCHSDYDEDDYDADCEDIDCKLMP
10 20 30
160 170 180 190 200 210
pF1KE3 PPPPPPGPMKKDKDQDAITCVSESGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQE
::::::::::::::::.:: :::.:: :::::::::: :::::::::: :::::::::::
XP_006 PPPPPPGPMKKDKDQDSITGVSENGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQE
40 50 60 70 80 90
220 230 240 250 260 270
pF1KE3 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWR
::::::::::::::::::::::::::::::::::::::::::::::.:::::::::::::
XP_006 ATQAESEDGKLTLPLAGIMQHDATKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWR
100 110 120 130 140 150
280 290 300 310 320 330
pF1KE3 SARRKRKK-HRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVP
:::::::: :::::::::::::::::::::::::::::::::::::::::.:::::::.:
XP_006 SARRKRKKKHRELIQEEQIQEVECSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAP
160 170 180 190 200 210
340 350 360 370 380 390
pF1KE3 VESKFSQSTGDVDKVTDTKPRVAEWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPV
:::::::::::.::::::::::::::::::::::::::: :::::::::::::::.::::
XP_006 VESKFSQSTGDIDKVTDTKPRVAEWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPV
220 230 240 250 260 270
400 410 420 430 440 450
pF1KE3 IKSRMMEEFRKLEESNGTDLLADENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGW
:::::.::::::::.:::::::::::::::::::::.:::::::.:::::::: ::::::
XP_006 IKSRMIEEFRKLEENNGTDLLADENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGW
280 290 300 310 320 330
460 470 480 490 500 510
pF1KE3 LPSIKTRNVMAYNVQQGFAPTLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE
::: :::.:::::::::: ::::::::::::::::::::::::::::::::::::::::
XP_006 LPSSMTRNAMAYNVQQGFAATLDDDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLE
340 350 360 370 380 390
520 530 540 550 560 570
pF1KE3 PPVLALDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNM
::::.:::::::::::::::::::::::::::::::::::::::::::::::.:::::::
XP_006 PPVLTLDPNDENLILEIPDEKEEATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNM
400 410 420 430 440 450
580 590 600 610 620 630
pF1KE3 SQPEVKDPWNLSNDEYYFPKQQGLRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFH
:::::::::::::::::.:::::::::::::::::::::.:: ::::::::::::.::::
XP_006 SQPEVKDPWNLSNDEYYYPKQQGLRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFH
460 470 480 490 500 510
640 650 660 670 680 690
pF1KE3 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDG
:::::::::::::::::::::::::::::::::::::::::::::.::::::::::::::
XP_006 RPPLKKYSFGALSQPGPHSVQPLLKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDG
520 530 540 550 560 570
700 710 720 730 740 750
pF1KE3 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DLILAEYSEENGPLMMQVGMATKIKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHP
580 590 600 610 620 630
760 770 780 790 800 810
pF1KE3 GQLLQALENNLFRAPVYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS
::::::.::::::::.::::::::::::::::::::::::::::::::::::::::::::
XP_006 GQLLQAFENNLFRAPIYLHKMPETDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNS
640 650 660 670 680 690
820 830 840 850 860 870
pF1KE3 RRANMHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG
.::: :::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 KRANTHIRDFLQVFIYRLFWKSKDRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTG
700 710 720 730 740 750
880 890 900 910 920 930
pF1KE3 MDSNWWVLKSDFRLPTEEEIRAKVSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENE
:::::::::::::::::::::: :::::::::::::::.:::::::::::::::::::::
XP_006 MDSNWWVLKSDFRLPTEEEIRAMVSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENE
760 770 780 790 800 810
940 950 960 970 980 990
pF1KE3 EDFQMKIDDEVHAAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK
:::::::::::..:::::::::::::::::::::::::::::::::::::::::::::::
