Result of FASTA (omim) for
pFN21AE3288
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3288, 740 aa
1>>>pF1KE3288 740 - 740 aa - 740 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 8.8730+/-0.000626; mu= 5.6018+/- 0.039
mean_var=369.7137+/-70.369, 0's: 0 Z-trim(116.8): 351 B-trim: 0 in 0/53
Lambda= 0.066702
statistics sampled from 27942 (28317) to 27942 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.67), E-opt: 0.2 (0.332), width: 16
Scan time: 13.000
The best scores are: opt bits E(85289)
NP_689786 (OMIM: 611344) ras and EF-hand domain-co ( 740) 4836 480.7 9.3e-135
XP_005251788 (OMIM: 611344) PREDICTED: ras and EF- ( 611) 3858 386.5 1.8e-106
XP_005251787 (OMIM: 611344) PREDICTED: ras and EF- ( 717) 2680 273.2 2.6e-72
NP_001138430 (OMIM: 614178) EF-hand calcium-bindin ( 731) 581 71.2 1.7e-11
XP_011519339 (OMIM: 614178) PREDICTED: EF-hand cal ( 493) 572 70.1 2.4e-11
XP_011519340 (OMIM: 614178) PREDICTED: EF-hand cal ( 493) 572 70.1 2.4e-11
XP_011519336 (OMIM: 614178) PREDICTED: EF-hand cal ( 732) 575 70.6 2.5e-11
XP_006719084 (OMIM: 614178) PREDICTED: EF-hand cal ( 732) 575 70.6 2.5e-11
XP_011519338 (OMIM: 614178) PREDICTED: EF-hand cal ( 732) 575 70.6 2.5e-11
NP_005361 (OMIM: 165040) ras-related protein Rab-8 ( 207) 520 64.6 4.7e-10
XP_011526322 (OMIM: 165040) PREDICTED: ras-related ( 215) 520 64.6 4.8e-10
NP_057614 (OMIM: 613532) ras-related protein Rab-8 ( 207) 511 63.7 8.5e-10
NP_783865 (OMIM: 609956) ras-related protein Rab-3 ( 216) 494 62.1 2.7e-09
NP_001317400 (OMIM: 609956) ras-related protein Ra ( 196) 487 61.4 4.1e-09
NP_001006639 (OMIM: 609956) ras-related protein Ra ( 223) 487 61.5 4.4e-09
NP_112243 (OMIM: 612565) ras-related protein Rab-1 ( 201) 486 61.3 4.4e-09
NP_001157461 (OMIM: 609956) ras-related protein Ra ( 228) 487 61.5 4.5e-09
NP_057215 (OMIM: 612672) ras-related protein Rab-1 ( 200) 477 60.4 8.1e-09
NP_004152 (OMIM: 179508) ras-related protein Rab-1 ( 205) 477 60.5 8.2e-09
NP_055168 (OMIM: 605455) ras-related protein Rab-2 ( 256) 477 60.6 9.4e-09
NP_001294982 (OMIM: 605455) ras-related protein Ra ( 190) 458 58.6 2.8e-08
NP_001272990 (OMIM: 605693) ras-related protein Ra ( 203) 454 58.2 3.8e-08
NP_001272988 (OMIM: 605693) ras-related protein Ra ( 203) 454 58.2 3.8e-08
NP_001272989 (OMIM: 605693) ras-related protein Ra ( 203) 454 58.2 3.8e-08
NP_055303 (OMIM: 605693) ras-related protein Rab-3 ( 203) 454 58.2 3.8e-08
NP_002861 (OMIM: 602672) ras-related protein Rab-1 ( 203) 450 57.8 4.9e-08
NP_001020471 (OMIM: 616448) ras-related protein Ra ( 244) 436 56.6 1.4e-07
XP_011526466 (OMIM: 179490) PREDICTED: ras-related ( 220) 433 56.3 1.6e-07
NP_002857 (OMIM: 179490) ras-related protein Rab-3 ( 220) 433 56.3 1.6e-07
NP_006852 (OMIM: 604199) ras-related protein Rab-3 ( 201) 432 56.1 1.6e-07
NP_004209 (OMIM: 604198) ras-related protein Rab-1 ( 218) 431 56.1 1.8e-07
NP_004274 (OMIM: 604350) ras-related protein Rab-3 ( 219) 429 55.9 2.1e-07
NP_004654 (OMIM: 605570) ras-related protein Rab-1 ( 216) 428 55.8 2.2e-07
NP_002856 (OMIM: 179509) ras-related protein Rab-2 ( 212) 426 55.6 2.5e-07
XP_016857447 (OMIM: 179510) PREDICTED: ras-related ( 219) 423 55.3 3.1e-07
NP_002858 (OMIM: 179510) ras-related protein Rab-3 ( 219) 423 55.3 3.1e-07
NP_004785 (OMIM: 300333) ras-related protein Rab-3 ( 237) 423 55.3 3.3e-07
NP_116235 (OMIM: 607466) ras-related protein Rab-2 ( 216) 417 54.7 4.6e-07
NP_001304844 (OMIM: 612829) ras-related protein Ra ( 225) 417 54.7 4.7e-07
