FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011 Please cite: W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448 Query: pF1KE3159, 378 aa 1>>>pF1KE3159 378 - 378 aa - 378 aa Library: human.CCDS.faa 18511270 residues in 32554 sequences Statistics: Expectation_n fit: rho(ln(x))= 5.8317+/-0.000827; mu= 14.2399+/- 0.050 mean_var=75.7527+/-14.691, 0's: 0 Z-trim(107.7): 20 B-trim: 0 in 0/52 Lambda= 0.147358 statistics sampled from 9743 (9760) to 9743 sequences Algorithm: FASTA (3.7 Nov 2010) [optimized] Parameters: BL50 matrix (15:-5), open/ext: -10/-2 ktup: 2, E-join: 1 (0.683), E-opt: 0.2 (0.3), width: 16 Scan time: 2.820 The best scores are: opt bits E(32554) CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 ( 407) 2605 563.1 1.5e-160 CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 ( 291) 1987 431.7 4e-121 CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 ( 241) 1620 353.6 1.1e-97 CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 ( 378) 1264 278.0 9.4e-75 CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 ( 378) 1262 277.6 1.3e-74 CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 ( 284) 504 116.4 3.2e-26 CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 ( 239) 364 86.6 2.5e-17 >>CCDS2242.2 METTL8 gene_id:79828|Hs108|chr2 (407 aa) initn: 2605 init1: 2605 opt: 2605 Z-score: 2995.8 bits: 563.1 E(32554): 1.5e-160 Smith-Waterman score: 2605; 100.0% identity (100.0% similar) in 378 aa overlap (1-378:1-378) 10 20 30 40 50 60 pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK 250 260 270 280 290 300 310 320 330 340 350 360 pF1KE3 PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS22 PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ 310 320 330 340 350 360 370 pF1KE3 NLVDRRLQVNRKKQVKMH :::::::::::::::::: CCDS22 NLVDRRLQVNRKKQVKMHRVWIQGKFQKPLHQTQNSSNMVSTLLSQD 370 380 390 400 >>CCDS82532.1 METTL8 gene_id:79828|Hs108|chr2 (291 aa) initn: 1987 init1: 1987 opt: 1987 Z-score: 2288.0 bits: 431.7 E(32554): 4e-121 Smith-Waterman score: 1987; 100.0% identity (100.0% similar) in 287 aa overlap (1-287:1-287) 10 20 30 40 50 60 pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA 10 20 30 40 50 60 70 80 90 100 110 120 pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK 70 80 90 100 110 120 130 140 150 160 170 180 pF1KE3 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 PEEKARESSWDHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEK 130 140 150 160 170 180 190 200 210 220 230 240 pF1KE3 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 HKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVK 190 200 210 220 230 240 250 260 270 280 290 300 pF1KE3 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLK ::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 SHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRTLFI 250 260 270 280 290 310 320 330 340 350 360 pF1KE3 PGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQ >>CCDS82531.1 METTL8 gene_id:79828|Hs108|chr2 (241 aa) initn: 1620 init1: 1620 opt: 1620 Z-score: 1867.6 bits: 353.6 E(32554): 1.1e-97 Smith-Waterman score: 1620; 100.0% identity (100.0% similar) in 237 aa overlap (51-287:1-237) 30 40 50 60 70 80 pF1KE3 YQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLLEEQVK :::::::::::::::::::::::::::::: CCDS82 MQWSKEEEAAARKKVKENSAVRVLLEEQVK 10 20 30 90 100 110 120 130 140 pF1KE3 YEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNR :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 YEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNR 40 50 60 70 80 90 150 160 170 180 190 200 pF1KE3 FSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRI :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 FSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRI 100 110 120 130 140 150 210 220 230 240 250 260 pF1KE3 LEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDD :::::::::::::::::::::::::::::::::::::::::::::::::::::::::::: CCDS82 LEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDD 160 170 180 190 200 210 270 280 290 300 310 320 pF1KE3 GLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRF ::::::::::::::::::::::::::: CCDS82 GLPYPFPDGILDVILLVFVLSSIHPDRTLFI 220 230 240 >>CCDS5803.2 METTL2B gene_id:55798|Hs108|chr7 (378 aa) initn: 1244 init1: 721 opt: 1264 Z-score: 1455.5 bits: 278.0 E(32554): 9.4e-75 Smith-Waterman score: 1264; 54.4% identity (78.2% similar) in 349 aa overlap (31-378:20-361) 10 20 30 40 50 60 pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA .:::.:.:::.::.:: ::...::.:. :: CCDS58 MAGSYPEGAPAILADKRQQFGSRFLSDPARVFHHNAWDNVEWSEEQAAA 10 20 30 40 70 80 90 100 110 120 pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK :..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ... CCDS58 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE . : .: . :. . . . : . :..: . :: : : ...: :. .. CCDS58 NHLK----DWFLENKSEVCECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTPPVEENV-TQ 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV : . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.::: CCDS58 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL ...: : ..:::::::.::. :: : : ::.:.:.::::.. ::.:: ..::::.:: CCDS58 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAVVPDKMQKAINRLSRLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE3 KPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEK :::::.:.::::::: .:::::::.::: ::::::::::.::::. :. ..: :.:.. CCDS58 KPGGMVLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV 290 300 310 320 330 340 360 370 pF1KE3 QNLVDRRLQVNRKKQVKMH :::::::::::: ::. :. CCDS58 QNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS 350 360 370 >>CCDS45752.1 METTL2A gene_id:339175|Hs108|chr17 (378 aa) initn: 1244 init1: 724 opt: 1262 Z-score: 1453.2 bits: 277.6 E(32554): 1.3e-74 Smith-Waterman score: 1262; 54.7% identity (77.9% similar) in 349 aa overlap (31-378:20-361) 10 20 30 40 50 60 pF1KE3 MNMIWRNSISCLRLGKVPHRYQSGYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAA .:::.: :::.::.:: ::...::.:. :: CCDS45 MAGSYPEGAPAVLADKRQQFGSRFLRDPARVFHHNAWDNVEWSEEQAAA 10 20 30 40 70 80 90 100 110 120 pF1KE3 ARKKVKENSAVRVLLEEQVKYEREASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQK :..::.::: :: :.:: :: .: :::. :::::.: :::::.::. ::::. : ... CCDS45 AERKVQENSIQRVCQEKQVDYEINAHKYWNDFYKIHENGFFKDRHWLFTEFPELAPSQNQ 50 60 70 80 90 100 130 140 150 160 170 pF1KE3 PEEKARESSW-DHVKTSATNRFSRMHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSE . : .: . :. . . . : . :..: . :: : : ...: :. .. CCDS45 NHLK----DWFLENKSEVPECRNNEDGPGLIMEEQH-KCSSKSLEHKTQTLPVEENV-TQ 110 120 130 140 150 160 180 190 200 210 220 230 pF1KE3 KHKKGPMETGLFPGSNATFRILEVGCGAGNSVFPILNTLENSPESFLYCCDFASGAVELV : . . . ::::.::.::::::::.::.:::::.: .:.: :.:::::.: :.::: CCDS45 