XP_006 EDFQMKIDDEVRTAPWNTTRAFIAAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQK
820 830 840 850 860 870
1000 1010 1020 1030 1040 1050
pF1KE3 DDKEPQAVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ
:::::: :::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 DDKEPQPVKKTVTGTDADLRRLSLKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQ
880 890 900 910 920 930
1060 1070 1080 1090 1100 1110
pF1KE3 AHSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSD
:.::::::::::::::::::::::::::::::::::::::::::::::::::: ::::::
XP_006 ARSGEGPMSKFARGSRFSVAEHQERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSD
940 950 960 970 980 990
1120 1130 1140 1150 1160 1170
pF1KE3 FEEMGKNIENMLQNKKTSSQLSREWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSL
:::::::::::::::::::::::: ::::::::.::::.::::::::::::: :::.:::
XP_006 FEEMGKNIENMLQNKKTSSQLSREREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSL
1000 1010 1020 1030 1040 1050
1180 1190 1200 1210 1220 1230
pF1KE3 KSSATGHCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKH
.:::::.::::::::::::::::::::::::::::::::::::::::.::.:::::::.:
XP_006 NSSATGRCLKIYRTFRDEEGKEYVRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQH
1060 1070 1080 1090 1100 1110
1240 1250 1260 1270 1280 1290
pF1KE3 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 REEMRKERRRIQEQLRRLKRNQEKEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTN
1120 1130 1140 1150 1160 1170
1300 1310 1320 1330 1340 1350
pF1KE3 KFCPLYYQTNVPPSKPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEV
::::::::::.:::.:::::::::::::::::::::::::::::::::.::::::.. ::
XP_006 KFCPLYYQTNAPPSNPVAMTEEQEEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEV
1180 1190 1200 1210 1220 1230
1360 1370 1380 1390 1400 1410
pF1KE3 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDM
:::::::::::::::::::::::::::::::: :::::::::::::::::::::::::::
XP_006 RRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDM
1240 1250 1260 1270 1280 1290
1420 1430 1440 1450 1460 1470
pF1KE3 RDLPNTHPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNS
::::::.::::::::::::::::::::::::::::::::: :::::::::::::::::::
XP_006 RDLPNTYPFHTPVNAKVVKDYYKIITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNS
1300 1310 1320 1330 1340 1350
1480 1490 1500 1510 1520 1530
pF1KE3 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_006 ATYNGPKHSLTQISQSMLDLCDEKLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVT
1360 1370 1380 1390 1400 1410
1540 1550 1560 1570 1580 1590
pF1KE3 QKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLIL
::::::::::::::::::::::::::.::::.::::::::::::::::::::::::::::
XP_006 QKMMAVPDSWPFHHPVNKKFVPDYYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLIL
1420 1430 1440 1450 1460 1470
1600 1610 1620 1630 1640 1650
pF1KE3 ANSVKYNGPESQYTKTAQEIVNICYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDP
::::::::::::::::::::::.::::.::::::::::::::::::::::::::::::::
XP_006 ANSVKYNGPESQYTKTAQEIVNVCYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDP
1480 1490 1500 1510 1520 1530
1660 1670 1680 1690 1700 1710
pF1KE3 MTPGPYTSQPPDMYDTNTSLSTSRDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLG
::::::: ::::.:::::::: ::::::::::::.::::: .:::::: : ::.::::
XP_006 MTPGPYTPQPPDLYDTNTSLSMSRDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLG
1540 1550 1560 1570 1580 1590
1720 1730 1740 1750 1760 1770
pF1KE3 EEDSDVDVEGYDDEEEDGKPKPPAPEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGE
:::::::.::::::::::::: ::::: ::::::::::::::::.:::::::::.::::
XP_006 EEDSDVDIEGYDDEEEDGKPKTPAPEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGE
1600 1610 1620 1630 1640 1650
1780 1790 1800 1810 1820
pF1KE3 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK
::::::::::::::::::::::::::::::: :::::::: :::. .
