Result of FASTA (ccds) for
pFN21AE3434
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3434, 886 aa
1>>>pF1KE3434 886 - 886 aa - 886 aa
Library: human.CCDS.faa
18511270 residues in 32554 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.3915+/-0.000822; mu= 8.9098+/- 0.050
mean_var=169.8908+/-33.825, 0's: 0 Z-trim(114.3): 75 B-trim: 0 in 0/52
Lambda= 0.098399
statistics sampled from 14796 (14871) to 14796 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.751), E-opt: 0.2 (0.457), width: 16
Scan time: 4.530
The best scores are: opt bits E(32554)
CCDS45961.1 PDE4A gene_id:5141|Hs108|chr19 ( 886) 5902 850.0 0
CCDS45962.1 PDE4A gene_id:5141|Hs108|chr19 ( 860) 5164 745.3 1.1e-214
CCDS45963.1 PDE4A gene_id:5141|Hs108|chr19 ( 825) 5158 744.4 1.9e-214
CCDS58649.1 PDE4A gene_id:5141|Hs108|chr19 ( 864) 5150 743.3 4.4e-214
CCDS12238.1 PDE4A gene_id:5141|Hs108|chr19 ( 647) 4147 600.8 2.5e-171
CCDS56370.1 PDE4D gene_id:5144|Hs108|chr5 ( 507) 2203 324.8 2.5e-88
CCDS56369.1 PDE4D gene_id:5144|Hs108|chr5 ( 518) 2203 324.8 2.5e-88
CCDS54858.1 PDE4D gene_id:5144|Hs108|chr5 ( 673) 2203 324.9 3.1e-88
CCDS56371.1 PDE4D gene_id:5144|Hs108|chr5 ( 679) 2203 324.9 3.1e-88
CCDS56372.1 PDE4D gene_id:5144|Hs108|chr5 ( 687) 2203 324.9 3.2e-88
CCDS56373.1 PDE4D gene_id:5144|Hs108|chr5 ( 745) 2203 324.9 3.4e-88
CCDS54859.1 PDE4D gene_id:5144|Hs108|chr5 ( 748) 2203 324.9 3.4e-88
CCDS47213.1 PDE4D gene_id:5144|Hs108|chr5 ( 809) 2203 324.9 3.6e-88
CCDS72802.1 PDE4B gene_id:5142|Hs108|chr1 ( 503) 2174 320.7 4.3e-87
CCDS30743.1 PDE4B gene_id:5142|Hs108|chr1 ( 564) 2174 320.7 4.7e-87
CCDS30742.1 PDE4B gene_id:5142|Hs108|chr1 ( 721) 2174 320.8 5.7e-87
CCDS632.1 PDE4B gene_id:5142|Hs108|chr1 ( 736) 2174 320.8 5.8e-87
CCDS46016.1 PDE4C gene_id:5143|Hs108|chr19 ( 606) 2070 306.0 1.4e-82
CCDS42523.1 PDE4C gene_id:5143|Hs108|chr19 ( 680) 2070 306.0 1.5e-82
CCDS12373.1 PDE4C gene_id:5143|Hs108|chr19 ( 712) 2070 306.0 1.6e-82
CCDS5175.1 PDE7B gene_id:27115|Hs108|chr6 ( 450) 742 117.4 6.1e-26
CCDS34901.1 PDE7A gene_id:5150|Hs108|chr8 ( 456) 720 114.2 5.4e-25
CCDS56538.1 PDE7A gene_id:5150|Hs108|chr8 ( 482) 720 114.3 5.6e-25
CCDS34190.1 PDE8B gene_id:8622|Hs108|chr5 ( 830) 619 100.1 1.8e-20
CCDS34192.1 PDE8B gene_id:8622|Hs108|chr5 ( 788) 612 99.0 3.5e-20
CCDS34191.1 PDE8B gene_id:8622|Hs108|chr5 ( 838) 612 99.1 3.7e-20
CCDS34193.1 PDE8B gene_id:8622|Hs108|chr5 ( 865) 612 99.1 3.8e-20
CCDS4037.1 PDE8B gene_id:8622|Hs108|chr5 ( 885) 612 99.1 3.8e-20
CCDS42947.1 PDE9A gene_id:5152|Hs108|chr21 ( 433) 606 98.0 3.8e-20
CCDS42944.1 PDE9A gene_id:5152|Hs108|chr21 ( 459) 606 98.1 4e-20
CCDS33571.1 PDE9A gene_id:5152|Hs108|chr21 ( 465) 606 98.1 4.1e-20
CCDS42946.1 PDE9A gene_id:5152|Hs108|chr21 ( 466) 606 98.1 4.1e-20
CCDS33570.1 PDE9A gene_id:5152|Hs108|chr21 ( 491) 606 98.1 4.2e-20
CCDS42943.1 PDE9A gene_id:5152|Hs108|chr21 ( 492) 606 98.1 4.3e-20
CCDS42941.1 PDE9A gene_id:5152|Hs108|chr21 ( 507) 606 98.1 4.4e-20
