Result of FASTA (omim) for
pFN21AE3234
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3234, 546 aa
1>>>pF1KE3234 546 - 546 aa - 546 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.9363+/-0.000396; mu= 16.7027+/- 0.025
mean_var=146.8381+/-31.576, 0's: 0 Z-trim(116.5): 247 B-trim: 965 in 2/49
Lambda= 0.105841
statistics sampled from 27460 (27802) to 27460 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.684), E-opt: 0.2 (0.326), width: 16
Scan time: 10.630
The best scores are: opt bits E(85289)
NP_001156956 (OMIM: 613317) DDB1- and CUL4-associa ( 546) 3747 584.5 2.8e-166
NP_079506 (OMIM: 613317) DDB1- and CUL4-associated ( 546) 3747 584.5 2.8e-166
NP_852002 (OMIM: 613317) DDB1- and CUL4-associated ( 520) 3306 517.2 5e-146
NP_004805 (OMIM: 607797) U5 small nuclear ribonucl ( 357) 296 57.3 9.1e-08
NP_056975 (OMIM: 605585) pre-mRNA-processing facto ( 579) 242 49.4 3.7e-05
NP_438172 (OMIM: 609012) WD repeat-containing prot ( 334) 238 48.5 4e-05
XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-c ( 334) 238 48.5 4e-05
NP_060058 (OMIM: 609012) WD repeat-containing prot ( 334) 238 48.5 4e-05
NP_001093207 (OMIM: 616850) WD repeat domain-conta ( 315) 215 44.9 0.00044
NP_115708 (OMIM: 616850) WD repeat domain-containi ( 315) 215 44.9 0.00044
XP_016878126 (OMIM: 609540) PREDICTED: WD repeat-c ( 270) 209 43.9 0.00076
XP_005247749 (OMIM: 610863,615185) PREDICTED: guan ( 340) 210 44.2 0.00079
NP_067642 (OMIM: 610863,615185) guanine nucleotide ( 340) 210 44.2 0.00079
XP_006713784 (OMIM: 610863,615185) PREDICTED: guan ( 340) 210 44.2 0.00079
NP_002065 (OMIM: 139380,613065,616973) guanine nuc ( 340) 207 43.7 0.0011
XP_016856548 (OMIM: 139380,613065,616973) PREDICTE ( 340) 207 43.7 0.0011
NP_001269468 (OMIM: 139380,613065,616973) guanine ( 340) 207 43.7 0.0011
XP_016856549 (OMIM: 139380,613065,616973) PREDICTE ( 340) 207 43.7 0.0011
XP_016856550 (OMIM: 139380,613065,616973) PREDICTE ( 340) 207 43.7 0.0011
NP_001269467 (OMIM: 139380,613065,616973) guanine ( 240) 200 42.5 0.0018
NP_002066 (OMIM: 139130,145500,617024) guanine nuc ( 340) 201 42.8 0.0021
NP_001271137 (OMIM: 603812) DDB1- and CUL4-associa ( 326) 200 42.6 0.0022
XP_006720360 (OMIM: 603812) PREDICTED: DDB1- and C ( 977) 206 44.1 0.0023
NP_001309196 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 198 42.2 0.0025
NP_001309195 (OMIM: 607795,615922) U4/U6 small nuc ( 279) 198 42.2 0.0025
XP_006720361 (OMIM: 603812) PREDICTED: DDB1- and C ( 976) 203 43.7 0.0032
NP_001231855 (OMIM: 607795,615922) U4/U6 small nuc ( 521) 198 42.6 0.0037
NP_004688 (OMIM: 607795,615922) U4/U6 small nuclea ( 522) 198 42.6 0.0037
NP_003852 (OMIM: 603812) DDB1- and CUL4-associated ( 942) 200 43.2 0.0043
NP_001271135 (OMIM: 603812) DDB1- and CUL4-associa ( 941) 197 42.7 0.0059
NP_001284500 (OMIM: 139130,145500,617024) guanine ( 339) 190 41.1 0.0066
>>NP_001156956 (OMIM: 613317) DDB1- and CUL4-associated (546 aa)
initn: 3747 init1: 3747 opt: 3747 Z-score: 3106.3 bits: 584.5 E(85289): 2.8e-166
Smith-Waterman score: 3747; 99.8% identity (100.0% similar) in 546 aa overlap (1-546:1-546)
10 20 30 40 50 60
pF1KE3 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_001 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
490 500 510 520 530 540
pF1KE3 PFSSPQ
::::::
NP_001 PFSSPQ
