Result of FASTA (omim) for
pFN21AE2760
FASTA searches a protein or DNA sequence data bank 36.3.4 Apr, 2011
Please cite:
W.R. Pearson & D.J. Lipman PNAS (1988) 85:2444-2448
Query: pF1KE2760, 251 aa
1>>>pF1KE2760 251 - 251 aa - 251 aa
Library: /omim/omim.rfq.tfa
64236559 residues in 92054 sequences
Statistics: Expectation_n fit: rho(ln(x))= 4.6282+/-0.000275; mu= 19.4078+/- 0.017
mean_var=66.3537+/-13.328, 0's: 0 Z-trim(119.1): 35 B-trim: 0 in 0/51
Lambda= 0.157450
statistics sampled from 33913 (33955) to 33913 sequences
Algorithm: FASTA (3.7 Nov 2010) [optimized]
Parameters: BL50 matrix (15:-5), open/ext: -10/-2
ktup: 2, E-join: 1 (0.736), E-opt: 0.2 (0.369), width: 16
Scan time: 3.120
The best scores are: opt bits E(92054)
NP_001257340 (OMIM: 607110) DNA dC->dU-editing enz ( 357) 1378 321.2 1.7e-87
NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme ( 382) 1378 321.2 1.8e-87
XP_016884131 (OMIM: 608993) DNA dC->dU-editing enz ( 227) 1140 266.9 2.4e-71
XP_024307947 (OMIM: 608993) DNA dC->dU-editing enz ( 373) 1127 264.2 2.6e-70
NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme ( 373) 1127 264.2 2.6e-70
NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme ( 386) 760 180.8 3.3e-45
NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme ( 190) 710 169.2 5.2e-42
XP_024307946 (OMIM: 608993) DNA dC->dU-editing enz ( 442) 703 167.9 2.9e-41
XP_016884085 (OMIM: 609900) DNA dC->dU-editing enz ( 455) 677 162.0 1.8e-39
NP_001336367 (OMIM: 607113) DNA dC->dU-editing enz ( 194) 652 156.0 4.9e-38
NP_068594 (OMIM: 607113) DNA dC->dU-editing enzyme ( 384) 654 156.7 5.9e-38
XP_016884392 (OMIM: 607113) DNA dC->dU-editing enz ( 524) 654 156.8 7.4e-38
NP_001336365 (OMIM: 607113) DNA dC->dU-editing enz ( 373) 609 146.5 6.9e-35
XP_024307986 (OMIM: 607750) DNA dC->dU-editing enz ( 227) 557 134.5 1.7e-31
NP_001350710 (OMIM: 609900) DNA dC->dU-editing enz ( 202) 530 128.3 1.1e-29
NP_065712 (OMIM: 605257,605258) single-stranded DN ( 198) 413 101.7 1.1e-21
NP_001336366 (OMIM: 607113) DNA dC->dU-editing enz ( 317) 403 99.6 7.5e-21
XP_016884393 (OMIM: 607113) DNA dC->dU-editing enz ( 457) 403 99.8 9.7e-21
NP_663745 (OMIM: 607109) DNA dC->dU-editing enzyme ( 199) 379 94.0 2.3e-19
NP_001257335 (OMIM: 607109) DNA dC->dU-editing enz ( 181) 364 90.6 2.3e-18
XP_011528292 (OMIM: 610976) DNA dC->dU-editing enz ( 203) 339 84.9 1.3e-16
XP_011528293 (OMIM: 610976) DNA dC->dU-editing enz ( 203) 339 84.9 1.3e-16
NP_001159474 (OMIM: 610976) DNA dC->dU-editing enz ( 182) 336 84.2 1.9e-16
NP_861438 (OMIM: 610976) DNA dC->dU-editing enzyme ( 183) 336 84.2 1.9e-16
XP_011528294 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 336 84.2 2e-16
NP_001159475 (OMIM: 610976) DNA dC->dU-editing enz ( 200) 336 84.2 2e-16
NP_006780 (OMIM: 604797) C->U-editing enzyme APOBE ( 224) 335 84.0 2.6e-16
NP_001317272 (OMIM: 605257,605258) single-stranded ( 188) 313 79.0 7.3e-15
NP_001291495 (OMIM: 600130) C->U-editing enzyme AP ( 236) 310 78.4 1.4e-14
NP_001635 (OMIM: 600130) C->U-editing enzyme APOBE ( 236) 310 78.4 1.4e-14
XP_011519075 (OMIM: 605257,605258) single-stranded ( 145) 307 77.5 1.5e-14
NP_005880 (OMIM: 600130) C->U-editing enzyme APOBE ( 191) 295 74.9 1.3e-13
NP_001159476 (OMIM: 610976) DNA dC->dU-editing enz ( 154) 249 64.4 1.5e-10