CCDS42945.1 PDE9A gene_id:5152|Hs108|chr21 ( 526) 606 98.1 4.5e-20
CCDS33568.1 PDE9A gene_id:5152|Hs108|chr21 ( 533) 606 98.1 4.5e-20
CCDS33567.1 PDE9A gene_id:5152|Hs108|chr21 ( 540) 606 98.1 4.6e-20
CCDS42942.1 PDE9A gene_id:5152|Hs108|chr21 ( 552) 606 98.1 4.7e-20
CCDS33569.1 PDE9A gene_id:5152|Hs108|chr21 ( 567) 606 98.1 4.8e-20
CCDS13690.1 PDE9A gene_id:5152|Hs108|chr21 ( 593) 606 98.1 5e-20
CCDS74612.1 PDE1A gene_id:5136|Hs108|chr2 ( 501) 548 89.8 1.3e-17
CCDS58741.1 PDE1A gene_id:5136|Hs108|chr2 ( 519) 548 89.9 1.3e-17
CCDS33344.1 PDE1A gene_id:5136|Hs108|chr2 ( 535) 548 89.9 1.4e-17
CCDS2285.1 PDE1A gene_id:5136|Hs108|chr2 ( 545) 548 89.9 1.4e-17
CCDS5437.1 PDE1C gene_id:5137|Hs108|chr7 ( 634) 538 88.5 4.2e-17
CCDS55099.1 PDE1C gene_id:5137|Hs108|chr7 ( 709) 538 88.5 4.6e-17
CCDS55100.1 PDE1C gene_id:5137|Hs108|chr7 ( 769) 538 88.5 4.9e-17
CCDS73477.1 PDE1B gene_id:5153|Hs108|chr12 ( 495) 528 87.0 9.2e-17
CCDS53800.1 PDE1B gene_id:5153|Hs108|chr12 ( 516) 528 87.0 9.5e-17
>>CCDS45961.1 PDE4A gene_id:5141|Hs108|chr19 (886 aa)
initn: 5902 init1: 5902 opt: 5902 Z-score: 4533.7 bits: 850.0 E(32554): 0
Smith-Waterman score: 5902; 100.0% identity (100.0% similar) in 886 aa overlap (1-886:1-886)
10 20 30 40 50 60
pF1KE3 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQ
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 PHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGR
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDW
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 CLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEI
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 PSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTD
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 QEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYML
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 TLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDM
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 VLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 LYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADL
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 VHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEE
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 ISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLT
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 QQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLP
790 800 810 820 830 840
850 860 870 880
pF1KE3 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 STAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
850 860 870 880
>>CCDS45962.1 PDE4A gene_id:5141|Hs108|chr19 (860 aa)
initn: 5150 init1: 5150 opt: 5164 Z-score: 3967.7 bits: 745.3 E(32554): 1.1e-214
Smith-Waterman score: 5164; 95.4% identity (96.7% similar) in 830 aa overlap (59-886:37-860)
30 40 50 60 70 80
pF1KE3 PPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRP--IERADAMDTSDRPGLRTTRMSW
: :.:: . .. .: : .: :.