NP_612462 (OMIM: 612829) ras-related protein Rab-3 ( 227) 415 54.5 5.4e-07
NP_741995 (OMIM: 300774) ras-related protein Rab-3 ( 213) 411 54.1 6.8e-07
NP_065120 (OMIM: 612942) ras-related protein Rab-2 ( 213) 409 53.9 7.8e-07
NP_067075 (OMIM: 602207,614222) ras-related protei ( 206) 405 53.5 1e-06
NP_057406 (OMIM: 612673) ras-related protein Rab-1 ( 215) 401 53.2 1.3e-06
NP_001157462 (OMIM: 609956) ras-related protein Ra ( 186) 398 52.8 1.5e-06
XP_016873867 (OMIM: 612565) PREDICTED: ras-related ( 237) 399 53.0 1.6e-06
NP_004153 (OMIM: 179512) ras-related protein Rab-5 ( 215) 396 52.7 1.9e-06
NP_002860 (OMIM: 179513) ras-related protein Rab-6 ( 208) 393 52.4 2.2e-06
NP_071894 (OMIM: 602206) ras-related protein Rab-1 ( 212) 392 52.3 2.4e-06
NP_112586 (OMIM: 605950,615222) ras-related protei ( 229) 392 52.3 2.5e-06
>>NP_689786 (OMIM: 611344) ras and EF-hand domain-contai (740 aa)
initn: 4836 init1: 4836 opt: 4836 Z-score: 2540.3 bits: 480.7 E(85289): 9.3e-135
Smith-Waterman score: 4836; 100.0% identity (100.0% similar) in 740 aa overlap (1-740:1-740)
10 20 30 40 50 60
pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSAL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 QSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSAL
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK
490 500 510 520 530 540
550 560 570 580 590 600
pF1KE3 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ
550 560 570 580 590 600
610 620 630 640 650 660
pF1KE3 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD
610 620 630 640 650 660
670 680 690 700 710 720
pF1KE3 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI
670 680 690 700 710 720
730 740
pF1KE3 TNLTGTNSKKSPQMKNCCNG
::::::::::::::::::::
NP_689 TNLTGTNSKKSPQMKNCCNG
730 740
>>XP_005251788 (OMIM: 611344) PREDICTED: ras and EF-hand (611 aa)
initn: 3858 init1: 3858 opt: 3858 Z-score: 2032.5 bits: 386.5 E(85289): 1.8e-106
Smith-Waterman score: 3858; 100.0% identity (100.0% similar) in 597 aa overlap (144-740:15-611)
120 130 140 150 160 170
pF1KE3 ALATSCGPASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNF
::::::::::::::::::::::::::::::
XP_005 MEEGLQTWRPPEPGREEQVSTLYQNINLVEPRLIQPYEHVIKNF
10 20 30 40
180 190 200 210 220 230
pF1KE3 IREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 IREIRLQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALS
50 60 70 80 90 100
240 250 260 270 280 290
pF1KE3 DLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEA
110 120 130 140 150 160
300 310 320 330 340 350
pF1KE3 QTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 QTNIAFLQSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSN
170 180 190 200 210 220
360 370 380 390 400 410
pF1KE3 DGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DGLRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCD
230 240 250 260 270 280
420 430 440 450 460 470
pF1KE3 SLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 SLALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGG
290 300 310 320 330 340
480 490 500 510 520 530
pF1KE3 DASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 DASDTDVPDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNA
350 360 370 380 390 400
540 550 560 570 580 590
pF1KE3 KSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQ
410 420 430 440 450 460
600 610 620 630 640 650
pF1KE3 LWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVG
470 480 490 500 510 520
660 670 680 690 700 710