XP_006 DDEEDAGSDEEGDNPFSAIQLSESGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSY
1660 1670 1680 1690 1700 1710
XP_006 EGDGGEASHGLEDSNISYGSYEEPDPKSNTQDTSFSSIGGYEVSEEEEDEEEEEQRSGPS
1720 1730 1740 1750 1760 1770
>>XP_005262354 (OMIM: 300966,313650,314250) PREDICTED: t (1906 aa)
initn: 11043 init1: 9207 opt: 10407 Z-score: 8315.4 bits: 1551.9 E(85289): 0
Smith-Waterman score: 11450; 93.5% identity (97.0% similar) in 1824 aa overlap (1-1817:1-1803)
10 20 30 40 50
pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSIT----
130 140 150 160 170
180 190 200 210 220 230
pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.::::::: ::::::::::::::::::::::::::::::::::
XP_005 -----------------GEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
180 190 200 210
240 250 260 270 280 290
pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
460 470 480 490 500 510
540 550 560 570 580 590
pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
520 530 540 550 560 570
600 610 620 630 640 650
pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
580 590 600 610 620 630
660 670 680 690 700 710
pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
640 650 660 670 680 690
720 730 740 750 760 770
pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
700 710 720 730 740 750
780 790 800 810 820 830
pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
760 770 780 790 800 810
840 850 860 870 880 890
pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
820 830 840 850 860 870
900 910 920 930 940 950
pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
880 890 900 910 920 930
960 970 980 990 1000 1010
pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
940 950 960 970 980 990
1020 1030 1040 1050 1060 1070
pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
XP_005 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1000 1010 1020 1030 1040 1050
1080 1090 1100 1110 1120 1130
pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
XP_005 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1060 1070 1080 1090 1100 1110
1140 1150 1160 1170 1180 1190
pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY
: ::::::::.::::.::::::::::::: :::.:::.:::::.::::::::::::::::
XP_005 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1120 1130 1140 1150 1160 1170
1200 1210 1220 1230 1240 1250
pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::.::.:::::::.::::::::::::::::::::::::
XP_005 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1180 1190 1200 1210 1220 1230
1260 1270 1280 1290 1300 1310
pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ
:::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::
XP_005 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1240 1250 1260 1270 1280 1290
1320 1330 1340 1350 1360 1370
pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
:::::::::::::::::::::::::.::::::.. :::::::::::::::::::::::::
XP_005 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1300 1310 1320 1330 1340 1350
1380 1390 1400 1410 1420 1430
pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK
::::::::: :::::::::::::::::::::::::::::::::.::::::::::::::::
XP_005 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1360 1370 1380 1390 1400 1410
1440 1450 1460 1470 1480 1490
pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
XP_005 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1420 1430 1440 1450 1460 1470
1500 1510 1520 1530 1540 1550
pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1480 1490 1500 1510 1520 1530
1560 1570 1580 1590 1600 1610
pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI
:::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::.
XP_005 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1540 1550 1560 1570 1580 1590
1620 1630 1640 1650 1660 1670
pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS
::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: :
XP_005 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1600 1610 1620 1630 1640 1650
1680 1690 1700 1710 1720 1730
pF1KE3 RDASVFQDESNLSVLDISTATPEKQ---MCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPP
:::::::::::.::::: .:::::: : ::.:::::::::::.::::::::::::: :
XP_005 RDASVFQDESNMSVLDIPSATPEKQVTQMRQGRGRLGEEDSDVDIEGYDDEEEDGKPKTP
1660 1670 1680 1690 1700 1710
1740 1750 1760 1770 1780 1790
pF1KE3 APEG--GDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSE
:::: ::::::::::::::::.:::::::::.:::::::::::::::::::::::::::
XP_005 APEGEDGDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSE
1720 1730 1740 1750 1760 1770
1800 1810 1820
pF1KE3 SGSDSDVGYGGIRPKQPFMLQHASGEHKDGHGK
:::::::: :::::::: :::. .
