Result of FASTA (omim) for
pFN21AE3184
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3184, 422 aa
1>>>pF1KE3184 422 - 422 aa - 422 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.6343+/-0.000375; mu= 16.2306+/- 0.023
mean_var=84.2628+/-16.792, 0's: 0 Z-trim(114.1): 56 B-trim: 1093 in 1/53
Lambda= 0.139719
statistics sampled from 23716 (23772) to 23716 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.658), E-opt: 0.2 (0.279), width: 16
Scan time: 9.140
The best scores are: opt bits E(85289)
NP_060708 (OMIM: 212350,610345,614691) acylglycero ( 422) 2821 578.6 1e-164
XP_011514699 (OMIM: 212350,610345,614691) PREDICTE ( 422) 2821 578.6 1e-164
XP_005250080 (OMIM: 212350,610345,614691) PREDICTE ( 350) 2328 479.2 7.1e-135
XP_005257823 (OMIM: 603730) PREDICTED: sphingosine ( 384) 278 66.0 1.9e-10
NP_001136073 (OMIM: 603730) sphingosine kinase 1 i ( 384) 278 66.0 1.9e-10
NP_001136074 (OMIM: 603730) sphingosine kinase 1 i ( 384) 278 66.0 1.9e-10
NP_068807 (OMIM: 603730) sphingosine kinase 1 isof ( 398) 278 66.0 1.9e-10
NP_892010 (OMIM: 603730) sphingosine kinase 1 isof ( 470) 278 66.1 2.2e-10
NP_001191087 (OMIM: 607092) sphingosine kinase 2 i ( 595) 251 60.7 1.2e-08
XP_006723355 (OMIM: 607092) PREDICTED: sphingosine ( 618) 251 60.7 1.2e-08
NP_001191089 (OMIM: 607092) sphingosine kinase 2 i ( 618) 251 60.7 1.2e-08
XP_011525436 (OMIM: 607092) PREDICTED: sphingosine ( 618) 251 60.7 1.2e-08
NP_001191088 (OMIM: 607092) sphingosine kinase 2 i ( 654) 251 60.7 1.2e-08
XP_011525435 (OMIM: 607092) PREDICTED: sphingosine ( 654) 251 60.7 1.2e-08
NP_064511 (OMIM: 607092) sphingosine kinase 2 isof ( 654) 251 60.7 1.2e-08
XP_016882497 (OMIM: 607092) PREDICTED: sphingosine ( 716) 251 60.7 1.3e-08
XP_016882498 (OMIM: 607092) PREDICTED: sphingosine ( 448) 218 53.9 9.3e-07
NP_001230805 (OMIM: 607092) sphingosine kinase 2 i ( 448) 218 53.9 9.3e-07
NP_963842 (OMIM: 608380,608381) ceramide kinase-li ( 532) 217 53.8 1.2e-06
XP_016882499 (OMIM: 607092) PREDICTED: sphingosine ( 401) 185 47.3 8.6e-05
XP_016884398 (OMIM: 610307) PREDICTED: ceramide ki ( 500) 182 46.7 0.00016
NP_073603 (OMIM: 610307) ceramide kinase [Homo sap ( 537) 182 46.7 0.00016
>>NP_060708 (OMIM: 212350,610345,614691) acylglycerol ki (422 aa)
initn: 2821 init1: 2821 opt: 2821 Z-score: 3078.3 bits: 578.6 E(85289): 1e-164
Smith-Waterman score: 2821; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422)
10 20 30 40 50 60
pF1KE3 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_060 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP
370 380 390 400 410 420
pF1KE3 TQ
::
NP_060 TQ
>>XP_011514699 (OMIM: 212350,610345,614691) PREDICTED: a (422 aa)
initn: 2821 init1: 2821 opt: 2821 Z-score: 3078.3 bits: 578.6 E(85289): 1e-164
Smith-Waterman score: 2821; 100.0% identity (100.0% similar) in 422 aa overlap (1-422:1-422)
10 20 30 40 50 60
pF1KE3 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV
310 320 330 340 350 360
370 380 390 400 410 420
pF1KE3 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_011 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP
370 380 390 400 410 420
pF1KE3 TQ
::
XP_011 TQ
>>XP_005250080 (OMIM: 212350,610345,614691) PREDICTED: a (350 aa)
initn: 2328 init1: 2328 opt: 2328 Z-score: 2542.4 bits: 479.2 E(85289): 7.1e-135
Smith-Waterman score: 2328; 100.0% identity (100.0% similar) in 349 aa overlap (1-349:1-349)
10 20 30 40 50 60
pF1KE3 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 MTVFFKTLRNHWKKTTAGLCLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 KKATVFLNPAACKGKARTLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENTDVII
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 VAGGDGTLQEVVTGVLRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNKVQHITDATL
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 AIVKGETVPLDVLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFST
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 LKEWPQTHQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQPQDALSQEVSP
250 260 270 280 290 300
310 320 330 340 350 360
pF1KE3 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLHV
:::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 EVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGK
310 320 330 340 350
370 380 390 400 410 420
pF1KE3 EGTECLQASQCTLLIPEGAGGSFSIDSEEYEAMPVEVKLLPRKLQFFCDPRKREQMLTSP
>>XP_005257823 (OMIM: 603730) PREDICTED: sphingosine kin (384 aa)
initn: 184 init1: 70 opt: 278 Z-score: 308.6 bits: 66.0 E(85289): 1.9e-10
Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:16-227)
40 50 60 70 80 90
pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS
.. :.::: . :::: ::.... :.: .
XP_005 MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA
10 20 30 40
100 110 120 130 140
pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI
.. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :.
XP_005 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA
.: : ..:. .: .: ..: . .:. :: . . :...:... . .:.
XP_005 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP
. .: :: . :. .. :: :: ... . :. .:... ..: :. : ..
XP_005 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT
.::
XP_005 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA
230 240 250 260 270 280
>>NP_001136073 (OMIM: 603730) sphingosine kinase 1 isofo (384 aa)
initn: 184 init1: 70 opt: 278 Z-score: 308.6 bits: 66.0 E(85289): 1.9e-10
Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:16-227)
40 50 60 70 80 90
pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS
.. :.::: . :::: ::.... :.: .
NP_001 MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA
10 20 30 40
100 110 120 130 140
pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI
.. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :.
NP_001 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA
.: : ..:. .: .: ..: . .:. :: . . :...:... . .:.
NP_001 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP
. .: :: . :. .. :: :: ... . :. .:... ..: :. : ..
NP_001 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT
.::
NP_001 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA
230 240 250 260 270 280
>>NP_001136074 (OMIM: 603730) sphingosine kinase 1 isofo (384 aa)
initn: 184 init1: 70 opt: 278 Z-score: 308.6 bits: 66.0 E(85289): 1.9e-10
Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:16-227)
40 50 60 70 80 90
pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS
.. :.::: . :::: ::.... :.: .
NP_001 MDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA
10 20 30 40
100 110 120 130 140
pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI
.. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :.
NP_001 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL
50 60 70 80 90 100
150 160 170 180 190 200
pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA
.: : ..:. .: .: ..: . .:. :: . . :...:... . .:.
NP_001 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS
110 120 130 140 150 160
210 220 230 240 250 260
pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP
. .: :: . :. .. :: :: ... . :. .:... ..: :. : ..
NP_001 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT
170 180 190 200 210 220
270 280 290 300 310 320
pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT
.::
NP_001 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA
230 240 250 260 270 280
>>NP_068807 (OMIM: 603730) sphingosine kinase 1 isoform (398 aa)
initn: 184 init1: 70 opt: 278 Z-score: 308.4 bits: 66.0 E(85289): 1.9e-10
Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:30-241)
40 50 60 70 80 90
pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS
.. :.::: . :::: ::.... :.: .
