Result of FASTA (omim) for
pFN21AE3129
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3129, 322 aa
1>>>pF1KE3129 322 - 322 aa - 322 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.3060+/-0.000415; mu= 15.1438+/- 0.026
mean_var=53.2175+/-11.283, 0's: 0 Z-trim(109.2): 52 B-trim: 864 in 1/48
Lambda= 0.175811
statistics sampled from 17312 (17360) to 17312 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.581), E-opt: 0.2 (0.204), width: 16
Scan time: 7.560
The best scores are: opt bits E(85289)
NP_071411 (OMIM: 611132) ribokinase isoform 1 [Hom ( 322) 2060 530.7 1.6e-150
NP_001274509 (OMIM: 611132) ribokinase isoform 2 [ ( 255) 1611 416.8 2.4e-116
NP_006479 (OMIM: 229800,614058) ketohexokinase iso ( 298) 149 46.0 0.00012
NP_000212 (OMIM: 229800,614058) ketohexokinase iso ( 298) 148 45.7 0.00014
XP_005264353 (OMIM: 229800,614058) PREDICTED: keto ( 299) 148 45.7 0.00014
>>NP_071411 (OMIM: 611132) ribokinase isoform 1 [Homo sa (322 aa)
initn: 2060 init1: 2060 opt: 2060 Z-score: 2823.5 bits: 530.7 E(85289): 1.6e-150
Smith-Waterman score: 2060; 100.0% identity (100.0% similar) in 322 aa overlap (1-322:1-322)
10 20 30 40 50 60
pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITPATSLEALTMARRSGVKTLFNPAP
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE3 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 AIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKRGCQVVIITLGAEG
190 200 210 220 230 240
250 260 270 280 290 300
pF1KE3 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_071 CVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAFYLAYYPNLSLEDMLNRSNFIAAV
250 260 270 280 290 300
310 320
pF1KE3 SVQAAGTQSSYPYKKDLPLTLF
::::::::::::::::::::::
NP_071 SVQAAGTQSSYPYKKDLPLTLF
310 320
>>NP_001274509 (OMIM: 611132) ribokinase isoform 2 [Homo (255 aa)
initn: 1611 init1: 1611 opt: 1611 Z-score: 2209.7 bits: 416.8 E(85289): 2.4e-116
Smith-Waterman score: 1611; 100.0% identity (100.0% similar) in 255 aa overlap (68-322:1-255)
40 50 60 70 80 90
pF1KE3 TGETIHGHKFFIGFGGKGANQCVQAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEF
::::::::::::::::::::::::::::::
NP_001 MTSMVCKVGKDSFGNDYIENLKQNDISTEF
10 20 30
100 110 120 130 140 150
pF1KE3 TYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITP
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TYQTKDAATGTASIIVNNEGQNIIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLEITP
40 50 60 70 80 90
160 170 180 190 200 210
pF1KE3 ATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADA
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 ATSLEALTMARRSGVKTLFNPAPAIADLDPQFYTLSDVFCCNESEAEILTGLTVGSAADA
100 110 120 130 140 150
220 230 240 250 260 270
pF1KE3 GEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAF
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GEAALVLLKRGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKVKAVDTTGAGDSFVGALAF
160 170 180 190 200 210
280 290 300 310 320
pF1KE3 YLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF
:::::::::::::::::::::::::::::::::::::::::::::
NP_001 YLAYYPNLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF
220 230 240 250
>>NP_006479 (OMIM: 229800,614058) ketohexokinase isoform (298 aa)
initn: 177 init1: 96 opt: 149 Z-score: 204.5 bits: 46.0 E(85289): 0.00012
Smith-Waterman score: 149; 21.5% identity (54.2% similar) in 284 aa overlap (14-280:2-269)
10 20 30 40 50 60
pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
: .. :: . :..::... :: :. . ::...:.:.
NP_006 MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCT
10 20 30 40
70 80 90 100 110
pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDIS-TEFTYQTKDAATGTASIIVNNEGQN
. ::: ... ... .. . .... .. .. ..:.: . : .. :.:: . :
NP_006 VLSLLGAPCAFMGSMAPGHVADFLVADFRRRGVDVSQVAWQSK-GDTPSSCCIINNSNGN
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE3 IIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE---ITPATSLEALTMARRSGVKTLF
... ..: :. :. . :: . :.. : .. : . : .: ...
NP_006 RTIVLHDTSL----PDVSAT----DFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTR
110 120 130 140 150
180 190 200 210 220
pF1KE3 NPAP-----AIADLDP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLK
.: .. : :.. .:: ... :. : :. :: .: .. ..
NP_006 QPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHL-GFQ--SAEEALRGLYGRVR
160 170 180 190 200 210
230 240 250 260 270 280
pF1KE3 RGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV---KAVDTTGAGDSFVGALAFYLAYYP
.: :.. . . :: .:. :. : . .. ..::: ::::.: ... : :.