>>NP_079506 (OMIM: 613317) DDB1- and CUL4-associated fac (546 aa)
initn: 3747 init1: 3747 opt: 3747 Z-score: 3106.3 bits: 584.5 E(85289): 2.8e-166
Smith-Waterman score: 3747; 99.8% identity (100.0% similar) in 546 aa overlap (1-546:1-546)
10 20 30 40 50 60
pF1KE3 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 SKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_079 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
370 380 390 400 410 420
430 440 450 460 470 480
pF1KE3 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
430 440 450 460 470 480
490 500 510 520 530 540
pF1KE3 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_079 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
490 500 510 520 530 540
pF1KE3 PFSSPQ
::::::
NP_079 PFSSPQ
>>NP_852002 (OMIM: 613317) DDB1- and CUL4-associated fac (520 aa)
initn: 3306 init1: 3306 opt: 3306 Z-score: 2742.6 bits: 517.2 E(85289): 5e-146
Smith-Waterman score: 3521; 95.1% identity (95.2% similar) in 546 aa overlap (1-546:1-520)
10 20 30 40 50 60
pF1KE3 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQVLAYLLRRGQVRLVQG
::::::::::::::::::::::::::::::::::::::::::::
NP_852 MGSRNSSSAGSGSGDPSEGLPRRGAGLRRSEEEEEEDEDVDLAQ----------------
10 20 30 40
70 80 90 100 110 120
pF1KE3 GGAANLQFIQALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 ----------ALLDSEEENDRAWDGRLGDRYNPPVDATPDTRELEFNEIKTQVELATGQL
50 60 70 80 90
130 140 150 160 170 180
pF1KE3 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 GLRRAAQKHSFPRMLHQRERGLCHRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIY
100 110 120 130 140 150
190 200 210 220 230 240
pF1KE3 SKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
::::::::::::::::::::::::::.:::::::::::::::::::::::::::::::::
NP_852 SKDGQIFMSACQDQTIRLYDCRYGRFRKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD
160 170 180 190 200 210
250 260 270 280 290 300
pF1KE3 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 YIHICNIYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRT
220 230 240 250 260 270
310 320 330 340 350 360
pF1KE3 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 LQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITF
280 290 300 310 320 330
370 380 390 400 410 420
pF1KE3 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 IDSKGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKL
340 350 360 370 380 390
430 440 450 460 470 480
pF1KE3 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 KLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLT
400 410 420 430 440 450
490 500 510 520 530 540
pF1KE3 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_852 NHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSST
460 470 480 490 500 510
pF1KE3 PFSSPQ
::::::
NP_852 PFSSPQ
520
>>NP_004805 (OMIM: 607797) U5 small nuclear ribonucleopr (357 aa)
initn: 362 init1: 130 opt: 296 Z-score: 260.4 bits: 57.3 E(85289): 9.1e-08
Smith-Waterman score: 315; 25.7% identity (56.2% similar) in 338 aa overlap (174-509:68-353)
150 160 170 180 190 200
pF1KE3 HRGSFSLGEQSRVISHFLPNDLGFTDSYSQKAFCGIYSKDGQIFMSACQDQTIRLYDCRY
...: . .:. . :: :. : :.. :
NP_004 QATPGALLQAGPPRCSSLQAPIMLLSGHEGEVYCCKFHPNGSTLASAGFDRLILLWNV-Y
40 50 60 70 80 90
210 220 230 240 250 260
pF1KE3 GRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYGEGDTHTALDLRPDE
: .. ..:... : .:... .. ::. .:.:. .: . .. ...: . .