CCDS45 LGRIPELQLVAFPVAVAAEDEAFLPEPLAPRAPRRPRSPPSSPVFFASPSPTFRR-RLRL
10 20 30 40 50 60
90 100 110 120 130 140
pF1KE3 PSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF
: . : .. ::.: :::::::::::::::::::::::::::::::::::::::
CCDS45 LRSCQDLGR-QAWAGAG----FEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESF
70 80 90 100 110 120
150 160 170 180 190 200
pF1KE3 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 LYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSN
130 140 150 160 170 180
210 220 230 240 250 260
pF1KE3 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 KRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRML
190 200 210 220 230 240
270 280 290 300 310 320
pF1KE3 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 NRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPV
250 260 270 280 290 300
330 340 350 360 370 380
pF1KE3 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 PHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYA
310 320 330 340 350 360
390 400 410 420 430 440
pF1KE3 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 GGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTH
370 380 390 400 410 420
450 460 470 480 490 500
pF1KE3 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 VLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHH
430 440 450 460 470 480
510 520 530 540 550 560
pF1KE3 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 LAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVT
490 500 510 520 530 540
570 580 590 600 610 620
pF1KE3 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGME
550 560 570 580 590 600
630 640 650 660 670 680
pF1KE3 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 ISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQS
610 620 630 640 650 660
690 700 710 720 730 740
pF1KE3 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 PSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEAL
670 680 690 700 710 720
750 760 770 780 790 800
pF1KE3 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 DATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAV
730 740 750 760 770 780
810 820 830 840 850 860
pF1KE3 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTF
790 800 810 820 830 840
870 880
pF1KE3 GEDTSALPAPGGGGSGGDPT
::::::::::::::::::::
CCDS45 GEDTSALPAPGGGGSGGDPT
850 860
>>CCDS45963.1 PDE4A gene_id:5141|Hs108|chr19 (825 aa)
initn: 5158 init1: 5158 opt: 5158 Z-score: 3963.3 bits: 744.4 E(32554): 1.9e-214
Smith-Waterman score: 5158; 99.6% identity (99.6% similar) in 784 aa overlap (103-886:42-825)
80 90 100 110 120 130
pF1KE3 TSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLV
: : :::::::::::::::::::::::::
CCDS45 RPPALALPPTGPESLTHFPFSDEDTRRHPPGRSVSFEAENGPTPSPGRSPLDSQASPGLV
20 30 40 50 60 70
140 150 160 170 180 190
pF1KE3 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE3 SNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYR
140 150 160 170 180 190
260 270 280 290 300 310
pF1KE3 SVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 SVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQ
200 210 220 230 240 250
320 330 340 350 360 370
pF1KE3 APRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 APRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENL
260 270 280 290 300 310
380 390 400 410 420 430
pF1KE3 NKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 NKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAY
320 330 340 350 360 370
440 450 460 470 480 490
pF1KE3 HNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 HNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSEL
380 390 400 410 420 430
500 510 520 530 540 550
pF1KE3 ALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 ALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTL
440 450 460 470 480 490
560 570 580 590 600 610
pF1KE3 LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 LADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAE
500 510 520 530 540 550
620 630 640 650 660 670
pF1KE3 FFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 FFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTL
560 570 580 590 600 610
680 690 700 710 720 730
pF1KE3 EDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 EDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQE
620 630 640 650 660 670
740 750 760 770 780 790
pF1KE3 ALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 ALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVA
680 690 700 710 720 730
800 810 820 830 840 850
pF1KE3 PDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS45 PDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREH
740 750 760 770 780 790
860 870 880
pF1KE3 QAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
