Result of FASTA (omim) for
pFN21AE3045
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE3045, 184 aa
1>>>pF1KE3045 184 - 184 aa - 184 aa
Library: /omim/omim.rfq.tfa
60827320 residues in 85289 sequences
Statistics: Expectation_n fit: rho(ln(x))= 6.3437+/-0.00027; mu= 9.6531+/- 0.017
mean_var=101.8004+/-20.343, 0's: 0 Z-trim(122.9): 21 B-trim: 949 in 1/55
Lambda= 0.127116
statistics sampled from 41641 (41662) to 41641 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.818), E-opt: 0.2 (0.488), width: 16
Scan time: 6.650
The best scores are: opt bits E(85289)
NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precu ( 184) 1275 242.9 2.2e-64
XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 i ( 221) 1275 242.9 2.5e-64
XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 i ( 240) 1275 243.0 2.7e-64
NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 pr ( 143) 763 148.9 3.3e-36
NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [H ( 114) 754 147.2 8.6e-36
XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 i ( 168) 622 123.1 2.3e-28
NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo ( 168) 622 123.1 2.3e-28
XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 i ( 186) 622 123.1 2.5e-28
NP_005445 (OMIM: 603777) cerberus precursor [Homo ( 267) 242 53.6 3.2e-07
NP_001191014 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06
NP_001191013 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06
NP_005371 (OMIM: 600613) neuroblastoma suppressor ( 181) 219 49.2 4.3e-06
NP_001265093 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06
NP_001265095 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06
NP_001265094 (OMIM: 600613) neuroblastoma suppress ( 181) 219 49.2 4.3e-06
NP_001191015 (OMIM: 600613) neuroblastoma suppress ( 215) 219 49.3 4.9e-06
NP_877421 (OMIM: 600613) neuroblastoma suppressor ( 216) 219 49.3 4.9e-06
NP_689867 (OMIM: 609068) DAN domain family member ( 189) 159 38.2 0.0091
>>NP_037504 (OMIM: 603054) gremlin-1 isoform 1 precursor (184 aa)
initn: 1275 init1: 1275 opt: 1275 Z-score: 1276.9 bits: 242.9 E(85289): 2.2e-64
Smith-Waterman score: 1275; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:1-184)
10 20 30 40 50 60
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE3 GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE3 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_037 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS
130 140 150 160 170 180
pF1KE3 IDLD
::::
NP_037 IDLD
>>XP_016877566 (OMIM: 603054) PREDICTED: gremlin-1 isofo (221 aa)
initn: 1275 init1: 1275 opt: 1275 Z-score: 1275.8 bits: 242.9 E(85289): 2.5e-64
Smith-Waterman score: 1275; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:38-221)
10 20 30
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ
::::::::::::::::::::::::::::::
XP_016 GSGGVLGRPLESAGWSIRRIHDVCICRSPSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ
10 20 30 40 50 60
40 50 60 70 80 90
pF1KE3 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK
70 80 90 100 110 120
100 110 120 130 140 150
pF1KE3 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT
130 140 150 160 170 180
160 170 180
pF1KE3 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
::::::::::::::::::::::::::::::::::
XP_016 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
190 200 210 220
>>XP_005254358 (OMIM: 603054) PREDICTED: gremlin-1 isofo (240 aa)
initn: 1275 init1: 1275 opt: 1275 Z-score: 1275.2 bits: 243.0 E(85289): 2.7e-64
Smith-Waterman score: 1275; 100.0% identity (100.0% similar) in 184 aa overlap (1-184:57-240)
10 20 30
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ
::::::::::::::::::::::::::::::
XP_005 PAPSPGGSGRGRTQRHASKAQAPRTRRTDSMSRTAYTVGALLLLLGTLLPAAEGKKKGSQ
30 40 50 60 70 80
40 50 60 70 80 90
pF1KE3 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 GAIPPPDKAQHNDSEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLK
90 100 110 120 130 140
100 110 120 130 140 150
pF1KE3 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_005 RDWCKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFT
150 160 170 180 190 200
160 170 180