XP_005 SGSDSDVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEE
1780 1790 1800 1810 1820 1830
>>NP_620278 (OMIM: 300966,313650,314250) transcription i (1872 aa)
initn: 11044 init1: 9207 opt: 9783 Z-score: 7816.9 bits: 1459.7 E(85289): 0
Smith-Waterman score: 11200; 92.2% identity (95.7% similar) in 1819 aa overlap (1-1817:1-1769)
10 20 30 40 50
pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
NP_620 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
NP_620 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.::
NP_620 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSIT----
130 140 150 160 170
180 190 200 210 220 230
pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.::::::: ::::::::::::::::::::::::::::::::::
NP_620 -----------------GEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
180 190 200 210
240 250 260 270 280 290
pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
NP_620 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
220 230 240 250 260 270
300 310 320 330 340 350
pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
NP_620 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
280 290 300 310 320 330
360 370 380 390 400 410
pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
NP_620 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
340 350 360 370 380 390
420 430 440 450 460 470
pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
NP_620 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
400 410 420 430 440 450
480 490 500 510 520 530
pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
NP_620 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
460 470 480 490 500 510
540 550 560 570 580 590
pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
NP_620 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
520 530 540 550 560 570
600 610 620 630 640 650
pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
NP_620 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
580 590 600 610 620 630
660 670 680 690 700 710
pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
NP_620 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
640 650 660 670 680 690
720 730 740 750 760 770
pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
NP_620 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
700 710 720 730 740 750
780 790 800 810 820 830
pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
NP_620 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
760 770 780 790 800 810
840 850 860 870 880 890
pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
820 830 840 850 860 870
900 910 920 930 940 950
pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
NP_620 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
880 890 900 910 920 930
960 970 980 990 1000 1010
pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::::
NP_620 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQPVKKTVTGTDADLRRLS
940 950 960 970 980 990
1020 1030 1040 1050 1060 1070
pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
::::::::::::::::::::::::::::::::::::::.:::::::::::::::::::::
NP_620 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQARSGEGPMSKFARGSRFSVAEHQ
1000 1010 1020 1030 1040 1050
1080 1090 1100 1110 1120 1130
pF1KE3 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSISAEDSDFEEMGKNIENMLQNKKTSSQLSR
:::::::::::::::::::::::::::::: :::::::::::::::::::::::::::::
NP_620 ERYKEECQRIFDLQNKVLSSTEVLSTDTDSSSAEDSDFEEMGKNIENMLQNKKTSSQLSR
1060 1070 1080 1090 1100 1110
1140 1150 1160 1170 1180 1190
pF1KE3 EWEEQERKELRRMLLVAGSAASGNNHRDDVTASMTSLKSSATGHCLKIYRTFRDEEGKEY
: ::::::::.::::.::::::::::::: :::.:::.:::::.::::::::::::::::
NP_620 EREEQERKELQRMLLAAGSAASGNNHRDDDTASVTSLNSSATGRCLKIYRTFRDEEGKEY
1120 1130 1140 1150 1160 1170
1200 1210 1220 1230 1240 1250
pF1KE3 VRCETVRKPAVIDAYVRIRTTKDEKFIQKFALFDEKHREEMRKERRRIQEQLRRLKRNQE
::::::::::::::::::::::::.::.:::::::.::::::::::::::::::::::::
NP_620 VRCETVRKPAVIDAYVRIRTTKDEEFIRKFALFDEQHREEMRKERRRIQEQLRRLKRNQE
1180 1190 1200 1210 1220 1230
1260 1270 1280 1290 1300 1310
pF1KE3 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNVPPSKPVAMTEEQ
:::::::::::::::::::::::::::::::::::::::::::::::.:::.::::::::
NP_620 KEKLKGPPEKKPKKMKERPDLKLKCGACGAIGHMRTNKFCPLYYQTNAPPSNPVAMTEEQ
1240 1250 1260 1270 1280 1290
1320 1330 1340 1350 1360 1370
pF1KE3 EEELEKTVIHNDNEELIKVEGTKIVFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVG
:::::::::::::::::::::::::.::::::.. :::::::::::::::::::::::::
NP_620 EEELEKTVIHNDNEELIKVEGTKIVLGKQLIESADEVRRKSLVLKFPKQQLPPKKKRRVG
1300 1310 1320 1330 1340 1350
1380 1390 1400 1410 1420 1430
pF1KE3 TTVHCDYLNIPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYK
::::::::: :::::::::::::::::::::::::::::::::.::::::::::::::::
NP_620 TTVHCDYLNRPHKSIHRRRTDPMVTLSSILESIINDMRDLPNTYPFHTPVNAKVVKDYYK
1360 1370 1380 1390 1400 1410
1440 1450 1460 1470 1480 1490
pF1KE3 IITRPMDLQTLRENVRKCLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
::::::::::::::::: ::::::::::::::::::::::::::::::::::::::::::
NP_620 IITRPMDLQTLRENVRKRLYPSREEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDE
1420 1430 1440 1450 1460 1470
1500 1510 1520 1530 1540 1550
pF1KE3 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_620 KLKEKEDKLARLEKAINPLLDDDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPD
1480 1490 1500 1510 1520 1530
1560 1570 1580 1590 1600 1610
pF1KE3 YYKMIVNPVDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNI
:::.::::.::::::::::::::::::::::::::::::::::::::::::::::::::.