NP_068 MDPVVGCGRGLFGFVFSAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA
10 20 30 40 50
100 110 120 130 140
pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI
.. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :.
NP_068 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL
60 70 80 90 100 110
150 160 170 180 190 200
pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA
.: : ..:. .: .: ..: . .:. :: . . :...:... . .:.
NP_068 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS
120 130 140 150 160 170
210 220 230 240 250 260
pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP
. .: :: . :. .. :: :: ... . :. .:... ..: :. : ..
NP_068 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT
180 190 200 210 220 230
270 280 290 300 310 320
pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT
.::
NP_068 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA
240 250 260 270 280 290
>>NP_892010 (OMIM: 603730) sphingosine kinase 1 isoform (470 aa)
initn: 184 init1: 70 opt: 278 Z-score: 307.4 bits: 66.1 E(85289): 2.2e-10
Smith-Waterman score: 278; 26.5% identity (62.3% similar) in 215 aa overlap (62-270:102-313)
40 50 60 70 80 90
pF1KE3 KHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFLNPAACKGKARTLFEKNAAPILHLS
.. :.::: . :::: ::.... :.: .
NP_892 TAPGTPWQREPRVEVMDPAGGPRGVLPRPCRVLVLLNPRGGKGKALQLFRSHVQPLLAEA
80 90 100 110 120 130
100 110 120 130 140
pF1KE3 GMDVTIVKTDYEGQAKKLL--ELMENTDVIIVAGGDGTLQEVVTGVLRRTDEATFSKIPI
.. :.. :. ...:..:. : . :...: .::: ..:::.:...: : : . :.
NP_892 EISFTLMLTERRNHARELVRSEELGRWDALVVMSGDGLMHEVVNGLMERPDWETAIQKPL
140 150 160 170 180 190
150 160 170 180 190 200
pF1KE3 GFIPLGETSSLSHTLFAESG-NKVQH---ITDATLAIVKGETVPLDVLQIKGEKEQPVFA
.: : ..:. .: .: ..: . .:. :: . . :...:... . .:.
NP_892 CSLPAGSGNALAASLNHYAGYEQVTNEDLLTNCTLLLCRRLLSPMNLLSLHTASGLRLFS
200 210 220 230 240 250
210 220 230 240 250 260
pF1KE3 MTGLRWGSFRDAGVKVSKYWYLGPLKIKAAHFFSTLKEWPQTHQASISYTGPTERPPNEP
. .: :: . :. .. :: :: ... . :. .:... ..: :. : ..
NP_892 VLSLAWGFIADVDLESEKYRRLGEMRFTLGTFLRLAAL--RTYRGRLAYL-PVGRVGSKT
260 270 280 290 300
270 280 290 300 310 320
pF1KE3 EETPVQRPSLYRRILRRLASYWAQPQDALSQEVSPEVWKDVQLSTIELSITTRNNQLDPT
.::
NP_892 PASPVVVQQGPVDAHLVPLEEPVPSHWTVVPDEDFVLVLALLHSHLGSEMFAAPMGRCAA
310 320 330 340 350 360
>>NP_001191087 (OMIM: 607092) sphingosine kinase 2 isofo (595 aa)
initn: 152 init1: 70 opt: 251 Z-score: 276.5 bits: 60.7 E(85289): 1.2e-08
Smith-Waterman score: 272; 24.3% identity (55.9% similar) in 272 aa overlap (50-301:109-380)
20 30 40 50 60 70
pF1KE3 CLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFL--NPAACKGKAR
:. : :. . ..: :: . .: :
NP_001 DGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAW
80 90 100 110 120 130
80 90 100 110 120 130
pF1KE3 TLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENT--DVIIVAGGDGTLQEVVTGV
.... :.. .:.. ....:. ...:..:.. . . : :....::: :.::..:.