pF1KE3 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
::::::::::::::::::::::::::::::::::
XP_005 TMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
210 220 230 240
>>NP_001178252 (OMIM: 603054) gremlin-1 isoform 2 precur (143 aa)
initn: 777 init1: 755 opt: 763 Z-score: 771.0 bits: 148.9 E(85289): 3.3e-36
Smith-Waterman score: 904; 77.7% identity (77.7% similar) in 184 aa overlap (1-184:1-143)
10 20 30 40 50 60
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKAQHNDSEQTQSPQQPGSRNRGR
:::::::::::::::::::::::::::::::::::::::
NP_001 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDKA---------------------
10 20 30
70 80 90 100 110 120
pF1KE3 GQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG
::::::::::::::::::::::::::::::::::::::::
NP_001 --------------------LHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCYG
40 50 60 70
130 140 150 160 170 180
pF1KE3 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 QCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCIS
80 90 100 110 120 130
pF1KE3 IDLD
::::
NP_001 IDLD
140
>>NP_001178251 (OMIM: 603054) gremlin-1 isoform 3 [Homo (114 aa)
initn: 754 init1: 754 opt: 754 Z-score: 763.5 bits: 147.2 E(85289): 8.6e-36
Smith-Waterman score: 754; 100.0% identity (100.0% similar) in 105 aa overlap (80-184:10-114)
50 60 70 80 90 100
pF1KE3 PQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCN
::::::::::::::::::::::::::::::
NP_001 MSRTAYTVGALHVTERKYLKRDWCKTQPLKQTIHEEGCN
10 20 30
110 120 130 140 150 160
pF1KE3 SRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKR
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 SRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKR
40 50 60 70 80 90
170 180
pF1KE3 VTRVKQCRCISIDLD
:::::::::::::::
NP_001 VTRVKQCRCISIDLD
100 110
>>XP_011542551 (OMIM: 608832) PREDICTED: gremlin-2 isofo (168 aa)
initn: 675 init1: 614 opt: 622 Z-score: 630.3 bits: 123.1 E(85289): 2.3e-28
Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (12-183:9-162)
10 20 30 40 50
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDSEQTQSPQQPGSRNRG
:.:...:. .::..:. :::: : : .. :.::. : .
XP_011 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIK-------
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY
::: :::::: :::::::: ::::::::.::. :::: ::::.:::::
XP_011 ------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY
60 70 80 90
120 130 140 150 160 170
pF1KE3 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCI
:::::::::::..::: :::::.::::.. :...: :.:: :.:: . :.. .::::::.
XP_011 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCM
100 110 120 130 140 150
180
pF1KE3 SIDLD
:..:
XP_011 SVNLSDSDKQ
160
>>NP_071914 (OMIM: 608832) gremlin-2 precursor [Homo sap (168 aa)
initn: 675 init1: 614 opt: 622 Z-score: 630.3 bits: 123.1 E(85289): 2.3e-28
Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (12-183:9-162)
10 20 30 40 50
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDSEQTQSPQQPGSRNRG
:.:...:. .::..:. :::: : : .. :.::. : .
NP_071 MFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNSERWQHQIK-------
10 20 30 40 50
60 70 80 90 100 110
pF1KE3 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY
::: :::::: :::::::: ::::::::.::. :::: ::::.:::::
NP_071 ------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVSEEGCRSRTILNRFCY
60 70 80 90
120 130 140 150 160 170
pF1KE3 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPPTKKKRVTRVKQCRCI
:::::::::::..::: :::::.::::.. :...: :.:: :.:: . :.. .::::::.
NP_071 GQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPPFRLKKIQKVKQCRCM
100 110 120 130 140 150
180
pF1KE3 SIDLD
:..:
NP_071 SVNLSDSDKQ
160
>>XP_005273283 (OMIM: 608832) PREDICTED: gremlin-2 isofo (186 aa)
initn: 675 init1: 614 opt: 622 Z-score: 629.6 bits: 123.1 E(85289): 2.5e-28
Smith-Waterman score: 647; 55.5% identity (75.1% similar) in 173 aa overlap (12-183:27-180)
10 20 30 40
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQGAIPPPDK-AQHNDS
:.:...:. .::..:. :::: : : .. :.:
XP_005 MRALRAESTSGSRQTPCRMFWKLSLSLFLVAVLVKVAEARKNRPAGAIPSPYKDGSSNNS
10 20 30 40 50 60
50 60 70 80 90 100
pF1KE3 EQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIH
:. : . ::: :::::: :::::::: ::::::::.::.
