Result of FASTA (omim) for
pFN21AE3325
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3325, 921 aa
1>>>pF1KE3325 921 - 921 aa - 921 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 12.6844+/-0.00046; mu= -9.5555+/- 0.029
mean_var=613.2849+/-133.013, 0's: 0 Z-trim(123.4): 296 B-trim: 33 in 1/57
Lambda= 0.051790
statistics sampled from 42877 (43274) to 42877 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.778), E-opt: 0.2 (0.507), width: 16
Scan time: 15.260
The best scores are: opt bits E(85289)
NP_775869 (OMIM: 610737) kinase suppressor of Ras ( 921) 6375 492.1 5.4e-138
XP_011536526 (OMIM: 610737) PREDICTED: kinase supp ( 948) 6343 489.7 2.9e-137
XP_016874697 (OMIM: 610737) PREDICTED: kinase supp ( 936) 6047 467.6 1.3e-130
XP_011536527 (OMIM: 610737) PREDICTED: kinase supp ( 829) 5788 448.2 8e-125
XP_011536528 (OMIM: 610737) PREDICTED: kinase supp ( 742) 4937 384.5 1e-105
XP_011536530 (OMIM: 610737) PREDICTED: kinase supp ( 647) 4296 336.6 2.5e-91
XP_011536531 (OMIM: 610737) PREDICTED: kinase supp ( 619) 4118 323.2 2.4e-87
XP_016874698 (OMIM: 610737) PREDICTED: kinase supp ( 620) 4022 316.1 3.5e-85
XP_016874699 (OMIM: 610737) PREDICTED: kinase supp ( 515) 3497 276.7 2e-73
XP_016880756 (OMIM: 601132) PREDICTED: kinase supp ( 909) 2183 178.9 1e-43
XP_016880758 (OMIM: 601132) PREDICTED: kinase supp ( 876) 1948 161.3 1.9e-38
XP_016880757 (OMIM: 601132) PREDICTED: kinase supp ( 901) 1946 161.1 2.2e-38
NP_055053 (OMIM: 601132) kinase suppressor of Ras ( 762) 1701 142.8 6.4e-33
XP_011523732 (OMIM: 601132) PREDICTED: kinase supp ( 899) 1701 142.8 7.1e-33
XP_016880767 (OMIM: 601132) PREDICTED: kinase supp ( 587) 1694 142.1 7.7e-33
XP_016880766 (OMIM: 601132) PREDICTED: kinase supp ( 605) 1694 142.1 7.9e-33
XP_011523733 (OMIM: 601132) PREDICTED: kinase supp ( 898) 1696 142.5 9.2e-33
XP_016880764 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33
XP_016880763 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33
XP_016880765 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33
XP_016880762 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33
XP_016880760 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33
XP_016880761 (OMIM: 601132) PREDICTED: kinase supp ( 786) 1694 142.2 9.4e-33
XP_016880759 (OMIM: 601132) PREDICTED: kinase supp ( 804) 1694 142.3 9.5e-33
XP_011523731 (OMIM: 601132) PREDICTED: kinase supp ( 923) 1694 142.3 1e-32
XP_006722217 (OMIM: 601132) PREDICTED: kinase supp ( 887) 1689 141.9 1.3e-32
XP_016868047 (OMIM: 115150,163950,164757,211980,61 ( 807) 643 63.7 4.1e-09
XP_016868048 (OMIM: 115150,163950,164757,211980,61 ( 798) 615 61.6 1.8e-08
NP_004324 (OMIM: 115150,163950,164757,211980,61370 ( 766) 595 60.1 4.8e-08
XP_005250102 (OMIM: 115150,163950,164757,211980,61 ( 767) 595 60.1 4.8e-08
XP_016880769 (OMIM: 601132) PREDICTED: kinase supp ( 524) 581 58.9 7.7e-08
XP_016880768 (OMIM: 601132) PREDICTED: kinase supp ( 541) 575 58.4 1.1e-07
XP_011542211 (OMIM: 311010) PREDICTED: serine/thre ( 387) 547 56.2 3.7e-07
XP_006724592 (OMIM: 311010) PREDICTED: serine/thre ( 611) 549 56.6 4.5e-07
XP_011542208 (OMIM: 311010) PREDICTED: serine/thre ( 611) 549 56.6 4.5e-07
NP_001243125 (OMIM: 311010) serine/threonine-prote ( 609) 548 56.5 4.7e-07
NP_001645 (OMIM: 311010) serine/threonine-protein ( 606) 547 56.4 5e-07
XP_011542210 (OMIM: 311010) PREDICTED: serine/thre ( 606) 547 56.4 5e-07
XP_005265416 (OMIM: 164760,611553,611554,615916) P ( 534) 511 53.7 2.9e-06
XP_005265415 (OMIM: 164760,611553,611554,615916) P ( 567) 511 53.7 3.1e-06
XP_011532277 (OMIM: 164760,611553,611554,615916) P ( 567) 511 53.7 3.1e-06
XP_005265414 (OMIM: 164760,611553,611554,615916) P ( 615) 511 53.7 3.2e-06
XP_016862455 (OMIM: 164760,611553,611554,615916) P ( 615) 511 53.7 3.2e-06
XP_005265412 (OMIM: 164760,611553,611554,615916) P ( 648) 511 53.8 3.3e-06
NP_002871 (OMIM: 164760,611553,611554,615916) RAF ( 648) 511 53.8 3.3e-06
XP_011532276 (OMIM: 164760,611553,611554,615916) P ( 648) 511 53.8 3.3e-06
NP_002437 (OMIM: 600137) mitogen-activated protein ( 954) 376 43.9 0.0047
>>NP_775869 (OMIM: 610737) kinase suppressor of Ras 2 [H (921 aa)
initn: 6375 init1: 6375 opt: 6375 Z-score: 2598.4 bits: 492.1 E(85289): 5.4e-138
Smith-Waterman score: 6375; 100.0% identity (100.0% similar) in 921 aa overlap (1-921:1-921)
10 20 30 40 50 60
pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 MIDLSISNLEGLRTKCATSNDLTQKEIRTLESKLVKYFSRQLSCKKKVALQERNAELDGF
