Result of FASTA (omim) for
pFN21AE3469
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3469, 1451 aa
1>>>pF1KE3469 1451 - 1451 aa - 1451 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 9.9456+/-0.000567; mu= 4.3613+/- 0.035
mean_var=573.1354+/-125.074, 0's: 0 Z-trim(117.0): 105 B-trim: 1023 in 1/60
Lambda= 0.053573
statistics sampled from 28585 (28683) to 28585 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.677), E-opt: 0.2 (0.336), width: 16
Scan time: 17.000
The best scores are: opt bits E(85289)
NP_112562 (OMIM: 605792) inactive serine/threonine (1451) 9664 764.4 0
NP_938207 (OMIM: 605792) inactive serine/threonine (1491) 7120 567.8 2.2e-160
NP_001188386 (OMIM: 605792) inactive serine/threon (1497) 7098 566.1 7.2e-160
XP_011523331 (OMIM: 605792) PREDICTED: inactive se (1532) 5505 443.0 8.4e-123
XP_016880349 (OMIM: 605792) PREDICTED: inactive se (1310) 5159 416.1 8.7e-115
XP_016880350 (OMIM: 605792) PREDICTED: inactive se (1099) 4502 365.2 1.5e-99
>>NP_112562 (OMIM: 605792) inactive serine/threonine-pro (1451 aa)
initn: 9664 init1: 9664 opt: 9664 Z-score: 4063.1 bits: 764.4 E(85289): 0
Smith-Waterman score: 9664; 100.0% identity (100.0% similar) in 1451 aa overlap (1-1451:1-1451)
10 20 30 40 50 60
pF1KE3 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
970 980 990 1000 1010 1020
1030 1040 1050 1060 1070 1080
pF1KE3 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSTSSPIEEDFEGIQGAFAQPQVSG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSTSSPIEEDFEGIQGAFAQPQVSG
1030 1040 1050 1060 1070 1080
1090 1100 1110 1120 1130 1140
pF1KE3 EEKFQMRKILGKNAEILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 EEKFQMRKILGKNAEILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSIS
1090 1100 1110 1120 1130 1140
1150 1160 1170 1180 1190 1200
pF1KE3 YEPDSSFKEASCKTPKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 YEPDSSFKEASCKTPKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWN
1150 1160 1170 1180 1190 1200
1210 1220 1230 1240 1250 1260
pF1KE3 SQEFIQTLSDDFISVRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 SQEFIQTLSDDFISVRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSS
1210 1220 1230 1240 1250 1260
1270 1280 1290 1300 1310 1320
pF1KE3 PPHATQRRSLPKVEAFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 PPHATQRRSLPKVEAFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTA
1270 1280 1290 1300 1310 1320
1330 1340 1350 1360 1370 1380
pF1KE3 NDQRHLEEQETDSKKEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 NDQRHLEEQETDSKKEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDL
1330 1340 1350 1360 1370 1380
1390 1400 1410 1420 1430 1440
pF1KE3 PKGSERETNIKDQKVGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_112 PKGSERETNIKDQKVGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSR
1390 1400 1410 1420 1430 1440
1450
pF1KE3 IIVLDQSDLSD
:::::::::::
NP_112 IIVLDQSDLSD
1450
>>NP_938207 (OMIM: 605792) inactive serine/threonine-pro (1491 aa)
initn: 7104 init1: 7104 opt: 7120 Z-score: 3000.4 bits: 567.8 E(85289): 2.2e-160
Smith-Waterman score: 9523; 97.3% identity (97.3% similar) in 1483 aa overlap (1-1443:1-1483)
10 20 30 40 50 60
pF1KE3 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQ
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 CTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDST
850 860 870 880 890 900
910 920 930 940 950 960
pF1KE3 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 RMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESE
910 920 930 940 950 960
970 980 990 1000 1010 1020
pF1KE3 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 AENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLG
970 980 990 1000 1010 1020
1030 1040 1050
pF1KE3 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS-----------------------
:::::::::::::::::::::::::::::::::::::
NP_938 SFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTP
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090 1100
pF1KE3 -----------------TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS
:::::::::::::::::::::::::::::::::::::::::::
NP_938 DGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRS
1090 1100 1110 1120 1130 1140
1110 1120 1130 1140 1150 1160
pF1KE3 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 QFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHA
1150 1160 1170 1180 1190 1200
1170 1180 1190 1200 1210 1220
pF1KE3 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 PTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAK
1210 1220 1230 1240 1250 1260
1230 1240 1250 1260 1270 1280
