Result of FASTA (omim) for
pFN21AE3121
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3121, 307 aa
1>>>pF1KE3121 307 - 307 aa - 307 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 5.7949+/-0.000307; mu= 14.8999+/- 0.019
mean_var=92.4844+/-18.927, 0's: 0 Z-trim(119.1): 15 B-trim: 912 in 1/59
Lambda= 0.133364
statistics sampled from 32754 (32769) to 32754 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.743), E-opt: 0.2 (0.384), width: 16
Scan time: 4.860
The best scores are: opt bits E(85289)
NP_004605 (OMIM: 188250,609560,617069) thymidine k ( 265) 1840 363.5 2.7e-100
NP_001166114 (OMIM: 188250,609560,617069) thymidin ( 234) 1521 302.0 7.3e-82
NP_001258863 (OMIM: 188250,609560,617069) thymidin ( 216) 1454 289.1 5.2e-78
NP_001166115 (OMIM: 188250,609560,617069) thymidin ( 240) 1290 257.6 1.8e-68
NP_001166116 (OMIM: 188250,609560,617069) thymidin ( 247) 1162 233.0 4.7e-61
NP_001258979 (OMIM: 188250,609560,617069) thymidin ( 168) 1149 230.4 2e-60
NP_001258864 (OMIM: 188250,609560,617069) thymidin ( 146) 716 147.0 2.1e-35
NP_000779 (OMIM: 125450) deoxycytidine kinase [Hom ( 260) 321 71.2 2.5e-12
XP_011530949 (OMIM: 251880,601465,617068,617070) P ( 271) 309 68.9 1.3e-11
NP_001305791 (OMIM: 251880,601465,617068,617070) d ( 174) 302 67.4 2.3e-11
NP_001305792 (OMIM: 251880,601465,617068,617070) d ( 174) 302 67.4 2.3e-11
NP_001305789 (OMIM: 251880,601465,617068,617070) d ( 180) 289 64.9 1.4e-10
NP_001305790 (OMIM: 251880,601465,617068,617070) d ( 180) 289 64.9 1.4e-10
NP_550438 (OMIM: 251880,601465,617068,617070) deox ( 277) 289 65.1 1.9e-10
>>NP_004605 (OMIM: 188250,609560,617069) thymidine kinas (265 aa)
initn: 1840 init1: 1840 opt: 1840 Z-score: 1921.6 bits: 363.5 E(85289): 2.7e-100
Smith-Waterman score: 1840; 100.0% identity (100.0% similar) in 265 aa overlap (43-307:1-265)
20 30 40 50 60 70
pF1KE3 SRRRPTAGLAVVRADSHKKEPRASGSARPAMLLWPLRGWAARALRCFGPGSRGSPASGPG
::::::::::::::::::::::::::::::
NP_004 MLLWPLRGWAARALRCFGPGSRGSPASGPG
10 20 30
80 90 100 110 120 130
pF1KE3 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR
40 50 60 70 80 90
140 150 160 170 180 190
pF1KE3 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS
100 110 120 130 140 150
200 210 220 230 240 250
pF1KE3 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
160 170 180 190 200 210
260 270 280 290 300
pF1KE3 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
220 230 240 250 260
>>NP_001166114 (OMIM: 188250,609560,617069) thymidine ki (234 aa)
initn: 1521 init1: 1521 opt: 1521 Z-score: 1590.7 bits: 302.0 E(85289): 7.3e-82
Smith-Waterman score: 1521; 100.0% identity (100.0% similar) in 224 aa overlap (84-307:11-234)
60 70 80 90 100 110
pF1KE3 RALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFS
::::::::::::::::::::::::::::::
NP_001 MGAFCQRPSSDKEQEKEKKSVICVEGNIASGKTTCLEFFS
10 20 30 40
120 130 140 150 160 170
pF1KE3 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL
50 60 70 80 90 100
180 190 200 210 220 230