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 PQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 PQLRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLS
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 CLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 CLRNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 CHTSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVT
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 TVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 TVTPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPK
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 AKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 AKKKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFS
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 ANTLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKC
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 TKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 TKEAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHI
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 PVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 PVPYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKY
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 KQQFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESE
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 DDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 DDFEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEV
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 AIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 AIRLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYS
670 680 690 700 710 720
730 740 750 760 770 780
pF1KE3 VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 VVRDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSI
730 740 750 760 770 780
790 800 810 820 830 840
pF1KE3 SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 SGVLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHA
790 800 810 820 830 840
850 860 870 880 890 900
pF1KE3 REWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_775 REWPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLE
850 860 870 880 890 900
910 920
pF1KE3 KLPKRNRRLSHPGHFWKSAEL
:::::::::::::::::::::
NP_775 KLPKRNRRLSHPGHFWKSAEL
910 920
>>XP_011536526 (OMIM: 610737) PREDICTED: kinase suppress (948 aa)
initn: 6343 init1: 3306 opt: 6343 Z-score: 2585.4 bits: 489.7 E(85289): 2.9e-137
Smith-Waterman score: 6343; 99.8% identity (99.8% similar) in 921 aa overlap (1-921:30-948)
10 20 30
pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE
:::::::::::::::::::::::::::::::
XP_011 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
:::::::::::::::::::::::::::::::::::::::::::: ::::::::::::::
XP_011 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRG--ARLVRTESVPCDIN
430 440 450 460 470
460 470 480 490 500 510
pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
480 490 500 510 520 530
520 530 540 550 560 570
pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
540 550 560 570 580 590
580 590 600 610 620 630
pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
600 610 620 630 640 650
640 650 660 670 680 690
pF1KE3 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
660 670 680 690 700 710
700 710 720 730 740 750
pF1KE3 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
720 730 740 750 760 770
760 770 780 790 800 810
pF1KE3 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
780 790 800 810 820 830
820 830 840 850 860 870
pF1KE3 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
840 850 860 870 880 890
880 890 900 910 920
pF1KE3 KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
900 910 920 930 940
>>XP_016874697 (OMIM: 610737) PREDICTED: kinase suppress (936 aa)
initn: 6046 init1: 6046 opt: 6047 Z-score: 2465.9 bits: 467.6 E(85289): 1.3e-130
Smith-Waterman score: 6047; 97.4% identity (98.0% similar) in 906 aa overlap (1-905:30-930)
10 20 30
pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE
:::::::::::::::::::::::::::::::
XP_016 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE3 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE3 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
730 740 750 760 770 780
760 770 780 790 800 810
pF1KE3 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEIIRQL
790 800 810 820 830 840
820 830 840 850 860 870
pF1KE3 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQIGMG
850 860 870 880 890 900
880 890 900 910 920
pF1KE3 KEIS-DILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
:::: . . : : : : .. ::. :.