pF1KE3 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 KLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHH
1270 1280 1290 1300 1310 1320
1290 1300 1310 1320 1330 1340
pF1KE3 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 IDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSM
1330 1340 1350 1360 1370 1380
1350 1360 1370 1380 1390 1400
pF1KE3 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_938 LLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKR
1390 1400 1410 1420 1430 1440
1410 1420 1430 1440 1450
pF1KE3 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
:::::::::::::::::::::::::::::::::::::::::::
NP_938 KREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
1450 1460 1470 1480 1490
>>NP_001188386 (OMIM: 605792) inactive serine/threonine- (1497 aa)
initn: 5678 init1: 5678 opt: 7098 Z-score: 2991.2 bits: 566.1 E(85289): 7.2e-160
Smith-Waterman score: 9501; 96.9% identity (96.9% similar) in 1489 aa overlap (1-1443:1-1489)
10 20 30 40 50 60
pF1KE3 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
130 140 150 160 170 180
190 200 210 220 230
pF1KE3 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGK------FYLTGATQMAYLGSLPVIGEKE
:::::::::::::::::::::::::::::::: ::::::::::::::::::::::
NP_001 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKAMPWFQFYLTGATQMAYLGSLPVIGEKE
190 200 210 220 230 240
240 250 260 270 280 290
pF1KE3 VIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSS
250 260 270 280 290 300
300 310 320 330 340 350
pF1KE3 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQI
310 320 330 340 350 360
360 370 380 390 400 410
pF1KE3 SDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLY
370 380 390 400 410 420
420 430 440 450 460 470
pF1KE3 NWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRL
430 440 450 460 470 480
480 490 500 510 520 530
pF1KE3 PKPYYDIVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKPYYDIVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDV
490 500 510 520 530 540
540 550 560 570 580 590
pF1KE3 NVYLGLTSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NVYLGLTSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQ
550 560 570 580 590 600
600 610 620 630 640 650
pF1KE3 DAPCPAPFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DAPCPAPFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQV
610 620 630 640 650 660
660 670 680 690 700 710
pF1KE3 DELKSMEEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DELKSMEEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKS
670 680 690 700 710 720
720 730 740 750 760 770
pF1KE3 NLNNMSTTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWAT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NLNNMSTTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWAT
730 740 750 760 770 780
780 790 800 810 820 830
pF1KE3 SREFTNAYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SREFTNAYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQN
790 800 810 820 830 840
840 850 860 870 880 890
pF1KE3 TDEQFQCTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TDEQFQCTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPS
850 860 870 880 890 900
900 910 920 930 940 950
pF1KE3 CHWDSTRMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 CHWDSTRMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSS
910 920 930 940 950 960
960 970 980 990 1000 1010
pF1KE3 LTLESEAENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LTLESEAENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHG
970 980 990 1000 1010 1020
1020 1030 1040 1050
pF1KE3 RQPRLGSFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS-----------------
:::::::::::::::::::::::::::::::::::::::::::
NP_001 RQPRLGSFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDIT
1030 1040 1050 1060 1070 1080
1060 1070 1080 1090
pF1KE3 -----------------------TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNA
:::::::::::::::::::::::::::::::::::::
NP_001 DEFLTPDGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNA
1090 1100 1110 1120 1130 1140
1100 1110 1120 1130 1140 1150
pF1KE3 EILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 EILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKT
1150 1160 1170 1180 1190 1200
1160 1170 1180 1190 1200 1210
pF1KE3 PKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFIS
1210 1220 1230 1240 1250 1260
1220 1230 1240 1250 1260 1270
pF1KE3 VRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVE
1270 1280 1290 1300 1310 1320
1280 1290 1300 1310 1320 1330
pF1KE3 AFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSK
1330 1340 1350 1360 1370 1380