::::::::::::::::::::::::::::::::::
CCDS45 QAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
800 810 820
>>CCDS58649.1 PDE4A gene_id:5141|Hs108|chr19 (864 aa)
initn: 5150 init1: 5150 opt: 5150 Z-score: 3956.9 bits: 743.3 E(32554): 4.4e-214
Smith-Waterman score: 5150; 100.0% identity (100.0% similar) in 779 aa overlap (108-886:86-864)
80 90 100 110 120 130
pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGA
::::::::::::::::::::::::::::::
CCDS58 DPGVPLPPRPTTLPLLIPPRISITRAENDSFEAENGPTPSPGRSPLDSQASPGLVLHAGA
60 70 80 90 100 110
140 150 160 170 180 190
pF1KE3 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 ATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSL
120 130 140 150 160 170
200 210 220 230 240 250
pF1KE3 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 LTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEM
180 190 200 210 220 230
260 270 280 290 300 310
pF1KE3 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 ASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPR
240 250 260 270 280 290
320 330 340 350 360 370
pF1KE3 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 PSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGL
300 310 320 330 340 350
380 390 400 410 420 430
pF1KE3 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 NIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLH
360 370 380 390 400 410
440 450 460 470 480 490
pF1KE3 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 AADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYN
420 430 440 450 460 470
500 510 520 530 540 550
pF1KE3 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 DESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLK
480 490 500 510 520 530
560 570 580 590 600 610
pF1KE3 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 TMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQG
540 550 560 570 580 590
620 630 640 650 660 670
pF1KE3 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 DRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRD
600 610 620 630 640 650
680 690 700 710 720 730
pF1KE3 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 WYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQ
660 670 680 690 700 710
740 750 760 770 780 790
pF1KE3 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 GLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFS
720 730 740 750 760 770
800 810 820 830 840 850
pF1KE3 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS58 SREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKR
780 790 800 810 820 830
860 870 880
pF1KE3 ACSACAGTFGEDTSALPAPGGGGSGGDPT
:::::::::::::::::::::::::::::
CCDS58 ACSACAGTFGEDTSALPAPGGGGSGGDPT
840 850 860
>>CCDS12238.1 PDE4A gene_id:5141|Hs108|chr19 (647 aa)
initn: 4147 init1: 4147 opt: 4147 Z-score: 3189.2 bits: 600.8 E(32554): 2.5e-171
Smith-Waterman score: 4147; 99.8% identity (100.0% similar) in 626 aa overlap (261-886:22-647)
240 250 260 270 280 290
pF1KE3 ARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTT
.:::::::::::::::::::::::::::::
CCDS12 MPLVDFFCETCSKPWLVGWWDQFKRMLNRELTHLSEMSRSGNQVSEYISTT
10 20 30 40 50
300 310 320 330 340 350
pF1KE3 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS
60 70 80 90 100 110
360 370 380 390 400 410
pF1KE3 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI
120 130 140 150 160 170
420 430 440 450 460 470
pF1KE3 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA
180 190 200 210 220 230
480 490 500 510 520 530
pF1KE3 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR
240 250 260 270 280 290
540 550 560 570 580 590
pF1KE3 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA
300 310 320 330 340 350
600 610 620 630 640 650
pF1KE3 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV
360 370 380 390 400 410
660 670 680 690 700 710
pF1KE3 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE
420 430 440 450 460 470
720 730 740 750 760 770
pF1KE3 LTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 LTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASL
480 490 500 510 520 530
780 790 800 810 820 830
pF1KE3 EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 EAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVS
540 550 560 570 580 590
840 850 860 870 880
pF1KE3 EHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::
CCDS12 EHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
600 610 620 630 640
>>CCDS56370.1 PDE4D gene_id:5144|Hs108|chr5 (507 aa)
initn: 2480 init1: 2119 opt: 2203 Z-score: 1699.3 bits: 324.8 E(32554): 2.5e-88
Smith-Waterman score: 2462; 74.3% identity (88.0% similar) in 510 aa overlap (257-759:1-491)
230 240 250 260 270 280
pF1KE3 CQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEY
:::.:::::::::::::::::::::::::.