XP_016884132 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 233 60.6 1.4e-09
NP_001006667 (OMIM: 608993) DNA dC->dU-editing enz ( 101) 233 60.6 1.4e-09
>>NP_001257340 (OMIM: 607110) DNA dC->dU-editing enzyme (357 aa)
initn: 1378 init1: 1378 opt: 1378 Z-score: 1692.2 bits: 321.2 E(92054): 1.7e-87
Smith-Waterman score: 1378; 95.5% identity (97.0% similar) in 199 aa overlap (1-199:1-199)
10 20 30 40 50 60
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_001 FKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_001 ARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG
:::::::::: . .::
NP_001 LHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCN
190 200 210 220 230 240
>--
initn: 380 init1: 181 opt: 333 Z-score: 409.4 bits: 83.8 E(92054): 5e-16
Smith-Waterman score: 373; 39.9% identity (63.6% similar) in 173 aa overlap (20-190:201-353)
10 20 30 40
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLL
::.:.:.. : :.::::: .: .:
NP_001 WYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEV--ER-LDNGT
180 190 200 210 220
50 60 70 80 90 100
pF1KE2 WDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPD--CVAKLAEF
: :. : .: :: : :.: . ...:::.::.:: . :.... :
NP_001 W---VLMDQ---------HMGFL---C-NELDPAQIYRVTWFISWSPCFSWGCAGEVRAF
230 240 250 260 270
110 120 130 140 150 160
pF1KE2 LSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQ
:.:. .: : : :::.: : . :..:: : .:::.:.:: :.:: :::..::: .:
NP_001 LQENTHVRLRIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFVYRQGCP
280 290 300 310 320 330
170 180 190 200 210 220
pF1KE2 FMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGS
:.:: ..:. : :. ::.
NP_001 FQPWDGLEEHSQALSGRLRAILQNQGN
340 350
>>NP_004891 (OMIM: 607110) DNA dC->dU-editing enzyme APO (382 aa)
initn: 1378 init1: 1378 opt: 1378 Z-score: 1691.8 bits: 321.2 E(92054): 1.8e-87
Smith-Waterman score: 1378; 95.5% identity (97.0% similar) in 199 aa overlap (1-199:1-199)
10 20 30 40 50 60
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
::::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
10 20 30 40 50 60
70 80 90 100 110 120
pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
:.::::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_004 FKPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
70 80 90 100 110 120
130 140 150 160 170 180
pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
::::::::::::::::::::::::: ::::::::::::::::::::::::::::::::::
NP_004 ARLYYYWERDYRRALCRLSQAGARVTIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
130 140 150 160 170 180
190 200 210 220 230 240
pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG
:::::::::: . .::
NP_004 LHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVLMDQHMGFLCN
190 200 210 220 230 240
>--
initn: 352 init1: 181 opt: 392 Z-score: 481.4 bits: 97.2 E(92054): 4.8e-20
Smith-Waterman score: 392; 38.5% identity (65.4% similar) in 179 aa overlap (20-190:201-378)
10 20 30 40
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLL
::.:.:.. : :.:::::. . . .:
NP_004 WYKFDENYAFLHRTLKEILRYLMDPDTFTFNFNNDPLVLRRRQTYLCYEVERLDNGTWVL
180 190 200 210 220 230
50 60 70 80 90 100
pF1KE2 WDT--GVF--RGQVYFEPQY--HAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPD--CV
: : . ... . : :::. ::. . :: . ...:::.::.:: . :.