pF1KE3 MERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQ
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQ
110 120 130 140 150 160
240 250 260 270 280 290
pF1KE3 RLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQN
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 RLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQN
170 180 190 200 210 220
300
pF1KE3 RDRILTPENRKHCP
::::::::::::::
NP_001 RDRILTPENRKHCP
230
>>NP_001258863 (OMIM: 188250,609560,617069) thymidine ki (216 aa)
initn: 1454 init1: 1454 opt: 1454 Z-score: 1521.5 bits: 289.1 E(85289): 5.2e-78
Smith-Waterman score: 1454; 100.0% identity (100.0% similar) in 213 aa overlap (95-307:4-216)
70 80 90 100 110 120
pF1KE3 GSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEP
::::::::::::::::::::::::::::::
NP_001 MTSICVEGNIASGKTTCLEFFSNATDVEVLTEP
10 20 30
130 140 150 160 170 180
pF1KE3 VSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYI
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYI
40 50 60 70 80 90
190 200 210 220 230 240
pF1KE3 FVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEK
100 110 120 130 140 150
250 260 270 280 290 300
pF1KE3 VIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 VIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRK
160 170 180 190 200 210
pF1KE3 HCP
:::
NP_001 HCP
>>NP_001166115 (OMIM: 188250,609560,617069) thymidine ki (240 aa)
initn: 1339 init1: 1290 opt: 1290 Z-score: 1350.3 bits: 257.6 E(85289): 1.8e-68
Smith-Waterman score: 1616; 90.6% identity (90.6% similar) in 265 aa overlap (43-307:1-240)
20 30 40 50 60 70
pF1KE3 SRRRPTAGLAVVRADSHKKEPRASGSARPAMLLWPLRGWAARALRCFGPGSRGSPASGPG
::::::::::::::::::::::::::::::
NP_001 MLLWPLRGWAARALRCFGPGSRGSPASGPG
10 20 30
80 90 100 110 120 130
pF1KE3 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR
:::::::::::::::::::::: :::::::::::::
NP_001 PRRVQRRAWPPDKEQEKEKKSV-------------------------VLTEPVSKWRNVR
40 50 60
140 150 160 170 180 190
pF1KE3 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS
70 80 90 100 110 120
200 210 220 230 240 250
pF1KE3 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
130 140 150 160 170 180
260 270 280 290 300
pF1KE3 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
190 200 210 220 230 240
>>NP_001166116 (OMIM: 188250,609560,617069) thymidine ki (247 aa)
initn: 1162 init1: 1162 opt: 1162 Z-score: 1217.1 bits: 233.0 E(85289): 4.7e-61
Smith-Waterman score: 1666; 93.2% identity (93.2% similar) in 265 aa overlap (43-307:1-247)
20 30 40 50 60 70
pF1KE3 SRRRPTAGLAVVRADSHKKEPRASGSARPAMLLWPLRGWAARALRCFGPGSRGSPASGPG
::::::::::::::::::::::::::::::
NP_001 MLLWPLRGWAARALRCFGPGSRGSPASGPG
10 20 30
80 90 100 110 120 130
pF1KE3 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVEVLTEPVSKWRNVR
:::::::::::::::::::::::::::::::::::::::::::::::
NP_001 PRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNATDVE-------------
40 50 60 70
140 150 160 170 180 190
pF1KE3 GHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 -----GLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRS
80 90 100 110 120 130
200 210 220 230 240 250
pF1KE3 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 GKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQRLKKRCREEEKVIPLEYLE
140 150 160 170 180 190
260 270 280 290 300
pF1KE3 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
:::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 AIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLELFEQNRDRILTPENRKHCP
200 210 220 230 240
>>NP_001258979 (OMIM: 188250,609560,617069) thymidine ki (168 aa)
initn: 1149 init1: 1149 opt: 1149 Z-score: 1205.9 bits: 230.4 E(85289): 2e-60
Smith-Waterman score: 1149; 100.0% identity (100.0% similar) in 168 aa overlap (140-307:1-168)
110 120 130 140 150 160
pF1KE3 EFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVS
::::::::::::::::::::::::::::::
NP_001 MYHDASRWGLTLQTYVQLTMLDRHTRPQVS
10 20 30
170 180 190 200 210 220
pF1KE3 SVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPE
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SVRLMERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPE
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE3 TCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLEL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 TCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSLFPMAAPVLVIEADHHMERMLEL
100 110 120 130 140 150
290 300
pF1KE3 FEQNRDRILTPENRKHCP
::::::::::::::::::
NP_001 FEQNRDRILTPENRKHCP
160
>>NP_001258864 (OMIM: 188250,609560,617069) thymidine ki (146 aa)
initn: 716 init1: 716 opt: 716 Z-score: 756.5 bits: 147.0 E(85289): 2.1e-35
Smith-Waterman score: 716; 100.0% identity (100.0% similar) in 108 aa overlap (84-191:11-118)
60 70 80 90 100 110
pF1KE3 RALRCFGPGSRGSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFS
::::::::::::::::::::::::::::::
NP_001 MGAFCQRPSSDKEQEKEKKSVICVEGNIASGKTTCLEFFS
10 20 30 40
120 130 140 150 160 170
pF1KE3 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 NATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSVRL
50 60 70 80 90 100
180 190 200 210 220 230
pF1KE3 MERSIHSARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDLIVYLRTNPETCYQ
::::::::::::::::::
NP_001 MERSIHSARYIFVENLYRRNTWKQFTISMRSGSSKAAFSPWQPLFW
110 120 130 140
>>NP_000779 (OMIM: 125450) deoxycytidine kinase [Homo sa (260 aa)
initn: 436 init1: 169 opt: 321 Z-score: 342.2 bits: 71.2 E(85289): 2.5e-12
Smith-Waterman score: 447; 33.9% identity (64.2% similar) in 254 aa overlap (78-299:6-259)
50 60 70 80 90 100
pF1KE3 LRGWAARALRCFGPGSRGSPASGPGPRRVQRRAWPP-DKEQEKEKKSVICVEGNIASGKT
.:. : . .: . . : .:::::.::.
NP_000 MATPPKRSCPSFSASSEGTRIKKISIEGNIAAGKS
10 20 30
110 120 130 140 150
pF1KE3 TCLEFFSN-ATDVEVLTEPVSKWRNVR---------------GHNPLGLMYHDASRWGLT
: ...... : ::. :::..: ::. : : : .::. ::..:
NP_000 TFVNILKQLCEDWEVVPEPVARWCNVQSTQDEFEELTMSQKNGGNVLQMMYEKPERWSFT
40 50 60 70 80 90
160 170 180 190 200
pF1KE3 LQTYV-------QLTMLDRHTRPQVSSVRLMERSIHSARYIFVENLYRSGKMPEVDYVVL
.:::. ::. :. . . . : ..:::..: ::::. :::.: : :.....