pF1KE3 NKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 NKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTD
530 540 550 560 570 580
720 730 740
pF1KE3 KDDSRSITNLTGTNSKKSPQMKNCCNG
:::::::::::::::::::::::::::
XP_005 KDDSRSITNLTGTNSKKSPQMKNCCNG
590 600 610
>>XP_005251787 (OMIM: 611344) PREDICTED: ras and EF-hand (717 aa)
initn: 2634 init1: 2634 opt: 2680 Z-score: 1419.1 bits: 273.2 E(85289): 2.6e-72
Smith-Waterman score: 4640; 96.9% identity (96.9% similar) in 740 aa overlap (1-740:1-717)
10 20 30 40 50 60
pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MEADGDGEELARLRSVFAACDANRSGRLEREEFRALCTELRVRPADAEAVFQRLDADRDG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AITFQEFARGFLGSLRGGRRRDWGPLDPAPAVSEAGPETHDSEEDEGDEDAAAALATSCG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PASPGRAWQDFQARLGDEAKFIPREEQVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQ
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 STEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQYE
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFL
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 QSELDALKSDYADQSLNTERDLEIIRAYTEDRNSLERQIEILQTANRKLHDSNDGLRSAL
:::::::::::::::::::: :::::::::::::::::
XP_005 QSELDALKSDYADQSLNTER-----------------------TANRKLHDSNDGLRSAL
310 320 330
370 380 390 400 410 420
pF1KE3 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDP
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE3 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDV
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE3 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 PDIRDEETFGLEDVASVLDWKPQGSVSEGSIVSSSRKPISALSPQTDLVDDNAKSFSSQK
460 470 480 490 500 510
550 560 570 580 590 600
pF1KE3 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQ
520 530 540 550 560 570
610 620 630 640 650 660
pF1KE3 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 ERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRD
580 590 600 610 620 630
670 680 690 700 710 720
pF1KE3 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 TAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSI
640 650 660 670 680 690
730 740
pF1KE3 TNLTGTNSKKSPQMKNCCNG
::::::::::::::::::::
XP_005 TNLTGTNSKKSPQMKNCCNG
700 710
>>NP_001138430 (OMIM: 614178) EF-hand calcium-binding do (731 aa)
initn: 677 init1: 454 opt: 581 Z-score: 327.4 bits: 71.2 E(85289): 1.7e-11
Smith-Waterman score: 859; 27.7% identity (59.5% similar) in 751 aa overlap (2-738:44-730)
10 20 30
pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE
...:. : . . : .:::. .: . :.
NP_001 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK
20 30 40 50 60 70
40 50 60 70 80
pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP
... : :: . . : ::. :::: .: .: :::. :: . : . ..: : .
NP_001 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ
80 90 100 110 120 130
90 100 110 120 130 140
pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE
. : ..:: :: :: : . : .: ::: . : . :
NP_001 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES
140 150 160 170
150 160 170 180 190 200
pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE
.:. :. ... ::.:.. .: . .: ... : ..: :.:: ....:
NP_001 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ
:::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : ..
NP_001 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII
..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:.
NP_001 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI
: . ... .: .:...:. :..:.: : ..: :.. . :. . .