NP_004 GDCDNYATLKGHS-G-AVMELHYNTDGS-MLFSASTD--KTVAVW-DSETGERVKRLKGH
100 110 120 130 140 150
270 280 290 300 310 320
pF1KE3 RRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNAVAFADISSQIL
:. . . : :..:: . ..: .. . ..: .. .: ::.: : :.::.
NP_004 TSFVNSCYPARRGPQLVCTGSDDGTVKLWDIRK-KAAIQTFQNTYQVLAVTFNDTSDQII
160 170 180 190 200
330 340 350 360 370 380
pF1KE3 FSGGDDAICKVWDRRTMREDDPKPVGALAGHQDGITFIDSKGDARYLISNSKDQTIKLWD
::: : :::: .:.. : . .. :: :..: .. .... ::.::. :.:...::
NP_004 -SGGIDNDIKVWD---LRQN--KLTYTMRGHADSVTGLSLSSEGSYLLSNAMDNTVRVWD
210 220 230 240 250 260
390 400 410 420 430 440
pF1KE3 IRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLPGDSSLMTYRG--HGVLHTLI
.: :. .: : .:. ..: :. ..:.
NP_004 VRPFAPKE--------------------------RCVKI--------FQGNVHNFEKNLL
270 280
450 460 470 480 490 500
pF1KE3 RCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHKACVRDVSWHPFEEKIVSS
:: .:: :.. : .: . : :.: : .:. :: .: . . .:..:: : :.:.
NP_004 RCSWSP---DGSK-IAAGSADRFVYVWDTTSRRILYKLPGHAGSINEVAFHPDEPIIISA
290 300 310 320 330 340
510 520 530 540
pF1KE3 SWDGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTPFSSPQ
: : : .
NP_004 SSDKRLYMGEIQ
350
>>NP_056975 (OMIM: 605585) pre-mRNA-processing factor 17 (579 aa)
initn: 141 init1: 73 opt: 242 Z-score: 213.5 bits: 49.4 E(85289): 3.7e-05
Smith-Waterman score: 242; 24.4% identity (55.4% similar) in 307 aa overlap (224-510:294-578)
200 210 220 230 240 250
pF1KE3 QTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSD-YIHICNIYGEGD
: . : ..:.: : : :.. ..:::
NP_056 NLRSTMPPEKCYLPKKQIHVWSGHTKGVSAVRLFPLSGHLLLSCSMDCKIKLWEVYGE--
270 280 290 300 310 320
260 270 280 290 300 310
pF1KE3 THTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDDVNA
. : . . :: .: .. : . :..: : : ..: : .. .. ... .
NP_056 -RRCLRTFIGHSK-AVRDICFNTAGTQFLSAAYDRYLKLWDTETGQCISRFTNRKVPYCV
330 340 350 360 370
320 330 340 350 360
pF1KE3 VAFADISSQILFSGG--DDAICKVWDRRT--MREDDPKPVGALAGHQDGITFIDSKGDAR
: ..: :: .: : : . :: :. . .. . .::. . :.:.: . :
NP_056 KFNPDEDKQNLFVAGMSDKKIVQ-WDIRSGEIVQEYDRHLGAV----NTIVFVD---ENR
380 390 400 410 420 430
370 380 390 400 410
pF1KE3 YLISNSKDQTIKLW--DIR---RFSSREGMEASRQAATQQNWDYRW---QQVPKK-----
..:.: :.....: :: .. .. .:.. . :. . . .: :.. ..
NP_056 RFVSTSDDKSLRVWEWDIPVDFKYIAEPSMHS--MPAVTLSPNGKWLACQSMDNQILIFG
440 450 460 470 480
420 430 440 450 460 470
pF1KE3 AWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHI
: ...: .. ..:: : . ::: : .. :: ..::. ..: . ..