XP_005 ERWQHQIK-------------------EVLASSQEALVVTERKYLKSDWCKTQPLRQTVS
70 80 90 100
110 120 130 140 150 160
pF1KE3 EEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCPELQPP
:::: ::::.::::::::::::::::..::: :::::.::::.. :...: :.:: :.::
XP_005 EEGCRSRTILNRFCYGQCNSFYIPRHVKKEEESFQSCAFCKPQRVTSVLVELECPGLDPP
110 120 130 140 150 160
170 180
pF1KE3 TKKKRVTRVKQCRCISIDLD
. :.. .::::::.:..:
XP_005 FRLKKIQKVKQCRCMSVNLSDSDKQ
170 180
>>NP_005445 (OMIM: 603777) cerberus precursor [Homo sapi (267 aa)
initn: 289 init1: 132 opt: 242 Z-score: 250.7 bits: 53.6 E(85289): 3.2e-07
Smith-Waterman score: 252; 28.9% identity (53.9% similar) in 180 aa overlap (20-178:68-241)
10 20 30 40
pF1KE3 MSRTAYTVGALLLLLGTLLPAAEGKKKGSQ-----GAI-PPPDKAQHND
::.::... . : . :.. .: .
NP_005 NQRELPTGNHEEAEEKPDLFVAVPHLVATSPAGEGQRQREKMLSRFGRFWKKPEREMHPS
40 50 60 70 80 90
50 60 70 80 90
pF1KE3 SEQTQSPQQPGSRNRGRGQGRGTAMPGEEVLESSQEALH-------------VTERKYLK
.. . : ::... . : : . : ... : . : .
NP_005 RDSDSEPFPPGTQSLIQPID-GMKMEKSPLREEAKKFWHHFMFRKTPASQGVILPIKSHE
100 110 120 130 140 150
100 110 120 130 140
pF1KE3 RDW--CKTQPLKQTIHEEGCNSRTIINRFCYGQCNSFYIPRHIRKEEGSFQSCSFCKPKK
: :.: :..::: .:::.. .. : .:.:.:.: ..: .. : ::: : : :
NP_005 VHWETCRTVPFSQTITHEGCEKVVVQNNLCFGKCGSVHFPGAAQH---SHTSCSHCLPAK
160 170 180 190 200 210
150 160 170 180
pF1KE3 FTTMMVTLNCPELQPPTKKKRVTRVKQCRCISIDLD
:::: . ::: ::. . : : :..:.:
NP_005 FTTMHLPLNCTELS--SVIKVVMLVEECQCKVKTEHEDGHILHAGSQDSFIPGVSA
220 230 240 250 260
>>NP_001191014 (OMIM: 600613) neuroblastoma suppressor o (181 aa)
initn: 213 init1: 193 opt: 219 Z-score: 230.4 bits: 49.2 E(85289): 4.3e-06
Smith-Waterman score: 219; 32.2% identity (58.9% similar) in 90 aa overlap (90-178:31-120)
60 70 80 90 100 110
pF1KE3 RGQGRGTAMPGEEVLESSQEALHVTERKYLKRDWCKTQPLKQTIHEEGCNSRTIINRFCY
: ::... . : . . ::....: :: :
NP_001 MMLRVLVGAVLPAMLLAAPPPINKLALFPDKSAWCEAKNITQIVGHSGCEAKSIQNRACL
10 20 30 40 50 60
120 130 140 150 160 170
pF1KE3 GQCNSFYIPRHIRKEEGSFQSCSFCKPKKFTTMMVTLNCP-ELQPPTKKKRVTRVKQCRC
::: :. .: . . :. :. : : . .:::.:: . . : : : .. .: :
NP_001 GQCFSYSVPNTFPQSTESLVHCDSCMPAQSMWEIVTLECPGHEEVPRVDKLVEKILHCSC
70 80 90 100 110 120
180
pF1KE3 ISIDLD
NP_001 QACGKEPSHEGLSVYVQGEDGPGSQPGTHPHPHPHPHPGGQTPEPEDPPGAPHTEEEGAE
130 140 150 160 170 180
184 residues in 1 query sequences
60827320 residues in 85289 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Sun Nov 6 04:55:11 2016 done: Sun Nov 6 04:55:12 2016
Total Scan time: 6.650 Total Display time: -0.010
Function used was FASTA [36.3.4 Apr, 2011]