CCDS56 MASNKFKRMLNRELTHLSEMSRSGNQVSEF
10 20 30
290 300 310 320 330 340
pF1KE3 ISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNS
::.::::::.::::::::.::.::.. .:::::.:.::::::.:
CCDS56 ISNTFLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMHSSS
40 50 60 70
350 360 370 380 390 400
pF1KE3 LNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLK
:.::.::::::::.::..::.:::..:::::..: ... .:.: :: ::. :::::::::
CCDS56 LTNSSIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLK
80 90 100 110 120 130
410 420 430 440 450 460
pF1KE3 KFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAA
:.:::::..::..::::::::::::::..:::::.:::::::.::::.:::::::::::
CCDS56 TFKIPVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAA
140 150 160 170 180 190
470 480 490 500 510 520
pF1KE3 LFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLS
.::.:::::::::::::::::::::::::::: :::::::::::::::::.::::::::.
CCDS56 IFASAIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLT
200 210 220 230 240 250
530 540 550 560 570 580
pF1KE3 KRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNM
:.:::::::::::.::::::::::.::::::::::::::::::::::::::::::::.::
CCDS56 KKQRQSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNM
260 270 280 290 300 310
590 600 610 620 630 640
pF1KE3 VHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFI
:::::::::::::.:::::::::: :::.:::::::::::::::::::.:::::::::::
CCDS56 VHCADLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFI
320 330 340 350 360 370
650 660 670 680 690 700
pF1KE3 DYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDK
::::::::::::::::::::.:::::::::.:: :.: ::::: :.. .: . .:
CCDS56 DYIVHPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG--RQGQTEK
380 390 400 410 420 430
710 720 730 740 750
pF1KE3 FQFELTLEEEEE---EEISMAQIP----CTAQEALTAQGLSGVEEALDATIAWEASPAQE
:::::::::. : :. : .:. :. ...: .: ..: :: . :: .:
CCDS56 FQFELTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEE
440 450 460 470 480 490
760 770 780 790 800 810
pF1KE3 SLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSP
CCDS56 ESQPEACVIDDRSPDT
500
>>CCDS56369.1 PDE4D gene_id:5144|Hs108|chr5 (518 aa)
initn: 2462 init1: 2119 opt: 2203 Z-score: 1699.2 bits: 324.8 E(32554): 2.5e-88
Smith-Waterman score: 2444; 74.3% identity (87.9% similar) in 506 aa overlap (261-759:16-502)
240 250 260 270 280 290
pF1KE3 ARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTT
:::::::::::::::::::::::::.::.:
CCDS56 MPEANYLLSVSWGYIKFKRMLNRELTHLSEMSRSGNQVSEFISNT
10 20 30 40
300 310 320 330 340 350
pF1KE3 FLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNS
:::::.::::::::.::.::.. .:::::.:.::::::.::.::
CCDS56 FLDKQHEVEIPSPTQKEKEKKK-----------------RPMSQISGVKKLMHSSSLTNS
50 60 70 80
360 370 380 390 400 410
pF1KE3 NIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRI
.::::::::.::..::.:::..:::::..: ... .:.: :: ::. ::::::::: :.:
CCDS56 SIPRFGVKTEQEDVLAKELEDVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKI
90 100 110 120 130 140
420 430 440 450 460 470
pF1KE3 PVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAA
::::..::..::::::::::::::..:::::.:::::::.::::.:::::::::::.::.