XP_016 KEISGSYSIEIWM----ETPGFP-FIPSLERNVKKLFGKYC
910 920 930
>>XP_011536527 (OMIM: 610737) PREDICTED: kinase suppress (829 aa)
initn: 5788 init1: 5788 opt: 5788 Z-score: 2361.9 bits: 448.2 E(85289): 8e-125
Smith-Waterman score: 5788; 100.0% identity (100.0% similar) in 829 aa overlap (93-921:1-829)
70 80 90 100 110 120
pF1KE3 LRHWFRIVDVRKEVLEEISPGQLSLEDLLEMTDEQVCETVEKYGANREECARLNASLSCL
::::::::::::::::::::::::::::::
XP_011 MTDEQVCETVEKYGANREECARLNASLSCL
10 20 30
130 140 150 160 170 180
pF1KE3 RNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RNVHMSGGNLSKQDWTIQWPTTETGKENNPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCH
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE3 TSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TSPTPGAPVYTHVDRLTVDAYPGLCPPPPLESGHRSLPPSPRQRHAVRTPPRTPNIVTTV
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE3 TPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPGTPPMRKKNKLKPPGTPPPSSRKLIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAK
160 170 180 190 200 210
310 320 330 340 350 360
pF1KE3 KKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSAN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKSKPLNLKIHSSVGSCENIPSQQRSPLLSERSLRSFFVGHAPFLPSTPPVHTEANFSAN
220 230 240 250 260 270
370 380 390 400 410 420
pF1KE3 TLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TLSVPRWSPQIPRRDLGNSIKHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTK
280 290 300 310 320 330
430 440 450 460 470 480
pF1KE3 EAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EAPPCHLLIIHRGDPARLVRTESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPV
340 350 360 370 380 390
490 500 510 520 530 540
pF1KE3 PYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PYQPDSSSNPSSTTSSTPSSPAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQ
400 410 420 430 440 450
550 560 570 580 590 600
pF1KE3 QFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 QFIFPDVVPVPETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDD
460 470 480 490 500 510
610 620 630 640 650 660
pF1KE3 FEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 FEEMNLSLLSARSFPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAI
520 530 540 550 560 570
670 680 690 700 710 720
pF1KE3 RLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RLIDIERDNEDQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVV
580 590 600 610 620 630
730 740 750 760 770 780
pF1KE3 RDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RDAKIVLDVNKTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISG
640 650 660 670 680 690
790 800 810 820 830 840
pF1KE3 VLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHARE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VLQAGRREDKLRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHARE
700 710 720 730 740 750
850 860 870 880 890 900
pF1KE3 WPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 WPFKTQPAEAIIWQMGTGMKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKL
760 770 780 790 800 810
910 920
pF1KE3 PKRNRRLSHPGHFWKSAEL
:::::::::::::::::::
XP_011 PKRNRRLSHPGHFWKSAEL
820
>>XP_011536528 (OMIM: 610737) PREDICTED: kinase suppress (742 aa)
initn: 4937 init1: 4937 opt: 4937 Z-score: 2018.9 bits: 384.5 E(85289): 1e-105
Smith-Waterman score: 4937; 100.0% identity (100.0% similar) in 710 aa overlap (1-710:30-739)
10 20 30
pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE
:::::::::::::::::::::::::::::::
XP_011 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
610 620 630 640 650 660
640 650 660 670 680 690
pF1KE3 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 IPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQTRHE
670 680 690 700 710 720
700 710 720 730 740 750
pF1KE3 NVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYLHAK
:::::::::::::::::::
XP_011 NVVLFMGACMSPPHLAIITRPV
730 740
>>XP_011536530 (OMIM: 610737) PREDICTED: kinase suppress (647 aa)
initn: 4296 init1: 4296 opt: 4296 Z-score: 1760.7 bits: 336.6 E(85289): 2.5e-91
Smith-Waterman score: 4296; 99.8% identity (100.0% similar) in 623 aa overlap (299-921:25-647)
270 280 290 300 310 320
pF1KE3 LIHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRS
:.::::::::::::::::::::::::::::
XP_011 MYNKKAKMEPNASESAIPARRQRQPRAKKKSKPLNLKIHSSVGSCENIPSQQRS
10 20 30 40 50
330 340 350 360 370 380
pF1KE3 PLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PLLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFST
60 70 80 90 100 110
390 400 410 420 430 440
pF1KE3 KYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPC
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPC
120 130 140 150 160 170
450 460 470 480 490 500
pF1KE3 DINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 DINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLP
180 190 200 210 220 230
510 520 530 540 550 560
pF1KE3 PSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVT
240 250 260 270 280 290
570 580 590 600 610 620
pF1KE3 SNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQ
300 310 320 330 340 350
630 640 650 660 670 680
pF1KE3 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREVMAYRQT
360 370 380 390 400 410
690 700 710 720 730 740
pF1KE3 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIVKGMGYL
420 430 440 450 460 470
750 760 770 780 790 800
pF1KE3 HAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 HAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCHLAPEII
480 490 500 510 520 530
810 820 830 840 850 860
pF1KE3 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 RQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMKPNLSQI
540 550 560 570 580 590
870 880 890 900 910 920
pF1KE3 GMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
:::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 GMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
600 610 620 630 640
>>XP_011536531 (OMIM: 610737) PREDICTED: kinase suppress (619 aa)
initn: 4118 init1: 4118 opt: 4118 Z-score: 1689.1 bits: 323.2 E(85289): 2.4e-87
Smith-Waterman score: 4118; 100.0% identity (100.0% similar) in 588 aa overlap (1-588:30-617)
10 20 30
pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE
:::::::::::::::::::::::::::::::
XP_011 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
:::::::::::::::::
XP_011 ILEGNPLLQIEVEPTSEPV
610
>>XP_016874698 (OMIM: 610737) PREDICTED: kinase suppress (620 aa)
initn: 4022 init1: 4022 opt: 4022 Z-score: 1650.3 bits: 316.1 E(85289): 3.5e-85
Smith-Waterman score: 4022; 100.0% identity (100.0% similar) in 573 aa overlap (1-573:30-602)
10 20 30
pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTLE
:::::::::::::::::::::::::::::::
XP_016 MDEENMTKSEEQQPLSLQKALQQCELVQNMIDLSISNLEGLRTKCATSNDLTQKEIRTLE
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDLL
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 EMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKENN
130 140 150 160 170 180
160 170 180 190 200 210
pF1KE3 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPPP
190 200 210 220 230 240
220 230 240 250 260 270
pF1KE3 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LESGHRSLPPSPRQRHAVRTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKLIH
250 260 270 280 290 300
280 290 300 310 320 330
pF1KE3 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSPLL
310 320 330 340 350 360
340 350 360 370 380 390
pF1KE3 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 SERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTKYW
370 380 390 400 410 420
400 410 420 430 440 450
pF1KE3 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVRTESVPCDIN
430 440 450 460 470 480
460 470 480 490 500 510
pF1KE3 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 NPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLPPSA
490 500 510 520 530 540
520 530 540 550 560 570
pF1KE3 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQVILHPVTSNP
550 560 570 580 590 600
580 590 600 610 620 630
pF1KE3 ILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQTSIFLQEWD
::
XP_016 ILTWYISEIKGAATCRGIWC
610 620
>>XP_016874699 (OMIM: 610737) PREDICTED: kinase suppress (515 aa)
initn: 3497 init1: 3497 opt: 3497 Z-score: 1439.3 bits: 276.7 E(85289): 2e-73
Smith-Waterman score: 3497; 99.8% identity (100.0% similar) in 509 aa overlap (413-921:7-515)
390 400 410 420 430 440
pF1KE3 KHRFSTKYWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDPARLVR
.:::::::::::::::::::::::::::::
XP_016 MFVPLVRLKCHNKCTKEAPPCHLLIIHRGDPARLVR
10 20 30
450 460 470 480 490 500
pF1KE3 TESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TESVPCDINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSS
40 50 60 70 80 90
510 520 530 540 550 560
pF1KE3 PAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PAPPLPPSATPPSPLHPSPQCTRQQKNFNLPASHYYKYKQQFIFPDVVPVPETPTRAPQV
100 110 120 130 140 150
570 580 590 600 610 620
pF1KE3 ILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 ILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSARSFPRKASQ
160 170 180 190 200 210
630 640 650 660 670 680
pF1KE3 TSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 TSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNEDQLKAFKREV
220 230 240 250 260 270
690 700 710 720 730 740
pF1KE3 MAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVNKTRQIAQEIV
280 290 300 310 320 330
750 760 770 780 790 800
pF1KE3 KGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCH
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 KGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDKLRIQNGWLCH
340 350 360 370 380 390
810 820 830 840 850 860
pF1KE3 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 LAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEAIIWQMGTGMK
400 410 420 430 440 450
870 880 890 900 910 920
pF1KE3 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 PNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLSHPGHFWKSAEL
460 470 480 490 500 510
>>XP_016880756 (OMIM: 601132) PREDICTED: kinase suppress (909 aa)
initn: 2413 init1: 1305 opt: 2183 Z-score: 905.8 bits: 178.9 E(85289): 1e-43
Smith-Waterman score: 2722; 49.2% identity (70.8% similar) in 941 aa overlap (1-921:47-885)
10 20 30
pF1KE3 MIDLSISNLEGLRTKCATSNDLTQKEIRTL
.::.::..:.:::::::.::::::.:::::
XP_016 GGGGGDAAAAEGGAGAAASRALQQCGQLQKLIDISIGSLRGLRTKCAVSNDLTQQEIRTL
20 30 40 50 60 70
40 50 60 70 80 90
pF1KE3 ESKLVKYFSRQLSCKKKVALQERNAELDGFPQLRHWFRIVDVRKEVLEEISPGQLSLEDL
:.:::.:. .: .:: .:: ::. ::...:.. :. .:: ::..:: : .:.:. :
XP_016 EAKLVRYICKQRQCKLSVAPGERTPELNSYPRFSDWLYTFNVRPEVVQEI-PRDLTLDAL
80 90 100 110 120 130
100 110 120 130 140 150
pF1KE3 LEMTDEQVCETVEKYGANREECARLNASLSCLRNVHMSGGNLSKQDWTIQWPTTETGKEN
:::.. .: ::... ::. .::.::. .:.:::.: ::. :.: . : . .. .:.
XP_016 LEMNEAKVKETLRRCGASGDECGRLQYALTCLRKVTGLGGE-HKEDSS--WSSLDARRES
140 150 160 170 180 190
160 170 180 190 200 210
pF1KE3 NPVCPPEPTPWIRTHLSQSPRVPSKCVQHYCHTSPTPGAPVYTHVDRLTVDAYPGLCPPP
. : . : : :. . . ... : . ..:.: :. :
XP_016 G--SGPSTDTLSAASLPWPP--GSSQLGRAGNSAQGPRS--------ISVSALPASDSPT
200 210 220 230 240
220 230 240 250 260
pF1KE3 PLESGHRSLPPSPRQRHAV-RTPPRTPNIVTTVTPPGTPPMRKKNKLKPPGTPPPSSRKL
: : ..: . :: : ::. . . .::: :: .:...::::: :::: :::.
XP_016 P--SFSEGLSDTCIPLHASGRLTPRA--LHSFITPPTTPQLRRHTKLKPPRTPPPPSRKV
250 260 270 280 290
270 280 290 300 310 320
pF1KE3 IHLIPGFTALHRSKSHEFQLGHRVDEAHTPKAKKKSKPLNLKIHSSVGSCENIPSQQRSP
..:.:.: .: :::::: :::.:.:..
