Result of FASTA (omim) for
pFN21AE3142
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3142, 353 aa
1>>>pF1KE3142 353 - 353 aa - 353 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 10.2133+/-0.00036; mu= -5.8777+/- 0.022
mean_var=261.7932+/-54.509, 0's: 0 Z-trim(122.6): 12 B-trim: 1396 in 1/56
Lambda= 0.079267
statistics sampled from 41077 (41089) to 41077 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.794), E-opt: 0.2 (0.482), width: 16
Scan time: 9.530
The best scores are: opt bits E(85289)
NP_001276927 (OMIM: 187950,600044) thrombopoietin ( 353) 2335 279.7 6.9e-75
NP_000451 (OMIM: 187950,600044) thrombopoietin iso ( 353) 2335 279.7 6.9e-75
NP_001276957 (OMIM: 187950,600044) thrombopoietin ( 353) 2335 279.7 6.9e-75
NP_001276932 (OMIM: 187950,600044) thrombopoietin ( 493) 2335 279.8 9.1e-75
NP_001171068 (OMIM: 187950,600044) thrombopoietin ( 349) 2285 273.9 3.6e-73
NP_001276951 (OMIM: 187950,600044) thrombopoietin ( 349) 2285 273.9 3.6e-73
NP_001276956 (OMIM: 187950,600044) thrombopoietin ( 286) 1035 130.9 3.3e-30
NP_001276926 (OMIM: 187950,600044) thrombopoietin ( 286) 1035 130.9 3.3e-30
XP_016862596 (OMIM: 187950,600044) PREDICTED: thro ( 422) 985 125.3 2.4e-28
NP_001171069 (OMIM: 187950,600044) thrombopoietin ( 319) 842 108.9 1.6e-23
NP_001276955 (OMIM: 187950,600044) thrombopoietin ( 319) 842 108.9 1.6e-23
>>NP_001276927 (OMIM: 187950,600044) thrombopoietin isof (353 aa)
initn: 2335 init1: 2335 opt: 2335 Z-score: 1465.4 bits: 279.7 E(85289): 6.9e-75
Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:1-353)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
250 260 270 280 290 300
310 320 330 340 350
pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
310 320 330 340 350
>>NP_000451 (OMIM: 187950,600044) thrombopoietin isoform (353 aa)
initn: 2335 init1: 2335 opt: 2335 Z-score: 1465.4 bits: 279.7 E(85289): 6.9e-75
Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:1-353)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
250 260 270 280 290 300
310 320 330 340 350
pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_000 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
310 320 330 340 350
>>NP_001276957 (OMIM: 187950,600044) thrombopoietin isof (353 aa)
initn: 2335 init1: 2335 opt: 2335 Z-score: 1465.4 bits: 279.7 E(85289): 6.9e-75
Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:1-353)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
250 260 270 280 290 300
310 320 330 340 350
pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
310 320 330 340 350
>>NP_001276932 (OMIM: 187950,600044) thrombopoietin isof (493 aa)
initn: 2335 init1: 2335 opt: 2335 Z-score: 1463.3 bits: 279.8 E(85289): 9.1e-75
Smith-Waterman score: 2335; 100.0% identity (100.0% similar) in 353 aa overlap (1-353:141-493)
10 20 30
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDL
::::::::::::::::::::::::::::::
NP_001 QEPKPPPWPQEGFRGEAPNREPRQPDTPARMELTELLLVVMLLLTARLTLSSPAPPACDL
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE3 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL
180 190 200 210 220 230
100 110 120 130 140 150
pF1KE3 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFL
240 250 260 270 280 290
160 170 180 190 200 210
pF1KE3 SFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTAS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SFQHLLRGKVRFLMLVGGSTLCVRRAPPTTAVPSRTSLVLTLNELPNRTSGLLETNFTAS
300 310 320 330 340 350
220 230 240 250 260 270
pF1KE3 ARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLG
360 370 380 390 400 410
280 290 300 310 320 330
pF1KE3 APDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 APDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAP
420 430 440 450 460 470
340 350
pF1KE3 TPTPTSPLLNTSYTHSQNLSQEG
:::::::::::::::::::::::
NP_001 TPTPTSPLLNTSYTHSQNLSQEG
480 490
>>NP_001171068 (OMIM: 187950,600044) thrombopoietin isof (349 aa)
initn: 1486 init1: 1486 opt: 2285 Z-score: 1434.6 bits: 273.9 E(85289): 3.6e-73
Smith-Waterman score: 2285; 98.9% identity (98.9% similar) in 353 aa overlap (1-353:1-349)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
:::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGALQSLLGTQ----GRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
130 140 150 160 170
190 200 210 220 230 240
pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
240 250 260 270 280 290
310 320 330 340 350
pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
300 310 320 330 340
>>NP_001276951 (OMIM: 187950,600044) thrombopoietin isof (349 aa)
initn: 1486 init1: 1486 opt: 2285 Z-score: 1434.6 bits: 273.9 E(85289): 3.6e-73
Smith-Waterman score: 2285; 98.9% identity (98.9% similar) in 353 aa overlap (1-353:1-349)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
:::::::::::: ::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLGALQSLLGTQ----GRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRRAPPTT
130 140 150 160 170
190 200 210 220 230 240
pF1KE3 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSL
180 190 200 210 220 230
250 260 270 280 290 300
pF1KE3 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 DQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPP
240 250 260 270 280 290
310 320 330 340 350
pF1KE3 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
:::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
300 310 320 330 340
>>NP_001276956 (OMIM: 187950,600044) thrombopoietin isof (286 aa)
initn: 1070 init1: 1029 opt: 1035 Z-score: 663.3 bits: 130.9 E(85289): 3.3e-30
Smith-Waterman score: 1037; 62.3% identity (74.7% similar) in 308 aa overlap (1-300:1-284)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170
pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRR-----
::::::::::::::::::::::::::::::::::::::: . .:: . :. .
NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKD--FWIVGDKLHCLSQNYWLW
130 140 150 160 170
180 190 200 210 220 230
pF1KE3 APPTTA-VPSRTSLVLTLN-ELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLL
: ..: . :. : : ..:. . . : . .:: :.:.. . :
NP_001 ASEVAAGIQSQDSWSAEPNLQVPGPNPRIPEQD----TRT-----LEWNSW---TLSWTL
180 190 200 210 220
240 250 260 270 280 290
pF1KE3 NQTSRSLDQIPG-YLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGY
.: :: :: .: :.. : .:. : .. :. :: . . .:: . . ..
NP_001 TQDPRS----PGHFLRNIRHRLPATQ-----PPAWIFSFPNPSSYWT-VYALPSSTHLAH
230 240 250 260 270
300 310 320 330 340 350
pF1KE3 SPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQE
.:. ::
NP_001 PCGPAPPPAS
280
>>NP_001276926 (OMIM: 187950,600044) thrombopoietin isof (286 aa)
initn: 1070 init1: 1029 opt: 1035 Z-score: 663.3 bits: 130.9 E(85289): 3.3e-30
Smith-Waterman score: 1037; 62.3% identity (74.7% similar) in 308 aa overlap (1-300:1-284)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170
pF1KE3 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKVRFLMLVGGSTLCVRR-----
::::::::::::::::::::::::::::::::::::::: . .:: . :. .
NP_001 LLGALQSLLGTQLPPQGRTTAHKDPNAIFLSFQHLLRGKD--FWIVGDKLHCLSQNYWLW
130 140 150 160 170
180 190 200 210 220 230
pF1KE3 APPTTA-VPSRTSLVLTLN-ELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLL
: ..: . :. : : ..:. . . : . .:: :.:.. . :
NP_001 ASEVAAGIQSQDSWSAEPNLQVPGPNPRIPEQD----TRT-----LEWNSW---TLSWTL
180 190 200 210 220
240 250 260 270 280 290
pF1KE3 NQTSRSLDQIPG-YLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGY
.: :: :: .: :.. : .:. : .. :. :: . . .:: . . ..
NP_001 TQDPRS----PGHFLRNIRHRLPATQ-----PPAWIFSFPNPSSYWT-VYALPSSTHLAH
230 240 250 260 270
300 310 320 330 340 350
pF1KE3 SPSPTHPPTGQYTLFPLPPTLPTPVVQLHPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQE
.:. ::
NP_001 PCGPAPPPAS
280
>>XP_016862596 (OMIM: 187950,600044) PREDICTED: thrombop (422 aa)
initn: 842 init1: 842 opt: 985 Z-score: 629.9 bits: 125.3 E(85289): 2.4e-28
Smith-Waterman score: 987; 61.0% identity (73.4% similar) in 308 aa overlap (1-300:141-420)
10 20 30
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDL
::::::::::::::::::::::::::::::
XP_016 QEPKPPPWPQEGFRGEAPNREPRQPDTPARMELTELLLVVMLLLTARLTLSSPAPPACDL
120 130 140 150 160 170
40 50 60 70 80 90
pF1KE3 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RVLSKLLRDSHVLHSRLSQCPEVHPLPTPVLLPAVDFSLGEWKTQMEETKAQDILGAVTL
180 190 200 210 220 230
100 110 120 130 140 150
pF1KE3 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGTQLPPQGRTTAHKDPNAIFL
::::::::::::::::::::::::::::::::::::::::: :::::::::::::::
XP_016 LLEGVMAARGQLGPTCLSSLLGQLSGQVRLLLGALQSLLGT----QGRTTAHKDPNAIFL
240 250 260 270 280
160 170 180 190 200
pF1KE3 SFQHLLRGKVRFLMLVGGSTLCVRR-----APPTTA-VPSRTSLVLTLN-ELPNRTSGLL
::::::::: . .:: . :. . : ..: . :. : : ..:. . .