KISDLEICADEFPGSSATYRILEVGCGVGNTVFPILQT-NNDPGLFVYCCDFSSTAIELV 170 180 190 200 210 220 240 250 260 270 280 290 pF1KE3 KSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLL ...: : ..:::::::.::. :: : : ::.:.:.::::.: ::.:: ..::::.:: CCDS45 QTNSEYDPSRCFAFVHDLCDEEKSYPVPKGSLDIIILIFVLSAIVPDKMQKAINRLSRLL 230 240 250 260 270 280 300 310 320 330 340 350 pF1KE3 KPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEK :::::.:.::::::: .:::::::.::: ::::::::::.::::. :. ..: :.:.. CCDS45 KPGGMMLLRDYGRYDMAQLRFKKGQCLSGNFYVRGDGTRVYFFTQEELDTLFTTAGLEKV 290 300 310 320 330 340 360 370 pF1KE3 QNLVDRRLQVNRKKQVKMH :::::::::::: ::. :. CCDS45 QNLVDRRLQVNRGKQLTMYRVWIQCKYCKPLLSSTS 350 360 370 >>CCDS43056.1 METTL6 gene_id:131965|Hs108|chr3 (284 aa) initn: 630 init1: 443 opt: 504 Z-score: 584.3 bits: 116.4 E(32554): 3.2e-26 Smith-Waterman score: 515; 34.1% identity (53.8% similar) in 320 aa overlap (54-373:16-253) 30 40 50 60 70 80 pF1KE3 GYHPVAPLGSRILTDPAKVFEHNMWDHMQWSKEEEAAARKKVKENSAVRVLLEEQVKYER :.::: :.:..... ...: : :. CCDS43 MASLQRKGLQARILTSEEEE-----KLKRDQTLVSDFKQQ-KLEQ 10 20 30 90 100 110 120 130 140 pF1KE3 EASKYWDTFYKIHKNKFFKDRNWLLREFPEILPVDQKPEEKARESSWDHVKTSATNRFSR ::.: :: ::: ....:::::.: ::: :. CCDS43 EAQKNWDLFYKRNSTNFFKDRHWTTREFEEL----------------------------- 40 50 60 70 150 160 170 180 190 200 pF1KE3 MHCPTVPDEKNHYEKSSGSSEGQSKTESDFSNLDSEKHKKGPMETGLFPGSNATFRILEV : :.: . .::. CCDS43 RSCREFEDQK--------------------------------------------LTMLEA 80 210 220 230 240 250 260 pF1KE3 GCGAGNSVFPILNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLP :::.:: .::.: :..:. : : :::. :.: ::.. : . .: .: :. : : CCDS43 GCGVGNCLFPLL---EEDPNIFAYACDFSPRAIEYVKQNPLYDTERCKVFQCDLTKDDLL 90 100 110 120 130 140 270 280 290 300 310 320 pF1KE3 YPFPDGILDVILLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKG : .::..:.::::..:::.:. :.. . :.:::: .:::::: ::...:::: . CCDS43 DHVPPESVDVVMLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKAS 150 160 170 180 190 200 330 340 350 360 370 pF1KE3 HCLSENFYVRGDGTRAYFFTKGEVHSMFCKASLDEKQNLVDRRLQVNRKKQVKMH :.:::::: ::::.:::: . ..: .. .: : : ::.:. CCDS43 SKLGENFYVRQDGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQ 210 220 230 240 250 260 CCDS43 SKFLKPPKNPSPVVLGLDPKS 270 280 >>CCDS77706.1 METTL6 gene_id:131965|Hs108|chr3 (239 aa) initn: 492 init1: 334 opt: 364 Z-score: 424.6 bits: 86.6 E(32554): 2.5e-17 Smith-Waterman score: 364; 45.0% identity (69.0% similar) in 129 aa overlap (245-373:80-208) 220 230 240 250 260 270 pF1KE3 LNTLENSPESFLYCCDFASGAVELVKSHSSYRATQCFAFVHDVCDDGLPYPFPDGILDVI : . .: .: :. : : : .::. CCDS77 KRNSTNFFKDRHWTTREFEELRSCREQNPLYDTERCKVFQCDLTKDDLLDHVPPESVDVV 50 60 70 80 90 100 280 290 300 310 320 330 pF1KE3 LLVFVLSSIHPDRMQGVVNRLSKLLKPGGMLLFRDYGRYDKTQLRFKKGHCLSENFYVRG .:.::::..:::.:. :.. . :.:::: .:::::: ::...:::: . :.:::::: CCDS77 MLIFVLSAVHPDKMHLVLQNIYKVLKPGKSVLFRDYGLYDHAMLRFKASSKLGENFYVRQ 110 120 130 140 150 160 340 350 360 370 pF1KE3 DGTRAYFFTKGEVHSMFCKASLDEKQNLVDRRLQVNRKKQVKMH ::::.:::: . ..: .. .: : : ::.:. CCDS77 DGTRSYFFTDDFLAQLFMDTGYEEVVNEYVFRETVNKKEGLCVPRVFLQSKFLKPPKNPS 170 180 190 200 210 220 CCDS77 PVVLGLDPKS 230 378 residues in 1 query sequences 18511270 residues in 32554 library sequences Tcomplib [36.3.4 Apr, 2011] (8 proc) start: Mon Nov 7 03:20:42 2016 done: Mon Nov 7 03:20:42 2016 Total Scan time: 2.820 Total Display time: 0.020 Function used was FASTA [36.3.4 Apr, 2011]