NP_620 YYKVIVNPMDLETIRKNISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNV
1540 1550 1560 1570 1580 1590
1620 1630 1640 1650 1660 1670
pF1KE3 CYQTITEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTS
::::.::::::::::::::::::::::::::::::::::::::: ::::.:::::::: :
NP_620 CYQTLTEYDEHLTQLEKDICTAKEAALEEAELESLDPMTPGPYTPQPPDLYDTNTSLSMS
1600 1610 1620 1630 1640 1650
1680 1690 1700 1710 1720 1730
pF1KE3 RDASVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPE
:::::::::::.::::: .::::::. : :: :
NP_620 RDASVFQDESNMSVLDIPSATPEKQVTQ--------------EGED--------------
1660 1670 1680 1690
1740 1750 1760 1770 1780 1790
pF1KE3 GGDGDLADEEEGTVQQPEASVLYEDLLISEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS
::::::::::::::::.:::::::::.::::::::::::::::::::::::::::::::
NP_620 -GDGDLADEEEGTVQQPQASVLYEDLLMSEGEDDEEDAGSDEEGDNPFSAIQLSESGSDS
1700 1710 1720 1730 1740 1750
1800 1810 1820
pF1KE3 DVGYGGIRPKQPFMLQHASGEHKDGHGK
::: :::::::: :::. .
NP_620 DVGSGGIRPKQPRMLQENTRMDMENEESMMSYEGDGGEASHGLEDSNISYGSYEEPDPKS
1760 1770 1780 1790 1800 1810
>>XP_005262357 (OMIM: 300966,313650,314250) PREDICTED: t (999 aa)
initn: 4953 init1: 4785 opt: 6499 Z-score: 5196.6 bits: 973.9 E(85289): 0
Smith-Waterman score: 6499; 94.8% identity (98.3% similar) in 997 aa overlap (1-995:1-997)
10 20 30 40 50
pF1KE3 MRPGCDLLLRAAATVTAA-IMSDSDSEEDSSGGGPFTLAGILFGNISGAGQLEGESVLDD
: ::::::::.:::.::: ::::.::.:::.:::::.:::.:::::.:::::::::::::
XP_005 MGPGCDLLLRTAATITAAAIMSDTDSDEDSAGGGPFSLAGFLFGNINGAGQLEGESVLDD
10 20 30 40 50 60
60 70 80 90 100 110
pF1KE3 ECKKHLAGLGALGLGSLITELTANEELTGTGGALVNDEGWIRSTEDAVDYSDINEVAEDE
:::::::::::::::::::::::::::::: :::::::::.:::::::::::::::::::
XP_005 ECKKHLAGLGALGLGSLITELTANEELTGTDGALVNDEGWVRSTEDAVDYSDINEVAEDE
70 80 90 100 110 120
120 130 140 150 160 170
pF1KE3 SQRHQQTMGSLQPLYHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDAITCVSE
:.:.:::::::::: ::::::::::::::::::::::::::::::::::::::.:: :::
XP_005 SRRYQQTMGSLQPLCHSDYDEDDYDADCEDIDCKLMPPPPPPPGPMKKDKDQDSITGVSE
130 140 150 160 170 180
180 190 200 210 220 230
pF1KE3 SGEDIILPSIIAPSFLASEKVDFSSYSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
.:: :::::::::: :::::::::: ::::::::::::::::::::::::::::::::::
XP_005 NGEGIILPSIIAPSSLASEKVDFSSSSDSESEMGPQEATQAESEDGKLTLPLAGIMQHDA
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 TKLLPSVTELFPEFRPGKVLRFLHLFGPGKNVPSVWRSARRKRKK-HRELIQEEQIQEVE
:::::::::::::::::::::::.::::::::::::::::::::: ::::::::::::::
XP_005 TKLLPSVTELFPEFRPGKVLRFLRLFGPGKNVPSVWRSARRKRKKKHRELIQEEQIQEVE
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 CSVESEVSQKSLWNYDYAPPPPPEQCLADDEITMMVPVESKFSQSTGDVDKVTDTKPRVA
:::::::::::::::::::::::::::.:::::::.::::::::::::.:::::::::::
XP_005 CSVESEVSQKSLWNYDYAPPPPPEQCLSDDEITMMAPVESKFSQSTGDIDKVTDTKPRVA
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 EWRYGPARLWYDMLGVSEDGSGFDYGFKLRKTQHEPVIKSRMMEEFRKLEESNGTDLLAD
:::::::::::::::: :::::::::::::::.:::::::::.::::::::.::::::::