NP_056 AQNRFRL---NKKKIFKGHMVAGYACQVDFSPDMS----YVISGDGNGKLNIWDWKTTKL
490 500 510 520 530 540
480 490 500 510 520 530
pF1KE3 VKKLTNH-KACVRDVSWHPFEE-KIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPA
... : :.:. : ::: : :... .::: ..::
NP_056 YSRFKAHDKVCIGAV-WHPHETSKVITCGWDGLIKLWD
550 560 570
540
pF1KE3 PVPQSSTPFSSPQ
>>NP_438172 (OMIM: 609012) WD repeat-containing protein (334 aa)
initn: 302 init1: 113 opt: 238 Z-score: 212.9 bits: 48.5 E(85289): 4e-05
Smith-Waterman score: 285; 23.9% identity (51.7% similar) in 360 aa overlap (162-511:33-331)
140 150 160 170 180
pF1KE3 PRMLHQRERGLCHRGSFSLGEQSRVISHFLPN-DLGFTDSYSQKAFCGI-YSKDGQIFMS
:: : :: . :: .. .: .:. . :
NP_438 TEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLAS
10 20 30 40 50 60
190 200 210 220 230 240
pF1KE3 ACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYG
. :. :... :.:. :.:... .: : :::.. :.: .. .: . ..: .. .
NP_438 SSADKLIKIWGAYDGKFE--KTISGHKLGIS--DVAWSSDSNLLVSASDDKTLKIWDV-S
70 80 90 100 110
250 260 270 280 290 300
pF1KE3 EGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDD
: .: . . :: . .. ...:. : . ..: . .. . .: :
NP_438 SGKCLKTLKGHSNY----VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP
120 130 140 150 160 170
310 320 330 340 350 360
pF1KE3 VNAVAFADISSQILFSGGDDAICKVWDR------RTMREDDPKPVGALAGHQDGITFIDS
:.:: : .: :. :.. :..:..:: .:. .:: :: .:.
NP_438 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPV----------SFVKF
180 190 200 210 220
370 380 390 400 410 420
pF1KE3 KGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLP
. ...:... . :.:.:::: .
NP_438 SPNGKYILAATLDNTLKLWDYSK-------------------------------------
230 240
430 440 450 460 470 480
pF1KE3 GDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHK
. : :: :: .. : :. . :: ..: :: . : ...: . .::.:: .:
NP_438 -GKCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT
250 260 270 280 290 300
490 500 510 520 530 540
pF1KE3 ACVRDVSWHPFEEKIVSSSW--DGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTP
: ... :: :. :.:.. : ...::.
NP_438 DVVISTACHPTENIIASAALENDKTIKLWKSDC
310 320 330
>>XP_005272220 (OMIM: 609012) PREDICTED: WD repeat-conta (334 aa)
initn: 302 init1: 113 opt: 238 Z-score: 212.9 bits: 48.5 E(85289): 4e-05
Smith-Waterman score: 285; 23.9% identity (51.7% similar) in 360 aa overlap (162-511:33-331)
140 150 160 170 180
pF1KE3 PRMLHQRERGLCHRGSFSLGEQSRVISHFLPN-DLGFTDSYSQKAFCGI-YSKDGQIFMS
:: : :: . :: .. .: .:. . :
XP_005 TEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLAS
10 20 30 40 50 60
190 200 210 220 230 240
pF1KE3 ACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYG
. :. :... :.:. :.:... .: : :::.. :.: .. .: . ..: .. .
XP_005 SSADKLIKIWGAYDGKFE--KTISGHKLGIS--DVAWSSDSNLLVSASDDKTLKIWDV-S
70 80 90 100 110
250 260 270 280 290 300
pF1KE3 EGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDD
: .: . . :: . .. ...:. : . ..: . .. . .: :
XP_005 SGKCLKTLKGHSNY----VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP
120 130 140 150 160 170
310 320 330 340 350 360
pF1KE3 VNAVAFADISSQILFSGGDDAICKVWDR------RTMREDDPKPVGALAGHQDGITFIDS
:.:: : .: :. :.. :..:..:: .:. .:: :: .:.
XP_005 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPV----------SFVKF
180 190 200 210 220
370 380 390 400 410 420
pF1KE3 KGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLP
. ...:... . :.:.:::: .
XP_005 SPNGKYILAATLDNTLKLWDYSK-------------------------------------
230 240
430 440 450 460 470 480
pF1KE3 GDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHK
. : :: :: .. : :. . :: ..: :: . : ...: . .::.:: .:
XP_005 -GKCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT
250 260 270 280 290 300
490 500 510 520 530 540
pF1KE3 ACVRDVSWHPFEEKIVSSSW--DGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTP
: ... :: :. :.:.. : ...::.