1340 1350 1360 1370 1380 1390
pF1KE3 KEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQK
1390 1400 1410 1420 1430 1440
1400 1410 1420 1430 1440 1450
pF1KE3 VGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
:::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
1450 1460 1470 1480 1490
>>XP_011523331 (OMIM: 605792) PREDICTED: inactive serine (1532 aa)
initn: 8051 init1: 5502 opt: 5505 Z-score: 2325.7 bits: 443.0 E(85289): 8.4e-123
Smith-Waterman score: 9157; 94.5% identity (94.5% similar) in 1483 aa overlap (1-1402:1-1483)
10 20 30 40 50 60
pF1KE3 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSRAVRLPVPCPVQLGTLRNDSLEAQLHEYVKQGNYVKVKKILKKGIYVDAVNSLGQTAL
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FVAALLGLRKFVDVLVDYGSDPNHRCFDGSTPVHAAAFSGNQWILSKLLDAGGDLRLHDE
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLVYSPSWCG
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEKEVIQADD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHSSKLRHPY
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQISDALRY
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPE
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYD
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGL
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPA
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSM
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTN
730 740 750 760 770 780
790 800 810 820
pF1KE3 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRM-----------------
:::::::::::::::::::::::::::::::::::::::::::
XP_011 AYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMVRDFQGGHFGKRSRKRN
790 800 810 820 830 840
830 840 850
pF1KE3 ------------------------LPTLCDPGKQNTDEQFQCTQGAKDSLETSRIQNTSS
::::::::::::::::::::::::::::::::::::
XP_011 GCGWKPFTQVSKVNTGDQSEISHQLPTLCDPGKQNTDEQFQCTQGAKDSLETSRIQNTSS
850 860 870 880 890 900
860 870 880 890 900 910
pF1KE3 QGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDSTRMSVEPVSSEIYNAESRNK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDSTRMSVEPVSSEIYNAESRNK
910 920 930 940 950 960
920 930 940 950 960 970
pF1KE3 DDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESEAENEPDALLQPPIRSPENT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESEAENEPDALLQPPIRSPENT
970 980 990 1000 1010 1020
980 990 1000 1010 1020 1030
pF1KE3 DWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLGSFTSIRHPSPRQKEQPEHS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLGSFTSIRHPSPRQKEQPEHS
1030 1040 1050 1060 1070 1080
1040 1050
pF1KE3 EAFQASSDTLVAVEKSYS----------------------------------------TS
:::::::::::::::::: ::
XP_011 EAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTPDGEYFYSSTAQENLALETS
1090 1100 1110 1120 1130 1140
1060 1070 1080 1090 1100 1110
pF1KE3 SPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRSQFQPVRSTEDEQEETSKES
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRSQFQPVRSTEDEQEETSKES
1150 1160 1170 1180 1190 1200
1120 1130 1140 1150 1160 1170
pF1KE3 PKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHAPTSVSTPLSPGSVSSAASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHAPTSVSTPLSPGSVSSAASQ
1210 1220 1230 1240 1250 1260
1180 1190 1200 1210 1220 1230
pF1KE3 YKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAKKLDSLLTSSETPPSRLTGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 YKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAKKLDSLLTSSETPPSRLTGL
1270 1280 1290 1300 1310 1320
1240 1250 1260 1270 1280 1290
pF1KE3 KRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHHIDELPPPSQELLDDIELLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHHIDELPPPSQELLDDIELLK
1330 1340 1350 1360 1370 1380
1300 1310 1320 1330 1340 1350
pF1KE3 QQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSMLLSKETEDLGEDTERAHST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSMLLSKETEDLGEDTERAHST
1390 1400 1410 1420 1430 1440
1360 1370 1380 1390 1400 1410
pF1KE3 LDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKRKREDSITPERRKSEGVLGT
:::::::::::::::::::::::::::::::::::::::::::
XP_011 LDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKRKREDSITPERRKSEGVLGT
1450 1460 1470 1480 1490 1500
1420 1430 1440 1450
pF1KE3 SEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
XP_011 SEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
1510 1520 1530
>>XP_016880349 (OMIM: 605792) PREDICTED: inactive serine (1310 aa)
initn: 5134 init1: 5134 opt: 5159 Z-score: 2181.8 bits: 416.1 E(85289): 8.7e-115
Smith-Waterman score: 8232; 94.2% identity (94.2% similar) in 1340 aa overlap (144-1443:1-1302)