CCDS56 PVDTLITYLMTLEDHYHADVAYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFAS
150 160 170 180 190 200
480 490 500 510 520 530
pF1KE3 AIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQR
:::::::::::::::::::::::::::: :::::::::::::::::.::::::::.:.::
CCDS56 AIHDVDHPGVSNQFLINTNSELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQR
210 220 230 240 250 260
540 550 560 570 580 590
pF1KE3 QSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCA
:::::::::.::::::::::.::::::::::::::::::::::::::::::::.::::::
CCDS56 QSLRKMVIDIVLATDMSKHMNLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCA
270 280 290 300 310 320
600 610 620 630 640 650
pF1KE3 DLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIV
:::::::::.:::::::::: :::.:::::::::::::::::::.:::::::::::::::
CCDS56 DLSNPTKPLQLYRQWTDRIMEEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIV
330 340 350 360 370 380
660 670 680 690 700 710
pF1KE3 HPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFE
::::::::::::::::.:::::::::.:: :.: ::::: :.. .: . .:::::
CCDS56 HPLWETWADLVHPDAQDILDTLEDNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFE
390 400 410 420 430 440
720 730 740 750 760
pF1KE3 LTLEEEEE---EEISMAQIP----CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEV
:::::. : :. : .:. :. ...: .: ..: :: . :: .:
CCDS56 LTLEEDGESDTEKDSGSQVEEDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQP
450 460 470 480 490 500
770 780 790 800 810 820
pF1KE3 MAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPA
CCDS56 EACVIDDRSPDT
510
>>CCDS54858.1 PDE4D gene_id:5144|Hs108|chr5 (673 aa)
initn: 2997 init1: 2119 opt: 2203 Z-score: 1697.5 bits: 324.9 E(32554): 3.1e-88
Smith-Waterman score: 3068; 72.1% identity (87.3% similar) in 663 aa overlap (108-759:17-657)
80 90 100 110 120 130
pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPG--LVLHA
:...:: : :::::: ..::: :.:.:
CCDS54 MMHVNNFPFRRHSWICFDVDNGT--SAGRSPLDPMTSPGSGLILQA
10 20 30 40
140 150 160 170 180 190
pF1KE3 GAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNF
. . ::::::::::::::::.:::.::::::..:. :..:::::::::::::::.::.::
CCDS54 NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
50 60 70 80 90 100
200 210 220 230 240 250
pF1KE3 SLLTNVP--VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRS
. :::. .:: ::::. . . :::..::. :.:: ::::::::::.::::.:: .:
CCDS54 AALTNLQDRAPS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHS
110 120 130 140 150 160
260 270 280 290 300 310
pF1KE3 VSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQA
::::::.:::::::::::::::::::::::::.::.::::::.::::::::.::.::..
CCDS54 VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK-
170 180 190 200 210 220
320 330 340 350 360 370
pF1KE3 PRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLN
.:::::.:.::::::.::.::.::::::::.::..::.:::..:
CCDS54 ----------------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVN
230 240 250 260
380 390 400 410 420 430
pF1KE3 KWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYH
::::..: ... .:.: :: ::. ::::::::: :.:::::..::..:::::::::::::
CCDS54 KWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
270 280 290 300 310 320
440 450 460 470 480 490
pF1KE3 NSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELA
:..:::::.:::::::.::::.:::::::::::.::.:::::::::::::::::::::::
CCDS54 NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELA
330 340 350 360 370 380
500 510 520 530 540 550
pF1KE3 LMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLL
::::: :::::::::::::::::.::::::::.:.:::::::::::.::::::::::.::
CCDS54 LMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLL
390 400 410 420 430 440
560 570 580 590 600 610
pF1KE3 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEF
::::::::::::::::::::::::::::::.:::::::::::::::.:::::::::: ::
CCDS54 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEF
450 460 470 480 490 500
620 630 640 650 660 670
pF1KE3 FQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLE
:.:::::::::::::::::::.:::::::::::::::::::::::::::::::.::::::
CCDS54 FRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
510 520 530 540 550 560
680 690 700 710 720
pF1KE3 DNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQIP---
:::.:: :.: ::::: :.. .: . .::::::::::. : :. : .:.