NP_001 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW
360 370 380 390 400
390 400 410 420 430 440
pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST
.. : . ::. . : ::. .:. . ... : .:.. ... : . . : .
NP_001 KKRSGSVIGKYVDSRGILRSQS----EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG-
410 420 430 440 450
450 460 470 480 490
pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL
.:. . : ..: .:.:. .:.. : :. .. . :
NP_001 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS
460 470 480 490 500
500 510 520 530 540 550
pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF
: ::.. :. .. . .: . . : .... . .. .:::..:..::::.::
NP_001 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF
510 520 530 540 550 560
560 570 580 590 600 610
pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV
: :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....:::::::
NP_001 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV
570 580 590 600 610 620
620 630 640 650 660 670
pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK
...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::.
NP_001 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ
630 640 650 660 670
680 690 700 710 720 730
pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC
:: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.:
NP_001 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC
680 690 700 710 720
740
pF1KE3 CNG
:
NP_001 CG
730
>>XP_011519339 (OMIM: 614178) PREDICTED: EF-hand calcium (493 aa)
initn: 554 init1: 454 opt: 572 Z-score: 324.6 bits: 70.1 E(85289): 2.4e-11
Smith-Waterman score: 683; 27.7% identity (62.3% similar) in 538 aa overlap (209-738:1-492)
180 190 200 210 220 230
pF1KE3 LQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQ
:.:.:.. ... . .. . ..:...
XP_011 MEQQIKSEKEQFLLKDTERFQARSQELEQK
10 20 30
240 250 260 270 280 290
pF1KE3 YETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIA
. .:. .: ..:: : .. ..: : . :.. ::.. ..: ... ..
XP_011 LLCKEQELEQLTQKQKRLEGQC--TALHHDKHETKAENTKLKLTNQELARELERTSWELQ
40 50 60 70 80
300 310 320 330 340 350
pF1KE3 FLQSELDALKSDYADQSLNTERDLEIIR---AYTEDRNSLERQIEILQTANRKLHDSNDG
:..:..:... .:. :...:. : . ... .: .:...:. :..:.: :
XP_011 DAQQQLESLQQEAC--KLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD-
90 100 110 120 130 140
360 370 380 390 400 410
pF1KE3 LRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSL
..: :.. . :. . . .. : . ::. . : :::.: .:. . .
XP_011 ------ICFQK-NKAAKANTAASRASWKKRSGSVIGKYVDSRGILRSSQS---EEEEEVF
150 160 170 180 190
420 430 440 450 460 470
pF1KE3 ALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDA
.. : .:.. ... : . . : . .:. . : ..: .:.:.
XP_011 GI--P-RRSSLGLSGYPLTEEEPGTG---EPGPGG-----PYPRPLRRIISVEED-----
200 210 220 230
480 490 500 510 520 530
pF1KE3 SDTDVPDIRD---EETFG-LEDVASVLDWKPQGSVSEGSIVS-SSRKPISALSPQTDLVD
.:.. : :. .. . : : ::.. :. .. . .: . . :
XP_011 ---PLPQLLDGGFEQPLSKCSEEEEVSDQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCK
240 250 260 270 280 290
540 550 560 570 580 590
pF1KE3 DNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERT
.... . .. .:::..:..::::.::: :.:...: ...::.:.:...::: ::. ..
XP_011 EESSPSAPDRLFKIVFVGNSAVGKTSFLRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQV
300 310 320 330 340 350
600 610 620 630 640 650
pF1KE3 VLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIM
.:::::::::::.: :....:::::::...::.: ..:::..:.:.. .:.:. . ::..
XP_011 ALQLWDTAGQERYRCITQQFFRKADGVIVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVL
360 370 380 390 400 410
660 670 680 690 700 710
pF1KE3 LVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKK
:.::: : .: .. :: .::.:: . .: : :: .: : :..::::: .:.