NP_000 FQTYACLSRIRAQLASLNGKLKDAEKPVLFFERSVYSDRYIFASNLYESECMNETEWTIY
100 110 120 130 140 150
210 220 230 240 250 260
pF1KE3 SEWFDWILRNMDVSVDL--IVYLRTNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEW
..: ::. .. :..: :.::...:::: .:. : :.::. ::::::: .:. :: :
NP_000 QDWHDWMNNQFGQSLELDGIIYLQATPETCLHRIYLRGRNEEQGIPLEYLEKLHYKHESW
160 170 180 190 200 210
270 280 290 300
pF1KE3 LIKGSL-----FPMAAPVLVIEADHHMERMLE-LFEQNRDRILTPENRKHCP
:.. .: . . .:.:...... .. : : :. .. . :
NP_000 LLHRTLKTNFDYLQEVPILTLDVNEDFKDKYESLVEKVKEFLSTL
220 230 240 250 260
>>XP_011530949 (OMIM: 251880,601465,617068,617070) PREDI (271 aa)
initn: 389 init1: 164 opt: 309 Z-score: 329.5 bits: 68.9 E(85289): 1.3e-11
Smith-Waterman score: 375; 31.9% identity (65.2% similar) in 207 aa overlap (95-280:41-247)
70 80 90 100 110 120
pF1KE3 GSPASGPGPRRVQRRAWPPDKEQEKEKKSVICVEGNIASGKTTCLEFFSNA-TDVEVLTE
. .::::: ::.: ....... . .: ::
XP_011 LRAPFSSMAKSPLEGVSSSRGLHAGRGPRRLSIEGNIAVGKSTFVKLLTKTYPEWHVATE
20 30 40 50 60 70
130 140 150 160 170
pF1KE3 PVSKWRNVRGH------------NPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQVSSV
::. :.:... : : .::.. .::. :.::. :. : . .: ..
XP_011 PVATWQNIQAAGTQKACTAQSLGNLLDMMYREPARWSYTFQTFSFLSRLKVQLEPFPEKL
80 90 100 110 120 130
180 190 200 210 220
pF1KE3 RLMERSIHS-ARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL--IVYLRTNP
.. .. ::::..::...:.. .... . ..: ...: .. . : ..::...:
XP_011 LQARKPVQIFERYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQASP
140 150 160 170 180 190
230 240 250 260 270 280
pF1KE3 ETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSL---FP--MAAPVLVIEADHHM
..: .:: .: ::::: : : ::: .: :: :::. . : : ::::....
XP_011 QVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVNDDF
200 210 220 230 240 250
290 300
pF1KE3 ERMLELFEQNRDRILTPENRKHCP
XP_011 SEEVTKQEDLMREVNTFVKNL
260 270
>>NP_001305791 (OMIM: 251880,601465,617068,617070) deoxy (174 aa)
initn: 315 init1: 164 opt: 302 Z-score: 324.9 bits: 67.4 E(85289): 2.3e-11
Smith-Waterman score: 302; 32.7% identity (67.3% similar) in 150 aa overlap (139-280:1-150)
110 120 130 140 150 160
pF1KE3 LEFFSNATDVEVLTEPVSKWRNVRGHNPLGLMYHDASRWGLTLQTYVQLTMLDRHTRPQV
.::.. .::. :.::. :. : . .:
NP_001 MMYREPARWSYTFQTFSFLSRLKVQLEPFP
10 20 30
170 180 190 200 210 220
pF1KE3 SSVRLMERSIHS-ARYIFVENLYRSGKMPEVDYVVLSEWFDWILRNMDVSVDL--IVYLR
.. .. .. ::::..::...:.. .... . ..: ...: .. . : ..::.
NP_001 EKLLQARKPVQIFERYIFAKNLFENGSLSDIEWHIYQDWHSFLLWEFASRITLHGFIYLQ
40 50 60 70 80 90
230 240 250 260 270 280
pF1KE3 TNPETCYQRLKKRCREEEKVIPLEYLEAIHHLHEEWLIKGSL---FP--MAAPVLVIEAD
..:..: .:: .: ::::: : : ::: .: :: :::. . : : ::::....
NP_001 ASPQVCLKRLYQRAREEEKGIELAYLEQLHGQHEAWLIHKTTKLHFEALMNIPVLVLDVN
100 110 120 130 140 150
290 300
pF1KE3 HHMERMLELFEQNRDRILTPENRKHCP
NP_001 DDFSEEVTKQEDLMREVNTFVKNL
160 170
307 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 03:27:56 2016 done: Sun Nov 6 03:27:57 2016
Total Scan time: 4.860 Total Display time: 0.000
Function used was FASTA [36.3.4 Apr, 2011]