CCDS54 DNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDT
570 580 590 600 610 620
730 740 750 760 770 780
pF1KE3 -CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQST
:. ...: .: ..: :: . :: .:
CCDS54 SCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
630 640 650 660 670
790 800 810 820 830 840
pF1KE3 GSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEV
>>CCDS56371.1 PDE4D gene_id:5144|Hs108|chr5 (679 aa)
initn: 2997 init1: 2119 opt: 2203 Z-score: 1697.5 bits: 324.9 E(32554): 3.1e-88
Smith-Waterman score: 3068; 72.1% identity (87.3% similar) in 663 aa overlap (108-759:23-663)
80 90 100 110 120 130
pF1KE3 GLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPG--LVLHA
:...:: : :::::: ..::: :.:.:
CCDS56 MSIIMKPRSRSTSSLRTAEAVCFDVDNGT--SAGRSPLDPMTSPGSGLILQA
10 20 30 40 50
140 150 160 170 180 190
pF1KE3 GAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNF
. . ::::::::::::::::.:::.::::::..:. :..:::::::::::::::.::.::
CCDS56 NFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVRNNF
60 70 80 90 100 110
200 210 220 230 240 250
pF1KE3 SLLTNVP--VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRS
. :::. .:: ::::. . . :::..::. :.:: ::::::::::.::::.:: .:
CCDS56 AALTNLQDRAPS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQTRHS
120 130 140 150 160
260 270 280 290 300 310
pF1KE3 VSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQA
::::::.:::::::::::::::::::::::::.::.::::::.::::::::.::.::..
CCDS56 VSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEKKK-
170 180 190 200 210 220
320 330 340 350 360 370
pF1KE3 PRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLN
.:::::.:.::::::.::.::.::::::::.::..::.:::..:
CCDS56 ----------------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELEDVN
230 240 250 260 270
380 390 400 410 420 430
pF1KE3 KWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYH
::::..: ... .:.: :: ::. ::::::::: :.:::::..::..:::::::::::::
CCDS56 KWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADVAYH
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE3 NSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELA
:..:::::.:::::::.::::.:::::::::::.::.:::::::::::::::::::::::
CCDS56 NNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNSELA
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE3 LMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLL
::::: :::::::::::::::::.::::::::.:.:::::::::::.::::::::::.::
CCDS56 LMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHMNLL
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE3 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEF
::::::::::::::::::::::::::::::.:::::::::::::::.:::::::::: ::
CCDS56 ADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIMEEF
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE3 FQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLE
:.:::::::::::::::::::.:::::::::::::::::::::::::::::::.::::::
CCDS56 FRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILDTLE
520 530 540 550 560 570
680 690 700 710 720
pF1KE3 DNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQIP---
:::.:: :.: ::::: :.. .: . .::::::::::. : :. : .:.
CCDS56 DNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFELTLEEDGESDTEKDSGSQVEEDT
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE3 -CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQST
:. ...: .: ..: :: . :: .:
CCDS56 SCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
640 650 660 670
790 800 810 820 830 840
pF1KE3 GSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEV
>>CCDS56372.1 PDE4D gene_id:5144|Hs108|chr5 (687 aa)
initn: 2997 init1: 2119 opt: 2203 Z-score: 1697.4 bits: 324.9 E(32554): 3.2e-88
Smith-Waterman score: 3071; 71.9% identity (87.1% similar) in 666 aa overlap (105-759:28-671)
80 90 100 110 120 130
pF1KE3 DRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPG--LV
: :...:: : :::::: ..::: :.