XP_011 LLGNKLD------NEKEREVPRGLGEQLATENNLIFYECSAYSGHNTKESLLHLARFLKE
420 430 440 450 460 470
720 730 740
pF1KE3 RTDKDDSRSITNLTGTNSKKSPQMKNCCNG
. .: : : .: .:: :.::
XP_011 Q--EDTVREDTIQVGHPAKK----KSCCG
480 490
>>XP_011519340 (OMIM: 614178) PREDICTED: EF-hand calcium (493 aa)
initn: 554 init1: 454 opt: 572 Z-score: 324.6 bits: 70.1 E(85289): 2.4e-11
Smith-Waterman score: 683; 27.7% identity (62.3% similar) in 538 aa overlap (209-738:1-492)
180 190 200 210 220 230
pF1KE3 LQSTEMENLAIAVKRAQDKAAMQLSELEEEMDQRIQAAEHKTRKDEKRKAEEALSDLRRQ
:.:.:.. ... . .. . ..:...
XP_011 MEQQIKSEKEQFLLKDTERFQARSQELEQK
10 20 30
240 250 260 270 280 290
pF1KE3 YETEVGDLQVTIKKLRKLEEQSKRVSQKEDVAALKKQIYDLSMENQKVKKDLLEAQTNIA
. .:. .: ..:: : .. ..: : . :.. ::.. ..: ... ..
XP_011 LLCKEQELEQLTQKQKRLEGQC--TALHHDKHETKAENTKLKLTNQELARELERTSWELQ
40 50 60 70 80
300 310 320 330 340 350
pF1KE3 FLQSELDALKSDYADQSLNTERDLEIIR---AYTEDRNSLERQIEILQTANRKLHDSNDG
:..:..:... .:. :...:. : . ... .: .:...:. :..:.: :
XP_011 DAQQQLESLQQEAC--KLHQEKEMEVYRVTESLQREKAGLLKQLDFLRERNKHLRDERD-
90 100 110 120 130 140
360 370 380 390 400 410
pF1KE3 LRSALENSYSKFNRSLHINNISPGNTISRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSL
..: :.. . :. . . .. : . ::. . : :::.: .:. . .
XP_011 ------ICFQK-NKAAKANTAASRASWKKRSGSVIGKYVDSRGILRSSQS---EEEEEVF
150 160 170 180 190
420 430 440 450 460 470
pF1KE3 ALCDPLQRTNCEVDSLPESCFDSGLSTLRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDA
.. : .:.. ... : . . : . .:. . : ..: .:.:.
XP_011 GI--P-RRSSLGLSGYPLTEEEPGTG---EPGPGG-----PYPRPLRRIISVEED-----
200 210 220 230
480 490 500 510 520 530
pF1KE3 SDTDVPDIRD---EETFG-LEDVASVLDWKPQGSVSEGSIVS-SSRKPISALSPQTDLVD
.:.. : :. .. . : : ::.. :. .. . .: . . :
XP_011 ---PLPQLLDGGFEQPLSKCSEEEEVSDQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCK
240 250 260 270 280 290
540 550 560 570 580 590
pF1KE3 DNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENISATLGVDFQMKTLIVDGERT
.... . .. .:::..:..::::.::: :.:...: ...::.:.:...::: ::. ..
XP_011 EESSPSAPDRLFKIVFVGNSAVGKTSFLRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQV
300 310 320 330 340 350
600 610 620 630 640 650
pF1KE3 VLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLNIREWVDMIEDAAHETVPIM
.:::::::::::.: :....:::::::...::.: ..:::..:.:.. .:.:. . ::..
XP_011 ALQLWDTAGQERYRCITQQFFRKADGVIVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVL
360 370 380 390 400 410
660 670 680 690 700 710
pF1KE3 LVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSAKDGSNIVEAVLHLAREVKK
:.::: : .: .. :: .::.:: . .: : :: .: : :..::::: .:.