NP_006 KGA-VLVCAWAEEGADALG---PDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGR
220 230 240 250 260 270
290 300 310 320
pF1KE3 NLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF
NP_006 SVQEALRFGCQVAGKKCGLQGFDGIV
280 290
>>NP_000212 (OMIM: 229800,614058) ketohexokinase isoform (298 aa)
initn: 163 init1: 82 opt: 148 Z-score: 203.1 bits: 45.7 E(85289): 0.00014
Smith-Waterman score: 148; 20.5% identity (53.7% similar) in 283 aa overlap (14-280:2-269)
10 20 30 40 50 60
pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
: .. :: . :..::... :: :. . ::...:.:.
NP_000 MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCT
10 20 30 40
70 80 90 100 110 120
pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYIENLKQNDISTEFTYQTKDAATGTASIIVNNEGQNI
. ::: ... ... .. ...:.. ... ..: ... :..:.:.
NP_000 VLSLLGAPCAFMGSMAPGHVADFVLDDLRRYSVDLRYTVFQTTGSVPIATVIINE-----
50 60 70 80 90 100
130 140 150 160 170
pF1KE3 IVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE---ITPATSLEALTMARRSGVKTLFN
..:. .: . ... . :: . :.. : .. : . : .: ... .
NP_000 ---ASGSRTILYYDRSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTRQ
110 120 130 140 150 160
180 190 200 210 220
pF1KE3 PAP-----AIADLDP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLKR
: .. : :.. .:: ... :. : :. :: .: .. ...
NP_000 PPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHL-GFQ--SAEEALRGLYGRVRK
170 180 190 200 210
230 240 250 260 270 280
pF1KE3 GCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV---KAVDTTGAGDSFVGALAFYLAYYPN
: :.. . . :: .:. :. : . .. ..::: ::::.: ... : :.
NP_000 GA-VLVCAWAEEGADALG---PDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGRS
220 230 240 250 260 270
290 300 310 320
pF1KE3 LSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF
NP_000 VQEALRFGCQVAGKKCGLQGFDGIV
280 290
>>XP_005264353 (OMIM: 229800,614058) PREDICTED: ketohexo (299 aa)
initn: 165 init1: 84 opt: 148 Z-score: 203.1 bits: 45.7 E(85289): 0.00014
Smith-Waterman score: 148; 20.4% identity (54.2% similar) in 284 aa overlap (14-280:2-270)
10 20 30 40 50 60
pF1KE3 MAASGEPQRQWQEEVAAVVVVGSCMTDLVSLTSRLPKTGETIHGHKFFIGFGGKGANQCV
: .. :: . :..::... :: :. . ::...:.:.
XP_005 MEEKQILCVGLVVLDVISLVDKYPKEDSEIRCLSQRWQRGGNASNSCT
10 20 30 40
70 80 90 100 110
pF1KE3 QAARLGAMTSMVCKVGKDSFGNDYI-ENLKQNDISTEFTYQTKDAATGTASIIVNNEGQN
. ::: ... ... ..... ..:.. ... ..: ... :..:.:.
XP_005 VLSLLGAPCAFMGSMAPGHVADSFVLDDLRRYSVDLRYTVFQTTGSVPIATVIINE----
50 60 70 80 90 100
120 130 140 150 160 170
pF1KE3 IIVIVAGANLLLNTEDLRAAANVISRAKVMVCQLE---ITPATSLEALTMARRSGVKTLF
..:. .: . ... . :: . :.. : .. : . : .: ...
XP_005 ----ASGSRTILYYDRSLPDVSATDFEKVDLTQFKWIHIEGRNASEQVKMLQRIDAHNTR
110 120 130 140 150 160
180 190 200 210 220
pF1KE3 NPAP-----AIADLDP-----QFYTLSDVFCCNESEAEILTGLTVGSAADAGEAALVLLK
.: .. : :.. .:: ... :. : :. :: .: .. ..
XP_005 QPPEQKIRVSVEVEKPREELFQLFGYGDVVFVSKDVAKHL-GFQ--SAEEALRGLYGRVR
170 180 190 200 210
230 240 250 260 270 280
pF1KE3 RGCQVVIITLGAEGCVVLSQTEPEPKHIPTEKV---KAVDTTGAGDSFVGALAFYLAYYP
.: :.. . . :: .:. :. : . .. ..::: ::::.: ... : :.
XP_005 KGA-VLVCAWAEEGADALG---PDGKLLHSDAFPPPRVVDTLGAGDTFNASVIFSLSQGR
220 230 240 250 260 270
290 300 310 320
pF1KE3 NLSLEDMLNRSNFIAAVSVQAAGTQSSYPYKKDLPLTLF
XP_005 SVQEALRFGCQVAGKKCGLQGFDGIV
280 290
322 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 18:35:00 2016 done: Sun Nov 6 18:35:01 2016
Total Scan time: 7.560 Total Display time: -0.020
Function used was FASTA [36.3.4 Apr, 2011]