CCDS56 MAFVWDPLGATVPGPSTRAKSRLRFSKSYSFDVDNGT--SAGRSPLDPMTSPGSGLI
10 20 30 40 50
140 150 160 170 180 190
pF1KE3 LHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVR
:.:. . ::::::::::::::::.:::.::::::..:. :..:::::::::::::::.::
CCDS56 LQANFVHSQRRESFLYRSDSDYDLSPKSMSRNSSIASDIHGDDLIVTPFAQVLASLRTVR
60 70 80 90 100 110
200 210 220 230 240 250
pF1KE3 SNFSLLTNVP--VPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQT
.::. :::. .:: ::::. . . :::..::. :.:: ::::::::::.::::.::
CCDS56 NNFAALTNLQDRAPS-KRSPMCNQPSINKATITEEAYQKLASETLEELDWCLDQLETLQT
120 130 140 150 160 170
260 270 280 290 300 310
pF1KE3 YRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREK
.:::::::.:::::::::::::::::::::::::.::.::::::.::::::::.::.::
CCDS56 RHSVSEMASNKFKRMLNRELTHLSEMSRSGNQVSEFISNTFLDKQHEVEIPSPTQKEKEK
180 190 200 210 220 230
320 330 340 350 360 370
pF1KE3 QQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELE
.. .:::::.:.::::::.::.::.::::::::.::..::.:::
CCDS56 KK-----------------RPMSQISGVKKLMHSSSLTNSSIPRFGVKTEQEDVLAKELE
240 250 260 270
380 390 400 410 420 430
pF1KE3 NLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADV
..:::::..: ... .:.: :: ::. ::::::::: :.:::::..::..::::::::::
CCDS56 DVNKWGLHVFRIAELSGNRPLTVIMHTIFQERDLLKTFKIPVDTLITYLMTLEDHYHADV
280 290 300 310 320 330
440 450 460 470 480 490
pF1KE3 AYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNS
::::..:::::.:::::::.::::.:::::::::::.::.::::::::::::::::::::
CCDS56 AYHNNIHAADVVQSTHVLLSTPALEAVFTDLEILAAIFASAIHDVDHPGVSNQFLINTNS
340 350 360 370 380 390
500 510 520 530 540 550
pF1KE3 ELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHM
:::::::: :::::::::::::::::.::::::::.:.:::::::::::.::::::::::
CCDS56 ELALMYNDSSVLENHHLAVGFKLLQEENCDIFQNLTKKQRQSLRKMVIDIVLATDMSKHM
400 410 420 430 440 450
560 570 580 590 600 610
pF1KE3 TLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIM
.::::::::::::::::::::::::::::::::.:::::::::::::::.::::::::::
CCDS56 NLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLQNMVHCADLSNPTKPLQLYRQWTDRIM
460 470 480 490 500 510
620 630 640 650 660 670
pF1KE3 AEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILD
:::.:::::::::::::::::::.:::::::::::::::::::::::::::::::.:::
CCDS56 EEFFRQGDRERERGMEISPMCDKHNASVEKSQVGFIDYIVHPLWETWADLVHPDAQDILD
520 530 540 550 560 570
680 690 700 710 720
pF1KE3 TLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEE---EEISMAQIP
::::::.:: :.: ::::: :.. .: . .::::::::::. : :. : .:.
CCDS56 TLEDNREWYQSTIPQSPSPAPDDPEEG--RQGQTEKFQFELTLEEDGESDTEKDSGSQVE
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE3 ----CTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQA
:. ...: .: ..: :: . :: .:
CCDS56 EDTSCSDSKTLCTQDSESTEIPLDEQVEEEAVGEEEESQPEACVIDDRSPDT
640 650 660 670 680
790 800 810 820 830 840
pF1KE3 QSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTA
886 residues in 1 query sequences
18511270 residues in 32554 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 03:14:58 2016 done: Mon Nov 7 03:14:58 2016
Total Scan time: 4.530 Total Display time: 0.240
Function used was FASTA [36.3.4 Apr, 2011]