XP_011 LLGNKLD------NEKEREVPRGLGEQLATENNLIFYECSAYSGHNTKESLLHLARFLKE
420 430 440 450 460 470
720 730 740
pF1KE3 RTDKDDSRSITNLTGTNSKKSPQMKNCCNG
. .: : : .: .:: :.::
XP_011 Q--EDTVREDTIQVGHPAKK----KSCCG
480 490
>>XP_011519336 (OMIM: 614178) PREDICTED: EF-hand calcium (732 aa)
initn: 677 init1: 454 opt: 575 Z-score: 324.3 bits: 70.6 E(85289): 2.5e-11
Smith-Waterman score: 873; 28.0% identity (59.8% similar) in 751 aa overlap (2-738:44-731)
10 20 30
pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE
...:. : . . : .:::. .: . :.
XP_011 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK
20 30 40 50 60 70
40 50 60 70 80
pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP
... : :: . . : ::. :::: .: .: :::. :: . : . ..: : .
XP_011 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ
80 90 100 110 120 130
90 100 110 120 130 140
pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE
. : ..:: :: :: : . : .: ::: . : . :
XP_011 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES
140 150 160 170
150 160 170 180 190 200
pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE
.:. :. ... ::.:.. .: . .: ... : ..: :.:: ....:
XP_011 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ
:::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : ..
XP_011 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII
..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:.
XP_011 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI
: . ... .: .:...:. :..:.: : ..: :.. . :. . .
XP_011 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW
360 370 380 390 400
390 400 410 420 430 440
pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST
.. : . ::. . : :::.: .:. . ... : .:.. ... : . . : .
XP_011 KKRSGSVIGKYVDSRGILRSSQS---EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG-
410 420 430 440 450
450 460 470 480 490
pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL
.:. . : ..: .:.:. .:.. : :. .. . :
XP_011 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS
460 470 480 490 500
500 510 520 530 540 550
pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF
: ::.. :. .. . .: . . : .... . .. .:::..:..::::.::
XP_011 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF
510 520 530 540 550 560
560 570 580 590 600 610
pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV
: :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....:::::::
XP_011 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV
570 580 590 600 610 620
620 630 640 650 660 670
pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK
...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::.
XP_011 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ
630 640 650 660 670
680 690 700 710 720 730
pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC
:: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.:
XP_011 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC
680 690 700 710 720 730
740
pF1KE3 CNG
:
XP_011 CG
>>XP_006719084 (OMIM: 614178) PREDICTED: EF-hand calcium (732 aa)
initn: 677 init1: 454 opt: 575 Z-score: 324.3 bits: 70.6 E(85289): 2.5e-11
Smith-Waterman score: 873; 28.0% identity (59.8% similar) in 751 aa overlap (2-738:44-731)
10 20 30
pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE
...:. : . . : .:::. .: . :.
XP_006 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK
20 30 40 50 60 70
40 50 60 70 80
pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP
... : :: . . : ::. :::: .: .: :::. :: . : . ..: : .
XP_006 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ
80 90 100 110 120 130
90 100 110 120 130 140
pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE
. : ..:: :: :: : . : .: ::: . : . :
XP_006 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES
140 150 160 170
150 160 170 180 190 200
pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE
.:. :. ... ::.:.. .: . .: ... : ..: :.:: ....:
XP_006 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ
:::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : ..
XP_006 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII
..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:.
XP_006 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI
: . ... .: .:...:. :..:.: : ..: :.. . :. . .
XP_006 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW
360 370 380 390 400
390 400 410 420 430 440
pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST
.. : . ::. . : :::.: .:. . ... : .:.. ... : . . : .
XP_006 KKRSGSVIGKYVDSRGILRSSQS---EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG-
410 420 430 440 450
450 460 470 480 490
pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL
.:. . : ..: .:.:. .:.. : :. .. . :
XP_006 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS
460 470 480 490 500
500 510 520 530 540 550
pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF
: ::.. :. .. . .: . . : .... . .. .:::..:..::::.::
XP_006 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF
510 520 530 540 550 560
560 570 580 590 600 610
pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV
: :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....:::::::
XP_006 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV
570 580 590 600 610 620
620 630 640 650 660 670
pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK
...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::.