XP_005 EWRYGPARLWYDMLGVPEDGSGFDYGFKLRKTEHEPVIKSRMIEEFRKLEENNGTDLLAD
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 ENFLMVTQLHWEDSIIWDGEDIKHKGTKPQGASLAGWLPSIKTRNVMAYNVQQGFAPTLD
:::::::::::::.:::::::.:::::::: ::::::::: :::.:::::::::: :::
XP_005 ENFLMVTQLHWEDDIIWDGEDVKHKGTKPQRASLAGWLPSSMTRNAMAYNVQQGFAATLD
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLALDPNDENLILEIPDEKEE
:::::::::::::::::::::::::::::::::::::::::.::::::::::::::::::
XP_005 DDKPWYSIFPIDNEDLVYGRWEDNIIWDAQAMPRLLEPPVLTLDPNDENLILEIPDEKEE
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 ATSNSPSKESKKESSLKKSRILLGKTGVIREEPQQNMSQPEVKDPWNLSNDEYYFPKQQG
:::::::::::::::::::::::::::::.::::::::::::::::::::::::.:::::
XP_005 ATSNSPSKESKKESSLKKSRILLGKTGVIKEEPQQNMSQPEVKDPWNLSNDEYYYPKQQG
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE3 LRGTFGGNIIQHSIPAMELWQPFFPTHMGPIKIRQFHRPPLKKYSFGALSQPGPHSVQPL
::::::::::::::::.:: ::::::::::::.:::::::::::::::::::::::::::
XP_005 LRGTFGGNIIQHSIPAVELRQPFFPTHMGPIKLRQFHRPPLKKYSFGALSQPGPHSVQPL
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE3 LKHIKKKAKMREQERQASGGGELFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
::::::::::::::::::::::.:::::::::::::::::::::::::::::::::::::
XP_005 LKHIKKKAKMREQERQASGGGEMFFMRTPQDLTGKDGDLILAEYSEENGPLMMQVGMATK
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE3 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQALENNLFRAPVYLHKMPE
:::::::::::::::::::::::::::::::::::::::::::.::::::::.:::::::
XP_005 IKNYYKRKPGKDPGAPDCKYGETVYCHTSPFLGSLHPGQLLQAFENNLFRAPIYLHKMPE
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE3 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSRRANMHIRDFLQVFIYRLFWKSK
:::::::::::::::::::::::::::::::::::::.::: ::::::::::::::::::
XP_005 TDFLIIRTRQGYYIRELVDIFVVGQQCPLFEVPGPNSKRANTHIRDFLQVFIYRLFWKSK
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE3 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAK
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DRPRRIRMEDIKKAFPSHSESSIRKRLKLCADFKRTGMDSNWWVLKSDFRLPTEEEIRAM
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE3 VSPEQCCAYYSMIAAKQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVHAAPWNTTRAFI
:::::::::::::::.::::::::::::::::::::::::::::::::..::::::::::
XP_005 VSPEQCCAYYSMIAAEQRLKDAGYGEKSFFAPEEENEEDFQMKIDDEVRTAPWNTTRAFI
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE3 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKDDKEPQAVKKTVTGTDADLRRLS
:::::::::::::::::::::::::::::::::::::
XP_005 AAMKGKCLLEVTGVADPTGCGEGFSYVKIPNKPTQQKVG
970 980 990
1020 1030 1040 1050 1060 1070
pF1KE3 LKNAKQLLRKFGVPEEEIKKLSRWEVIDVVRTMSTEQAHSGEGPMSKFARGSRFSVAEHQ
>>NP_001276975 (OMIM: 607576) cat eye syndrome critical (1300 aa)
initn: 217 init1: 217 opt: 263 Z-score: 212.0 bits: 52.0 E(85289): 4.6e-05
Smith-Waterman score: 276; 24.2% identity (55.6% similar) in 360 aa overlap (1373-1710:104-444)
1350 1360 1370 1380 1390 1400
pF1KE3 VFGKQLIENVHEVRRKSLVLKFPKQQLPPKKKRRVGTTVHCDYLNIPHKSIHRRRTDPMV
..:.. . :.: . : .. :.