NP_004 MDQHMGFLCNEAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCA
240 250 260 270 280 290
110 120 130 140 150 160
pF1KE2 AKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFV
... ::.:. .: : : :::.: : . :..:: : .:::.:.:: :.:: :::..::
NP_004 GEVRAFLQENTHVRLRIFAARIYDY-DPLYKEALQMLRDAGAQVSIMTYDEFEYCWDTFV
300 310 320 330 340
170 180 190 200 210 220
pF1KE2 YNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRS
: .: :.:: ..:. : :. ::.
NP_004 YRQGCPFQPWDGLEEHSQALSGRLRAILQNQGN
350 360 370 380
>>XP_016884131 (OMIM: 608993) DNA dC->dU-editing enzyme (227 aa)
initn: 1145 init1: 952 opt: 1140 Z-score: 1402.6 bits: 266.9 E(92054): 2.4e-71
Smith-Waterman score: 1140; 75.6% identity (85.3% similar) in 217 aa overlap (1-216:1-214)
10 20 30 40 50 60
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::::::
XP_016 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
.:..:::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_016 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.::::
XP_016 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF
120 130 140 150 160 170
190 200 210 220 230
pF1KE2 LHRTLKEILRLRIFSVAFTA-AMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVP
:::::::::: :. . . .: .: ::.: :
XP_016 LHRTLKEILRAT--SIHLRGRPPHSLGSPTWLLPSPWHNRICHKTGRKWA
180 190 200 210 220
240 250
pF1KE2 GKCVRSFRRTHT
>>XP_024307947 (OMIM: 608993) DNA dC->dU-editing enzyme (373 aa)
initn: 1125 init1: 952 opt: 1127 Z-score: 1383.8 bits: 264.2 E(92054): 2.6e-70
Smith-Waterman score: 1127; 82.6% identity (90.5% similar) in 190 aa overlap (1-190:1-189)
10 20 30 40 50 60
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::::::
XP_024 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
.:..:::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_024 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.::::
XP_024 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG
::::::::::
XP_024 LHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFR
180 190 200 210 220 230
>--
initn: 694 init1: 694 opt: 694 Z-score: 852.3 bits: 165.8 E(92054): 1.1e-40
Smith-Waterman score: 694; 50.3% identity (73.2% similar) in 183 aa overlap (7-189:190-372)
10 20 30
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC
:::: :: :: .:.: :::. .:::
XP_024 VYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLC
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE2 YEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTP
. ... . .: . : ::::.:: : . ::: ::::::: . : ...::..::.:
XP_024 FTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSP
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE2 CPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYC
::.:....::::..: ::.::: .:::::.:. ::...: ::: :: :.:: :..: ::
XP_024 CPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYC
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE2 WENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSW
:::::::. . : :: . :. :: :.:::
XP_024 WENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
340 350 360 370
220 230 240 250
pF1KE2 TRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT
>>NP_660341 (OMIM: 608993) DNA dC->dU-editing enzyme APO (373 aa)
initn: 1125 init1: 952 opt: 1127 Z-score: 1383.8 bits: 264.2 E(92054): 2.6e-70
Smith-Waterman score: 1127; 82.6% identity (90.5% similar) in 190 aa overlap (1-190:1-189)
10 20 30 40 50 60
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::::::
NP_660 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
.:..:::::::::::::::::::::::::::::::::::::::::::.:::::::::::
NP_660 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA
60 70 80 90 100 110
130 140 150 160 170 180
pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAF
::::::::::::::::::::::::::::: ::::::::::::.::: ::::::::.::::
NP_660 ARLYYYWERDYRRALCRLSQAGARVKIMDDEEFAYCWENFVYSEGQPFMPWYKFDDNYAF
120 130 140 150 160 170
190 200 210 220 230 240
pF1KE2 LHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPG
::::::::::
NP_660 LHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSPVSWKRGVFR
180 190 200 210 220 230
>--
initn: 694 init1: 694 opt: 694 Z-score: 852.3 bits: 165.8 E(92054): 1.1e-40
Smith-Waterman score: 694; 50.3% identity (73.2% similar) in 183 aa overlap (7-189:190-372)