XP_006 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ
630 640 650 660 670
680 690 700 710 720 730
pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC
:: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.:
XP_006 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC
680 690 700 710 720 730
740
pF1KE3 CNG
:
XP_006 CG
>>XP_011519338 (OMIM: 614178) PREDICTED: EF-hand calcium (732 aa)
initn: 677 init1: 454 opt: 575 Z-score: 324.3 bits: 70.6 E(85289): 2.5e-11
Smith-Waterman score: 873; 28.0% identity (59.8% similar) in 751 aa overlap (2-738:44-731)
10 20 30
pF1KE3 MEADGDGEELARLRSVFAACDANRSGRLERE
...:. : . . : .:::. .: . :.
XP_011 RLGQGSGQGPKGSGACLHPLDSLEQKETQEQTSGQLVMLRKAQEFFQTCDAEGKGFIARK
20 30 40 50 60 70
40 50 60 70 80
pF1KE3 EFRALCTELRVRPADAEAVFQRLDADRDGAITFQEFARGF---LGSLRGGRRRDWGPLDP
... : :: . . : ::. :::: .: .: :::. :: . : . ..: : .
XP_011 DMQRLHKELPLSLEELEDVFDALDADGNGYLTPQEFTTGFSHFFFSQNNPSQEDAG--EQ
80 90 100 110 120 130
90 100 110 120 130 140
pF1KE3 APAVSEAGPETHDSEEDEGD--EDAAAALATSCGPASPGRAWQDFQARLGDEAKFIPREE
. : ..:: :: :: : . : .: ::: . : . :
XP_011 VAQRHEEKVYLSRGDEDLGDMGEDEEAQF----------RMLMD---RLGAQ-KVLEDES
140 150 160 170
150 160 170 180 190 200
pF1KE3 QVSTLYQNINLVEPRLIQPYEHVIKNFIREIRLQSTEMENLAIAVKRAQDKAAMQLSELE
.:. :. ... ::.:.. .: . .: ... : ..: :.:: ....:
XP_011 DVKQLWLQLKKEEPHLLSNFEDFLTRIISQLQEAHEEKNELECALKRKIAAYDEEIQHLY
180 190 200 210 220 230
210 220 230 240 250 260
pF1KE3 EEMDQRIQAAEHK-TRKDEKRKAEEALSDLRRQYETEVGDLQVTIKKLRKLEEQSKRVSQ
:::.:.:.. ... :: .: .. ..:... . .:. .: ..:: : ..
XP_011 EEMEQQIKSEKEQFLLKDTERFQARS-QELEQKLLCKEQELEQLTQKQKRLEGQC--TAL
240 250 260 270 280 290
270 280 290 300 310 320
pF1KE3 KEDVAALKKQIYDLSMENQKVKKDLLEAQTNIAFLQSELDALKSDYADQSLNTERDLEII
..: : . :.. ::.. ..: ... .. :..:..:... .:. :...:.
XP_011 HHDKHETKAENTKLKLTNQELARELERTSWELQDAQQQLESLQQEAC--KLHQEKEMEVY
300 310 320 330 340 350
330 340 350 360 370 380
pF1KE3 R---AYTEDRNSLERQIEILQTANRKLHDSNDGLRSALENSYSKFNRSLHINNISPGNTI
: . ... .: .:...:. :..:.: : ..: :.. . :. . .
XP_011 RVTESLQREKAGLLKQLDFLRERNKHLRDERD-------ICFQK-NKAAKANTAASRASW
360 370 380 390 400
390 400 410 420 430 440
pF1KE3 SRSSPKFIGHSPQPLGYDRSSRSSYVDEDCDSLALCDPLQRTNCEVDSLPESCFDSGLST
.. : . ::. . : :::.: .:. . ... : .:.. ... : . . : .