NP_001 GPGQGTWWLLCQTEEEWRQVTESFRERTSLRERQLYKLLSEDFLPEICNMIAQKGKRPQR
80 90 100 110 120 130
1410 1420 1430 1440 1450 1460
pF1KE3 TLSSILESIINDMRDLPNTHPFHTPVNAKVVKDYYKIIT--RPMDLQTLRENVRKCLYPS
: . . ..: .. .. .::: ... :. : : . : . ... .. :
NP_001 TKAELHPRWMSDHLSIKPVKQEETPVLTRIEKQKRKEEEEERQILLAVQKKEQEQML---
140 150 160 170 180 190
1470 1480 1490 1500 1510
pF1KE3 REEFREHLELIVKNSATYNGPKHSLTQISQSMLDLCDEKLKEKEDKL-----ARLEKAIN
.:: ...:: :: :. . :. . .. : ..: . ..: : :: .
NP_001 KEERKRELEEKVK--AVEDRAKRRKLREERAWLLAQGKELPPELSHLDPNSPMREEKKTK
200 210 220 230 240
1520 1530 1540 1550 1560 1570
pF1KE3 PLLD-DDDQVAFSFILDNIVTQKMMAVPDSWPFHHPVNKKFVPDYYKMIVNPVDLETIRK
:.. ::: .:. .:: . ..: ::::: .::.....:.::..: :.:. ...:
NP_001 DLFELDDDFTAMYKVLDVVKAHK-----DSWPFLEPVDESYAPNYYQIIKAPMDISSMEK
250 260 270 280 290 300
1580 1590 1600 1610 1620
pF1KE3 NISKHKYQSRESFLDDVNLILANSVKYNGPESQYTKTAQEIVNICYQTITEY--------
... : ..: :..:.. .. : :::: :.::: .... .... ..
NP_001 KLNGGLYCTKEEFVNDMKTMFRNCRKYNGESSEYTKMSDNLERCFHRAMMKHFPGEDGDT
310 320 330 340 350 360
1630 1640 1650 1660 1670 1680
pF1KE3 DEHL-----TQLEKDICTAKEAALEEAELESLDPMTPGPYTSQPPDMYDTNTSLSTSRDA
::.. . :: : ... .. .: :: : .: : : . . :: .: :
NP_001 DEEFWIREDEKREKRRSRAGRSGGSHVWTRSRDP--EGSSRKQQP-MENGGKSLPPTRRA
370 380 390 400 410 420
1690 1700 1710 1720 1730 1740
pF1KE3 -SVFQDESNLSVLDISTATPEKQMCQGQGRLGEEDSDVDVEGYDDEEEDGKPKPPAPEGG
: .:.:. :.. : ... ..::
NP_001 PSSGDDQSS------SSTQPPREVGTSNGRGFSHPLHCGGTPSQAPFLNQMRPAVPGTFG
430 440 450 460 470
1826 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 07:16:12 2016 done: Tue Nov 8 07:16:15 2016
Total Scan time: 19.080 Total Display time: 1.330
Function used was FASTA [36.3.4 Apr, 2011]