120 130 140 150 160 170
pF1KE3 DLRLHDERGQNPKTWALTAGKERSTQIVEFMQRCASHMQAIIQGFSYDLLKKIDSPQRLV
::::::::::::::::::::::::::::::
XP_016 MQRCASHMQAIIQGFSYDLLKKIDSPQRLV
10 20 30
180 190 200 210 220 230
pF1KE3 YSPSWCGGLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YSPSWCGGLVQGNPNGSPNRLLKAGVISAQNIYSFGFGKFYLTGATQMAYLGSLPVIGEK
40 50 60 70 80 90
240 250 260 270 280 290
pF1KE3 EVIQADDEPTFSFFSGPYMVMTNLVWNGSRVTVKELNLPTHPHCSRLRLADLLIAEQEHS
:::::::::::::::::::::::
XP_016 EVIQADDEPTFSFFSGPYMVMTN-------------------------------------
100 110
300 310 320 330 340 350
pF1KE3 SKLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQ
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 -KLRHPYLLQLMAVCLSQDLEKTRLVYERITIGTLFSVLHERRSQFPVLHMEVIVHLLLQ
120 130 140 150 160 170
360 370 380 390 400 410
pF1KE3 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ISDALRYLHFQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQL
180 190 200 210 220 230
420 430 440 450 460 470
pF1KE3 YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 YNWAAPEVILQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVR
240 250 260 270 280 290
480 490 500 510 520 530
pF1KE3 LPKPYYDIVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LPKPYYDIVKSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPD
300 310 320 330 340 350
540 550 560 570 580 590
pF1KE3 VNVYLGLTSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VNVYLGLTSEHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQN
360 370 380 390 400 410
600 610 620 630 640 650
pF1KE3 QDAPCPAPFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QDAPCPAPFMAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQ
420 430 440 450 460 470
660 670 680 690 700 710
pF1KE3 VDELKSMEEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 VDELKSMEEELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAK
480 490 500 510 520 530
720 730 740 750 760 770
pF1KE3 SNLNNMSTTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SNLNNMSTTEEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWA
540 550 560 570 580 590
780 790 800 810 820 830
pF1KE3 TSREFTNAYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSREFTNAYKLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQ
600 610 620 630 640 650
840 850 860 870 880 890
pF1KE3 NTDEQFQCTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NTDEQFQCTQGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASP
660 670 680 690 700 710
900 910 920 930 940 950
pF1KE3 SCHWDSTRMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SCHWDSTRMSVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQS
720 730 740 750 760 770
960 970 980 990 1000 1010
pF1KE3 SLTLESEAENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SLTLESEAENEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQH
780 790 800 810 820 830
1020 1030 1040 1050
pF1KE3 GRQPRLGSFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS----------------
::::::::::::::::::::::::::::::::::::::::::::
XP_016 GRQPRLGSFTSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDI
840 850 860 870 880 890
1060 1070 1080 1090
pF1KE3 ------------------------TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKN
::::::::::::::::::::::::::::::::::::
XP_016 TDEFLTPDGEYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKN
900 910 920 930 940 950
1100 1110 1120 1130 1140 1150
pF1KE3 AEILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 AEILPRSQFQPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCK
960 970 980 990 1000 1010
1160 1170 1180 1190 1200 1210
pF1KE3 TPKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPKINHAPTSVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFI
1020 1030 1040 1050 1060 1070
1220 1230 1240 1250 1260 1270
pF1KE3 SVRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVRERAKKLDSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKV
1080 1090 1100 1110 1120 1130
1280 1290 1300 1310 1320 1330
pF1KE3 EAFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EAFSQHHIDELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDS
1140 1150 1160 1170 1180 1190
1340 1350 1360 1370 1380 1390
pF1KE3 KKEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KKEDSSMLLSKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQ
1200 1210 1220 1230 1240 1250
1400 1410 1420 1430 1440 1450
pF1KE3 KVGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KVGEEKRKREDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
1260 1270 1280 1290 1300 1310
>>XP_016880350 (OMIM: 605792) PREDICTED: inactive serine (1099 aa)
initn: 4486 init1: 4486 opt: 4502 Z-score: 1908.1 bits: 365.2 E(85289): 1.5e-99