XP_005 DVVISTACHPTENIIASAALENDKTIKLWKSDC
310 320 330
>>NP_060058 (OMIM: 609012) WD repeat-containing protein (334 aa)
initn: 302 init1: 113 opt: 238 Z-score: 212.9 bits: 48.5 E(85289): 4e-05
Smith-Waterman score: 285; 23.9% identity (51.7% similar) in 360 aa overlap (162-511:33-331)
140 150 160 170 180
pF1KE3 PRMLHQRERGLCHRGSFSLGEQSRVISHFLPN-DLGFTDSYSQKAFCGI-YSKDGQIFMS
:: : :: . :: .. .: .:. . :
NP_060 TEEKKPETEAARAQPTPSSSATQSKPTPVKPNYALKFTLAGHTKAVSSVKFSPNGEWLAS
10 20 30 40 50 60
190 200 210 220 230 240
pF1KE3 ACQDQTIRLYDCRYGRFHKFKSIKARDVGWSVLDVAFTPDGNHFLYSSWSDYIHICNIYG
. :. :... :.:. :.:... .: : :::.. :.: .. .: . ..: .. .
NP_060 SSADKLIKIWGAYDGKFE--KTISGHKLGIS--DVAWSSDSNLLVSASDDKTLKIWDV-S
70 80 90 100 110
250 260 270 280 290 300
pF1KE3 EGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQNRRTLQIESHEDD
: .: . . :: . .. ...:. : . ..: . .. . .: :
NP_060 SGKCLKTLKGHSNY----VFCCNFNPQSNLIVSGSFDESVRIWDVKTGKCLKTLPAHSDP
120 130 140 150 160 170
310 320 330 340 350 360
pF1KE3 VNAVAFADISSQILFSGGDDAICKVWDR------RTMREDDPKPVGALAGHQDGITFIDS
:.:: : .: :. :.. :..:..:: .:. .:: :: .:.
NP_060 VSAVHFNRDGSLIV-SSSYDGLCRIWDTASGQCLKTLIDDDNPPV----------SFVKF
180 190 200 210 220
370 380 390 400 410 420
pF1KE3 KGDARYLISNSKDQTIKLWDIRRFSSREGMEASRQAATQQNWDYRWQQVPKKAWRKLKLP
. ...:... . :.:.:::: .
NP_060 SPNGKYILAATLDNTLKLWDYSK-------------------------------------
230 240
430 440 450 460 470 480
pF1KE3 GDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGHIVKKLTNHK
. : :: :: .. : :. . :: ..: :: . : ...: . .::.:: .:
NP_060 -GKCLKTYTGH---KNEKYCIFANFSVTGGKWIVSGSEDNLVYIWNLQTKEIVQKLQGHT
250 260 270 280 290 300
490 500 510 520 530 540
pF1KE3 ACVRDVSWHPFEEKIVSSSW--DGNLRLWQYRQAEYFQDDMPESEECASAPAPVPQSSTP
: ... :: :. :.:.. : ...::.
NP_060 DVVISTACHPTENIIASAALENDKTIKLWKSDC
310 320 330
>>NP_001093207 (OMIM: 616850) WD repeat domain-containin (315 aa)
initn: 154 init1: 70 opt: 215 Z-score: 194.2 bits: 44.9 E(85289): 0.00044
Smith-Waterman score: 224; 23.0% identity (52.7% similar) in 317 aa overlap (210-521:16-312)
180 190 200 210 220 230
pF1KE3 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGW-SVLDVAFTPDGNHFLYSSW
: .:. : : .: : :. :::. : .
NP_001 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGS
10 20 30 40
240 250 260 270 280 290
pF1KE3 SDYIHICN-IYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQN
. ... : . : : : . . :.. : : :. . .:..: . ..: ..