XP_011 KKRSGSVIGKYVDSRGILRSSQS---EEEEEVFGI--P-RRSSLGLSGYPLTEEEPGTG-
410 420 430 440 450
450 460 470 480 490
pF1KE3 LRDPNEYDSEVEYKHQRGFQRSHGVQESFGGDASDTDVPDIRD---EETFG-LEDVASVL
.:. . : ..: .:.:. .:.. : :. .. . :
XP_011 --EPGPGG-----PYPRPLRRIISVEED--------PLPQLLDGGFEQPLSKCSEEEEVS
460 470 480 490 500
500 510 520 530 540 550
pF1KE3 DWKPQGSVSEGSIVS-SSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSF
: ::.. :. .. . .: . . : .... . .. .:::..:..::::.::
XP_011 DQGVQGQIPEAPPLKLTPTSPRGQPVGKEALCKEESSPSAPDRLFKIVFVGNSAVGKTSF
510 520 530 540 550 560
560 570 580 590 600 610
pF1KE3 LMRLCKNEFRENISATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGV
: :.:...: ...::.:.:...::: ::. ...:::::::::::.: :....:::::::
XP_011 LRRFCEDRFSPGMAATVGIDYRVKTLNVDNSQVALQLWDTAGQERYRCITQQFFRKADGV
570 580 590 600 610 620
620 630 640 650 660 670
pF1KE3 LLLYDVTCEKSFLNIREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEK
...::.: ..:::..:.:.. .:.:. . ::..:.::: : .: .. :: .::.
XP_011 IVMYDLTDKQSFLSVRRWLSSVEEAVGDRVPVLLLGNKLD------NEKEREVPRGLGEQ
630 640 650 660 670
680 690 700 710 720 730
pF1KE3 LAMTYGALFCETSAKDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNC
:: . .: : :: .: : :..::::: .:.. .: : : .: .:: :.:
XP_011 LATENNLIFYECSAYSGHNTKESLLHLARFLKEQ--EDTVREDTIQVGHPAKK----KSC
680 690 700 710 720 730
740
pF1KE3 CNG
:
XP_011 CG
>>NP_005361 (OMIM: 165040) ras-related protein Rab-8A [H (207 aa)
initn: 510 init1: 397 opt: 520 Z-score: 301.5 bits: 64.6 E(85289): 4.7e-10
Smith-Waterman score: 520; 45.7% identity (72.8% similar) in 173 aa overlap (542-714:9-175)
520 530 540 550 560 570
pF1KE3 VSSSRKPISALSPQTDLVDDNAKSFSSQKAYKIVLAGDAAVGKSSFLMRLCKNEFRENIS
.:..: ::..:::. :.:. .. : ..
NP_005 MAKTYDYLFKLLLIGDSGVGKTCVLFRFSEDAFNSTFI
10 20 30
580 590 600 610 620 630
pF1KE3 ATLGVDFQMKTLIVDGERTVLQLWDTAGQERFRSIAKSYFRKADGVLLLYDVTCEKSFLN
.:.:.::...:. .::.: ::.::::::::::.:. .:.: : :..:.::.: :::: :
NP_005 STIGIDFKIRTIELDGKRIKLQIWDTAGQERFRTITTAYYRGAMGIMLVYDITNEKSFDN
40 50 60 70 80 90
640 650 660 670 680 690
pF1KE3 IREWVDMIEDAAHETVPIMLVGNKADIRDTAATEGQKCVPGHFGEKLAMTYGALFCETSA
::.:. ::. : : :..::: :. : .. : . :::::. :: : ::::
NP_005 IRNWIRNIEEHASADVEKMILGNKCDVND------KRQVSKERGEKLALDYGIKFMETSA
100 110 120 130 140 150
700 710 720 730 740
pF1KE3 KDGSNIVEAVLHLAREVKKRTDKDDSRSITNLTGTNSKKSPQMKNCCNG
: . :. .: . :::..: . ::
NP_005 KANINVENAFFTLARDIKAKMDKKLEGNSPQGSNQGVKITPDQQKRSSFFRCVLL
160 170 180 190 200
740 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 05:37:31 2016 done: Sun Nov 6 05:37:33 2016
Total Scan time: 13.000 Total Display time: 0.180
Function used was FASTA [36.3.4 Apr, 2011]