XP_016 FQLLPSFPTLTRSKSHESQLGNRIDDVS--------------------------------
300 310 320
330 340 350 360 370 380
pF1KE3 LLSERSLRSFFVGHAPFLPSTPPVHTEANFSANTLSVPRWSPQIPRRDLGNSIKHRFSTK
:.: : ..:. :::. :::.: :. ::::::
XP_016 -----SMR-FDLSHG-------------------------SPQMVRRDIGLSVTHRFSTK
330 340 350
390 400 410 420 430 440
pF1KE3 YWMSQTCTVCGKGMLFGLKCKNCKLKCHNKCTKEAPPCHLLIIHRGDP-ARLVRTESVPC
:.::.: :: :.:.::.:::.:.:::::::::::: :.. .. : .:: ::::::
XP_016 SWLSQVCHVCQKSMIFGVKCKHCRLKCHNKCTKEAPACRISFL----PLTRLRRTESVPS
360 370 380 390 400
450 460 470 480 490 500
pF1KE3 DINNPLRKPPRYSDLHISQTLPKTNKINKDHIPVPYQPDSSSNPSSTTSSTPSSPAPPLP
:::::. : .. :.. ::::. .:.: :. . ::::::::::::::::::: .:
XP_016 DINNPV---DRAAEPHFG-TLPKA-LTKKEHPPAMNHLDSSSNPSSTTSSTPSSPAP-FP
410 420 430 440 450 460
510 520 530 540 550
pF1KE3 PSATPPS---PLHPSPQCTRQQKNFNLP-ASHYYK--------YKQQF---IFPDVVPVP
:..: : : .::: .. :: .: :.: .: .. : : ..:.:
XP_016 TSSNPSSATTPPNPSPGQRDSRFNFPVPSAGHCWKCLLIAESLKENAFNISAFAHAAPLP
470 480 490 500 510 520
560 570 580 590 600 610
pF1KE3 ETPTRAPQVILHPVTSNPILEGNPLLQIEVEPTSENEEVHDEAEESEDDFEEMNLSLLSA
:. : . : . .::.. . :.: : : ..:::..::. ... :
XP_016 EA---ADGTRLDDQPKADVLEAH---EAEAE---EPEAGKSEAEDDEDEVDDLPSSRRPW
530 540 550 560 570
620 630 640 650 660 670
pF1KE3 RS-FPRKASQTSIFLQEWDIPFEQLEIGELIGKGRFGQVYHGRWHGEVAIRLIDIERDNE
:. . :::::::..::::::::::.:.:: ::.::.:.:..:::::::::::.... :.
XP_016 RGPISRKASQTSVYLQEWDIPFEQVELGEPIGQGRWGRVHRGRWHGEVAIRLLEMDGHNQ
580 590 600 610 620 630
680 690 700 710 720 730
pF1KE3 DQLKAFKREVMAYRQTRHENVVLFMGACMSPPHLAIITSLCKGRTLYSVVRDAKIVLDVN
:.:: ::.::: :::::::::::::::::.:::::::::.::::::.: ::: : ::.:
XP_016 DHLKLFKKEVMNYRQTRHENVVLFMGACMNPPHLAIITSFCKGRTLHSFVRDPKTSLDIN
640 650 660 670 680 690
740 750 760 770 780 790
pF1KE3 KTRQIAQEIVKGMGYLHAKGILHKDLKSKNVFYDNGKVVITDFGLFSISGVLQAGRREDK
:::::::::.:::::::::::.::::::::::::::::::::::::.::::.. ::::..
XP_016 KTRQIAQEIIKGMGYLHAKGIVHKDLKSKNVFYDNGKVVITDFGLFGISGVVREGRRENQ
700 710 720 730 740 750
800 810 820 830 840 850
pF1KE3 LRIQNGWLCHLAPEIIRQLSPDTEEDKLPFSKHSDVFALGTIWYELHAREWPFKTQPAEA
:.... :::.:::::.:...: .::.::::: .::.:.::.::::.::.::.:.: :::
XP_016 LKLSHDWLCYLAPEIVREMTPGKDEDQLPFSKAADVYAFGTVWYELQARDWPLKNQAAEA
760 770 780 790 800 810
860 870 880 890 900 910
pF1KE3 IIWQMGTG--MKPNLSQIGMGKEISDILLFCWAFEQEERPTFTKLMDMLEKLPKRNRRLS
:::.:.: :: :.....:::.:.:: ::::. .:::.:. :::::::::: :::::
XP_016 SIWQIGSGEGMKRVLTSVSLGKEVSEILSACWAFDLQERPSFSLLMDMLEKLPKLNRRLS
820 830 840 850 860 870
920
pF1KE3 HPGHFWKSAEL
:::::::::..
XP_016 HPGHFWKSADINSSKVVPRFERFGLGVLESSNPKM
880 890 900
921 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Mon Nov 7 16:12:15 2016 done: Mon Nov 7 16:12:17 2016
Total Scan time: 15.260 Total Display time: 0.270
Function used was FASTA [36.3.4 Apr, 2011]