NP_001 QWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGL
140 150 160 170 180 190
140 150 160 170 180 190
pF1KE3 LRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNK----VQHITDATLAIVKGETVPLD
: : : :.:.:..: : ..:. .. ..: . .. . . .: . .: :::
NP_001 LDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLD
200 210 220 230 240 250
200 210 220 230 240
pF1KE3 VLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGP--------LKIKAAHFF-STLK
.:.. . . :.. .. :: :. .. .. :: : . . : . . :.
NP_001 LLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLS
260 270 280 290 300 310
250 260 270 280 290
pF1KE3 EWPQT-HQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQP--QDALSQEVS
: : . :: . . : .: :: : . . :.: .: : : ::.. :
NP_001 YLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGS
320 330 340 350 360 370
300 310 320 330 340 350
pF1KE3 PEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLH
::
NP_001 PEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKAALHSPVSEGAPVIPPSS
380 390 400 410 420 430
>>XP_006723355 (OMIM: 607092) PREDICTED: sphingosine kin (618 aa)
initn: 152 init1: 70 opt: 251 Z-score: 276.3 bits: 60.7 E(85289): 1.2e-08
Smith-Waterman score: 272; 24.3% identity (55.9% similar) in 272 aa overlap (50-301:132-403)
20 30 40 50 60 70
pF1KE3 CLLTWGGHWLYGKHCDNLLRRAACQEAQVFGNQLIPPNAQVKKATVFL--NPAACKGKAR
:. : :. . ..: :: . .: :
XP_006 DGAATYEENRAEAQRWATALTCLLRGLPLPGDGEITPDLLPRPPRLLLLVNPFGGRGLAW
110 120 130 140 150 160
80 90 100 110 120 130
pF1KE3 TLFEKNAAPILHLSGMDVTIVKTDYEGQAKKLLELMENT--DVIIVAGGDGTLQEVVTGV
.... :.. .:.. ....:. ...:..:.. . . : :....::: :.::..:.
XP_006 QWCKNHVLPMISEAGLSFNLIQTERQNHARELVQGLSLSEWDGIVTVSGDGLLHEVLNGL
170 180 190 200 210 220
140 150 160 170 180 190
pF1KE3 LRRTDEATFSKIPIGFIPLGETSSLSHTLFAESGNK----VQHITDATLAIVKGETVPLD
: : : :.:.:..: : ..:. .. ..: . .. . . .: . .: :::
XP_006 LDRPDWEEAVKMPVGILPCGSGNALAGAVNQHGGFEPALGLDLLLNCSLLLCRGGGHPLD
230 240 250 260 270 280
200 210 220 230 240
pF1KE3 VLQIKGEKEQPVFAMTGLRWGSFRDAGVKVSKYWYLGP--------LKIKAAHFF-STLK
.:.. . . :.. .. :: :. .. .. :: : . . : . . :.
XP_006 LLSVTLASGSRCFSFLSVAWGFVSDVDIQSERFRALGSARFTLGTVLGLATLHTYRGRLS
290 300 310 320 330 340
250 260 270 280 290
pF1KE3 EWPQT-HQASISYTGPTERPPNEPEETPVQRPSLYRRILRRLASYWAQP--QDALSQEVS
: : . :: . . : .: :: : . . :.: .: : : ::.. :
XP_006 YLPATVEPASPTPAHSLPRAKSELTLTPDPAPPMAHSPLHRSVSDLPLPLPQPALASPGS
350 360 370 380 390 400
300 310 320 330 340 350
pF1KE3 PEVWKDVQLSTIELSITTRNNQLDPTSKEDFLNICIEPDTISKGDFITIGSRKVRNPKLH
::
XP_006 PEPLPILSLNGGGPELAGDWGGAGDAPLSPDPLLSSPPGSPKAALHSPVSEGAPVIPPSS
410 420 430 440 450 460
422 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 01:37:40 2016 done: Sun Nov 6 01:37:42 2016
Total Scan time: 9.140 Total Display time: 0.040
Function used was FASTA [36.3.4 Apr, 2011]