XP_016 SFQHLLRGKD--FWIVGDKLHCLSQNYWLWASEVAAGIQSQDSWSAEPNLQVPGPNPRIP
290 300 310 320 330 340
210 220 230 240 250 260
pF1KE3 ETNFTASARTTGSGLLKWQQGFRAKIPGLLNQTSRSLDQIPG-YLNRIHELLNGTRGLFP
: . .:: :.:.. . :.: :: :: .: :.. : .:.
XP_016 EQD----TRT-----LEWNSW---TLSWTLTQDPRS----PGHFLRNIRHRLPATQ----
350 360 370 380
270 280 290 300 310 320
pF1KE3 GPSRRTLGAPDISSGTSDTGSLPPNLQPGYSPSPTHPPTGQYTLFPLPPTLPTPVVQLHP
: .. :. :: . . .:: . . .. .:. ::
XP_016 -PPAWIFSFPNPSSYWT-VYALPSSTHLAHPCGPAPPPAS
390 400 410 420
330 340 350
pF1KE3 LLPDPSAPTPTPTSPLLNTSYTHSQNLSQEG
>>NP_001171069 (OMIM: 187950,600044) thrombopoietin isof (319 aa)
initn: 867 init1: 842 opt: 842 Z-score: 543.3 bits: 108.9 E(85289): 1.6e-23
Smith-Waterman score: 850; 51.9% identity (65.8% similar) in 345 aa overlap (1-336:1-319)
10 20 30 40 50 60
pF1KE3 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MELTELLLVVMLLLTARLTLSSPAPPACDLRVLSKLLRDSHVLHSRLSQCPEVHPLPTPV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 LLPAVDFSLGEWKTQMEETKAQDILGAVTLLLEGVMAARGQLGPTCLSSLLGQLSGQVRL
70 80 90 100 110 120
130 140 150 160 170
pF1KE3 LLGALQSLLGTQLPPQGRTTAH----KDPNAIFLSFQHLLRGKVRFLMLVGGSTL-CVRR
:::::::::::: . . : : .: : .:. : .: . : ..
NP_001 LLGALQSLLGTQDHSSQGSQCHLPELPTPAPRKGAFPDACR-RVHPLRQAGPTHHSCPQQ
130 140 150 160 170
180 190 200 210 220 230
pF1KE3 --APPTTAVPSRTSLVLTLNELPNRTSGLLETNFTASARTTGSGLLKWQQGFRAKIPGLL
. : : . .. .. ..: : :. : ...:. . :... :. :.:
NP_001 NLSSPHTERAPKQDFWIVGDKLHC-----LSQNYWLWASEVAAGIQS-QDSWSAE-PNL-
180 190 200 210 220 230
240 250 260 270 280 290
pF1KE3 NQTSRSLDQIPGYLNRIHELLNGTRGLFPGPSRRTLGAPDISSGTSDTGSLPPNLQPGYS
:.:: :: : . :: : . :: . ... . : . :.. .
NP_001 --------QVPGPNPRIPE--QDTRTLEW--NSWTL-SWTLTQDPRSPGHFLRNIR--HR
240 250 260 270
300 310 320 330 340 350
pF1KE3 PSPTHPPTGQYTLFPLPPTLPTPVVQL--HPLLPDPSAPTPTPTSPLLNTSYTHSQNLSQ
:.::. .. :: : . : : : : : .:.: :.:
NP_001 LPATQPPAWIFS-FPNPSSYWT-VYALPSSTHLAHPCGPAPPPAS
280 290 300 310
pF1KE3 EG
353 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:51:10 2016 done: Sun Nov 6 04:51:12 2016
Total Scan time: 9.530 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]