NP_001 DKTLKLWNPLRG-----TLLRTYSGHG-YEVLDAAGSFDNSSLCSGGGDKAVVLWDVASG
50 60 70 80 90
300 310 320 330 340 350
pF1KE3 RRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDG
. . ....: ::.: : . . ...::. :. . :: :. : :.:: .: .::
NP_001 QVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSIRCWDCRSRR---PEPVQTLDEARDG
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE3 ITFIDSKGDARYLISNSKDQTIKLWDIRR---FSSREGMEASRQAATQQNWDYRWQQVPK
.. . : . . ....: : .. .:.: ::. : . .... ... .
NP_001 VSSV--KVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDS
160 170 180 190 200 210
420 430 440 450 460 470
pF1KE3 KAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGH
. : : : :.:: . . : .: . . : ::: .::. :
NP_001 -TLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT----HVVSCSEDGKVFFWDLVEGA
220 230 240 250 260
480 490 500 510 520 530
pF1KE3 IVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAP
.. : .. :.....:: : .... :... : :. : .:
NP_001 LALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCW--REEAYEAEDGAG
270 280 290 300 310
540
pF1KE3 VPQSSTPFSSPQ
>>NP_115708 (OMIM: 616850) WD repeat domain-containing p (315 aa)
initn: 154 init1: 70 opt: 215 Z-score: 194.2 bits: 44.9 E(85289): 0.00044
Smith-Waterman score: 224; 23.0% identity (52.7% similar) in 317 aa overlap (210-521:16-312)
180 190 200 210 220 230
pF1KE3 YSKDGQIFMSACQDQTIRLYDCRYGRFHKFKSIKARDVGW-SVLDVAFTPDGNHFLYSSW
: .:. : : .: : :. :::. : .
NP_115 MAFPEPKPRPPELPQKRLKTLDCGQGAVRAVRFNVDGNYCLTCGS
10 20 30 40
240 250 260 270 280 290
pF1KE3 SDYIHICN-IYGEGDTHTALDLRPDERRFAVFSIAVSSDGREVLGGANDGCLYVFDREQN
. ... : . : : : . . :.. : : :. . .:..: . ..: ..
NP_115 DKTLKLWNPLRG-----TLLRTYSGHG-YEVLDAAGSFDNSSLCSGGGDKAVVLWDVASG
50 60 70 80 90
300 310 320 330 340 350
pF1KE3 RRTLQIESHEDDVNAVAFADISSQILFSGGDDAICKVWDRRTMREDDPKPVGALAGHQDG
. . ....: ::.: : . . ...::. :. . :: :. : :.:: .: .::
NP_115 QVVRKFRGHAGKVNTVQFNE-EATVILSGSIDSSIRCWDCRSRR---PEPVQTLDEARDG
100 110 120 130 140 150
360 370 380 390 400 410
pF1KE3 ITFIDSKGDARYLISNSKDQTIKLWDIRR---FSSREGMEASRQAATQQNWDYRWQQVPK
.. . : . . ....: : .. .:.: ::. : . .... ... .
NP_115 VSSV--KVSDHEILAGSVDGRVRRYDLRMGQLFSDYVGSPITCTCFSRDGQCTLVSSLDS
160 170 180 190 200 210
420 430 440 450 460 470
pF1KE3 KAWRKLKLPGDSSLMTYRGHGVLHTLIRCRFSPIHSTGQQFIYSGCSTGKVVVYDLLSGH
. : : : :.:: . . : .: . . : ::: .::. :
NP_115 -TLRLLDKDTGELLGEYKGHKNQEYKLDCCLSERDT----HVVSCSEDGKVFFWDLVEGA
220 230 240 250 260
480 490 500 510 520 530
pF1KE3 IVKKLTNHKACVRDVSWHPFEEKIVSSSWDGNLRLWQYRQAEYFQDDMPESEECASAPAP
.. : .. :.....:: : .... :... : :. : .:
NP_115 LALALPVGSGVVQSLAYHPTEPCLLTA-MGGSVQCW--REEAYEAEDGAG
270 280 290 300 310
540
pF1KE3 VPQSSTPFSSPQ
546 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 14:29:17 2016 done: Sun Nov 6 14:29:18 2016
Total Scan time: 10.630 Total Display time: 0.080
Function used was FASTA [36.3.4 Apr, 2011]