Smith-Waterman score: 6905; 96.1% identity (96.3% similar) in 1091 aa overlap (393-1443:1-1091)
370 380 390 400 410 420
pF1KE3 FQGFIHRSLSSYAVHIISPGEARLTNLEYMLESEDRGVQRDLTRVPLPTQLYNWAAPEVI
...:::::::::::::::::::::::::::
XP_016 MNDEDRGVQRDLTRVPLPTQLYNWAAPEVI
10 20 30
430 440 450 460 470 480
pF1KE3 LQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LQKAATVKSDIYSFSMIMQEILTDDIPWKGLDGSVVKKAVVSGNYLEADVRLPKPYYDIV
40 50 60 70 80 90
490 500 510 520 530 540
pF1KE3 KSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGLTS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KSGIHVKQKDRTMNLQDIRYILKNDLKDFTGAQRTQPTESPRVQRYGLHPDVNVYLGLTS
100 110 120 130 140 150
550 560 570 580 590 600
pF1KE3 EHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPAPF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EHPRETPDMEIIELKEMGSQPHSPRVHSLFTEGTLDPQAPDPCLMARETQNQDAPCPAPF
160 170 180 190 200 210
610 620 630 640 650 660
pF1KE3 MAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSMEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAEEASSPSTGQPSLCSFEINEIYSGCLILEDDIEEPPGAASSLEADGPNQVDELKSMEE
220 230 240 250 260 270
670 680 690 700 710 720
pF1KE3 ELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMSTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELDKMEREACCFGSEDESSSKAETEYSFDDWDWQNGSLSSLSLPESTREAKSNLNNMSTT
280 290 300 310 320 330
730 740 750 760 770 780
pF1KE3 EEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTNAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EEYLISKCVLDLKIMQTIMHENDDRLRNIEQILDEVEMKQKEQEERMSLWATSREFTNAY
340 350 360 370 380 390
790 800 810 820 830 840
pF1KE3 KLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQCT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KLPLAVGPPSLNYIPPVLQLSGGQKPDTSGNYPTLPRFPRMLPTLCDPGKQNTDEQFQCT
400 410 420 430 440 450
850 860 870 880 890 900
pF1KE3 QGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDSTRM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QGAKDSLETSRIQNTSSQGRPRESTAQAKATQFNSALFTLSSHRQGPSASPSCHWDSTRM
460 470 480 490 500 510
910 920 930 940 950 960
pF1KE3 SVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESEAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVEPVSSEIYNAESRNKDDGKVHLKWKMEVKEMAKKAATGQLTVPPWHPQSSLTLESEAE
520 530 540 550 560 570
970 980 990 1000 1010 1020
pF1KE3 NEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLGSF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NEPDALLQPPIRSPENTDWQRVIEYHRENDEPRGNGKFDKTGNNDCDSDQHGRQPRLGSF
580 590 600 610 620 630
1030 1040 1050
pF1KE3 TSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYS-------------------------
:::::::::::::::::::::::::::::::::::
XP_016 TSIRHPSPRQKEQPEHSEAFQASSDTLVAVEKSYSHQSMQSTCSPESSEDITDEFLTPDG
640 650 660 670 680 690
1060 1070 1080 1090 1100
pF1KE3 ---------------TSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRSQF
:::::::::::::::::::::::::::::::::::::::::::::
XP_016 EYFYSSTAQENLALETSSPIEEDFEGIQGAFAQPQVSGEEKFQMRKILGKNAEILPRSQF
700 710 720 730 740 750
1110 1120 1130 1140 1150 1160
pF1KE3 QPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHAPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 QPVRSTEDEQEETSKESPKELKEKDISLTDIQDLSSISYEPDSSFKEASCKTPKINHAPT
760 770 780 790 800 810
1170 1180 1190 1200 1210 1220
pF1KE3 SVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAKKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SVSTPLSPGSVSSAASQYKDCLESITFQVKTEFASCWNSQEFIQTLSDDFISVRERAKKL
820 830 840 850 860 870
1230 1240 1250 1260 1270 1280
pF1KE3 DSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHHID
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 DSLLTSSETPPSRLTGLKRLSSFIGAGSPSLVKACDSSPPHATQRRSLPKVEAFSQHHID
880 890 900 910 920 930
1290 1300 1310 1320 1330 1340
pF1KE3 ELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSMLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ELPPPSQELLDDIELLKQQQGSSTVLHENTASDGGGTANDQRHLEEQETDSKKEDSSMLL
940 950 960 970 980 990
1350 1360 1370 1380 1390 1400
pF1KE3 SKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKRKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKETEDLGEDTERAHSTLDEDLERWLQPPEESVELQDLPKGSERETNIKDQKVGEEKRKR
1000 1010 1020 1030 1040 1050
1410 1420 1430 1440 1450
pF1KE3 EDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
:::::::::::::::::::::::::::::::::::::::::
XP_016 EDSITPERRKSEGVLGTSEEDELKSCFWKRLGWSESSRIIVLDQSDLSD
1060 1070 1080 1090
1451 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Tue Nov 8 02:10:38 2016 done: Tue Nov 8 02:10:40 2016
Total Scan time: 17.000 Total Display time: 0.410
Function used was FASTA [36.3.4 Apr, 2011]