10 20 30
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLC
:::: :: :: .:.: :::. .:::
NP_660 VYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLC
160 170 180 190 200 210
40 50 60 70 80 90
pF1KE2 YEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTP
. ... . .: . : ::::.:: : . ::: ::::::: . : ...::..::.:
NP_660 FTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSP
220 230 240 250 260 270
100 110 120 130 140 150
pF1KE2 CPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYC
::.:....::::..: ::.::: .:::::.:. ::...: ::: :: :.:: :..: ::
NP_660 CPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFKYC
280 290 300 310 320 330
160 170 180 190 200 210
pF1KE2 WENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSW
:::::::. . : :: . :. :: :.:::
NP_660 WENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
340 350 360 370
220 230 240 250
pF1KE2 TRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT
>>NP_689639 (OMIM: 609900) DNA dC->dU-editing enzyme APO (386 aa)
initn: 1076 init1: 749 opt: 760 Z-score: 933.1 bits: 180.8 E(92054): 3.3e-45
Smith-Waterman score: 1133; 71.1% identity (80.9% similar) in 235 aa overlap (1-213:1-235)
10 20 30 40 50
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRG---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
NP_689 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 ---------QVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
.:::. . :::::::::::::.::: . :::::::::.:: ::.:...::
NP_689 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
110 120 130 140 150 160
pF1KE2 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQF
.::::::::::::::::: .::.: .: :: .:::::::::::.::::::::: :::: :
NP_689 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEDFAYCWENFVCNEGQPF
130 140 150 160 170 180
170 180 190 200 210
pF1KE2 MPWYKFDENYAFLHRTLKEILRL-------RIFSVAFTAAMRSCA---SWTWFLLCSWTR
:::::::.::: :::::::::: .:: : ...:. :: : .
NP_689 MPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKH
190 200 210 220 230 240
220 230 240 250
pF1KE2 PRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT
NP_689 HSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEV
250 260 270 280 290 300
>--
initn: 587 init1: 558 opt: 564 Z-score: 692.5 bits: 136.3 E(92054): 8.4e-32
Smith-Waterman score: 564; 48.3% identity (76.8% similar) in 151 aa overlap (40-190:236-386)
10 20 30 40 50 60
pF1KE2 ERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEM
.. . .: .. ::::.:: : . :::
NP_689 EAMYPHIFYFHFKNLLKACGRNESWLCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAER
210 220 230 240 250 260
70 80 90 100 110 120
pF1KE2 CFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWER
::::::: . : ...::..::.:::.:....::::..: ::.::: .::: :.:.
NP_689 CFLSWFCDDILSPNTNYEVTWYTSWSPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDT
270 280 290 300 310 320
130 140 150 160 170 180
pF1KE2 DYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEIL
::...:: ::: :: :::: :..:. ::.::::.. . : :: .. :. .:.: :.:::
NP_689 DYQEGLCSLSQEGASVKIMGYKDFVSCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREIL
330 340 350 360 370 380
190 200 210 220 230 240
pF1KE2 RLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRT
.
NP_689 Q
>>NP_055323 (OMIM: 607750) DNA dC->dU-editing enzyme APO (190 aa)
initn: 676 init1: 676 opt: 710 Z-score: 875.8 bits: 169.2 E(92054): 5.2e-42
Smith-Waterman score: 710; 53.9% identity (74.3% similar) in 191 aa overlap (1-190:1-190)
10 20 30 40 50
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVK-IKRGRSNLLWDTGVFRGQV
:::::::::. :: ::: .:.: :. ::::. :. ::: :: . : :::::.::
NP_055 MNPQIRNPMKAMYPGTFYFQFKNLWEANDRNETWLCFTVEGIKR-RSVVSWKTGVFRNQV
10 20 30 40 50
60 70 80 90 100 110
pF1KE2 YFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTIS
: . ::: ::::::: . : .:.::..::.:::::....::::..: ::.:::
NP_055 DSETHCHAERCFLSWFCDDILSPNTKYQVTWYTSWSPCPDCAGEVAEFLARHSNVNLTIF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 AARLYYYWERDYRRALCRLSQAGARVKIMDYEEFAYCWENFVYNEGQQFMPWYKFDENYA
.:::::. :...: ::: :. :.:::::.: :::::::::... : :: . :.
NP_055 TARLYYFQYPCYQEGLRSLSQEGVAVEIMDYEDFKYCWENFVYNDNEPFKPWKGLKTNFR
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 FLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASPGAVP
.:.: :.: :.
NP_055 LLKRRLRESLQ
180 190
>>XP_024307946 (OMIM: 608993) DNA dC->dU-editing enzyme (442 aa)
initn: 1101 init1: 703 opt: 703 Z-score: 862.4 bits: 167.9 E(92054): 2.9e-41
Smith-Waterman score: 967; 60.3% identity (66.1% similar) in 257 aa overlap (1-188:1-256)
10 20 30 40 50 60
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::::::
XP_024 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPRLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110 120
pF1KE2 FEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTISA
.:..:::::::::::::::::::::::::::::::::::::::::::.:::::::::::
XP_024 SQPEHHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFLAEHPNVTLTISA
60 70 80 90 100 110
130 140 150
pF1KE2 ARLYYYWERDYRRALCRLSQAGARVKIMDYE-----------------------------
::::::::::::::::::::::::::::: :
XP_024 ARLYYYWERDYRRALCRLSQAGARVKIMDDEGERWRGQGSVSGRNSMKDGWICNAMAGGV
120 130 140 150 160 170
160 170
pF1KE2 ----------------------------------------EFAYCWENFVYNEGQQFMPW
:::::::::::.::: ::::
XP_024 PGQPAGAGPALTATDSQETRPGSAGPGSGQSLTASCLFVSEFAYCWENFVYSEGQPFMPW
180 190 200 210 220 230
180 190 200 210 220 230
pF1KE2 YKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGA
::::.::::::::::::
XP_024 YKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESWLCFTMEVVKHHSP
240 250 260 270 280 290
>--
initn: 1107 init1: 703 opt: 703 Z-score: 862.4 bits: 167.9 E(92054): 2.9e-41
Smith-Waterman score: 703; 50.3% identity (73.5% similar) in 185 aa overlap (5-189:257-441)
10 20 30
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW
.::::: :: :: .:.: :::. .:
XP_024 NFVYSEGQPFMPWYKFDDNYAFLHRTLKEILRNPMEAMYPHIFYFHFKNLRKAYGRNESW
230 240 250 260 270 280
40 50 60 70 80 90
pF1KE2 LCYEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSW
::. ... . .: . : ::::.:: : . ::: ::::::: . : ...::..::
XP_024 LCFTMEVVKHHSPVSWKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW
290 300 310 320 330 340
100 110 120 130 140 150
pF1KE2 TPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFA
.:::.:....::::..: ::.::: .:::::.:. ::...: ::: :: :.:: :..:
XP_024 SPCPECAGEVAEFLARHSNVNLTIFTARLYYFWDTDYQEGLRSLSQEGASVEIMGYKDFK
350 360 370 380 390 400
160 170 180 190 200 210
pF1KE2 YCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLC
:::::::::. . : :: . :. :: :.:::
XP_024 YCWENFVYNDDEPFKPWKGLKYNFLFLDSKLQEILE
410 420 430 440
220 230 240 250
pF1KE2 SWTRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT
>>XP_016884085 (OMIM: 609900) DNA dC->dU-editing enzyme (455 aa)
initn: 1159 init1: 675 opt: 677 Z-score: 830.3 bits: 162.0 E(92054): 1.8e-39
Smith-Waterman score: 961; 58.7% identity (65.1% similar) in 269 aa overlap (1-188:1-269)
10 20 30 40 50
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRG---
:::::::::::::::::::::::::::::::::::::::::::::::::::::::::
XP_016 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGPVL
10 20 30 40 50 60
60 70 80 90 100
pF1KE2 ---------QVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSWTPCPDCVAKLAEFL
.:::. . :::::::::::::.::: . :::::::::.:: ::.:...::
XP_016 PKRQSNHRQEVYFRFENHAEMCFLSWFCGNRLPANRRFQITWFVSWNPCLPCVVKVTKFL
70 80 90 100 110 120
110 120 130 140 150
pF1KE2 SEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYE-----------------
.::::::::::::::::: .::.: .: :: .:::::::::::
XP_016 AEHPNVTLTISAARLYYYRDRDWRWVLLRLHKAGARVKIMDYEGERCRGQGSMTGRNSLR
130 140 150 160 170 180
pF1KE2 ----------------------------------------------------EFAYCWEN
.:::::::
XP_016 DGWICNAMAGGVPGQPAGVGLALIATDSQETRPGRAGPGSGESLSASHLFISDFAYCWEN
190 200 210 220 230 240
160 170 180 190 200 210
pF1KE2 FVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRP
:: :::: ::::::::.::: ::::::::
XP_016 FVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESWL
250 260 270 280 290 300
>--
initn: 1159 init1: 675 opt: 677 Z-score: 830.3 bits: 162.0 E(92054): 1.8e-39
Smith-Waterman score: 677; 47.8% identity (74.7% similar) in 186 aa overlap (5-190:270-455)
10 20 30
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTW
.::::: :: :: .:.: ::. .:
XP_016 NFVCNEGQPFMPWYKFDDNYASLHRTLKEILRNPMEAMYPHIFYFHFKNLLKACGRNESW
240 250 260 270 280 290
40 50 60 70 80 90
pF1KE2 LCYEVKIKRGRSNLLWDTGVFRGQVYFEPQYHAEMCFLSWFCGNQLPAYKCFQITWFVSW
::. ... . .: .. ::::.:: : . ::: ::::::: . : ...::..::
XP_016 LCFTMEVTKHHSAVFRKRGVFRNQVDPETHCHAERCFLSWFCDDILSPNTNYEVTWYTSW
300 310 320 330 340 350
100 110 120 130 140 150
pF1KE2 TPCPDCVAKLAEFLSEHPNVTLTISAARLYYYWERDYRRALCRLSQAGARVKIMDYEEFA
.:::.:....::::..: ::.::: .::: :.:. ::...:: ::: :: :::: :..:.
XP_016 SPCPECAGEVAEFLARHSNVNLTIFTARLCYFWDTDYQEGLCSLSQEGASVKIMGYKDFV
360 370 380 390 400 410
160 170 180 190 200 210
pF1KE2 YCWENFVYNEGQQFMPWYKFDENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLC
::.::::.. . : :: .. :. .:.: :.:::.
XP_016 SCWKNFVYSDDEPFKPWKGLQTNFRLLKRRLREILQ
420 430 440 450
220 230 240 250
pF1KE2 SWTRPRSTGSLGSSPGAPASPGAVPGKCVRSFRRTHT
>>NP_001336367 (OMIM: 607113) DNA dC->dU-editing enzyme (194 aa)
initn: 511 init1: 355 opt: 652 Z-score: 804.4 bits: 156.0 E(92054): 4.9e-38
Smith-Waterman score: 652; 50.3% identity (70.8% similar) in 195 aa overlap (1-190:1-194)
10 20 30 40 50 60
pF1KE2 MNPQIRNPMERMYRDTFYDNFENEPILYGRSYTWLCYEVKIKRGRSNLLWDTGVFRGQVY
:.:..:: .:::::::: :: :.::: :. .::::::: : : : :. .::::::
NP_001 MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTK-GPSRPPLDAKIFRGQVY
10 20 30 40 50
70 80 90 100 110
pF1KE2 FEPQYHAEMCFLSWFCG-NQLPAYKCFQITWFVSWTPCPDCVAKLAEFLSEHPNVTLTIS
: .:: :: :. :: .: . ...::..::.:: :. .: ::.: :.:::::
NP_001 SELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIF
60 70 80 90 100 110
120 130 140 150 160 170
pF1KE2 AARLYYYWERDYRRALCRLSQA--GAR--VKIMDYEEFAYCWENFVYNEGQQFMPWYKFD
.:::::.:. ::..:: : : : : .:::.:.:: .:: .:::.. . : :: ..
NP_001 VARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLP
120 130 140 150 160 170
180 190 200 210 220 230
pF1KE2 ENYAFLHRTLKEILRLRIFSVAFTAAMRSCASWTWFLLCSWTRPRSTGSLGSSPGAPASP
. : .:: : ::::
NP_001 KYYILLHIMLGEILR
180 190
251 residues in 1 query sequences
64236559 residues in 92054 library sequences
Tcomplib [36.3.4 Apr, 2011] (8 proc)
start: Thu Aug 1 17:04:06 2019 done: Thu Aug 1 17:04:06 2019
Total Scan time: 3.120 Total Display time: 0.030
Function used was FASTA [36.3.4 Apr, 2011]